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1. 发明申请

WO2012169798A3 NOVEL OXYNTOMODULIN DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR TREATING OBESITY COMPRISING THE SAME 审中-公开
标题翻译：用于治疗包含其的肥胖症的新型氧化色氨酸衍生物和药物组合物
公开(公告)号：WO2012169798A3
公开(公告)日：2013-02-14
申请号：PCT/KR2012004494
申请日：2012-06-07
申请人： HANMI SCIENCE CO LTD , JUNG SUNG YOUB , JANG MYUNG HYUN , SHEN LING AI , PARK YOUNG KYUNG , PARK YOUNG JIN , KWON SE CHANG
发明人： JUNG SUNG YOUB , JANG MYUNG HYUN , SHEN LING AI , PARK YOUNG KYUNG , PARK YOUNG JIN , KWON SE CHANG
IPC分类号： C07K14/605 , A61K38/26 , A61P3/04
CPC分类号： C07K14/605 , A61K38/00 , A61K38/177 , A61K38/22 , A61K38/26 , A61K45/06 , C07K14/575 , C07K14/705
摘要： The present invention relates to a novel peptide showing more excellent activities on a glucagon like peptide-1 receptor and a glucagon receptor than native oxyntomodulin, and a composition for the prevention or treatment of obesity comprising the peptide as an active ingredient. Unlike native oxyntomodulin, the novel peptide of the present invention reduces food intake, suppresses gastric emptying, and facilitates lipolysis with reduced side-effects, and also shows excellent receptor-activating effects. Thus, it can be widely used in the treatment of obesity with safety and efficacy.
摘要翻译：本发明涉及一种与天然胃泌酸调节素相比，胰高血糖素样肽-1受体和胰高血糖素受体的活性更优异的新型肽，以及用于预防或治疗包含该肽作为活性成分的肥胖症的组合物。与本发明的胃泌酸调节蛋白不同，本发明的新型肽减少食物摄入，抑制胃排空，促进脂肪分解，副作用降低，并且还显示出优异的受体激活作用。因此，可广泛用于治疗肥胖症的安全性和有效性。

2. 发明申请

WO2011142600A3 PHOTORESIST STRIPPER COMPOSITION 审中-公开
标题翻译：光电剥离组合物
公开(公告)号：WO2011142600A3
公开(公告)日：2012-03-15
申请号：PCT/KR2011003501
申请日：2011-05-12
申请人： ENF TECHNOLOGY CO LTD , PARK YOUNG JIN , HAN DOO SEOK , LEE SANG DAI , SHIN HYOSEOP
发明人： PARK YOUNG JIN , HAN DOO SEOK , LEE SANG DAI , SHIN HYOSEOP
IPC分类号： G03F7/42
CPC分类号： G03F7/425 , G03F7/426
摘要： A photoresist stripper composition comprising 0.5 to 5 % by weight of alkyl ammonium hydroxide; 60 to 90 % by weight of aprotic polar solvent; 0.1 to 3 % by weight of aromatic polyhydric alcohol; 0.1 to 5 % by weight of linear polyhydric alcohol; and 5 to 30 % by weight of water has an excellent capacity for stripping a positive and a negative photoresists, and dose not corrode a metal wiring under the photoresist.
摘要翻译：一种光致抗蚀剂剥离剂组合物，其包含0.5-5重量％的烷基氢氧化铵; 60〜90重量％的非质子极性溶剂; 0.1〜3重量％的芳族多元醇; 0.1〜5重量％的线性多元醇; 和5至30重量％的水具有优异的剥离正极和负极光致抗蚀剂的能力，并且不会腐蚀光刻胶下的金属布线。

