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    • 2. 发明申请
    • BENZOXAZOLE COMPOUNDS
    • 苯并噻唑化合物
    • WO2008134228A1
    • 2008-11-06
    • PCT/US2008/060183
    • 2008-04-14
    • H. LUNDBECK A/SBURNS, James, FordDELEON, John
    • BURNS, James, FordDELEON, John
    • A61P1/00A61K31/55C07D243/08
    • C07D263/58
    • The present invention is directed to benzoxazole compounds which are ltgands at the NPY Y5 receptor. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression, anxiety or obesity which comprises administering to the subject an amount of a compound of the subject invention. Furthermore, this invention also provides uses of a compound of the invention for the manufacture of a medicament for treating a subject suffering from depression, anxiety or obesity.
    • 本发明涉及作为NPY Y5受体的化合物的苯并恶唑化合物。 本发明还提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。 本发明还提供了治疗患有抑郁,焦虑或肥胖症的受试者的方法,其包括给予受试者一定量的本发明化合物。 此外,本发明还提供本发明化合物在制备用于治疗患有抑郁症,焦虑症或肥胖症的受试者的药物中的用途。