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1. 发明申请

WO2009042871A1 POLYPEPTIDES HAVING CELLOBIOHYDROLASE II ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：具有环糊精II活性的多肽和编码其的多核苷酸
公开(公告)号：WO2009042871A1
公开(公告)日：2009-04-02
申请号：PCT/US2008/077864
申请日：2008-09-26
申请人： NOVOZYMES A/S , MAIYURAN, Suchindra , HARRIS, Paul , DING, Hanshu , BROWN, Kimberly
发明人： MAIYURAN, Suchindra , HARRIS, Paul , DING, Hanshu , BROWN, Kimberly
IPC分类号： C12N9/42 , C11D3/386 , C12N15/56 , C12N5/10
CPC分类号： C12N9/2437 , C11D3/38645 , C12Y302/01091
摘要： The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
摘要翻译：本发明涉及具有纤维二糖水解酶活性的分离的多肽和编码多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

2. 发明申请

WO2009085859A3 POLYPEPTIDES HAVING CELLULOLYTIC ENHANCING ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
公开(公告)号：WO2009085859A3
公开(公告)日：2009-07-09
申请号：PCT/US2008/087231
申请日：2008-12-17
申请人： HARRIS, Paul , MAIYURAN, Suchindra , BROWN, Kimberly , NOVOZYMES A/S
发明人： HARRIS, Paul , MAIYURAN, Suchindra , BROWN, Kimberly
IPC分类号： C07K14/39 , C12N9/42
摘要： The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

3. 发明申请

WO2009085868A1 POLYPEPTIDES HAVING CELLULOLYTIC ENHANCING ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
公开(公告)号：WO2009085868A1
公开(公告)日：2009-07-09
申请号：PCT/US2008/087273
申请日：2008-12-17
申请人： NOVOZYMES A/S , HARRIS, Paul , MAIYURAN, Suchindra , BROWN, Kimberly
发明人： HARRIS, Paul , MAIYURAN, Suchindra , BROWN, Kimberly
IPC分类号： C07K14/37 , C12N9/42 , C12N15/74 , C11D3/386
CPC分类号： C12N9/2434 , C07K14/37 , C11D3/38645
摘要： The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

4. 发明申请

WO2009085864A2 POLYPEPTIDES HAVING CELLULOLYTIC ENHANCING ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：具有纤维增强活性的多肽和编码其的多核苷酸
公开(公告)号：WO2009085864A2
公开(公告)日：2009-07-09
申请号：PCT/US2008/087258
申请日：2008-12-17
申请人： NOVOZYMES A/S , HARRIS, Paul , MAIYURAN, Suchindra , BROWN, Kimberly
发明人： HARRIS, Paul , MAIYURAN, Suchindra , BROWN, Kimberly
IPC分类号： C07K14/39 , C12N9/42
CPC分类号： C12N9/2434 , C07K14/37 , C12P19/14
摘要： The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
摘要翻译：本发明涉及具有纤维素分解增强活性的分离的多肽和编码多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

5. 发明申请

WO2009085935A2 POLYPEPTIDES HAVING CELLULOLYTIC ENHANCING ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
公开(公告)号：WO2009085935A2
公开(公告)日：2009-07-09
申请号：PCT/US2008/087402
申请日：2008-12-18
申请人： NOVOZYMES A/S , HARRIS, Paul , MAIYURAN, Suchindra , BROWN, Kimberly
发明人： HARRIS, Paul , MAIYURAN, Suchindra , BROWN, Kimberly
IPC分类号： C12N9/24 , C12N9/42 , C12N15/56 , C12N1/15 , C12N1/21 , C12N5/10 , C12S3/02 , C12P19/14
CPC分类号： C12N9/2437 , C12N9/2434 , C12P19/14 , C12Y302/01004 , C12Y302/01021 , C12Y302/01091
摘要： The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

6. 发明申请

WO2015081139A1 ENZYME COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：酶组成及其用途
公开(公告)号：WO2015081139A1
公开(公告)日：2015-06-04
申请号：PCT/US2014/067503
申请日：2014-11-25
申请人： NOVOZYMES A/S , HARRIS, Paul , MAIYURAN, Suchindra , MCBRAYER, Brett , MUZZI-ERICHSEN, Gloria
发明人： HARRIS, Paul , MAIYURAN, Suchindra , MCBRAYER, Brett , MUZZI-ERICHSEN, Gloria
IPC分类号： C12N9/24 , C12N9/42 , C12P19/14
CPC分类号： C12P19/14 , C12N9/2402 , C12N9/2437 , C12N9/2445 , C12N9/248 , C12N9/2482 , C12P19/02 , C12P21/02 , C12P2203/00 , C12Y302/01004 , C12Y302/01008 , C12Y302/01021 , C12Y302/01037 , C12Y302/01091
摘要： The present invention relates to enzyme compositions and methods of producing and using the compositions for the saccharification of lignocellulosic material.
摘要翻译：本发明涉及酶组合物和制备和使用用于木质纤维素材料糖化的组合物的方法。

7. 发明申请

WO2020112911A1 IMPROVED FILAMENTOUS FUNGAL HOST CELLS 审中-公开
公开(公告)号：WO2020112911A1
公开(公告)日：2020-06-04
申请号：PCT/US2019/063459
申请日：2019-11-26
申请人： NOVOZYMES A/S , MAIYURAN, Suchindra
发明人： MAIYURAN, Suchindra , MCFARLAND, Sarah
IPC分类号： C07K14/37 , C12N15/80
摘要： The present invention relates to an isolated variant Ire1 polypeptide, comprising (a) an amino acid substitution at position 153 of the Trichoderma reesei Ire1 polypeptide of SEQ ID NO: 2; or (b) an amino acid substitution at a position corresponding to position 153 of the Trichoderma reesei Ire1 of SEQ ID NO: 2 and has at least 70%, but less than 100%, sequence identity to the amino acid sequence of SEQ ID NO: 2. The present invention also relates to a recombinant filamentous fungal host cell comprising the mutated ire1 gene encoding the variant Ire1 polypeptide for producing a secreted heterologous polypeptide of interest, a method for producing the secreted heterologous polypeptide of interest in the recombinant filamentous fungal host cell, and a method of improving the productivity or yield of the secreted heterologous polypeptide of interest in the recombinant filamentous fungal host cell.

