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1. 发明申请

WO1996037216A1 METHOD OF ADMINISTRATION OF IGF-I 审中-公开
标题翻译： IGF-I的施用方法
公开(公告)号：WO1996037216A1
公开(公告)日：1996-11-28
申请号：PCT/US1996006704
申请日：1996-05-09
申请人： GENENTECH, INC. , WASHINGTON UNIVERSITY
发明人： GENENTECH, INC. , WASHINGTON UNIVERSITY , CLARK, Ross, G. , GESUNDHEIT, Neil , HAMMERMAN, Marc, R. , MILLER, Steven, B.
IPC分类号： A61K38/30
CPC分类号： A61K38/30 , A61K38/556 , A61K38/2242 , A61K38/27 , A61K2300/00
摘要： A method is disclosed that comprises administering insulin-like growth factor-I (IGF-I) to a mammal so as to sustain its biological activity in the mammal comprising administering a therapeutically effective amount of IGF-I to the mammal to provide an exposure to IGF-I for a period of time that stimulates the maximum biological response in the mammal, then discontinuing said administration for a period of time equal to or less than the time period used for administration, and repeating this pattern of administration and discontinuance of administration for a period as long as necessary to achieve or maintain the desired biological response in the mammal.
摘要翻译：公开了一种方法，其包括向哺乳动物施用胰岛素样生长因子-I（IGF-I）以维持其在哺乳动物中的生物学活性，包括向哺乳动物施用治疗有效量的IGF-1以提供暴露于 IGF-I刺激哺乳动物最大生物反应的一段时间，然后停止所述施用一段时间等于或小于用于给药的时间段，并重复这种给药方式和中断给药方式只要在哺乳动物中达到或维持所需生物反应所必需的时间。

2. 发明申请

WO1996015148A2 LOW MOLECULAR WEIGHT PEPTIDOMIMETIC GROWTH HORMONE SECRETAGOGUES 审中-公开
标题翻译：低分子重量成纤维生长激素密码子
公开(公告)号：WO1996015148A2
公开(公告)日：1996-05-23
申请号：PCT/US1995014968
申请日：1995-11-16
申请人： GENENTECH, INC.
发明人： GENENTECH, INC. , SOMERS, Todd, C. , ELIAS, Kathleen, A. , CLARK, Ross, G. , McDOWELL, Robert, S. , STANLEY, Mark, S. , BURNIER, John, P. , RAWSON, Thomas, E.
IPC分类号： C07K14/60
CPC分类号： C07D401/12 , A61K38/00 , C07D209/20 , C07D211/62 , C07D403/12 , C07K5/0202 , C07K5/0205 , C07K5/0207 , C07K5/06078 , C07K5/0812 , C07K5/1016 , C07K5/1024 , C07K7/06 , C07K14/60
摘要： The present invention comprises growth hormone releasing peptides/peptidomimetics (GHRP) capable of causing release of growth hormone from the pituitary. Compositions containing the GHRP's of this invention are used to promote growth in mammals either alone or in combination with other growth promoting compounds, especially IGF-1. In a method of this invention GHRP's in combination with IGF-1 are used to treat Type II diabetes. An exemplary compound (1) of this invention is provided above.
摘要翻译：本发明包括生长激素释放肽/肽模拟物（GHFP），其能够从垂体中释放生长激素。包含本发明的GHRP的组合物用于促进哺乳动物单独或与其它生长促进化合物，特别是IGF-1组合的生长。在本发明的方法中，GHRP与IGF-1组合用于治疗II型糖尿病。以上提供了本发明的示例性化合物（1）。

3. 发明申请

WO1998006423A1 COMPOSITION COMPRISING INSULIN AND INSULIN-LIKE GROWTH FACTOR-I (IGF-I) 审中-公开
标题翻译：包含胰岛素和胰岛素样生长因子I（IGF-I）的组合物
公开(公告)号：WO1998006423A1
公开(公告)日：1998-02-19
申请号：PCT/US1997013566
申请日：1997-07-31
申请人： GENENTECH, INC.
发明人： GENENTECH, INC. , CLARK, Ross, G. , OESWEIN, James, Q. , YEUNG, Douglas, A.
IPC分类号： A61K38/30
CPC分类号： A61K9/0019 , A61K38/30 , A61K47/02 , A61K47/10 , A61K47/12 , A61K2300/00
摘要： Formulations containing NPH insulin are useful for treating hyperglycemic disorders, such as diabetes, in a mammal in need of treatment. One such formulation, which is preferably administered parenterally, more preferably by injection, comprises IGF-I and NPH insulin, in amounts of from or about 1 to 10 mg IGF-I and from or about 0.2 to 2 mg NPH insulin in a pharmaceutically acceptable carrier. Another such formulation comprises IGF-I and NPH insulin in an acetic acid salt buffer. Still another formulation comprises IGF-I and NPH insulin in a weight ratio of NPH insulin to IGF-I of from or about 10:1 to 1:50 (w/w), from or about 0.05 to 0.3 M of an osmolyte, from or about 0.1 to 10 mg/mL of a stabilizer, and from or about 5 to 100 mM of a buffer at from or about pH 5 to 7. A still further composition comprises NPH insulin in an acetic acid salt buffer.
摘要翻译：含有NPH胰岛素的制剂可用于治疗需要治疗的哺乳动物中的高血糖病症，例如糖尿病。一种这样的制剂，优选非肠道给药，更优选通过注射给药，包含IGF-1和NPH胰岛素，其量为约1-10mg IGF-I和约0.2至2mg NPH胰岛素，其药学上可接受的载体。另一种这样的制剂在乙酸盐缓冲液中包含IGF-1和NPH胰岛素。另一种制剂包含NPH胰岛素与IGF-I的重量比为约10:1至1:50（w / w）的IGF-I和NPH胰岛素，或约0.05至0.3M的渗透液，来自或约0.1至10mg / mL的稳定剂，和或约5至100mM的缓冲液，其pH值至约为5至7.还有一种组合物包含在乙酸盐缓冲液中的NPH胰岛素。

