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1. 发明申请

WO2012038831A3 A METHOD FOR DETECTING, QUANTIFYING AND MAPPING DAMAGE AND/OR REPAIR OF DNA STRANDS 审中-公开
标题翻译：检测，定量和定位DNA结构的损伤和/或修复的方法
公开(公告)号：WO2012038831A3
公开(公告)日：2012-05-24
申请号：PCT/IB2011002584
申请日：2011-09-22
申请人： GENOMIC VISION , CINQUE LUCIA , BENSIMON AARON
发明人： CINQUE LUCIA , BENSIMON AARON
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6834 , A61K33/24 , C12Q1/6804 , C12Q1/6806 , C12Q1/6886 , G01N33/5308 , Y10T436/143333 , C12Q2521/131 , C12Q2523/101 , C12Q2527/125 , C12Q2563/107
摘要： Methods and products for detecting in vitro the presence of damage on DNA or the presence of a biological response to damage on DNA at the molecular level. Molecular Combing or other nucleic acid stretching methods are employed together with compounds reacting with DNA, probes binding DNA, or nucleic acid monomers, especially labeled nucleic acid monomers.
摘要翻译：用于体外检测对DNA损伤的存在的方法和产物，或在分子水平上存在对DNA损伤的生物反应。分子梳理或其它核酸拉伸方法与与DNA反应的化合物，探针结合DNA或核酸单体，特别是标记的核酸单体一起使用。

2. 发明申请

WO2008125663A3 A FEATURE ADAPTED BEAMLET TRANSFORM APPARATUS AND ASSOCIATED METHODOLOGY OF DETECTING CURVILENEAR OBJECTS OF AN IMAGE 审中-公开
标题翻译：一种检测图像曲率半径目标的特征自适应圆束变换装置及相关方法
公开(公告)号：WO2008125663A3
公开(公告)日：2008-12-24
申请号：PCT/EP2008054508
申请日：2008-04-14
申请人： PASTEUR INSTITUT , GENOMIC VISION , BERLEMONT SYLVAIN , OLIVO-MARIN JEAN-CHRISTOPHE , BENSIMON AARON
发明人： BERLEMONT SYLVAIN , OLIVO-MARIN JEAN-CHRISTOPHE , BENSIMON AARON
IPC分类号： G06K9/46 , G06K9/52
CPC分类号： G06K9/4633 , G06K9/527
摘要： A method of detecting a curvilinear object of a noisy image. The method includes filtering the noisy image in accordance with a two dimensional line profile. The line profile is selected within a class of steerable filters. A beamlet coefficient is calculated in accordance with the filtering, wherein a coefficient above a predetermined threshold identifies a local feature
摘要翻译：一种检测有噪图像曲线对象的方法。该方法包括根据二维线轮廓过滤噪声图像。线轮廓是在一类可控过滤器中选择的。小波系数根据滤波来计算，其中高于预定阈值的系数识别局部特征

