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1. 发明申请

WO2006049854A3 DISRUPTIONS OF GENES ENCODING SECRETED PROTEINS, COMPOSITIONS AND METHODS RELATING THERETO 审中-公开
标题翻译：编码分泌蛋白质的组合物的组合物和方法的破坏
公开(公告)号：WO2006049854A3
公开(公告)日：2007-05-10
申请号：PCT/US2005037291
申请日：2005-10-18
申请人： GENENTECH INC , LEXICON GENETICS INC , BYERS-HORNER ALLISON ANNE , COMBS KATHERIN , DESAUVAGE FREDERIC , DING ZHIYONG , FRENCH DOROTHY , GONZALEZ LINO , MASSEY ERIN MARIE , MINZE LAURIE JEANETTE , MONTGOMERY CHUCK , PRAETOR ASJA , RANGEL CAROLINA , SHI ZHENG-ZHENG , SPARKS MARY JEAN , STALA JOY , VOGEL PETER , WILLIS-SEVAUX TRACY ELLEN , YE WEILAN
发明人： BYERS-HORNER ALLISON ANNE , COMBS KATHERIN , DESAUVAGE FREDERIC , DING ZHIYONG , FRENCH DOROTHY , GONZALEZ LINO , MASSEY ERIN MARIE , MINZE LAURIE JEANETTE , MONTGOMERY CHUCK , PRAETOR ASJA , RANGEL CAROLINA , SHI ZHENG-ZHENG , SPARKS MARY JEAN , STALA JOY , VOGEL PETER , WILLIS-SEVAUX TRACY ELLEN , YE WEILAN
IPC分类号： C07K14/47
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/035
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO194, PRO220, PRO241, PRO284, PRO331, PRO354, PRO355, PRO533, PRO541, PRO725, PRO937, PRO1014, PRO1120, PRO1182, PRO1325, PRO1382, PRO1410, PRO1555, PRO1556, PRO1760, PRO1787, PRO1868, PRO4326, PRO4332, PRO4346, PRO4400, PRO6003, PRO6094, PRO6244, PRO9820, PRO9828, PRO10274, PRO16090, PRO19644, PRO21340, PRO92165, PRO85143, PRO1124, PRO1026 or PRO23370 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译：本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。具体地，本发明提供转基因小鼠，其包括PRO194，PRO220，PRO241，PRO284，PRO331，PRO354，PRO355，PRO533，PRO541，PRO725，PRO937，PRO1014，PRO1120，PRO1182，PRO1325，PRO1382，PRO1410，PRO1555，PRO1556，PRO1760中的中断，PRO1787，PRO1868，PRO4326，PRO4332，PRO4346，PRO4400，PRO6003，PRO6094，PRO6244，PRO9820，PRO9828，PRO10274，PRO16090，PRO19644，PRO21340，PRO92165，PRO85143，PRO1124，PRO1026或PRO23370基因。这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱或发育异常。

