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1. 发明申请

WO0032776A3 SECRETED AMD TRANSMEMBRANE POLYPEPTIDES AND NUCLEIC ACIDS ENCODING THE SAME 审中-公开
标题翻译：分解的AMD转化子多核苷酸和编码其的核酸
公开(公告)号：WO0032776A3
公开(公告)日：2000-12-28
申请号：PCT/US9928301
申请日：1999-12-01
申请人： GENENTECH INC , BAKER KEVIN P , BOTSTEIN DAVID , EATON DAN L , FERRARA NAPOLEONE , FILVAROFF ELLEN , GERRITSEN MARY E , GODDARD AUDREY , GODOWSKI PAUL J , GRIMALDI CHRISTOPHER J , GURNEY AUSTIN L , HILLAN KENNETH J , KLJAVIN IVAR J , NAPIER MARY A , ROY MARGARET ANN , TUMAS DANIEL , WOOD WILLIAM I
发明人： BAKER KEVIN P , BOTSTEIN DAVID , EATON DAN L , FERRARA NAPOLEONE , FILVAROFF ELLEN , GERRITSEN MARY E , GODDARD AUDREY , GODOWSKI PAUL J , GRIMALDI CHRISTOPHER J , GURNEY AUSTIN L , HILLAN KENNETH J , KLJAVIN IVAR J , NAPIER MARY A , ROY MARGARET ANN , TUMAS DANIEL , WOOD WILLIAM I
IPC分类号： G01N33/50 , A61K35/76 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P19/02 , A61P29/00 , A61P35/00 , C07H21/04 , C07K14/47 , C07K14/78 , C07K16/18 , C07K19/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , G01N33/15 , G01N33/53 , G01N33/577 , C12N15/62
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K16/18 , C07K2317/24 , C07K2319/00 , C07K2319/02
摘要： The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：本发明涉及分泌和跨膜多肽以及编码这些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。

2. 发明申请

WO0036102A3 SECRETED AND TRANSMEMBRANE POLYPEPTIDES AND NUCLEIC ACIDS ENCODING THE SAME 审中-公开
标题翻译：分泌型和跨膜型多肽与编码相同的核酸
公开(公告)号：WO0036102A3
公开(公告)日：2000-11-09
申请号：PCT/US9928634
申请日：1999-12-01
申请人： GENENTECH INC , BOTSTEIN DAVID , DESNOYERS LUC , FERRARA NAPOLEONE , FONG SHERMAN , GAO WEI QIANG , GODDARD AUDREY , GURNEY AUSTIN L , PAN JAMES , ROY MARGARET ANN , STEWART TIMOTHY A , TUMAS DANIEL , WATANABE COLIN K , WOOD WILLIAM I
发明人： BOTSTEIN DAVID , DESNOYERS LUC , FERRARA NAPOLEONE , FONG SHERMAN , GAO WEI-QIANG , GODDARD AUDREY , GURNEY AUSTIN L , PAN JAMES , ROY MARGARET ANN , STEWART TIMOTHY A , TUMAS DANIEL , WATANABE COLIN K , WOOD WILLIAM I
IPC分类号： C12N15/09 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/46 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N15/02 , C12N15/12 , C12N15/62 , C12P21/02 , C12P21/08 , C12R1/91
CPC分类号： C12N9/001 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/28
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：本发明涉及新的多肽和编码这些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，结合本发明多肽的抗体以及产生本发明多肽的方法发明。

3. 发明申请

WO0053755A3 COMPOSITIONS AND METHODS FOR THE TREATMENT OF TUMOR 审中-公开
公开(公告)号：WO0053755A3
公开(公告)日：2001-02-08
申请号：PCT/US0000376
申请日：2000-01-06
申请人： GENENTECH INC , ASHKENAZI AVI J , BAKER KEVIN P , GODDARD AUDREY , GURNEY AUSTIN L , HILLAN KENNETH J , ROY MARGARET ANN , WATANABE COLIN K , WOOD WILLIAM I
发明人： ASHKENAZI AVI J , BAKER KEVIN P , GODDARD AUDREY , GURNEY AUSTIN L , HILLAN KENNETH J , ROY MARGARET ANN , WATANABE COLIN K , WOOD WILLIAM I
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N15/12 , A61K39/395 , C12N15/11 , C12N15/62 , C12Q1/68 , G01N33/574
CPC分类号： C07K14/70578 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K16/18 , C07K2319/00 , C12N2799/026
摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