3. 发明申请

WO2010035140A8 METHOD FOR ANALYZING D4Z4 TANDEM REPEAT ARRAYS OF NUCLEIC ACID AND KIT THEREFORE 审中-公开
标题翻译：分析D4Z4串联重复阵列的核酸和试剂盒的方法
公开(公告)号：WO2010035140A8
公开(公告)日：2010-08-05
申请号：PCT/IB2009007197
申请日：2009-09-25
申请人： GENOMIC VISION , UNIV AIX MARSEILLE II , ASSISTANCE PUBLIQUE DES HOPITA , WALRAFEN PIERRE , VANNIER ANNE , BENSIMON AARON , LEVY NICOLAS
发明人： WALRAFEN PIERRE , VANNIER ANNE , BENSIMON AARON , LEVY NICOLAS
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6834 , C12Q2600/112 , C12Q2600/154 , C12Q2600/172 , C40B30/04
摘要： The present invention relates to a method for analysing in vitro D4Z4 tandem repeat arrays of nucleic acid contained on nucleic acid representative of chromosomes, in particular on nucleic acid representative of Human chromosomes 4 and 10, and to a kit therefore. Said method is in particular suitable for determining the number of D4Z4 repeat units in said D4Z4 repeat arrays. Said method is based on stretching of nucleic acid and in particular on Molecular Combing and relies on the use of probes, especially nucleic acid probes, with a particular design. The invention also relates to a method for providing tools for the diagnosis of facioscapulohumeral muscular dystrophy (FSHD) and to a diagnostic kit therefore. The invention further relates to a method for identifying biochemical events and/or genetic in regions containing such tandem repeat arrays.
摘要翻译：本发明涉及用于分析代表染色体的核酸（特别是代表人类染色体4和10的核酸）上包含的核酸的体外D4Z4串联重复阵列的方法，并因此涉及试剂盒。所述方法特别适用于确定所述D4Z4重复阵列中的D4Z4重复单元的数量。所述方法基于核酸的拉伸，特别是基于分子梳理并且依赖于使用探针，特别是核酸探针，具有特定的设计。本发明还涉及用于提供诊断面肩肱型肌营养不良症（FSHD）的工具的方法和因此用于诊断试剂盒。本发明进一步涉及用于鉴定含有这种串联重复序列阵列的区域中的生化事件和/或遗传的方法。

4. 发明申请

WO0073503A2 USE OF THE COMBING PROCESS FOR THE IDENTIFICATION OF DNA ORIGINS OF REPLICATION 审中-公开
标题翻译：使用组合方法鉴定DNA原核生物
公开(公告)号：WO0073503A2
公开(公告)日：2000-12-07
申请号：PCT/IB0001240
申请日：2000-05-29
申请人： PASTEUR INSTITUT , CENTRE NAT RECH SCIENT , BENSIMON AARON , HERRICK JOHN , HYRIEN OLIVIER
发明人： BENSIMON AARON , HERRICK JOHN , HYRIEN OLIVIER
IPC分类号： C12Q1/68
CPC分类号： C12Q1/68 , C12Q1/6804 , C12Q2565/102 , C12Q2527/113 , C12Q2521/107
摘要： Eukaryotic genomes are duplicated by the activation of multiple bidirectional origins of replication. The replication programs of these cells depend on the temporal and spatial organisation of replication origins throughout the genome. To investigate the replication program in a higher eukaryote, we employed a technique called molecular combing. This technique allows for a quantitative analysis of DNA replication on a genome wide basis. As a model system, Xenopus laevis sperm chromatin were differentially labelled at successive time points after the beginning of DNA synthesis. Genomic DNA was then extracted and combed on a glass surface. Direct measurements made on the labelled DNA provided a comprehensive analysis of the spatial and temporal organisation of the X. leavis early embryo replication program and revealed that the number of replication origins activated per kilobase increases throughout the period of DNA synthesis.
摘要翻译：通过激活多个双向复制起点来复制真核基因组。这些细胞的复制程序取决于整个基因组中复制起点的时间和空间组织。为了研究高等真核生物中的复制程序，我们采用了一种称为分子梳理的技术。该技术允许在基因组广泛基础上定量分析DNA复制。作为模型系统，在DNA合成开始后的连续时间点，非洲爪蟾精子染色质被差异标记。然后提取基因组DNA并在玻璃表面上精梳。对标记DNA进行的直接测量提供了对X的空间和时间组织的全面分析。 leavis 早期胚胎复制程序，并显示在整个DNA合成期间每千碱激活的复制起点数量增加。