3. 发明申请

WO2011142600A2 PHOTORESIST STRIPPER COMPOSITION 审中-公开
标题翻译：光电剥离组合物
公开(公告)号：WO2011142600A2
公开(公告)日：2011-11-17
申请号：PCT/KR2011/003501
申请日：2011-05-12
申请人： ENF TECHNOLOGY CO., LTD. , PARK, Young Jin , HAN, Doo Seok , LEE, Sang Dai , SHIN, Hyoseop
发明人： PARK, Young Jin , HAN, Doo Seok , LEE, Sang Dai , SHIN, Hyoseop
IPC分类号： G03F7/42
CPC分类号： G03F7/425 , G03F7/426
摘要： A photoresist stripper composition comprising 0.5 to 5 % by weight of alkyl ammonium hydroxide; 60 to 90 % by weight of aprotic polar solvent; 0.1 to 3 % by weight of aromatic polyhydric alcohol; 0.1 to 5 % by weight of linear polyhydric alcohol; and 5 to 30 % by weight of water has an excellent capacity for stripping a positive and a negative photoresists, and dose not corrode a metal wiring under the photoresist.
摘要翻译：一种光致抗蚀剂剥离剂组合物，其包含0.5-5重量％的烷基氢氧化铵; 60〜90重量％的非质子极性溶剂; 0.1〜3重量％的芳族多元醇; 0.1〜5重量％的线性多元醇; 和5至30重量％的水具有优异的剥离正极和负极光致抗蚀剂的能力，并且不会腐蚀光刻胶下的金属布线。

4. 发明申请

WO2009069983A2 A PHARMACEUTICAL COMPOSITION FOR TREATING OBESITY-RELATED DISEASE COMPRISING INSULINOTROPIC PEPTIDE CONJUGATE 审中-公开
标题翻译：一种治疗与肥胖有关的疾病的药物组合物，其包含胰岛素肽递药共轭物
公开(公告)号：WO2009069983A2
公开(公告)日：2009-06-04
申请号：PCT/KR2008007074
申请日：2008-11-28
申请人： HANMI PHARMACEUTICAL CO LTD , SONG DAE HAE , KIM MIN YOUNG , PARK YOUNG JIN , KANG EUN HEE , JUNG SUNG YOUB , KWON SE CHANG , LEE GWAN SUN
发明人： SONG DAE HAE , KIM MIN YOUNG , PARK YOUNG JIN , KANG EUN HEE , JUNG SUNG YOUB , KWON SE CHANG , LEE GWAN SUN
IPC分类号： A61K38/16 , A61K39/39 , A61P3/04
CPC分类号： A61K38/26 , A61K31/137 , A61K38/22 , A61K38/2207 , A61K47/6811 , A61K47/6835 , A61K47/6889 , A61K2300/00
摘要： The present invention relates to a composition for treating obesity-related diseases comprising an insulinotropic peptide conjugate, more particularly, to a composition for treating obesity-related diseases comprising a conjugate prepared by covalently linking the insulinotropic peptide with a carrier substance via a non-peptidyl linker, and a method for treating obesity-related diseases by using the same. In particular, the composition for treating obesity-related diseases according to the present invention remarkably improves the efficacy of suppressing food intake and its duration to reduce body weight and body fat, thereby being useful for the treatment of obesity-related diseases.
摘要翻译：本发明涉及包含促胰岛素肽缀合物的用于治疗肥胖症相关疾病的组合物，更具体地涉及用于治疗肥胖症相关疾病的组合物，所述组合物包含通过非肽化合物将促胰岛素肽与载体物质共价连接而制备的缀合物接头，以及使用该接头治疗肥胖症相关疾病的方法。特别是，根据本发明的用于治疗肥胖相关疾病的组合物显着改善了抑制食物摄取的效力和减少体重和体脂肪的持续时间，由此可用于治疗肥胖相关疾病。