4. 发明申请

WO1991018621A1 THE COMBINATION OF GROWTH HORMONE AND INSULIN-LIKE GROWTH FACTOR-I ENHANCES GROWTH 审中-公开
标题翻译：生长激素与胰岛素样生长因子的组合增加增加
公开(公告)号：WO1991018621A1
公开(公告)日：1991-12-12
申请号：PCT/US1991003841
申请日：1991-05-31
申请人： GENENTECH, INC.
发明人： GENENTECH, INC. , CLARK, Ross, G. , CRONIN, Michael, J.
IPC分类号： A61K37/24
CPC分类号： A61K9/0019 , A61K38/27 , A61K38/30 , A61K47/10 , A61K47/12 , A61K47/26 , A61K2300/00
摘要： A method is disclosed for enhancing growth of a mammal by administration of a combination of effective amounts of IGF-I and GH so as to enhance the growth of the mammal over the enhancement in growth achieved using either IGF-I or GH alone in an amount equal to that used for either IGF-I or GH, respectively, in the combination. Preferably, the mammal is a child, the IGF-I is native-sequence, mature human IGF-I or human brain IGF-I, and the GH is native-sequence, mature human GH with or without a terminal methionine. In another preferred embodiment, the mammal is a non-human animal of economic importance such as a cow or pig.

5. 发明申请

WO1997026005A1 IGF-I IN COMBINATION WITH HYPOGLYCEMICS FOR TREATMENT OF DIABETES 审中-公开
标题翻译： IGF-I与用于治疗糖尿病的高血压组合
公开(公告)号：WO1997026005A1
公开(公告)日：1997-07-24
申请号：PCT/US1997000085
申请日：1997-01-10
申请人： GENENTECH, INC.
发明人： GENENTECH, INC. , CLARK, Ross, G. , MA, Yan, Hui
IPC分类号： A61K38/30
CPC分类号： A61K38/30 , A61K31/64 , A61K2300/00
摘要： A method is disclosed for better managing the progress of diabetes in mammals, particularly Type II diabetes, where IGF-I administration is combined with administering hypoglycemic agents. Preferably, the IGF-I is native sequence, mature human IGF-I and the hypoglycemic agents are insulin secretagogues such as the sulfonylurea. This combination of agents improves glycemic control in diabetes.
摘要翻译：公开了一种用于更好地管理哺乳动物，特别是II型糖尿病的糖尿病进展的方法，其中IGF-1给药与施用降血糖药物组合。优选地，IGF-I是天然序列，成熟的人IGF-1和降血糖剂是胰岛素促分泌剂，例如磺酰脲。这种药物组合可改善糖尿病的血糖控制。

6. 发明申请

WO1993000110A1 METHOD OF STIMULATING IMMUNE RESPONSE 审中-公开
标题翻译：刺激免疫应答的方法
公开(公告)号：WO1993000110A1
公开(公告)日：1993-01-07
申请号：PCT/US1992005189
申请日：1992-06-16
申请人： GENENTECH, INC.
发明人： GENENTECH, INC. , CLARK, Ross, G. , JARDIEU, Paula, M.
IPC分类号： A61K37/36
CPC分类号： A61K38/30 , A61K39/39 , A61K35/76 , A61K35/74 , A61K2300/00 , A61K38/27
摘要： A method is disclosed for stimulating a mammal's or avian's immune response, particularly immune-compromised mammals, by administration of IGF-I, alone or in combination with growth hormone. Preferably, the IGF-I is native-sequence, mature human IGF-I.
摘要翻译：公开了通过单独或与生长激素组合施用IGF-1来刺激哺乳动物或禽类的免疫应答，特别是免疫受损哺乳动物的方法。优选地，IGF-I是天然序列，成熟的人IGF-I。

