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1. 发明申请

WO2016081640A1 ANTI-TRANSFERRIN RECEPTOR / ANTI-BACE1 MULTISPECIFIC ANTIBODIES AND METHODS OF USE 审中-公开
标题翻译：抗转铁蛋白受体/抗体1多重抗体及其使用方法
公开(公告)号：WO2016081640A1
公开(公告)日：2016-05-26
申请号：PCT/US2015/061402
申请日：2015-11-18
申请人： GENENTECH, INC. , ADIMAB LLC
发明人： LIU, Yichin , ATWAL, Jasvinder , CHIU, Cecilia Pui Chi , WATTS, Ryan J. , WU, Yan , KRAULAND, Eric , FELDHAUS, Michael , ZHANG, Yin , ZUCHERO, Joy Yu , COUCH, Jessica , DENNIS, Mark S. , ERNST, James A. , LAZAR, Gregory A.
IPC分类号： C07K16/28 , C07K16/40 , C07K16/46 , C12N15/13 , A61K39/395 , A61P25/00
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/2881 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/41 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/528 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C12Y304/23046 , G01N33/6896 , G01N2333/70582 , G01N2333/96472 , G01N2800/28 , G01N2800/52
摘要： The present invention relates to bispecific antibodies that bind to transferrin receptor and BACE1 and methods of using the same.
摘要翻译：本发明涉及结合转铁蛋白受体和BACE1的双特异性抗体及其使用方法。

2. 发明申请

WO2016081639A1 ANTIBODIES AGAINST BACE1 AND USE THEREOF FOR NEURAL DISEASE IMMUNOTHERAPY 审中-公开
标题翻译：抗BACE1抗体及其用于神经疾病免疫疗法
公开(公告)号：WO2016081639A1
公开(公告)日：2016-05-26
申请号：PCT/US2015/061401
申请日：2015-11-18
申请人： GENENTECH, INC. , ADIMAB LLC
发明人： LIU, Yichin , ATWAL, Jasvinder , CHIU, Cecilia Pui Chi , WATTS, Ryan J. , WU, Yan , KRAULAND, Eric , FELDHAUS, Michael
IPC分类号： C07K16/40 , A61K39/395 , A61P25/28
CPC分类号： C07K16/40 , A61K47/6871 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C12Y304/23046 , G01N33/573 , G01N2333/96472 , G01N2800/28 , G01N2800/52
摘要： The invention provides antagonistic antibodies to BACl and methods of using the same for the treatment of neurological diseases and disorders.
摘要翻译：本发明提供了对BAC1的拮抗性抗体及其用于治疗神经疾病和病症的方法。

3. 发明申请

WO2021067404A2 CH1 DOMAIN VARIANTS ENGINEERED FOR PREFERENTIAL LIGHT CHAIN PAIRING AND MULTISPECIFIC ANTIBODIES COMPRISING THE SAME 审中-公开
公开(公告)号：WO2021067404A2
公开(公告)日：2021-04-08
申请号：PCT/US2020/053482
申请日：2020-09-30
申请人： ADIMAB, LLC
发明人： SIVASUBRAMANIAN, Arvind , SCHUTZ, Kevin , HELBLE, Michaela , KRAULAND, Eric , WIDBOOM, Paul
IPC分类号： C07K16/28 , C07K16/00 , C07K16/32 , A61P43/00 , C07K14/435 , C07K16/08 , H04N19/10
摘要： CH1 domain variants engineered for preferential binding to either a kappa CL domain or a lambda CL domain, as well as polypeptides, e.g., antibody heavy chains or antibodies, comprising such engineered CH1 domain variants, and pharmaceutical compositions comprising such CH1 domain variants and/or such polypeptides, and methods for making and using such CH1 domain variants are provided. The CH1 domain variants minimize heavy chain-light chain mispairing and promote cognate heavy chain-light chain pairing, thereby improving the generation of multispecific, e.g., bispecific, antibodies. Also provided are methods of making CH1 domain variant libraries and methods of identifying one or more CH1 domain variants.

4. 发明申请

WO2018208864A1 ANTI-CD3-BINDING DOMAINS AND ANTIBODIES COMPRISING THEM, AND METHODS FOR THEIR GENERATION AND USE 审中-公开
公开(公告)号：WO2018208864A1
公开(公告)日：2018-11-15
申请号：PCT/US2018/031705
申请日：2018-05-08
申请人： ADIMAB, LLC
发明人： WALKER, Laura M. , PEJCHAL, Robert , KRAULAND, Eric , VASQUEZ, Maximiliano , LEUNG, Monica Wai Ling
IPC分类号： A61K39/00 , A61K39/395 , C07K16/18 , C07K16/28 , C07K16/30 , C07K16/32
摘要： Anti-CD3 binding domains and antibodies comprising them, including multispecific antibodies, with, inter alia, desirable T-cell activation and (re)directed target cell killing potency and developability, profiles are provided, as well as methods for their identification, isolation, and generation, and methods for their preparation and use. Reagents for identifying, isolating, selecting, generating and characterizing CD3 binding domains and antibodies comprising them are also provided.