5. 发明申请

WO2012165915A3 COMPOSITION FOR TREATING DIABETES COMPRISING LONG-ACTING INSULIN CONJUGATE AND LONG-ACTING INSULINOTROPIC PEPTIDE CONJUGATE 审中-公开
公开(公告)号：WO2012165915A3
公开(公告)日：2012-12-06
申请号：PCT/KR2012/004367
申请日：2012-06-01
申请人： HANMI SCIENCE CO., LTD. , WOO, Young Eun , JANG, Myung Hyun , PARK, Young Jin , PARK, Young Kyung , LIM, Chang Ki , KWON, Se Chang
发明人： WOO, Young Eun , JANG, Myung Hyun , PARK, Young Jin , PARK, Young Kyung , LIM, Chang Ki , KWON, Se Chang
IPC分类号： A61K47/48 , A61K38/28 , A61K47/30 , A61P3/10
摘要： The present invention relates to a composition for the prevention or treatment of diabetes comprising a long-acting insulin conjugate and a long-acting insulinotropic peptide conjugate, and a therapeutic method for the treatment of diabetes, and more particularly, concurrent administration of the long-acting insulin conjugate and the long-acting insulinotropic peptide conjugate inhibits weight gain caused by insulin treatment, and vomiting and nausea caused by insulinotropic peptide treatment, and reduces the required dose of insulin, thereby remarkably improving drug compliance. Moreover, each of the long-acting insulin conjugate and the long-acting insulinotropic peptide conjugate of the present invention is prepared by linking insulin or insulinotropic peptide with an immunoglobulin Fc region via a non-peptidyl linker, thereby showing improved in-vivo duration of efficacy and stability.

6. 发明申请

WO2011122921A2 AN INSULIN CONJUGATE USING AN IMMUNOGLOBULIN FRAGMENT 审中-公开
标题翻译：胰岛素联合使用免疫球蛋白片段
公开(公告)号：WO2011122921A2
公开(公告)日：2011-10-06
申请号：PCT/KR2011/002331
申请日：2011-04-04
申请人： HANMI HOLDINGS CO., LTD. , SONG, Dae Hae , SHIN, Jae Hee , PARK, Young Jin , IM, Dae Seong , BAE, Sung Min , KWON, Se Chang
发明人： SONG, Dae Hae , SHIN, Jae Hee , PARK, Young Jin , IM, Dae Seong , BAE, Sung Min , KWON, Se Chang
IPC分类号： A61K38/28 , A61K9/20 , A61K47/40 , A61K47/34
CPC分类号： A61K38/28 , A61K47/68 , A61K47/6883 , C07K14/62 , C07K2319/30
摘要： The present invention relates to an insulin conjugate having improved in vivo duration and stability, which is prepared by covalently linking insulin with an immunoglobulin Fc region via a non-peptidyl polymer, a long-acting formulation comprising the same, and a preparation method thereof. The insulin conjugate of the present invention maintains in vivo activity of the peptide at a relatively high level and remarkably increases the serum half-life thereof, thereby greatly improving drug compliance upon insulin treatment.
摘要翻译：本发明涉及具有改善的体内持续时间和稳定性的胰岛素缀合物，其通过非肽基聚合物共价连接胰岛素与免疫球蛋白Fc区，包含其的长效制剂及其制备方法制备。本发明的胰岛素结合物以较高水平保持肽的体内活性，并显着增加血清的半衰期，从而大大提高了胰岛素治疗后的药物依从性。