8. 发明申请

WO2020123845A1 METHODS FOR INCREASING THE PRODUCTIVITY OF A FILAMENTOUS FUNGAL CELL IN THE PRODUCTION OF A POLYPEPTIDE 审中-公开
公开(公告)号：WO2020123845A1
公开(公告)日：2020-06-18
申请号：PCT/US2019/066046
申请日：2019-12-12
申请人： NOVOZYMES A/S , MAIYURAN, Suchindra
发明人： MAIYURAN, Suchindra , LOPEZ DE LEON, Alfredo , SHASKY, Jeffrey
IPC分类号： C12N15/80 , C07K14/37
摘要： The present invention relates to a mutant of a parent filamentous fungal cell, comprising a coding sequence of a polypeptide of interest under the transcriptional control of a promoter regulated by a transcription factor, wherein the gene encoding the transcription factor is modified in the parent filamentous fungal cell to produce the mutant rendering the mutant deficient in the production of the transcription factor, which increases the productivity of the mutant in the production of the polypeptide of interest, and/or reduces or eliminates the cellulase-negative phenotype in the resulting mutant. The present invention also relates to a method for constructing such a mutant and a method of producing a polypeptide of interest with such a mutant.

9. 发明申请

WO2011075677A2 METHODS FOR PRODUCING POLYPEPTIDES IN PROTEASE-DEFICIENT MUTANTS OF TRICHODERMA 审中-公开
标题翻译：用于在TRICHODERMA的蛋白酶缺陷型突变体中生产多肽的方法
公开(公告)号：WO2011075677A2
公开(公告)日：2011-06-23
申请号：PCT/US2010/061105
申请日：2010-12-17
申请人： NOVOZYMES, INC. , MAIYURAN, Suchindra , JANG, Abigall , BROWN, Kimberly , MERINO, Sandra , SHASKY, Jeffrey , ABBATE, Eric
发明人： MAIYURAN, Suchindra , JANG, Abigall , BROWN, Kimberly , MERINO, Sandra , SHASKY, Jeffrey , ABBATE, Eric
IPC分类号： C12N1/14 , C12N9/58 , C12N15/57 , C12N15/80 , C12P21/02
CPC分类号： C12P21/00 , C12N9/58 , C12N15/80 , C12P21/02
摘要： The present invention relates to mutants of a parent Trichoderma strain, comprising a polynucleotide encoding a polypeptide and one or more (several) genes selected from the group consisting of a first subtilisin-like serine protease gene, a first aspartic protease gene, a trypsin-like serine protease gene, a second subtilisin-like serine protease gene, and a second aspartic protease gene, wherein the one or more (several) genes are modified rendering the mutant strain deficient in the production of one or more (several) enzymes selected from the group consisting of a first subtilisin-like serine protease, a first aspartic protease, a trypsin-like serine protease, a second subtilisin-like serine protease, and a second aspartic protease, respectively, compared to the parent Trichoderma strain when cultivated under identical conditions. The present invention also relates to methods of producing a polypeptide in such mutants and methods for producing such mutants.
摘要翻译：本发明涉及亲本木霉属菌株的突变体，其包含编码多肽的多核苷酸和选自以下的一种或多种（几种）基因：第一枯草杆菌蛋白酶 - 丝氨酸蛋白酶基因，第一天冬氨酸蛋白酶基因，胰蛋白酶样丝氨酸蛋白酶基因，第二枯草杆菌蛋白酶样丝氨酸蛋白酶基因和第二天冬氨酸蛋白酶基因，其中所述一个或多个（几个）基因被修饰使得所述突变体选自第一枯草杆菌蛋白酶样丝氨酸蛋白酶，第一天冬氨酸蛋白酶，胰蛋白酶样丝氨酸蛋白酶，第二枯草杆菌蛋白酶样丝氨酸蛋白酶和第二枯草杆菌蛋白酶样丝氨酸蛋白酶的一种或多种（几种）酶产生缺陷的菌株当在相同条件下培养时，与亲本木霉属菌株相比，它们分别与天冬氨酸蛋白酶相比。本发明还涉及在这种突变体中生产多肽的方法和生产这种突变体的方法。

10. 发明申请

WO2011035027A2 POLYPEPTIDES HAVING CELLULOLYTIC ENHANCING ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：具有纤维素分解增强活性的多肽和编码该多肽的多核苷酸
公开(公告)号：WO2011035027A2
公开(公告)日：2011-03-24
申请号：PCT/US2010/049124
申请日：2010-09-16
申请人： NOVOZYMES, INC. , MAIYURAN, Suchindra , KRAMER, Randall , HARRIS, Paul
发明人： MAIYURAN, Suchindra , KRAMER, Randall , HARRIS, Paul
IPC分类号： C12N9/42
CPC分类号： C12N9/2437 , C11D3/386 , C11D3/38645 , C11D3/3869 , C12P19/02 , C12P19/14 , C12Y302/01 , Y02E50/16
摘要： The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
摘要翻译：本发明涉及具有纤维素分解增强活性的分离的多肽和编码所述多肽的分离的多核苷酸。本发明还涉及包含所述多核苷酸的核酸构建体，载体和宿主细胞以及生产和使用所述多肽的方法。

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