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1. 发明申请

WO2008134228A1 BENZOXAZOLE COMPOUNDS 审中-公开
标题翻译：苯并噻唑化合物
公开(公告)号：WO2008134228A1
公开(公告)日：2008-11-06
申请号：PCT/US2008/060183
申请日：2008-04-14
申请人： H. LUNDBECK A/S , BURNS, James, Ford , DELEON, John
发明人： BURNS, James, Ford , DELEON, John
IPC分类号： A61P1/00 , A61K31/55 , C07D243/08
CPC分类号： C07D263/58
摘要： The present invention is directed to benzoxazole compounds which are ltgands at the NPY Y5 receptor. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression, anxiety or obesity which comprises administering to the subject an amount of a compound of the subject invention. Furthermore, this invention also provides uses of a compound of the invention for the manufacture of a medicament for treating a subject suffering from depression, anxiety or obesity.
摘要翻译：本发明涉及作为NPY Y5受体的化合物的苯并恶唑化合物。本发明还提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供了治疗患有抑郁，焦虑或肥胖症的受试者的方法，其包括给予受试者一定量的本发明化合物。此外，本发明还提供本发明化合物在制备用于治疗患有抑郁症，焦虑症或肥胖症的受试者的药物中的用途。

2. 发明申请

WO2005069834A3 4-ARYL PIPERIDINES 审中-公开
公开(公告)号：WO2005069834A3
公开(公告)日：2006-04-27
申请号：PCT/US2005001131
申请日：2005-01-13
申请人： LUNDBECK & CO AS H , MARZABADI MOHAMMAD R , WETZEL JOHN M , CHEN CHIEN-AN , DELEON JOHN E , JIANG YU , LU KAI
发明人： MARZABADI MOHAMMAD R , WETZEL JOHN M , CHEN CHIEN-AN , DELEON JOHN E , JIANG YU , LU KAI
IPC分类号： C07D211/26 , A61K31/445 , C07D211/68 , C07D401/04 , C07D401/10 , C07D401/14
CPC分类号： C07D211/26
摘要： This invention is directed to 4-aryl piperidines and related heterocyclic compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of reducing the body mass of a subject which comprises administering to the subject an amount of a compound of the invention effective to reduce the body mass of the subject. This invention further provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject's depression and/or anxiety.
摘要翻译：本发明涉及作为黑色素浓缩激素-1（MCH1）受体的选择性拮抗剂的4-芳基哌啶和相关的杂环化合物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明提供通过将治疗有效量的本发明化合物与药学上可接受的载体组合而成的药物组合物。本发明还提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物与药学上可接受的载体组合。本发明还提供减少受试者体重的方法，其包括向受试者施用一定量的有效减少受试者体重的本发明化合物。本发明进一步提供了治疗患有抑郁症和/或焦虑症的受试者的方法，其包括给予受试者一定量的有效治疗受试者的抑郁症和/或焦虑症的本发明化合物。

3. 发明申请

WO2004005257A1 SECONDARY AMINO ANILINIC PIPERIDINES AS MCH1 ANTAGONISTS AND USES THEREOF 审中-公开
标题翻译：作为MCH1拮抗剂的二级氨基酸治疗剂及其用途
公开(公告)号：WO2004005257A1
公开(公告)日：2004-01-15
申请号：PCT/US2003/021391
申请日：2003-07-03
申请人： SYNAPTIC PHARMACEUTICAL CORPORATIONs , MARZABADI, Mohammad , JIANG, Allen , LU, Kai , CHEN, Chien-An , DELEON, John , WETZEL, John
发明人： MARZABADI, Mohammad , JIANG, Allen , LU, Kai , CHEN, Chien-An , DELEON, John , WETZEL, John
IPC分类号： C07D211/70
CPC分类号： C07D211/26 , C07D401/12
摘要： This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compounds of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of reducing the body mass of a subject which comprises administering to the subject an amount of a compound of the invention effective to reduce the body mass of the subject. This invention further provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject=s depression and/or anxiety. This invention further provides a method of treating a subject suffering from a urinary disorder.
摘要翻译：本发明涉及作为黑色素浓缩激素-1（MCH1）受体的选择性拮抗剂的化合物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明提供通过将治疗有效量的本发明化合物与药学上可接受的载体组合而成的药物组合物。本发明还提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物和药学上可接受的载体组合。本发明还提供减少受试者体重的方法，其包括给予受试者一定量的有效减少受试者体重的本发明化合物。本发明还提供了治疗患有抑郁症和/或焦虑症的受试者的方法，其包括给予受试者一定量的有效治疗受试者抑郁症和/或焦虑症的本发明化合物。本发明还提供了治疗患有尿失禁的受试者的方法。