5. 发明申请

WO2006040478A3 CUSTOMISABLE SECURE SYSTEM FOR RECOGNISING AND CONDITIONALLY USING ELECTRIC DEVICES AND METHOD FOR USE 审中-公开
标题翻译：用于识别和限制使用电气设备的自定义安全系统和使用方法
公开(公告)号：WO2006040478A3
公开(公告)日：2006-12-14
申请号：PCT/FR2005002529
申请日：2005-10-12
申请人： BENSIMON DAVID , BERNEMAN ARMAND , BENSIMON AARON , BERNEMAN DANIELLE
发明人： BENSIMON DAVID , BERNEMAN ARMAND , BENSIMON AARON , BERNEMAN DANIELLE
IPC分类号： H04L9/32 , G06K9/00 , G06K19/07 , H04L9/08
CPC分类号： G07C9/00658 , G06F21/34 , G07C9/00007 , G07C9/00817 , G07F7/125 , H04L9/32
摘要： The invention relates to a secure system comprising a customisable support associated with a reader enabling to conditionally turn on electrical or electronic devices by means of an identification and comparison circuit disposed on the substantial part of said devices after comparing data delivered by the support with data stored in a memory. Said memory contains at least one identification code for enabling at least one user to access to said device. The support also comprises at least two reserved areas, wherein at least one area is modifiable by the user. Said areas define a distinct code for associating the recognition of each code with distinct functions. A method for conditionally modifying recognition operations between the support, the reader and the reference memory is also disclosed.
摘要翻译：本发明涉及一种安全系统，其包括与读取器相关联的可定制的支持，其使得能够在将支持所传送的数据与存储的数据进行比较之后借助于设置在所述设备的大部分上的识别和比较电路有条件地打开电子或电子设备在记忆中所述存储器包含用于使至少一个用户能够访问所述设备的至少一个识别码。支持还包括至少两个保留区域，其中至少一个区域可由用户修改。所述区域定义用于将每个代码的识别与不同功能相关联的独特代码。还公开了用于有条件地修改支持，读取器和参考存储器之间的识别操作的方法。

6. 发明申请

WO0073503A9 USE OF THE COMBING PROCESS FOR THE IDENTIFICATION OF DNA ORIGINS OF REPLICATION 审中-公开
标题翻译：使用组合方法鉴定DNA原核生物
公开(公告)号：WO0073503A9
公开(公告)日：2002-03-07
申请号：PCT/IB0001240
申请日：2000-05-29
申请人： PASTEUR INSTITUT , CENTRE NAT RECH SCIENT , BENSIMON AARON , HERRICK JOHN , HYRIEN OLIVIER
发明人： BENSIMON AARON , HERRICK JOHN , HYRIEN OLIVIER
IPC分类号： C12Q1/68
CPC分类号： C12Q1/68 , C12Q1/6804 , C12Q2565/102 , C12Q2527/113 , C12Q2521/107
摘要： Eukaryotic genomes are duplicated by the activation of multiple bidirectional origins of replication. The replication programs of these cells depend on the temporal and spatial organisation of replication origins throughout the genome. To investigate the replication program in a higher eukaryote, we employed a technique called molecular combing. This technique allows for a quantitative analysis of DNA replication on a genome wide basis. As a model system, Xenopus laevis sperm chromatin were differentially labelled at successive time points after the beginning of DNA synthesis. Genomic DNA was then extracted and combed on a glass surface. Direct measurements made on the labelled DNA provided a comprehensive analysis of the spatial and temporal organisation of the X. leavis early embryo replication program and revealed that the number of replication origins activated per kilobase increases throughout the period of DNA synthesis.
摘要翻译：通过激活多个双向复制起点来复制真核基因组。这些细胞的复制程序取决于整个基因组中复制起点的时间和空间组织。为了研究高等真核生物中的复制程序，我们采用了一种称为分子梳理的技术。该技术允许在基因组广泛基础上定量分析DNA复制。作为模型系统，在DNA合成开始后的连续时间点，非洲爪蟾精子染色质被差异标记。然后提取基因组DNA并在玻璃表面上精梳。对标记DNA进行的直接测量提供了对X的空间和时间组织的全面分析。 leavis 早期胚胎复制程序，并显示在整个DNA合成期间每千碱激活的复制起点数量增加。

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