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1. 发明申请

WO0032776A3 SECRETED AMD TRANSMEMBRANE POLYPEPTIDES AND NUCLEIC ACIDS ENCODING THE SAME 审中-公开
标题翻译：分解的AMD转化子多核苷酸和编码其的核酸
公开(公告)号：WO0032776A3
公开(公告)日：2000-12-28
申请号：PCT/US9928301
申请日：1999-12-01
申请人： GENENTECH INC , BAKER KEVIN P , BOTSTEIN DAVID , EATON DAN L , FERRARA NAPOLEONE , FILVAROFF ELLEN , GERRITSEN MARY E , GODDARD AUDREY , GODOWSKI PAUL J , GRIMALDI CHRISTOPHER J , GURNEY AUSTIN L , HILLAN KENNETH J , KLJAVIN IVAR J , NAPIER MARY A , ROY MARGARET ANN , TUMAS DANIEL , WOOD WILLIAM I
发明人： BAKER KEVIN P , BOTSTEIN DAVID , EATON DAN L , FERRARA NAPOLEONE , FILVAROFF ELLEN , GERRITSEN MARY E , GODDARD AUDREY , GODOWSKI PAUL J , GRIMALDI CHRISTOPHER J , GURNEY AUSTIN L , HILLAN KENNETH J , KLJAVIN IVAR J , NAPIER MARY A , ROY MARGARET ANN , TUMAS DANIEL , WOOD WILLIAM I
IPC分类号： G01N33/50 , A61K35/76 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P19/02 , A61P29/00 , A61P35/00 , C07H21/04 , C07K14/47 , C07K14/78 , C07K16/18 , C07K19/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , G01N33/15 , G01N33/53 , G01N33/577 , C12N15/62
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K16/18 , C07K2317/24 , C07K2319/00 , C07K2319/02
摘要： The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：本发明涉及分泌和跨膜多肽以及编码这些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。

2. 发明申请

WO0109327A3 METHOD OF PREVENTING THE INJURY OR DEATH OF RETINAL CELLS AND TREATING OCULAR DISEASES 审中-公开
标题翻译：预防视网膜细胞损伤或死亡并治疗眼部疾病的方法
公开(公告)号：WO0109327A3
公开(公告)日：2001-08-02
申请号：PCT/US0020710
申请日：2000-07-28
申请人： GENENTECH INC , ASHKENAZI AVI J , BAKER KEVIN P , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , KLJAVIN IVAR J , LAFLEUR MONIQUE , MARK MELANIE R , MARSTERS SCOT A , PITTI ROBERT M , WATANABE COLIN K , WOOD WILLIAM I
发明人： ASHKENAZI AVI J , BAKER KEVIN P , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , KLJAVIN IVAR J , LAFLEUR MONIQUE , MARK MELANIE R , MARSTERS SCOT A , PITTI ROBERT M , WATANABE COLIN K , WOOD WILLIAM I
IPC分类号： A61K38/00 , A61K38/17 , C07K14/47 , C07K14/705 , C07K16/18 , C12N15/12 , C12N15/62
CPC分类号： C07K14/4703 , A61K38/00 , C07K14/70578 , G01N2800/164
摘要： The present invention relates to the use of PRO polypeptides to delay, prevent or rescue retinal neurons, including photoreceptors, other retinal cells or supportive cells (e.g. Müller cells or RPE cells) from injury and/or death. Conditions comprehended by treatment of the present PRO polypeptides (including variants), antibodies, compositions and articles of manufacture include: retinal detachment, age-related and other maculopathies, photic retinopathies, surgery-induced retinopathies (either mechanically or light-induced), toxic retinopathies including those resulting from foreign bodies in the eye, diabetic retinopathies, retinopathy of prematurity, viral retinopathies such as CMV or HIV retinopathy related to AIDS, uveitis, ischemic retinopathies due to venous or arterial occlusion or other vascular disorder, retinopathies due to trauma or penetrating lesions of the eye, peripheral vitreoretinopathy, and inherited retinal degenerations. Exemplary retinal degenerations include e.g., hereditary spastic paraplegia with retinal degeneration (Kjellin and Barnard-Scholz syndromes), retinitis pigmentosa, Stargardt disease, Usher syndrome (retinitis pigmentosa with congenital hearing loss), and Refsum syndrome (retinitis pigmentosa, hereditary hearing loss, and polyneuropathy). Additional disorders which result in death of retinal neurons include, retinal tears, detachment of the retina and pigment epithelium, degenerative myopia, acute retinal necrosis syndrome (ARN), traumatic chorioretinopathies or contusion (Purtscher's Retinopathy) and edema.
摘要翻译：本发明涉及PRO多肽用于延迟，预防或挽救视网膜神经元（包括光感受器，其他视网膜细胞或支持细胞（例如Müller细胞或RPE细胞）免受损伤和/或死亡）。通过治疗本发明的PRO多肽（包括变体），抗体，组合物和制造品而理解的病症包括：视网膜脱离，年龄相关性和其他黄斑病，光视网膜病，手术诱导的视网膜病（机械或光诱导），毒性视网膜病变，包括由眼内异物引起的视网膜病，糖尿病性视网膜病，早产儿视网膜病，病毒视网膜病如与AIDS有关的CMV或HIV视网膜病，葡萄膜炎，由于静脉或动脉闭塞或其他血管病导致的缺血性视网膜病，由创伤引起的视网膜病，穿透性眼部病变，外周玻璃体视网膜病变和遗传性视网膜变性。示例性视网膜变性包括例如具有视网膜变性（Kjellin和Barnard-Scholz综合征）的遗传性痉挛性截瘫，色素性视网膜炎，Stargardt病，Usher综合征（具有先天性听力丧失的视网膜色素变性）和Refsum综合征（视网膜色素变性，遗传性听力丧失和多发性神经病）。导致视网膜神经细胞死亡的其它疾病包括视网膜撕裂，视网膜和色素上皮脱离，退行性近视，急性视网膜坏死综合征（ARN），创伤性脉络膜视网膜病变或挫伤（Purtscher视网膜病变）和水肿。