7. 发明申请

WO2011087284A2 FOLDABLE MASSAGE CHAIR BED 审中-公开
标题翻译：可折叠按摩椅
公开(公告)号：WO2011087284A2
公开(公告)日：2011-07-21
申请号：PCT/KR2011000230
申请日：2011-01-12
申请人： PARK YOUNG JIN
发明人： PARK YOUNG JIN
CPC分类号： A47C9/005 , A61G13/009 , A61G13/105 , A61G13/1245
摘要： The present invention relates to a foldable structure of a massage chair that can also be used as a bed, and provides a foldable massage chair bed wherein the massage chair can be converted into a bed by adjustment of the angle of a chest rest thereof, and a user can thus get a massage in a lying down position, and which can be fully folded, while maintaining the stable fixation and assembly between frames when unfoloded. When the invention is used as a massage chair, a chest rest (40) is pulled upwards around a chest rest fixing part (10) and an arm rest (45) is spread out horizontally; when the invention is used as a massage bed, the chest rest (40) is laid flat horizontally and the arm rest (45) is connected horizontally to the chest rest (40), around an arm rest fixing part (30). In addition, a knee rest (60) is separated from a knee rest support link (65) and is folded at a level with a rear frame (70) when a front frame (50) and the rear frame (70) are folded around a frame connection part (15). When the front frame (50) and the rear frame (70) are unfolded, the knee rest support link (65) and the knee rest (60) are in line with each other, thereby forming a triangular support for the front frame (50) and the rear frame (70) for use as the knee rest (60).
摘要翻译：本发明涉及一种也可以用作床的按摩椅的可折叠结构，并且提供了可折叠的按摩椅床，其中按摩椅可以通过调节其胸部的角度而转换成床，以及因此，用户可以在躺下的位置获得按摩，并且可以完全折叠，同时在未被打开时保持框架之间的稳定的固定和组装。当本发明用作按摩椅时，胸围（40）被围绕胸部固定部分（10）向上拉，扶手（45）水平地展开; 当本发明用作按摩床时，胸部搁板（40）水平放置，并且扶手（45）围绕扶手固定部分（30）水平地连接到胸部支架（40）。此外，当将前框架（50）和后框架（70）折叠在一起时，膝盖托架（60）与膝盖支撑连杆（65）分离，并且与后框架（70）的水平面折叠框架连接部分（15）。当前框架（50）和后框架（70）展开时，膝盖支撑连杆（65）和膝盖座（60）彼此成直线，从而形成用于前框架（50）的三角形支撑件）和用于膝盖（60）的后框架（70）。

8. 发明申请

WO2007027523A2 VIDEO RELAY SYSTEM AND METHOD 审中-公开
标题翻译：视频继电器系统及方法
公开(公告)号：WO2007027523A2
公开(公告)日：2007-03-08
申请号：PCT/US2006033245
申请日：2006-08-25
申请人： HAMILTON RELAY INC , PARK YOUNG JIN , HAHN WAYNE , STEPHENS GREGORY
发明人： PARK YOUNG JIN , HAHN WAYNE , STEPHENS GREGORY
IPC分类号： H04N7/14
CPC分类号： H04N7/147
摘要： A video relay system for allowing impaired individuals to communicate across a network includes a first device capable of sending and receiving audio and video signals where the first device is coupled to a network and includes an application. The application on the first device is configured to communicate with a second device, regardless of whether the second device includes the application. The application is also configured to transmit to and receive from the second device a sign language video signal. When the first device is in a voice carryover mode, the application is configured to transmit an audio signal to the second device. When the first device is in a hearing carryover mode, the application is configured to receive an audio signal from the second device.
摘要翻译：允许受损个体通过网络通信的视频中继系统包括能够发送和接收音频和视频信号的第一设备，其中第一设备耦合到网络并且包括应用。第一设备上的应用被配置为与第二设备通信，而不管第二设备是否包括应用。该应用还被配置为向第二设备发送和接收手语视频信号。当第一设备处于语音转移模式时，应用被配置为将音频信号发送到第二设备。当第一设备处于听力传送模式时，应用被配置为从第二设备接收音频信号。

