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1. 发明申请

WO2007103977A2 A PHYSIOGENOMIC METHOD FOR PREDICTING CLINICAL OUTCOMES OF TREATMENTS IN PATIENTS 审中-公开
标题翻译：用于预测患者治疗临床结果的生理方法
公开(公告)号：WO2007103977A2
公开(公告)日：2007-09-13
申请号：PCT/US2007/063501
申请日：2007-03-07
申请人： GENOMAS, INC. , RUANO, Gualberto , WINDEMUTH, Andreas
发明人： RUANO, Gualberto , WINDEMUTH, Andreas
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172 , G06F19/18 , G06F19/24 , G06F19/3481 , G16H50/20 , Y02A90/26
摘要： A physiogenomic-based method for predicting the outcome of treatment regimens in human patients based upon association screening to identify genetic markers and related physiological characteristics that influence the disease status of a patient, the progression to disease and response to the treatment. By repeating the analysis quantitatively for each of multiple treatment regimens, a profile can be created for each patient to determine which of several treatment regimens are best suited to the patient's clinical needs.
摘要翻译：基于生理基因组的方法，用于基于关联筛选预测人类患者的治疗方案的结果，以鉴定影响患者的疾病状态，疾病进展和对治疗反应的遗传标记和相关生理特征。通过对多种治疗方案中的每一种进行定量重复分析，可以为每个患者创建一个分布图，以确定几种治疗方案中哪一种最适合于患者的临床需要。

2. 发明申请

WO2011156432A2 SCANNING MULTIFUNCTIONAL PARTICLES 审中-公开
标题翻译：扫描多功能颗粒
公开(公告)号：WO2011156432A2
公开(公告)日：2011-12-15
申请号：PCT/US2011/039529
申请日：2011-06-07
申请人： FIREFLY BIOWORKS, INC. , PREGIBON, Daniel, C. , MARINI, Davide, M. , STONER, Isaac , WINDEMUTH, Andreas , ERPS, Timothy
发明人： PREGIBON, Daniel, C. , MARINI, Davide, M. , STONER, Isaac , WINDEMUTH, Andreas , ERPS, Timothy
IPC分类号： G01N33/483 , G01N15/14 , C12Q1/68 , C12Q1/02 , G01N21/47
CPC分类号： C12Q1/6825 , C12Q1/6809 , C12Q1/6813 , C12Q1/6816 , C12Q1/6834 , C12Q1/6888 , C12Q1/689 , C12Q1/6895 , C12Q1/70 , G01N15/14 , G01N21/47 , G01N21/6428 , G01N33/6803 , C12Q2565/626 , C12Q2525/161 , C12Q2525/191 , C12Q2533/107
摘要： The present invention provides, among other things, methods and systems for characterizing multifunctional objects using a flow-through device, such as, a flow cytometer. In some embodiments, an inventive method according to the present invention includes one more steps of (a) interrogating a plurality of objects (e.g., particles), wherein each individual object (e.g., particle) comprises one or more interrogation regions detectable as a sequence of events; (b) recording multiple events, wherein each individual event corresponds to each individual interrogation region detectable above a pre-determined triggering threshold; (c) grouping the recorded multiple events, and (d) characterizing the plurality of objects based on the grouped events.
摘要翻译：本发明尤其提供了使用流通装置如流式细胞仪来表征多功能物体的方法和系统。在一些实施例中，根据本发明的发明方法包括以下步骤：（a）询问多个对象（例如，粒子），其中每个单个对象（例如，粒子）包括可被检测为序列的一个或多个询问区域的事件; （b）记录多个事件，其中每个单独的事件对应于在预先确定的触发阈值之上可检测的每个个别询问区域; （c）对记录的多个事件进行分组，以及（d）基于分组的事件来表征多个对象。

3. 发明申请

WO2011156434A2 NUCLEIC ACID DETECTION AND QUANTIFICATION BY POST-HYBRIDIZATION LABELING AND UNIVERSAL ENCODING 审中-公开
标题翻译：通过后期杂交标签和通用编码进行核酸检测和定量
公开(公告)号：WO2011156434A2
公开(公告)日：2011-12-15
申请号：PCT/US2011/039531
申请日：2011-06-07
申请人： FIREFLY BIOWORKS, INC. , PREGIBON, Daniel, C. , STONER, Isaac , WINDEMUTH, Andreas , ERPS, Timothy
发明人： PREGIBON, Daniel, C. , STONER, Isaac , WINDEMUTH, Andreas , ERPS, Timothy
IPC分类号： C12Q1/68 , C12N15/11 , G01N33/53
CPC分类号： C12Q1/6825 , C12Q1/6809 , C12Q1/6813 , C12Q1/6816 , C12Q1/6834 , C12Q1/6888 , C12Q1/689 , C12Q1/6895 , C12Q1/70 , G01N15/14 , G01N21/47 , G01N21/6428 , G01N33/6803 , C12Q2565/626 , C12Q2525/161 , C12Q2525/191 , C12Q2533/107
摘要： The present invention provides, among other things, methods and compositions for detecting and quantifying target nucleic acids via post-hybridization labeling. In some embodiments, the present invention provides a method for detecting the presence and/or abundance of target nucleic acids in a sample by (a) contacting a plurality of nucleic acid probes with a sample, each nucleic acid probe comprising a capturing sequence for binding a target nucleic acid and an adjacent adapter sequence for binding a universal adapter; (b) incubating the plurality of probes and the sample, in the presence of one or more universal adapters, under conditions that permit binding of both an individual target nucleic acid and an individual universal adapter to a same individual nucleic acid probe; (c) carrying out a reaction that allows coupling of the individual universal adapter to the individual target nucleic acid when hybridized to the same individual nucleic acid probe; (d) detecting the presence of the one or more universal adapters associated with the plurality of nucleic acid probes, thereby detecting the presence of the target nucleic acids in the sample. Typically, universal adapters are labeled with detectable moieties or other labeling groups to facilitate detection. In some embodiments, the plurality of nucleic acid probes suitable for the invention are attached to a substrate or object (e.g., microarray, or particle).
摘要翻译：本发明尤其提供了用于通过后杂交标记检测和定量靶核酸的方法和组合物。在一些实施方案中，本发明提供了通过（a）使多个核酸探针与样品接触来检测样品中靶核酸的存在和/或丰度的方法，每个核酸探针包含用于结合的捕获序列目标核酸和用于结合通用适配器的相邻适配器序列; （b）在一种或多种通用衔接子的存在下，在允许单独的靶核酸和单个通用衔接子与相同的单个核酸探针结合的条件下孵育多个探针和样品; （c）当与相同的单个核酸探针杂交时进行允许单个通用衔接子与单个靶核酸偶联的反应; （d）检测与多个核酸探针相关联的一个或多个通用适配器的存在，从而检测样品中靶核酸的存在。通常，通用衔接子用可检测部分或其他标记基团标记以便于检测。在一些实施方案中，适用于本发明的多个核酸探针连接到底物或物体（例如微阵列或颗粒）上。

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