专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2005092863A1 4-CARBOX PYRAZOLE DERIVATES USEFUL AS ANTI-VIRAL AGENTS 审中-公开
标题翻译： 4-羧基吡唑衍生物可用作反病毒剂
公开(公告)号：WO2005092863A1
公开(公告)日：2005-10-06
申请号：PCT/GB2005/001071
申请日：2005-03-22
申请人： GLAXO GROUP LIMITED , BRAVI, Gianpaolo , CORFIELD, John, Andrew , GRIMES, Richard, Martin , GUIDETTI, Rossella , LOVEGROVE, Victoria, Lucy, Helen , MORDAUNT, Jacqueline, Elizabeth , SHAH, Pritom , SLATER, Martin, John
发明人： BRAVI, Gianpaolo , CORFIELD, John, Andrew , GRIMES, Richard, Martin , GUIDETTI, Rossella , LOVEGROVE, Victoria, Lucy, Helen , MORDAUNT, Jacqueline, Elizabeth , SHAH, Pritom , SLATER, Martin, John
IPC分类号： C07D231/38
CPC分类号： C07D403/12 , C07D231/40 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D405/12 , C07D409/04 , C07D417/04 , C07D417/10 , C07D417/12 , C07D417/14
摘要： Novel antiviral compounds of Formula (I) : wherein: A represents hydroxy; R1 represents aryl, heteroaryl bonded through a ring carbon atom, or heterocyclyl bonded through a ring carbon atom, C1-6alkyl or -C5-9cycloalkyl, each of which may be optionally substituted; R2 represents substituted phenyl, or -(CH2)nC5-7cycloalkyl optionally substituted on the cycloalkyl; R3 represents heterocyclyl or heteroaryl; optionally substituted phenyl or optionally substituted -C1-6alkyl; R4 represents hydrogen; and salts, solvates and esters thereof, processes for their preparation, pharmaceutical compositions comprising them, and methods of using them in HCV treatment are provided.
摘要翻译：式（I）的新型抗病毒化合物：其中：A表示羟基; R1表示芳基，通过环碳原子键合的杂芳基，或通过环碳原子键合的杂环基，C 1-6烷基或-C 5-9环烷基，其各自可以任选被取代; 或R 2表示取代的苯基，或 - （CH 2）n C 5-7环烷基，其任选地被取代在环烷基上; R3表示杂环基或杂芳基; 任选取代的苯基或任选取代的C 1-6烷基; R4代表氢; 提供其盐，溶剂合物和酯，其制备方法，包含它们的药物组合物，以及在HCV治疗中使用它们的方法。