2. 发明申请

WO2006132788A3 TRANSGENIC MODELS FOR DIFFERENT GENES AND THEIR USE FOR GENE CHARACTERIZATION 审中-公开
标题翻译：不同基因的转基因模型及其基因特征的使用
公开(公告)号：WO2006132788A3
公开(公告)日：2007-07-26
申请号：PCT/US2006019651
申请日：2006-05-18
申请人： GENENTECH INC , LEXICON PHARMACEUTICALS INC , HORNER ALLISON ANNE BYERS , COMBS KATHERIN E , CULBERTSON LING LING , DESAUVAGE FREDERIC , DING ZHIYONG , EDWARDS JOEL , GIRGIS ROSEMARY , JUNGE HARALD , JUNUTULA JAGATH REDDY , MASSEY ERIN MARIE , MCLAIN DINA REBECCA , MONTGOMERY CHARLES A , PAYNE BOBBY JOE , PHILLIPS HEIDI , QIAN NI NANCY , RANGEL CAROLINA , SHI ZHENG-ZHENG , SPARKS MARY JEAN , STALA JOY , VOGEL PETER , SEVAUX TRACY ELLEN WILLIS , YE WEILAN
发明人： HORNER ALLISON ANNE BYERS , COMBS KATHERIN E , CULBERTSON LING LING , DESAUVAGE FREDERIC , DING ZHIYONG , EDWARDS JOEL , GIRGIS ROSEMARY , JUNGE HARALD , JUNUTULA JAGATH REDDY , MASSEY ERIN MARIE , MCLAIN DINA REBECCA , MONTGOMERY CHARLES A , PAYNE BOBBY JOE , PHILLIPS HEIDI , QIAN NI NANCY , RANGEL CAROLINA , SHI ZHENG-ZHENG , SPARKS MARY JEAN , STALA JOY , VOGEL PETER , SEVAUX TRACY ELLEN WILLIS , YE WEILAN
IPC分类号： A01K67/027 , C12N15/85 , G01N33/00
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N15/8509
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO69122, PRO204, PRO214, PRO222, PRO234, PRO265, PRO309, PRO332, PRO342, PRO356, PRO540, PRO618, PRO944, PRO994, PRO1079, PRO1110, PRO1122, PRO1138, PRO1190, PRO1272, PRO1286, PRO1295, PRO1309, PRO1316, PRO1383, PRO1384, PRO1431, PRO1434, PRO1475, PRO1481, PRO1568, PRO1573, PRO1599, PRO1604, PRO1605, PRO1693, PRO1753, PRO1755, PRO1777, PRO1788, PRO1864, PRO1925, PRO1926, PRO3566, PRO4330, PRO4423, PRO36935, PRO4977, PRO4979, PRO4980, PRO4981, PRO5801, PRO5995, PRO6001, PRO6095, PRO6182, PRO7170, PRO7171, PRO7436, PRO9912, PRO9917, PRO37337, PRO37496, PRO19646, PRO21718, PRO19820, PRO21201, PRO20026, PRO20110, PRO23203 or PRO35250 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译：本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。具体地，本发明提供转基因小鼠，其包括PRO69122，PRO204，PRO214，PRO222，PRO234，PRO265，PRO309，PRO332，PRO342，PRO356，PRO540，PRO618，PRO944，PRO994，PRO1079，PRO1110，PRO1122，PRO1138，PRO1190，PRO1272中的中断，PRO1286，PRO1295，PRO1309，PRO1316，PRO1383，PRO1384，PRO1431，PRO1434，PRO1475，PRO1481，PRO1568，PRO1573，PRO1599，PRO1604，PRO1605，PRO1693，PRO1753，PRO1755，PRO1777，PRO1788，PRO1864，PRO1925，PRO1926，PRO3566，PRO4330 ，PRO4423，PRO36935，PRO4977，PRO4979，PRO4980，PRO4981，PRO5801，PRO5995，PRO6001，PRO6095，PRO6182，PRO7170，PRO7171，PRO7436，PRO9912，PRO9917，PRO37337，PRO37496，PRO19646，PRO21718，PRO19820，PRO21201，PRO20026，PRO20110，PRO23203 或PRO35250基因。这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱或发育异常。