3. 发明申请

WO0053760A3 METHOD OF PREVENTING THE DEATH OF RETINAL NEURONS AND TREATING OCULAR DISEASES 审中-公开
标题翻译：预防神经元死亡和治疗眼部疾病的方法
公开(公告)号：WO0053760A3
公开(公告)日：2001-01-18
申请号：PCT/US0006319
申请日：2000-03-10
申请人： GENENTECH INC , FERRARA NAPOLEONE , GODDARD AUDREY , GURNEY AUSTIN L , HEBERT CAROLINE , HENZEL WILLIAM J , KABAKOFF RHONA C , KLEIN ROBERT D , KLJAVIN IVAR J , KUO SOPHIA S , FLEUR MONIQUE , WOOD WILLIAM I
发明人： FERRARA NAPOLEONE , GODDARD AUDREY , GURNEY AUSTIN L , HEBERT CAROLINE , HENZEL WILLIAM J , KABAKOFF RHONA C , KLEIN ROBERT D , KLJAVIN IVAR J , KUO SOPHIA S , LA FLEUR MONIQUE , WOOD WILLIAM I
IPC分类号： C07K14/47 , C12N15/12 , A61K38/17 , C07K14/52 , C07K16/18 , C12N15/62
CPC分类号： C07K14/4703 , C07K14/47 , C07K2317/24 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to the use of PRO200 (VEGF-E), PRO540, PRO846, PRO617, PRO538 (GFR alpha 3), PRO3664 (GFR alpha 3) or PRO770 (hFIZZ-1) polypeptides to delay, prevent or rescue retinal neurons, including photoreceptors, other retinal cells or supportive cells (e.g Müller cells or RPE cells) from injury and degradation. Conditions comprehended by treatment of the present PRO200 (VEGF-E), PRO540, PRO846, PRO617, PRO538 (GFR alpha 3), PRO3664 (GFR alpha 3) or PRO770 (hFIZZ-1) polypeptides (including variants), antibodies, compositions and articles of manufacture include: retinal detachment, age-related and other maculopathies, photic retinopathies, surgery-induced retinopathies (either mechanically or light-induced), toxic retinopathies including those resulting from foreign bodies in the eye, diabetic retinpathies, retinpathy of prematurity, viral retinopathies such as CMV or HIV retinopathy related to AIDS, uveitis, ischemic retinopathies due to venous or arterial occlusion or other vascular disorder, retinopathies due to trauma or penetrating lesions of the eye, peripheral vitreoretinopathy, and inherited retinal degenerations. Exemplary retinal degenerations include e.g., hereditary spastic paraplegia with retinal degeneration (Kjellin and Barnard-Scholz syndromes), retinitis pigmentosa, Stargardt disease, Usher syndrome (retinitis pigmentosa with congenital hearing loss), and Refsum syndrome (retinitis pigmentosa, hereditary hearing loss, and polyneuropathy). Additional disorders which result in death of retinal neurons include, retinal tears, detachment of the retina and pigment epithelium, degenerative myopia, acute retinal necrosis syndrome (ARN), traumatic chorioretinopathies or contusion (Purtscher's Retinopathy) and edema.
摘要翻译：本发明涉及PRO200（VEGF-E），PRO540，PRO846，PRO617，PRO538（GFRα3），PRO3664（GFRα3）或PRO770（hFIZZ-1）多肽延迟，预防或挽救视网膜神经元的用途，包括光感受器，其他视网膜细胞或支持细胞（如Müller细胞或RPE细胞）的损伤和降解。通过治疗本PROTIN（VEGF-E），PRO540，PRO846，PRO617，PRO538（GFRα3），PRO3664（GFRα3）或PRO770（hFIZZ-1）多肽（包括变体），抗体，组合物和制造产品包括：视网膜脱离，年龄相关性和其他黄斑病，光视网膜病变，手术诱导的视网膜病变（机械或光诱导），有毒视网膜病变，包括由眼睛异物引起的视网膜病变，糖尿病视网膜病变，早产儿视网膜病变，与AIDS相关的病毒性视网膜病变或HIV视网膜病变，葡萄膜炎，由于静脉或动脉闭塞或其他血管障碍引起的缺血性视网膜病变，由于外伤或穿透性眼睛损伤引起的视网膜病变，外周性玻璃体视网膜病变和遗传性视网膜变性。示例性视网膜变性包括例如具有视网膜变性的遗传性痉挛性截瘫（Kjellin和Barnard-Scholz综合征），色素性视网膜炎，Stargardt病，Usher综合征（具有先天性听力损失的色素性视网膜炎）和Refsum综合征（色素性视网膜炎，遗传性听力损失和多发性神经病）。导致视网膜神经元死亡的其他病症包括视网膜撕裂，视网膜和色素上皮剥离，退行性近视，急性视网膜坏死综合征（ARN），创伤性脉络膜视网膜病变或挫伤（Purtscher's Retinopathy）和水肿。