4. 发明申请

WO0015666A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF TUMOR 审中-公开
标题翻译：用于治疗肿瘤的组合物和方法
公开(公告)号：WO0015666A2
公开(公告)日：2000-03-23
申请号：PCT/US9920594
申请日：1999-09-08
申请人： GENENTECH INC , GODDARD AUDREY , GURNEY AUSTIN L , HILLAN KENNETH J , ROY MARGARET ANN , WOOD WILLIAM I , BOTSTEIN DAVID
发明人： GODDARD AUDREY , GURNEY AUSTIN L , HILLAN KENNETH J , ROY MARGARET ANN , WOOD WILLIAM I , BOTSTEIN DAVID
IPC分类号： G01N33/50 , A61K31/711 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , C07K14/47 , C07K16/00 , C07K16/18 , C07K16/22 , C07K16/28 , C07K16/32 , C12N20060101 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N5/16 , C12N15/09 , C12N15/11 , C12N15/12 , C12N15/13 , C12N15/63 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/574 , G01N33/577
CPC分类号： C07K14/47
摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as predictors of the prognosis of tumor treatment.
摘要翻译：本发明涉及用于诊断和治疗哺乳动物（包括人）中的肿瘤细胞生长和增殖的组合物和方法。本发明基于在肿瘤细胞基因组中扩增的基因的鉴定。预期这种基因扩增与相同组织类型的正常细胞相比，与基因产物的过度表达相关并且有助于肿瘤发生。因此，由扩增的基因编码的蛋白质被认为是某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。

5. 发明申请

WO9935170A8 COMPOSITIONS AND METHODS FOR THE TREATMENT OF TUMOR 审中-公开
标题翻译：用于治疗肿瘤的组合物和方法
公开(公告)号：WO9935170A8
公开(公告)日：1999-10-21
申请号：PCT/US9900106
申请日：1999-01-05
申请人： GENENTECH INC , BOTSTEIN DAVID , GODDARD AUDREY , GURNEY AUSTIN L , HILLAN KENNETH J , LAWRENCE DAVID A , ROY MARGARET ANN , WOOD WILLIAM I
发明人： BOTSTEIN DAVID , GODDARD AUDREY , GURNEY AUSTIN L , HILLAN KENNETH J , LAWRENCE DAVID A , ROY MARGARET ANN , WOOD WILLIAM I
IPC分类号： C07K14/47 , C07K16/30 , A61K39/395 , G01N33/574 , G01N33/577
CPC分类号： C07K14/47
摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act of predictors of the prognosis of tumor treatment.
摘要翻译：本发明涉及用于诊断和治疗哺乳动物（包括人）中的肿瘤细胞生长和增殖的组合物和方法。本发明基于鉴定在肿瘤细胞基因组中扩增的基因。预计这种基因扩增与基因产物的过表达有关并且有助于肿瘤发生。因此，由扩增基因编码的蛋白被认为是用于某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且可以用作肿瘤治疗预后的预测因子。

6. 发明申请

WO9935170A9 COMPOSITIONS AND METHODS FOR THE TREATMENT OF TUMOR 审中-公开
标题翻译：用于治疗肿瘤的组合物和方法
公开(公告)号：WO9935170A9
公开(公告)日：2000-03-09
申请号：PCT/US9900106
申请日：1999-01-05
申请人： GENENTECH INC , BOTSTEIN DAVID , GODDARD AUDREY , GURNEY AUSTIN L , HILLAN KENNETH J , LAWRENCE DAVID A , ROY MARGARET ANN , WOOD WILLIAM I
发明人： BOTSTEIN DAVID , GODDARD AUDREY , GURNEY AUSTIN L , HILLAN KENNETH J , LAWRENCE DAVID A , ROY MARGARET ANN , WOOD WILLIAM I
IPC分类号： C07K14/47 , C07K16/30 , A61K39/395 , G01N33/574 , G01N33/577
CPC分类号： C07K14/47
摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act of predictors of the prognosis of tumor treatment.
摘要翻译：本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。本发明基于在肿瘤细胞基因组中扩增的基因的鉴定。预期这种基因扩增与基因产物的过表达有关，并有助于肿瘤发生。因此，由扩增的基因编码的蛋白质被认为是某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。

7. 发明申请

WO9927100A9 FIBROBLAST GROWTH FACTOR-19 审中-公开
公开(公告)号：WO9927100A9
公开(公告)日：2000-05-11
申请号：PCT/US9825190
申请日：1998-11-25
申请人： GENENTECH INC , BOTSTEIN DAVID , GODDARD AUDREY , GURNEY AUSTIN L , HILLAN KENNETH J , LAWRENCE DAVID A , ROY MARGARET ANN
发明人： BOTSTEIN DAVID , GODDARD AUDREY , GURNEY AUSTIN L , HILLAN KENNETH J , LAWRENCE DAVID A , ROY MARGARET ANN
IPC分类号： C12N15/09 , C07K14/50 , C07K16/22 , C12N20060101 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/62 , C12P21/02 , C12P21/08
CPC分类号： C07K14/50 , C07K2319/00
摘要： The present invention is directed to novel polypeptides having homology to the PRO533 protein and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention, and methods for producing the polypeptides of the present invention. The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis and/or autocrine signaling. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act of predictors of the prognosis of tumor treatment. Furthermore, the compounds, compositions including antagonists and methods of the present invention are further expected to have therapeutic effect upon conditions characterized by FgF-19 modulation.
摘要翻译：本发明涉及与PRO533蛋白具有同源性的新多肽和编码那些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，与本发明的多肽结合的抗体，以及本发明多肽的制备方法发明。本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。本发明基于在肿瘤细胞基因组中扩增的基因的鉴定。预期这种基因扩增与基因产物的过度表达有关，并且有助于肿瘤发生和/或自分泌信号传导。因此，由扩增的基因编码的蛋白质被认为是某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。此外，进一步预期本发明的化合物，包括拮抗剂和方法的组合物对于以FgF-19调节为特征的病症具有治疗作用。