3. 发明申请

WO2006098887A3 GENE DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO 审中-公开
标题翻译：基因破坏，组合物和方法相关
公开(公告)号：WO2006098887A3
公开(公告)日：2007-08-09
申请号：PCT/US2006007353
申请日：2006-02-27
申请人： GENENTECH INC , LEXICON PHARMACEUTICALS INC , HORNER ALLISON ANNE BYERS , CLARKE CATHERINE ANNE B , COMBS KATHERIN E , DESAUVAGE FREDERIC , EDWARDS JOEL , GODOWSKI PAUL , GRANT DEANNA , HUANG WENHU , KETCHERSIDE LORELEI DIANE , MASSEY ERIN MARIE , MONTGOMERY CHARLES A , PAYNE BOBBY JOE , PETERSON ANDREW , QIAN NI NANCY , SCHRICK JEFFREY J , SHI ZHENG-ZHENG , SPARKS MARY JEAN , STALA JOY , VIATOR COLLEEN M , VOGEL PETER , YE WEILAN , YEH JUNG-HUA , DING ZHIYONG
发明人： HORNER ALLISON ANNE BYERS , CLARKE CATHERINE ANNE B , COMBS KATHERIN E , DESAUVAGE FREDERIC , EDWARDS JOEL , GODOWSKI PAUL , GRANT DEANNA , HUANG WENHU , KETCHERSIDE LORELEI DIANE , MASSEY ERIN MARIE , MONTGOMERY CHARLES A , PAYNE BOBBY JOE , PETERSON ANDREW , QIAN NI NANCY , SCHRICK JEFFREY J , SHI ZHENG-ZHENG , SPARKS MARY JEAN , STALA JOY , VIATOR COLLEEN M , VOGEL PETER , YE WEILAN , YEH JUNG-HUA , DING ZHIYONG
IPC分类号： A01K67/027 , A61K39/395 , C07K14/47 , C07K14/515 , C07K16/18 , C12N5/10 , G01N33/50
CPC分类号： C07K14/47 , A01K2217/075 , A61K2039/505 , G01N2500/00
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO179, PRO181, PRO244, PRO247, PRO269, PRO293, PRO298, PRO339, PRO341, PRO347, PRO531, PRO537, PRO718, PRO773, PRO860, PRO871, PRO872, PRO813, PRO828, PRO1100, PRO1114, PRO1115, PRO1126, PRO1133, PRO1154, PRO1185, PRO1194, PRO1287, PRO1291, PRO1293, PRO1310, PRO1312, PRO1335, PRO1339, PRO2155, PRO1356, PRO1385, PRO1412, PRO1487, PRO1758, PRO1779, PRO1785, PRO1889, PRO90318, PRO3434, PRO3579, PRO4322, PRO4343, PRO4347, PRO4403, PRO4976, PRO260, PRO6014, PRO6027, PRO6181, PRO6714, PRO9922, PRO7179, PRO7476, PRO9824, PRO19814, PRO19836, PRO20088, PRO70789, PRO50298, PRO51592, PRO1757, PRO4421, PRO9903, PRO1106, PRO1411, PRO1486, PRO1565, PRO4399 or PRO4404 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译：本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。具体地说，本发明提供转基因小鼠，其包括PRO179，PRO181，PRO244，PRO247，PRO269，PRO293，PRO298，PRO339，PRO341，PRO347，PRO531，PRO537，PRO718，PRO773，PRO860，PRO871，PRO872，PRO813，PRO828，PRO1100中的中断，PRO1114，PRO1115，PRO1126，PRO1133，PRO1154，PRO1185，PRO1194，PRO1287，PRO1291，PRO1293，PRO1310，PRO1312，PRO1335，PRO1339，PRO2155，PRO1356，PRO1385，PRO1412，PRO1487，PRO1758，PRO1779，PRO1785，PRO1889，PRO90318，PRO3434 ，PRO3579，PRO4322，PRO4343，PRO4347，PRO4403，PRO4976，PRO260，PRO6014，PRO6027，PRO6181，PRO6714，PRO9922，PRO7179，PRO7476，PRO9824，PRO19814，PRO19836，PRO20088，PRO70789，PRO50298，PRO51592，PRO1757，PRO4421，PRO9903，PRO1106 ，PRO1411，PRO1486，PRO1565，PRO4399或PRO4404基因。这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱或发育异常。