7. 发明申请

WO1993000109A1 METHOD OF STIMULATING IMMUNE RESPONSE USING GROWTH HORMONE 审中-公开
标题翻译：使用生长激素刺激免疫应答的方法
公开(公告)号：WO1993000109A1
公开(公告)日：1993-01-07
申请号：PCT/US1992004489
申请日：1992-05-29
申请人： GENENTECH, INC.
发明人： GENENTECH, INC. , CARLSSON, Lena, Mariana, Susann , CLARK, Ross, G. , CRONIN, Michael, J. , JARDIEU, Paula, M.
IPC分类号： A61K37/36
CPC分类号： C07K14/61 , A61K38/30 , A61K39/39 , A61K47/60 , A61K2039/55516 , A61K2300/00
摘要： Methods are disclosed for stimulating a mammal's or avian's growth hormone responsive tissues, particularly immune response tissues in immune-compromised mammals, by administration of growth hormone or growth hormone plus insulin-like growth factor-I. Preferably, the growth hormone is pegylated growth hormone.
摘要翻译：公开了通过施用生长激素或生长激素加胰岛素样生长因子-I来刺激哺乳动物或禽类生长激素反应性组织，特别是免疫受损的哺乳动物的免疫应答组织的方法。优选地，生长激素是聚乙二醇化生长激素。

8. 发明申请

WO1995028174A1 THE COMBINATION OF GROWTH HORMONE AND INSULIN-LIKE GROWTH FACTOR, FOR TREATING CONGESTIVE HEART FAILURE 审中-公开
标题翻译：生长激素和胰岛素样生长因子的组合，用于治疗心绞痛失败
公开(公告)号：WO1995028174A1
公开(公告)日：1995-10-26
申请号：PCT/US1995003755
申请日：1995-03-30
申请人： GENENTECH, INC.
发明人： GENENTECH, INC. , CLARK, Ross, G. , JIN, Hongkui , PAONI, Nicholas, F. , YANG, Renhui
IPC分类号： A61K38/30
CPC分类号： A61K38/30 , A61K38/27 , A61K2300/00
摘要： Methods of enhancing myocardial contractility and cardiac performance in a mammal with congestive heart failure are disclosed. In a first method a mammal with congestive heart failure is treated by administering to the mammal an effective amount of a combination of growth hormone (GH) and insulin-like growth factor (IGF-I). A second method comprises administering to the mammal an effective amount of a combination of GH and IGF-I in the presence of an ACE inhibitor. This method results in enhancement of myocardial contractility and cardiac performance above the level achieved with ACE inhibition alone. Preferably the mammal is a human.
摘要翻译：公开了增加充血性心力衰竭的哺乳动物心肌收缩力和心脏功能的方法。在第一种方法中，通过向哺乳动物施用有效量的生长激素（GH）和胰岛素样生长因子（IGF-I）的组合来治疗具有充血性心力衰竭的哺乳动物。第二种方法包括在ACE抑制剂存在下向哺乳动物施用有效量的GH和IGF-I的组合。这种方法导致心肌收缩力和心脏功能的提高高于仅通过ACE抑制实现的水平。优选地，哺乳动物是人。

9. 发明申请

WO1994006461A1 METHOD OF PROPHYLAXIS OF ACUTE RENAL FAILURE 审中-公开
标题翻译：急性肾功能衰竭的预防方法
公开(公告)号：WO1994006461A1
公开(公告)日：1994-03-31
申请号：PCT/US1993008734
申请日：1993-09-15
申请人： GENENTECH, INC.
发明人： GENENTECH, INC. , CLARK, Ross, G.
IPC分类号： A61K37/24
CPC分类号： A61K38/30 , A61K38/27 , A61K2300/00
摘要： A method is disclosed for the prophylactic treatment of mammals at risk for acute renal failure, whether due to renal ischemia or nephrotoxic damage. This method involves administering to the mammal, before or at the time that the acute renal failure is expected to occur or is occurring, an effective amount of IGF-I. Preferably, the IGF-I is native-sequence, mature human IGF-I.
摘要翻译：公开了用于预防性治疗急性肾衰竭风险的哺乳动物的方法，无论是由于肾脏缺血还是肾毒性损伤。该方法包括在预期发生或正在发生急性肾衰竭之前或期间向哺乳动物施用有效量的IGF-1。优选地，IGF-I是天然序列，成熟的人IGF-I。

10. 发明申请

WO1992013556A1 COMBINATION OF IGF-I AND IGFBP FOR ANABOLISM 审中-公开
标题翻译： IGF-I和IGFBP的组合用于ANABOLISM
公开(公告)号：WO1992013556A1
公开(公告)日：1992-08-20
申请号：PCT/US1992000345
申请日：1992-01-13
申请人： GENENTECH, INC.
发明人： GENENTECH, INC. , CLARK, Ross, G. , MUKKU, Venkat, R.
IPC分类号： A61K37/36
CPC分类号： C07K14/4743 , A61K38/30 , A61K2300/00
摘要： A method is disclosed for producing an anabolic state in a mammal by co-administration by subcutaneous injection of a combination of effective amounts of IGF-I and an IGF binding protein in a defined molar ratio in the absence of growth hormone so as to produce a greater anabolic response in the mammal than that achieved using IGF-I alone in an amount equal to that used for IGF-I in the combination. Preferably, the IGF-I is native-sequence, mature human IGF-I, the binding protein is IGFBP-3, and the mammal is human or a non-human animal of economic importance such as a cow or pig.

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