4. 发明申请

WO2005069834A2 4-ARYL PIPERIDINES 审中-公开
公开(公告)号：WO2005069834A2
公开(公告)日：2005-08-04
申请号：PCT/US2005/001131
申请日：2005-01-13
申请人： H. LUNDBECK A/S , MARZABADI, Mohammad, R. , WETZEL, John, M. , CHEN, Chien-An , DELEON, John, E. , JIANG, Yu , LU, Kai
发明人： MARZABADI, Mohammad, R. , WETZEL, John, M. , CHEN, Chien-An , DELEON, John, E. , JIANG, Yu , LU, Kai
IPC分类号： C07D211/26
CPC分类号： C07D211/26
摘要： This invention is directed to 4-aryl piperidines and related heterocyclic compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of reducing the body mass of a subject which comprises administering to the subject an amount of a compound of the invention effective to reduce the body mass of the subject. This invention further provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject’s depression and/or anxiety.
摘要翻译：本发明涉及作为黑色素浓缩激素-1（MCH1）受体的选择性拮抗剂的4-芳基哌啶和相关的杂环化合物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明提供通过将治疗有效量的本发明化合物与药学上可接受的载体组合而成的药物组合物。本发明还提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物与药学上可接受的载体组合。本发明还提供减少受试者体重的方法，其包括向受试者施用一定量的有效减少受试者体重的本发明化合物。本发明进一步提供了治疗患有抑郁症和/或焦虑症的受试者的方法，其包括向受试者施用有效治疗受试者的抑郁症和/或焦虑的量的本发明化合物。

5. 发明申请

WO2004004714A1 SPIROCYCLIC PIPERIDINES AS MCH1 ANTAGONISTS AND USES THEREOF 审中-公开
标题翻译：作为MCH1拮抗剂的螺环哌嗪类药物及其用途
公开(公告)号：WO2004004714A1
公开(公告)日：2004-01-15
申请号：PCT/US2003/021348
申请日：2003-07-03
申请人： SYNAPTIC PHARMACEUTICAL CORPORATION , MARZABADI, Mohammad , JIANG, Allen , LU, Kai , CHEN, Chien-An , DELEON, John , WETZEL, John
发明人： MARZABADI, Mohammad , JIANG, Allen , LU, Kai , CHEN, Chien-An , DELEON, John , WETZEL, John
IPC分类号： A61K31/438
CPC分类号： C07D221/20 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D491/10
摘要： This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of reducing the body mass of a subject which comprises administering to the subject an amount of a compound of the invention effective to reduce the body mass of the subject. This invention further provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject=s depression and/or anxiety. This invention further provides a method of treating a subject suffering from a urinary disorder.
摘要翻译：本发明涉及作为黑色素浓缩激素-1（MCH1）受体的选择性拮抗剂的化合物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明提供通过将治疗有效量的本发明化合物与药学上可接受的载体组合而成的药物组合物。本发明还提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物和药学上可接受的载体组合。本发明还提供减少受试者体重的方法，其包括给予受试者一定量的有效减少受试者体重的本发明化合物。本发明还提供了治疗患有抑郁症和/或焦虑症的受试者的方法，其包括给予受试者一定量的有效治疗受试者抑郁症和/或焦虑症的本发明化合物。本发明还提供了治疗患有尿失禁的受试者的方法。

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