2. 发明申请

WO2003037895A1 4-(6-MEMBERED)-HETEROARYL ACYL PYRROLIDINE DERIVATIVES AS HCV INHIBITORS 审中-公开
标题翻译： 4-（6-MEMBERED）-HETEROARYL ACYL吡咯烷衍生物作为HCV抑制剂
公开(公告)号：WO2003037895A1
公开(公告)日：2003-05-08
申请号：PCT/EP2002/012176
申请日：2002-10-30
申请人： GLAXO GROUP LIMITED , BRAVI, Gianpaolo , GUIDETTI, Rossella , HAIGH, David , HARTLEY, Charles, David , HOWES, Peter, David , JACKSON, Deborah, Lynette , LOVEGROVE, Victoria, Lucy, Helen , SHAH, Pritom , SLATER, Martin, John , WAREING, Katrina, Jane
发明人： BRAVI, Gianpaolo , GUIDETTI, Rossella , HAIGH, David , HARTLEY, Charles, David , HOWES, Peter, David , JACKSON, Deborah, Lynette , LOVEGROVE, Victoria, Lucy, Helen , SHAH, Pritom , SLATER, Martin, John , WAREING, Katrina, Jane
IPC分类号： C07D417/14
CPC分类号： C07D401/14 , C07D403/04 , C07D409/14 , C07D417/14
摘要： Novel anti-viral agents of Formula (I), wherein: A represents OR 1 , NR 1 R 2 , or R 1 wherein R 1 and R 2 are hydrogen, C 1-6 alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; or R 1 and R 2 together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group;B represents C(O)R 3 wherein R 3 is C 1-6 alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; C represents C 1-6 alkyl, aryl, heteroaryl or heterocyclyl; D represents a saturated or unsaturated optionally substituted 6-membered heterocyclic ring; E represents hydrogen or C 1-6 alkyl; F represents hydrogen, C 1-6 alkyl, aryl or heteroaryl; and G represents hydrogen, C 1-6 alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; and salts, solvates and esters thereof, processes for their preparation and methods of using them in HCV treatment are provided.
摘要翻译：式（I）的新型抗病毒剂，其中：A表示OR 1，NR 1 R 2或R 1，其中R 1和R 2为氢，C 1-6烷基，芳基，杂芳基，芳基烷基或杂芳基烷基; 或R 1和R 2与它们所连接的氮原子一起形成5或6元饱和环状基团; B表示C（O）R 3，其中R 3为C 1-6烷基，芳基，杂芳基，芳基烷基或杂芳基烷基; C代表C 1-6烷基，芳基，杂芳基或杂环基; D表示饱和或不饱和的任选取代的6元杂环; E表示氢或C 1-6烷基; F表示氢，C 1-6烷基，芳基或杂芳基; 和G表示氢，C 1-6烷基，杂环基烷基，芳基烷基或杂芳基烷基; 提供其盐，溶剂合物和酯，其制备方法及其在HCV治疗中的使用方法。

