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    • 1. 发明申请
    • PHARMACEUTICAL FORMULATION FOR TREATING CARDIOVASCULAR DISEASE
    • 用于治疗心血管疾病的药物制剂
    • WO2009127922A2
    • 2009-10-22
    • PCT/IB2009000331
    • 2009-02-23
    • HANALL PHARMACEUTICAL CO LTDKIM SUNG WUKJUN SUNG SOOKOO JA SEONGKIM JIN WOOKPARK SUN WOOJANG SEOK YOUNGLEE SANG JUJO YOUNG GWANLEE JUN YOUNG
    • KIM SUNG WUKJUN SUNG SOOKOO JA SEONGKIM JIN WOOKPARK SUN WOOJANG SEOK YOUNGLEE SANG JUJO YOUNG GWANLEE JUN YOUNG
    • A61K9/52A61K9/22A61K9/28A61K31/44A61K47/38A61P9/00
    • A61K31/44A61K9/209
    • The present invention provides a pharmaceutical formulation containing an immediate-release compartment and an extended-release compartment. The immediate-release compartment comprises a statin lipid-lowering drug, its isomer, or its pharmaceutically acceptable salt as a pharmacologically active ingredient and the extended-release compartment contains a dihydropyridine calcium channel blocker, its isomer, or its pharmaceutically acceptable salt as a pharmacologically active ingredient. The combined formulation of immediate-release, statin lipid-lowering drug and extended-release dihydropyridine calcium channel blocker, is pharmacologically, clinically, scientifically, and economically more useful than the single formulation of each of the drugs or a simple combination of the drugs, in preventing and treating cardiovascular disease, cardiopulmonary disease, pulmonary disease, or kidney disease in patients with metabolic syndrome and insulin resistance and patients with diabetes or suspected prediabetes. médicamentsThe formulation of the present invention allows different release times for the statin lipid-lowering drug and the dihydropyridine calcium channel blocker, and thus prevents mutual antagonism and side effects between the two drugs, and provides easy administration for patients simultaneously taking the two drugs simultaneously.
    • 本发明提供了含有速释隔室和缓释隔室的药物制剂。 速释隔室包含作为药理活性成分的他汀类降脂药,其异构体或其药学上可接受的盐,并且缓释室包含二氢吡啶类钙通道阻断剂,其异构体或其药学上可接受的盐,作为药理学 有效成分。 速释他汀类降脂药和缓释二氢吡啶钙通道阻滞剂的组合制剂在药理学,临床,科学和经济上比每种药物的单一制剂或药物的简单组合更有用, 用于预防和治疗代谢综合征和胰岛素抵抗患者中的心血管疾病,心肺疾病,肺病或肾病以及糖尿病或怀疑前驱糖尿病患者。 本发明的制剂允许他汀类降脂药和二氢吡啶类钙通道阻滞剂的释放时间不同,从而防止两种药物之间的相互拮抗和副作用,并且为同时服用两种药物的患者提供了容易的给药。
    • 2. 发明申请
    • PHARMACEUTICAL FORMULATION FOR TREATING CARDIOVASCULAR DISEASE
    • 用于治疗心血管疾病的药物制剂
    • WO2009127974A3
    • 2010-03-25
    • PCT/IB2009006277
    • 2009-02-23
    • HANALL PHARMACEUTICAL CO LTDKIM SUNG WUKJUN SUNG SOOKOO JA SEONGKIM JIN WOOKPARK SUN WOOJANG SEOK YOUNGLEE SANG JUJO YOUNG GWANLEE JUN YOUNG
    • KIM SUNG WUKJUN SUNG SOOKOO JA SEONGKIM JIN WOOKPARK SUN WOOJANG SEOK YOUNGLEE SANG JUJO YOUNG GWANLEE JUN YOUNG
    • A61K9/52A61K9/22A61K9/28A61K31/40A61K31/44A61K47/38A61P9/00A61P13/12
    • A61K31/44A61K9/209
    • The present invention provides a pharmaceutical formulation comprising: an early release portion comprising as a pharmaceutical active ingredient a statin-based hypolipidic agent, an isomer thereof, or a pharmaceutically acceptable salt thereof; and a slow release portion comprising as a pharmaceutical active ingredient a dihydropyridine-based calcium channel blocking agent, an isomer thereof, or a pharmaceutically acceptable salt thereof. When compared with a single formulation of each of the drugs or a simple combination formulation of the drugs, the pharmaceutical formulation according to the present invention comprising an early release portion comprising a statin-based hypolipidic agent and a slow release portion comprising a dihydropyridine-based calcium channel blocking agent is pharmaceutically, scientifically, and economically very useful in preventing or treating cardiovascular disease, pulmonary heart disease, pulmonary disease, or kidney disease of patients who have a metabolic syndrome, insulin resistance, diabetes, or prediabetes. The formulation of the present invention is effective in preventing antagonistic and side effects between the drugs by making the dissolution rate of the statin-based hypolipidic agent different from that of the dihydropyridine-based calcium channel blocking agent, and in facilitating patient compliance in taking the drugs by administering the two different drugs simultaneously.