9. 发明申请

WO2005047335A1 METHOD FOR THEMASS PRODUCTION OF IMMUNOGLOBULIN CONSTANT REGION 审中-公开
标题翻译：大量生产免疫球蛋白恒定区的方法
公开(公告)号：WO2005047335A1
公开(公告)日：2005-05-26
申请号：PCT/KR2004/002943
申请日：2004-11-13
申请人： HANMI PHARM. IND. CO., LTD. , JUNG, Sung, Youb , KIM, Jin, Sun , PARK, Young, Jin , CHOI, Ki-Doo , KWON, Se, Chang , LEE, Gwan, Sun
发明人： JUNG, Sung, Youb , KIM, Jin, Sun , PARK, Young, Jin , CHOI, Ki-Doo , KWON, Se, Chang , LEE, Gwan, Sun
IPC分类号： C07K19/00
CPC分类号： A61K47/68 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/505 , C07K14/535 , C07K14/56 , C07K14/61 , C07K16/46 , C07K19/00 , C07K2317/52 , C07K2317/732 , C07K2317/734 , C07K2319/30
摘要： Disclosed are a recombinant expression vector comprising a nucleotide sequence encoding an E. coli -derived signal sequence and a nucleotide sequence encoding an immunoglobulin constant region, and a transformant transformed with the expression vector. Also, disclosed is a method of mass-producing an immunoglobulin constant region by culturing the transformant and expressing the immunoglobulin constant region in a water-soluble form.
摘要翻译：公开了包含编码大肠杆菌来源的信号序列的核苷酸序列和编码免疫球蛋白恒定区的核苷酸序列的重组表达载体和用表达载体转化的转化体。此外，公开了通过培养转化体并以水溶性形式表达免疫球蛋白恒定区来大规模生产免疫球蛋白恒定区的方法。

10. 发明申请

WO2012165915A2 COMPOSITION FOR TREATING DIABETES COMPRISING LONG-ACTING INSULIN CONJUGATE AND LONG-ACTING INSULINOTROPIC PEPTIDE CONJUGATE 审中-公开
标题翻译：用于治疗包含长效胰岛素结合剂和长效胰岛素诱导性糖尿病的糖尿病的组合物
公开(公告)号：WO2012165915A2
公开(公告)日：2012-12-06
申请号：PCT/KR2012004367
申请日：2012-06-01
申请人： HANMI SCIENCE CO LTD , WOO YOUNG EUN , JANG MYUNG HYUN , PARK YOUNG JIN , PARK YOUNG KYUNG , LIM CHANG KI , KWON SE CHANG
发明人： WOO YOUNG EUN , JANG MYUNG HYUN , PARK YOUNG JIN , PARK YOUNG KYUNG , LIM CHANG KI , KWON SE CHANG
IPC分类号： A61K47/48 , A61K38/28 , A61K47/30 , A61P3/10
CPC分类号： A61K47/48415 , A61K38/26 , A61K38/28 , A61K47/68 , A61K47/6811 , A61K47/6883
摘要： The present invention relates to a composition for the prevention or treatment of diabetes comprising a long-acting insulin conjugate and a long-acting insulinotropic peptide conjugate, and a therapeutic method for the treatment of diabetes, and more particularly, concurrent administration of the long-acting insulin conjugate and the long-acting insulinotropic peptide conjugate inhibits weight gain caused by insulin treatment, and vomiting and nausea caused by insulinotropic peptide treatment, and reduces the required dose of insulin, thereby remarkably improving drug compliance. Moreover, each of the long-acting insulin conjugate and the long-acting insulinotropic peptide conjugate of the present invention is prepared by linking insulin or insulinotropic peptide with an immunoglobulin Fc region via a non-peptidyl linker, thereby showing improved in-vivo duration of efficacy and stability.
摘要翻译：本发明涉及一种用于预防或治疗糖尿病的组合物，其包含长效胰岛素缀合物和长效促胰岛素肽缀合物，以及用于治疗糖尿病的治疗方法，更具体地说，作用胰岛素结合物和长效促胰岛素肽结合物抑制胰岛素治疗引起的体重增加，以及由促胰岛素肽治疗引起的呕吐和恶心，并减少所需的胰岛素剂量，从而显着提高药物依从性。此外，本发明的长效胰岛素缀合物和长效促胰岛素肽缀合物中的每一种都是通过非肽基连接体将胰岛素或促胰岛素肽与免疫球蛋白Fc区连接而制备的，从而显示出改善的体内持续时间功效和稳定性。

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