3. 发明申请

WO2004096774A1 ACYL ISOINDOLINE DERIVATIVES AND ACYL ISOQUINOLINE DERIVATIVES AS ANTI-VIRAL AGENTS 审中-公开
标题翻译： ACYL ISOINDOLINE DORIVATIVES和ACYL ISOQUINOLINE DERIVATIVES作为反病毒代理
公开(公告)号：WO2004096774A1
公开(公告)日：2004-11-11
申请号：PCT/EP2004/004660
申请日：2004-04-29
申请人： GLAXO GROUP LIMITED , BRAVI, Gianpaolo , CORFIELD, John, Andrew , HAIGH, David , LOVEGROVE, Victoria, Lucy, Helen , SHAH, Pritom , SLATER, Martin, John
发明人： BRAVI, Gianpaolo , CORFIELD, John, Andrew , HAIGH, David , LOVEGROVE, Victoria, Lucy, Helen , SHAH, Pritom , SLATER, Martin, John
IPC分类号： C07D217/26
CPC分类号： C07D401/04 , C07D209/44 , C07D217/26 , C07D401/12 , C07D405/04 , C07D417/12
摘要： Anti-viral agents of Formula (I) wherein: R 3 represents aryl or heteroaryl; R 4 represents one or two substituents independently selected from hydrogen, C 1 - 6 alkyl, halo, OR A , C(O)NR B R C , C(O)R D , CO 2 H, CO 2 R D , NR B R C , NR E C(O)R D , NR E CO 2 R D , NR E C(O)NR F R G , NR E SO 2 R D , SO 2 NR F R G , SO 2 R D , nitro, cyano, heterocyclyl, heteroaryl, aryl, arylalkyl heteroarylalkyl or CF 3 ; R 5 and R 6 independently represent hydrogen, C 1-6 alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; n represents 0 or 1; when n represents 0, R 1 represents C(O)R H and R 2 represents C 1-6 alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; when n represents 1, either i) R 1 represents C(O)R H ; R 2 represents C 1-6 alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; and R 7 and R 8 independently represent hydrogen, C 1-6 alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; or ii) R 1 and R 2 independently represent hydrogen, C 1-6 alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; R 7 represents C(O)R H ; and R 8 represents C 1-6 alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; R A represents hydrogen, C 1-6 alkyl, arylalkyl, heteroarylalkyl, aryl or heteroaryl; R B and R C independently represent hydrogen, C 1-6 alkyl, aryl or heteroaryl; or R B and R C together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; R D is selected from the group consisting of C 1-6 alkyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl; R E represents hydrogen or C 1-6 alkyl; R F and R G are independently selected from the group consisting of hydrogen, C 1-6 alkyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl; or R F and R G together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; R H represents hydroxy or NR B R C ; and salts, solvates and esters thereof; provided that when R H is hydroxy, which is esterified to form -OR where R is selected from straight or branched chain alkyl, aralkyl, aryloxyalkyl, or aryl, then R is other than tert -butyl. Processes for their preparation and methods of using them in HCV treatment are provided.
摘要翻译：式（I）的抗病毒剂，其中：R 3表示芳基或杂芳基; R 4表示一个或两个独立地选自氢，C 1-6烷基，卤素，OR A，C（O）NR B，C（O）R D，CO 2 H， NRR，NR C，O，R D，NR E，CO 2 R D，NR C，C（O）NR F，氰基，杂环基，杂芳基，芳基，芳基烷基杂芳基烷基或CF 3; R 3，R 3，R 4， R 5和R 6独立地表示氢，C 1-6烷基，芳基，杂芳基，芳烷基或杂芳基烷基; n表示0或1; 当n表示0时，R 1表示C（O）R H，R 2表示C 1-6烷基，杂环基烷基，芳烷基或杂芳基烷基; 当n表示1时，i）R 1表示C（O）R H; R 2表示C 1-6烷基，杂环基烷基，芳烷基或杂芳基烷基; R 7和R 8独立地表示氢，C 1-6烷基，芳基，杂芳基，芳基烷基或杂芳基烷基; 或ii）R 1和R 2独立地表示氢，C 1-6烷基，芳基，杂芳基，芳基烷基或杂芳基烷基; R 7表示C（O）R H; 并且R 8表示C 1-6烷基，杂环基烷基，芳烷基或杂芳基烷基; R A表示氢，C 1-6烷基，芳基烷基，杂芳基烷基，芳基或杂芳基; R B和R C独立地表示氢，C 1-6烷基，芳基或杂芳基; 或R B和R C与它们所连接的氮原子一起形成5或6元饱和的环状基团; R D选自C 1-6烷基，芳基，杂芳基，芳基烷基和杂芳基烷基; R E表示氢或C 1-6烷基; R F和R G独立地选自氢，C 1-6烷基，芳基，杂芳基，芳基烷基和杂芳基烷基; 或R F和R G与它们所连接的氮原子一起形成5或6元饱和的环状基团; R H表示羟基或NR B; 及其盐，溶剂化物和酯; 条件是当R H是羟基时，其被酯化以形成-OR，其中R选自直链或支链烷基，芳烷基，芳氧基烷基或芳基，则R不是叔丁基。提供其制备方法及其在HCV治疗中的使用方法。