4. 发明申请

WO9945952A3 METHOD OF PREVENTING THE DEATH OF RETINAL NEURONS AND TREATING OCULAR DISEASES 审中-公开
标题翻译：预防神经元死亡和治疗眼部疾病的方法
公开(公告)号：WO9945952A3
公开(公告)日：2000-11-23
申请号：PCT/US9905375
申请日：1999-03-10
申请人： GENENTECH INC
发明人： KLJAVIN IVAR J , LA FLEUR MONIQUE
IPC分类号： A61K38/00 , A61K38/18 , A61P25/00 , A61P27/02 , A61P43/00
CPC分类号： A61K38/1825
摘要： The present invention relates to the use of FGF-5 polypeptides to delay, prevent or rescue retinal neurons, including photoreceptors, other retinal cells or supportive cells (e.g. Müller cells or RPE cells) from injury and degradation. Conditions comprehended by treatment of the present FGF-5 polypeptides (including variants), antibodies, compositions and articles of manufacture include: retinal detachment, age-related and other maculopathies, photic retinopathies, surgery-induced retinopathies (either mechanicallyy or light-induced), toxic retinopathies including those resulting from foreign bodies in the eye, diabetic retinopathies, retinopathy of prematurity, viral retinopathies such as CMV or HIV retinopathy related to AIDS, uveities, ischemic retinopathies due to venous or arterial occlusion or other vascular disorder, retinopathies due to trauma or penetrating lesions of the eye, peripheral vitreoretinopathy, and inherited retinal degenerations. Exemplary retinal degenerations include e.g., hereditary spastic paraplegia with retinal degeneration (Kjellin and Barnard-Scholz syndromes), retinis pigmentosa, Stargardt disease, Usher syndrome (retinits pigmentosa with congenital hearing loss), and Refsum syndrome (retinitis pigmentosa, hereditary hearing loss, and polyneuropathy). Additional disorders which result in death of retinal neurons include, retinal tears, detachment of the retina and pigment epithelium, degenerative myopia, acute retinal necrosis syndrome (ARN), traumatic chorioretinopathies or contusion (Purtscher's Retinopathy) and edema.
摘要翻译：本发明涉及FGF-5多肽延迟，预防或挽救视网膜神经元（包括光感受器，其他视网膜细胞或支持性细胞（例如Müller细胞或RPE细胞））免受损伤和降解的用途。通过治疗本发明的FGF-5多肽（包括变体），抗体，组合物和制品所理解的病症包括：视网膜脱离，年龄相关性和其他黄斑病变，光学视网膜病变，手术诱导的视网膜病变（机械地或光诱导的），包括由眼睛异物引起的有毒视网膜病变，糖尿病性视网膜病，早产儿视网膜病变，病毒性视网膜病变如CMV或艾滋病相关的HIV视网膜病变，葡萄膜炎，静脉或动脉闭塞或其他血管病变引起的缺血性视网膜病变，视网膜病变眼睛的创伤或穿透损伤，外周玻璃体视网膜病变和遗传性视网膜变性。示例性视网膜变性包括例如具有视网膜变性的遗传性痉挛性截瘫（Kjellin和Barnard-Scholz综合征），色素性视网膜色素变性，Stargardt病，Usher综合征（具有先天性听力损失的色素性视网膜色素变性）和Refsum综合征（色素性视网膜炎，遗传性听力损失和多发性神经病）。导致视网膜神经元死亡的其他病症包括视网膜撕裂，视网膜和色素上皮剥离，退行性近视，急性视网膜坏死综合征（ARN），创伤性脉络膜视网膜病变或挫伤（Purtscher's Retinopathy）和水肿。

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