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1. 发明申请

WO2011122921A2 AN INSULIN CONJUGATE USING AN IMMUNOGLOBULIN FRAGMENT 审中-公开
标题翻译：胰岛素联合使用免疫球蛋白片段
公开(公告)号：WO2011122921A2
公开(公告)日：2011-10-06
申请号：PCT/KR2011/002331
申请日：2011-04-04
申请人： HANMI HOLDINGS CO., LTD. , SONG, Dae Hae , SHIN, Jae Hee , PARK, Young Jin , IM, Dae Seong , BAE, Sung Min , KWON, Se Chang
发明人： SONG, Dae Hae , SHIN, Jae Hee , PARK, Young Jin , IM, Dae Seong , BAE, Sung Min , KWON, Se Chang
IPC分类号： A61K38/28 , A61K9/20 , A61K47/40 , A61K47/34
CPC分类号： A61K38/28 , A61K47/68 , A61K47/6883 , C07K14/62 , C07K2319/30
摘要： The present invention relates to an insulin conjugate having improved in vivo duration and stability, which is prepared by covalently linking insulin with an immunoglobulin Fc region via a non-peptidyl polymer, a long-acting formulation comprising the same, and a preparation method thereof. The insulin conjugate of the present invention maintains in vivo activity of the peptide at a relatively high level and remarkably increases the serum half-life thereof, thereby greatly improving drug compliance upon insulin treatment.
摘要翻译：本发明涉及具有改善的体内持续时间和稳定性的胰岛素缀合物，其通过非肽基聚合物共价连接胰岛素与免疫球蛋白Fc区，包含其的长效制剂及其制备方法制备。本发明的胰岛素结合物以较高水平保持肽的体内活性，并显着增加血清的半衰期，从而大大提高了胰岛素治疗后的药物依从性。

2. 发明申请

WO2010011096A2 A POLYPEPTIDE COMPLEX COMPRISING NON-PEPTIDYL POLYMER HAVING THREE FUNCTIONAL ENDS 审中-公开
标题翻译：包含具有三个功能末端的非肽聚合物的多肽复合物
公开(公告)号：WO2010011096A2
公开(公告)日：2010-01-28
申请号：PCT/KR2009/004114
申请日：2009-07-23
申请人： HANMI PHARMACEUTICAL CO., LTD. , SONG, Dae Hae , SHIN, Jae Hee , LEE, Mi Ji , HONG, Sung Hee , KWON, Se Chang , LEE, Gwan Sun
发明人： SONG, Dae Hae , SHIN, Jae Hee , LEE, Mi Ji , HONG, Sung Hee , KWON, Se Chang , LEE, Gwan Sun
IPC分类号： C07K19/00
CPC分类号： A61K47/48715 , A61K47/60 , A61K47/6811 , A61K47/6889 , C07K14/59 , C07K19/00 , C07K2319/31
摘要： Disclosed is a protein complex, comprising a physiologically active polypeptide, a dimeric protein and a non-peptidyl polymer having three functional ends(3-arm), with the linkage of both the physiologically active polypeptide and the dimeric protein to the 3-arm non-peptidyl polymer via respective covalent bonds. The protein complex guarantees the long acting activity and biostability of a physiologically active polypeptide. Having the ability to maintain the bioactivity of physiologically active polypeptides or peptides highly and to significantly improve the serum half life of the polypeptides or peptides, the protein complex can be applied to the development of sustained release formulations of various physiologically active polypeptide drugs. Also, it utilizes raw materials including the physiologically active polypeptides without significant loss, thereby increasing the production yield. Further, it can be easily purified.
摘要翻译：公开了一种蛋白质复合物，其包含生理活性多肽，二聚体蛋白质和具有三个功能末端（3-臂）的非肽基聚合物，其具有生理活性多肽和二聚体蛋白质与3-臂非 - - 肽基聚合物。蛋白质复合物保证生理活性多肽的长效和生物稳定性。具有维持生理活性多肽或肽的生物活性以及显着改善多肽或肽的血清半衰期的能力，蛋白质复合物可用于开发各种生理活性多肽药物的持续释放制剂。此外，它利用包括生理活性多肽的原料，而不会显着损失，从而提高产量。此外，它可以容易地纯化。