8. 发明申请

WO0037640A3 COMPOSITIONS AND METHODS FOR THE TREATMENT OF TUMOR 审中-公开
标题翻译：用于治疗肿瘤的组合物和方法
公开(公告)号：WO0037640A3
公开(公告)日：2000-12-28
申请号：PCT/US9930095
申请日：1999-12-16
申请人： GENENTECH INC , BOTSTEIN DAVID , GODDARD AUDREY , GURNEY AUSTIN L , HILLAN KENNETH , LAWRENCE DAVID A , ROY MARGARET ANN , WOOD WILLIAM I
发明人： BOTSTEIN DAVID , GODDARD AUDREY , GURNEY AUSTIN L , HILLAN KENNETH , LAWRENCE DAVID A , ROY MARGARET ANN , WOOD WILLIAM I
IPC分类号： G01N33/50 , A61K20060101 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , C07K20060101 , C07K14/47 , C07K16/18 , C07K19/00 , C12N20060101 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/09 , C12N15/11 , C12N15/12 , C12N15/62 , C12P21/02 , C12P21/08 , C12Q20060101 , C12Q1/02 , C12Q1/68 , G01N20060101 , G01N33/15 , G01N33/53
CPC分类号： C07K16/18 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K2317/24 , C07K2319/00 , C12N2799/026
摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：本发明涉及用于诊断和治疗哺乳动物（包括人）中的肿瘤细胞生长和增殖的组合物和方法。本发明基于鉴定在肿瘤细胞基因组中扩增的基因。与相同组织类型的正常细胞相比，预计这种基因扩增与基因产物的过度表达相关并且有助于肿瘤发生。因此，由扩增基因编码的蛋白质被认为是用于某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且可以充当肿瘤治疗预后的预测因子。本发明涉及新的多肽和编码这些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，结合本发明多肽的抗体以及产生本发明多肽的方法发明。

9. 发明申请

WO0037640A9 COMPOSITIONS AND METHODS FOR THE TREATMENT OF TUMOR 审中-公开
公开(公告)号：WO0037640A9
公开(公告)日：2000-11-02
申请号：PCT/US9930095
申请日：1999-12-16
申请人： GENENTECH INC , BOTSTEIN DAVID , GODDARD AUDREY , GURNEY AUSTIN L , HILLAN KENNETH , LAWRENCE DAVID A , ROY MARGARET ANN , WOOD WILLIAM I
发明人： BOTSTEIN DAVID , GODDARD AUDREY , GURNEY AUSTIN L , HILLAN KENNETH , LAWRENCE DAVID A , ROY MARGARET ANN , WOOD WILLIAM I
IPC分类号： G01N33/50 , A61K20060101 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , C07K20060101 , C07K14/47 , C07K16/18 , C07K19/00 , C12N20060101 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/09 , C12N15/11 , C12N15/12 , C12N15/62 , C12P21/02 , C12P21/08 , C12Q20060101 , C12Q1/02 , C12Q1/68 , G01N20060101 , G01N33/15 , G01N33/53
CPC分类号： C07K16/18 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K2317/24 , C07K2319/00 , C12N2799/026
摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

10. 发明申请

WO0043790A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF TUMOR 审中-公开
标题翻译：用于治疗肿瘤的组合物和方法
公开(公告)号：WO0043790A2
公开(公告)日：2000-07-27
申请号：PCT/US0001441
申请日：2000-01-19
申请人： GENENTECH INC , BOTSTEIN DAVID , GODDARD AUDREY , LAWRENCE DAVID A , PENNICA DIANE , ROY MARGARET ANN , WOOD WILLIAM I
发明人： BOTSTEIN DAVID , GODDARD AUDREY , LAWRENCE DAVID A , PENNICA DIANE , ROY MARGARET ANN , WOOD WILLIAM I
IPC分类号： G01N33/50 , A61K39/395 , A61K45/00 , A61P35/00 , C07K14/52 , C07K16/24 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/574 , G01N33/68 , C07K14/00
CPC分类号： C07K16/24 , C07K14/52
摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of cardiotrophin-1 gene amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Accordingly, the cardiotrophin-1 polypeptide encoded by the amplified gene is believed to be a useful target for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as a predictor of the prognosis of tumor treatment.
摘要翻译：本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。本发明基于在肿瘤细胞基因组中扩增的心肌营养因子-1基因的鉴定。预期这种基因扩增与基因产物的过表达有关，并有助于肿瘤发生。因此，由扩增的基因编码的心肌营养因子-1多肽被认为是某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。

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