    • 本发明提供一种药物制剂,其包含:早期释放部分,其包含作为药物活性成分的基于他汀类的降血糖剂,​​其异构体或其药学上可接受的盐; 以及缓释部分,其包含基于二氢吡啶的钙通道阻断剂,其异构体或其药学上可接受的盐作为药物活性成分。 当与药物的单一制剂或药物的简单组合制剂相比时,根据本发明的药物制剂包含早期释放部分,其包含基于他汀类的降血脂药和包含基于二氢吡啶的缓释部分 钙通道阻断剂在预防或治疗具有代谢综合征,胰岛素抵抗,糖尿病或糖尿病前期的患者的心血管疾病,肺心病,肺部疾病或肾脏疾病方面在药学,科学和经济上非常有用。 本发明的制剂通过使基于他汀类的降血糖剂与二氢吡啶类钙通道阻断剂的溶解速率不同而使药物的拮抗作用和副作用有效,并且为了便于患者服用 药物同时服用两种不同药物。
    • 4. 发明申请
    • ACTIVE ROBOTIC GAIT-TRAINING SYSTEM AND METHOD
    • 主动机器人训练系统及方法
    • WO2012138203A3
    • 2013-01-17
    • PCT/KR2012002678
    • 2012-04-09
    • UNIV YONSEI IACFKIM YOUNG HOHWANG SUNG JAESON JONG SANGKIM JUNG YOONPARK SUN WOORYU JE SEONGLEE MIN HYEON
    • KIM YOUNG HOHWANG SUNG JAESON JONG SANGKIM JUNG YOONPARK SUN WOORYU JE SEONGLEE MIN HYEON
    • A61H1/02A61H3/00A61N1/36B25J13/08
    • A61H1/0255A61H1/0262A61H2201/10A61H2201/163A61H2201/1642A61H2201/5069A61N1/36003A61N1/36014A63B21/00178A63B21/00181A63B21/4009A63B21/4011A63B22/0235A63B69/0064A63B71/0009A63B2022/0094A63B2213/004A63B2220/16
    • The present invention relates to an active robotic gait-training system and method, which involve measuring the tilt of a lower leg to estimate a gait cycle and enable a hip joint and a knee joint to operate by means of an actuator in accordance with the gait cycle, and which enable an ankle joint to operate by functional electrical stimulation (FES), thus enabling more active gait training for a person with dysbasia in accordance with the remaining walking ability of the person with dysbasia. According to the present invention, a robot-assisted gait-training system, including a thigh support unit, a hip joint support unit and a lower leg support unit, comprises: a toe-fixing ring which is arranged at the lower end of the lower leg support unit and to which a string, which is connected to a foot strap for covering a foot (tiptoe) part, is fixed; a tilt sensor attached to the lower end of the lower leg support unit or to one side of the foot strap; a control unit which generates an FES control signal, a hip joint angle control signal, and a knee joint angle control signal from the tilt signal received from the tilt sensor; a first linear actuator which receives the hip joint angle control signal from the control unit, and rotates the thigh support unit at a hip joint unit, which is a coupling unit between the thigh support unit and the hip joint support unit, in accordance with the hip joint angle control signal; and a second linear actuator which receives the knee joint angle control signal from the control unit, and rotates the lower leg support unit at a knee joint unit, which is a coupling unit between the lower leg support unit and the thigh support unit, in accordance with the knee joint angle control signal.
    • 本发明涉及一种主动机器人步态训练系统和方法,其涉及测量小腿的倾斜以估计步态循环,并且使得髋关节和膝关节能够根据步态通过致动器进行操作 循环,并且其使踝关节能够通过功能性电刺激(FES)进行操作,从而根据失聪者的剩余行走能力,使得对于具有失语症的人进行更积极的步态训练。 根据本发明,一种机器人辅助步态训练系统,包括大腿支撑单元,髋关节支撑单元和小腿支撑单元,包括:脚趾固定环,其布置在下部的下端 腿部支撑单元,并且连接到用于覆盖脚(脚尖)部分的脚带的绳索被固定; 倾斜传感器,其附接到小腿支撑单元的下端或者脚带的一侧; 控制单元,其根据从倾斜传感器接收的倾斜信号生成FES控制信号,髋关节角度控制信号和膝关节角度控制信号; 第一线性致动器,其接收来自控制单元的髋关节角度控制信号,并且在大腿支撑单元和髋关节支撑单元之间的联接单元的髋关节单元处,按照 髋关节角度控制信号; 以及第二线性致动器,其从所述控制单元接收所述膝关节角度控制信号,并且在所述小腿支撑单元和所述大腿支撑单元之间的联接单元的膝关节单元处,将所述小腿支撑单元旋转, 与膝关节角度控制信号。