4. 发明申请

WO2003037893A1 ACYL DIHYDRO PYRROLE DERIVATIVES AS HCV INHIBITORS 审中-公开
公开(公告)号：WO2003037893A1
公开(公告)日：2003-05-08
申请号：PCT/EP2002/012171
申请日：2002-10-30
申请人： GLAXO GROUP LIMITED , BRAVI, Gianpaolo , HOWES, Peter, David , LOVEGROVE, Victoria, Lucy, Helen , SHAH, Pritom , SLATER, Martin, John
发明人： BRAVI, Gianpaolo , HOWES, Peter, David , LOVEGROVE, Victoria, Lucy, Helen , SHAH, Pritom , SLATER, Martin, John
IPC分类号： C07D417/04
CPC分类号： C07D417/04
摘要： Novel anti-viral agents of Formula (I) wherein: A represents OR 1 , NR 1 R 2 , or R 1 wherein R 1 and R 2 are hydrogen, C 1-6 alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; or R 1 and R 2 together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; B represents C(O)R 3 wherein R 3 is C 1-6 alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; D represents C 1-6 alkyl, aryl, heteroaryl or heterocyclyl; E represents OR 1 , NR 1 R 2 , or R 1 wherein R 1 and R 2 are hydrogen, C 1-6 alkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl; or R 1 and R 2 together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; F represents hydrogen, C 1-6 alkyl, aryl or heteroaryl; and G represents hydrogen, C 1-6 alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; and salts and solvates thereof, processes for their preparation and methods of using them in HCV treatment are provided.
摘要翻译：式（I）的新型抗病毒剂，其中：A表示OR 1，NR 1 R 2或R 1，其中R 1和R 2为氢，C 1-6烷基，芳基，杂芳基，芳基烷基或杂芳基烷基; 或R 1和R 2与它们所连接的氮原子一起形成5或6元饱和环状基团; B表示C（O）R 3，其中R 3是C 1-6烷基，芳基，杂芳基，芳烷基或杂芳基烷基; D表示C 1-6烷基，芳基，杂芳基或杂环基; E表示OR 1，NR 1 R 2或R 1，其中R 1和R 2是氢，C 1-6烷基，芳基，杂芳基，芳烷基或杂芳基烷基; 或R 1和R 2与它们所连接的氮原子一起形成5或6元饱和环状基团; F表示氢，C 1-6烷基，芳基或杂芳基; 和G表示氢，C 1-6烷基，杂环基烷基，芳基烷基或杂芳基烷基; 并提供其盐和溶剂化物，其制备方法及其在HCV治疗中的使用方法。

5. 发明申请

WO2003037894A1 4-(5-MEMBERED)-HETEROARYL ACYL PYRROLIDINE DERIVATIVES AS HCV INHIBITORS 审中-公开
标题翻译： 4-（5-MEMBERED）-HETEROARYL ACYL吡咯烷酮衍生物作为HCV抑制剂
公开(公告)号：WO2003037894A1
公开(公告)日：2003-05-08
申请号：PCT/EP2002/012172
申请日：2002-10-30
申请人： GLAXO GROUP LIMITED , BRAVI, Gianpaolo , GOODLAND, Helen, Susanne , HAIGH, David , HARTLEY, Charles, David , LOVEGROVE, Victoria, Lucy, Helen , SHAH, Pritom , SLATER, Martin, John
发明人： BRAVI, Gianpaolo , GOODLAND, Helen, Susanne , HAIGH, David , HARTLEY, Charles, David , LOVEGROVE, Victoria, Lucy, Helen , SHAH, Pritom , SLATER, Martin, John
IPC分类号： C07D417/14
CPC分类号： C07D409/14 , C07D413/14 , C07D417/14
摘要： Novel anti-viral agents of Formula (I) wherein:A represents OR 1 , NR 1 R 2 , or R 1 wherein R 1 and R 2 are hydrogen, C 1-6 alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; or R 1 and R 2 together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; B represents C(O)R 3 wherein R 3 is C 1-6 alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; C represents C1-6alkyl, aryl, heteroaryl or heterocyclyl; D represents a saturated or unsaturated optionally substituted 5-membered heterocyclic ring; E represents hydrogen or C 1-6 alkyl; F represents hydrogen, C 1-6 alkyl, aryl or heteroaryl; and G represents hydrogen, C 1-6 alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; and salts and solvates thereof, processes for their preparation and methods of using them in HCV treatment are provided.
摘要翻译：式（I）的新型抗病毒剂，其中：A表示OR 1，NR 1 R 2或R 1，其中R 1和R 2为氢，C 1-6烷基，芳基，杂芳基，芳基烷基或杂芳基烷基; 或R 1和R 2与它们所连接的氮原子一起形成5或6元饱和环状基团; B表示C（O）R 3，其中R 3是C 1-6烷基，芳基，杂芳基，芳烷基或杂芳基烷基; C代表C 1-6烷基，芳基，杂芳基或杂环基; D表示饱和或不饱和的任选取代的5元杂环; E表示氢或C 1-6烷基; F表示氢，C 1-6烷基，芳基或杂芳基; 和G表示氢，C 1-6烷基，杂环基烷基，芳基烷基或杂芳基烷基; 并提供其盐和溶剂化物，其制备方法及其在HCV治疗中的使用方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式