5. 发明申请

WO2011140254A1 ANTIBODIES AGAINST EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) AND USES THEREOF 审中-公开
标题翻译：抗生殖因子受体（EGFR）抗体及其用途
公开(公告)号：WO2011140254A1
公开(公告)日：2011-11-10
申请号：PCT/US2011/035238
申请日：2011-05-04
申请人： ADIMAB, LLC , BUKHALID, Raghida , FELDHAUS, Michael , KING, Anne , KOHLI, Neeraj , KRAULAND, Eric
发明人： BUKHALID, Raghida , FELDHAUS, Michael , KING, Anne , KOHLI, Neeraj , KRAULAND, Eric
IPC分类号： A61K39/395
CPC分类号： C07K16/2863 , A61K39/39558 , A61K2039/507 , C07K16/40 , C07K2317/21 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： Anti- EGFR antibodies, therapeutic compositions comprising combinations of anti-EGFR antibodies, as well as methods for using such antibodies and compositions to treat EGFR-related disorders (e.g., cancers), are disclosed.
摘要翻译：公开了抗EGFR抗体，包含抗EGFR抗体组合的治疗组合物，以及使用这些抗体和组合物治疗EGFR相关病症（例如癌症）的方法。

6. 发明申请

WO2013006547A3 ANTIBODIES AGAINST EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) AND USES THEREOF 审中-公开
公开(公告)号：WO2013006547A3
公开(公告)日：2013-01-10
申请号：PCT/US2012/045235
申请日：2012-07-02
申请人： MERRIMACK PHARMACEUTICALS, INC. , ADIMAB, LLC , BUKHALID, Raghida , FELDHAUS, Michael , KING, Anne , KOHLI, Neeraj , KRAULAND, Eric , KEARNS, Jeffrey, David , LUGOVSKOY, Alexey, A. , NIELSEN, Ulrik
发明人： BUKHALID, Raghida , FELDHAUS, Michael , KING, Anne , KOHLI, Neeraj , KRAULAND, Eric , KEARNS, Jeffrey, David , LUGOVSKOY, Alexey, A. , NIELSEN, Ulrik
IPC分类号： A61K39/395 , C07K14/71 , C07K16/28
摘要： Anti- EGFR antibodies, therapeutic compositions comprising combinations of anti-EGFR antibodies, as well as methods for using such antibodies and compositions to treat EGFR-related disorders (e.g., cancers), are disclosed.

7. 发明申请

WO2021055669A1 FC VARIANTS WITH REDUCED EFFECTOR FUNCTION 审中-公开
公开(公告)号：WO2021055669A1
公开(公告)日：2021-03-25
申请号：PCT/US2020/051380
申请日：2020-09-18
申请人： ADIMAB, LLC
发明人： PEJCHAL, Robert , KRAULAND, Eric , VASQUEZ, Maximiliano , BROWN, Michael , COOPER, Anthony
IPC分类号： C07K16/00
摘要： The present invention provides Fc variants and polypeptides, e.g., antibodies and Fc fusion proteins, comprising such Fc variants. In particular, Fc variants with diminished effector function as a consequence of hinge region and CH2 domain mutations, e.g., LALE-PG, are provided. Such variants maintain antigen-binding and favorable developability profiles and may display improved expressability.

8. 发明申请

WO2015089080A3 POLYCLONAL MIXTURES OF ANTIBODIES, AND METHODS OF MAKING AND USING THEM 审中-公开
标题翻译：抗体的多克隆混合物，以及制备和使用它们的方法
公开(公告)号：WO2015089080A3
公开(公告)日：2015-06-18
申请号：PCT/US2014/069357
申请日：2014-12-09
申请人： ADIMAB, LLC
发明人： WALKER, Laura M. , KRAULAND, Eric , WITTRUP, Karl Dane
IPC分类号： C07K16/00 , A61K39/395
摘要： A method of broadening epitopic coverage of an antigen of interest, wherein a first sample of the antigen of interest is contacted with a first plurality of host cells collectively expressing a first library of antibodies. Host cells expressing antibodies that bind to the antigen are then collected from among the first plurality of host cells, and a composition is prepared comprising a polyclonal mixture of antibodies expressed by these host cells. A second sample of the antigen of interest is then contacted with an aliquot of the prepared composition and a second plurality of host cells collectively expressing a second library of antibodies. Host cells expressing antibodies that bind to the second sample of the antigen are then collected from among the second plurality of host cells.
摘要翻译：扩大感兴趣抗原的表位覆盖的方法，其中感兴趣抗原的第一样品与共同表达第一抗体库的第一多个宿主细胞接触。然后从第一批多个宿主细胞中收集表达与抗原结合的抗体的宿主细胞，并制备包含由这些宿主细胞表达的抗体的多克隆混合物的组合物。然后使目的抗原的第二样品与制备的组合物的等分试样和共同表达第二抗体库的第二多个宿主细胞接触。然后从第二多个宿主细胞中收集表达与第二抗原样品结合的抗体的宿主细胞。

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