4. 发明申请

WO2005058028A3 NOVEL GENE DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO 审中-公开
标题翻译：新的基因破坏，组合物和方法相关
公开(公告)号：WO2005058028A3
公开(公告)日：2006-05-18
申请号：PCT/US2004041721
申请日：2004-12-13
申请人： GENENTECH INC , LEXICON GENETICS INC , ANDERSON STEPHEN , BRENNAN JANE , DESAUVAGE FREDERIC , DING ZHIYONG , EDWARDS JOEL , FIKES NELDA , HUANG WENHU , OUYANG WENJUN , RANGEL CAROLINA , SANGHA MAMTA , SHI ZHENG-ZHENG , SPARKS MARY JEAN , TRACKEY JOSEPH , VETTER MELISSA , WANG CHING-YUN , WOODINGS JESSICA
发明人： ANDERSON STEPHEN , BRENNAN JANE , DESAUVAGE FREDERIC , DING ZHIYONG , EDWARDS JOEL , FIKES NELDA , HUANG WENHU , OUYANG WENJUN , RANGEL CAROLINA , SANGHA MAMTA , SHI ZHENG-ZHENG , SPARKS MARY JEAN , TRACKEY JOSEPH , VETTER MELISSA , WANG CHING-YUN , WOODINGS JESSICA
IPC分类号： A01K67/027
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0306
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO224, PRO9783, PRO1108, PRO34000, PRO240, PRO943, hu A33, PRO230, PRO178, PRO1199, PRO4333, PRO1336, PRO19598, PRO1083, hu TRPM2 or PRO1801 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译：本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。具体地说，本发明提供包含PRO224，PRO9783，PRO1108，PRO34000，PRO240，PRO943，hu A33，PRO230，PRO178，PRO1199，PRO4333，PRO1336，PRO19598，PRO1083，hu TRPM2或PRO1801基因中的中断的转基因小鼠。这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱或发育异常。

5. 发明申请

WO2006017279A3 METHODS AND COMPOSITIONS RELATED TO IDENTIFYING PROTEIN-PROTEIN INTERACTIONS 审中-公开
标题翻译：鉴定蛋白质 - 蛋白质相互作用相关的方法和组合
公开(公告)号：WO2006017279A3
公开(公告)日：2006-08-03
申请号：PCT/US2005024677
申请日：2005-07-12
申请人： UNIV TEXAS , DING ZHIYONG , MILLS GORDON
发明人： DING ZHIYONG , MILLS GORDON
IPC分类号： C07H21/02 , A01N63/00 , C07H21/04 , C12N5/02 , C12N7/00 , C12N9/00 , C12N15/63 , C12P21/06
CPC分类号： C12N15/1055
摘要： The present invention involves compositions and methods for assessing protein interactions in eukaryotic cells. Certain embodiments involve Retrovirus-Based Molecular Two-Hybrid Screens (ReMTH). Re MTH screens differ from other methods by performing screens in the native cellular hosts without cDNA library construction. Embodiments of the invention use the advantages of tagging endogenous genes with an exon encoding a marker fragment in combination with protein-fragment complementation assays (PCAs), which includes the complementation of at least two marker fragments to form a detectable marker complex. ReMTH vectors insert a nucleotide sequence encoding a first fragment of a marker, such as green fluorescent protein (GFP), into an endogenous gene resulting in expression of random endogenous genes tagged with a first marker fragment forming an endogenous prey protein or prey protein. ReMTH contain cells also express a bait protein that is fused with a second marker fragment. Prey/Bait interaction produces a reconstituted, detectable marker.
摘要翻译：本发明涉及用于评估真核细胞中蛋白质相互作用的组合物和方法。某些实施方案涉及基于逆转录病毒的分子双杂交筛选（ReMTH）。通过在没有cDNA文库构建的天然细胞宿主中进行筛选，Re MTH筛选与其它方法不同。本发明的实施方案利用将编码标记片段的外显子与蛋白质 - 片段互补测定（PCAs）结合的内源基因标记的优点，其包括至少两个标记片段的互补以形成可检测的标记物复合物。 ReMTH载体将编码标记物的第一片段（例如绿色荧光蛋白（GFP））的核苷酸序列插入到内源基因中，导致用形成内源猎物蛋白质或猎物蛋白质的第一标记片段标记的随机内源基因的表达。含有细胞的ReMTH还表达与第二标记片段融合的诱饵蛋白质。捕食/诱饵相互作用产生重建的可检测标记。

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