3. 发明申请

WO2010107256A2 METHOD FOR PREPARING A SITE-SPECIFIC PHYSIOLOGICALLY ACTIVE POLYPEPTIDE CONJUGATE 审中-公开
标题翻译：制备特异性生理活性多肽的方法
公开(公告)号：WO2010107256A2
公开(公告)日：2010-09-23
申请号：PCT/KR2010/001674
申请日：2010-03-18
申请人： HANMI PHARM. CO., LTD. , SONG, Dae Hae , SHIN, Jae Hee , LEE, Jae Min , PARK, Young Kyung , KWON, Se Chang , LEE, Gwan Sun
发明人： SONG, Dae Hae , SHIN, Jae Hee , LEE, Jae Min , PARK, Young Kyung , KWON, Se Chang , LEE, Gwan Sun
IPC分类号： C07K1/14 , C07K1/10 , C07K1/18
CPC分类号： C07K1/1077 , A61K47/60 , C07K14/575 , C07K14/605 , C07K14/62
摘要： The present invention provides a method for preparing a site-specific physiologically active polypeptide conjugate in a high yield by treating a physiologically active polypeptide with a non-peptidyl polymer in the presence of an alcohol at a specific pH, which can be desirably employed in the development of long acting formulations of various peptide drugs having high in-vivo activity and markedly prolonged in-blood half-life.
摘要翻译：本发明提供了一种通过在特定pH下在醇的存在下用非肽基聚合物处理生理活性多肽而以高产率制备位点特异性生理活性多肽缀合物的方法，其可以理想地用于开发具有高体内活性和明显延长的血液半衰期的各种肽药物的长效制剂。

4. 发明申请

WO2008082221A1 DEVICE FOR GENERATING ELECTRICITY USING BUOYANCY 审中-公开
标题翻译：使用BUOYANCY生成电力的装置
公开(公告)号：WO2008082221A1
公开(公告)日：2008-07-10
申请号：PCT/KR2007/006991
申请日：2007-12-28
申请人： SHIN, Jae Hee
发明人： SHIN, Jae Hee
IPC分类号： H02K57/00
CPC分类号： H02K53/00 , F03B17/02 , H02K7/1823 , Y02E10/20
摘要： The present invention relates to an electricity generation device using buoyancy of liquid. A discharging means for flowing a portion of liquid is disposed near a bottom of a tank containing the liquid. Liquid discharged from the discharging means passes through a bubble generating pipe. An air supplying outlet of an air supplying pipe is disposed in the bubble generating pipe. The air supplied from the air supplying outlet is sucked into the liquid discharged from the discharging means to generate bubbles. A motion converting means collects the discharged bubbles and converts a rise motion caused by the buoyancy of the collected bubbles into a rotary motion. A generator generates the electricity from the rotary motion caused by the motion converting means. Since air of an atmospheric pressure can be easily supplied into deeper water, the buoyancy is optimally used and the power generation efficiency becomes high.
摘要翻译：本发明涉及使用液体浮力的发电装置。用于使一部分液体流动的排出装置设置在容纳液体的罐的底部附近。从排出装置排出的液体通过发泡管。空气供给管的供气口设置在发泡管中。从供气出口供给的空气被吸入从排出装置排出的液体中，产生气泡。运动转换装置收集排出的气泡并将由收集的气泡的浮力引起的上升运动转换成旋转运动。发电机由运动转换装置产生的旋转运动产生电力。由于大气压的空气能够容易地供给到较深的水中，所以优选使用浮力，发电效率变高。

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