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1. 发明申请

WO2007035301A1 CELL MIGRATION ASSAY 审中-公开
标题翻译：细胞迁移测定
公开(公告)号：WO2007035301A1
公开(公告)日：2007-03-29
申请号：PCT/US2006/035276
申请日：2006-09-12
申请人： GE HEALTHCARE BIO-SCIENCES CORP. , YU, Liming , ZHAO, Lihong , BELETSKII, Anton , CHANNAVAJHALA, Padma
发明人： YU, Liming , ZHAO, Lihong , BELETSKII, Anton , CHANNAVAJHALA, Padma
IPC分类号： C12N5/06
CPC分类号： C12N5/069 , C12N2533/54 , G01N33/5005
摘要： The present invention provides compositions and methods for preparation of a three-dimensional transendothelial cell migration (TEM) assay. These compositions and methods are uniquely suited for the high throughput TEM assay, and for the analysis and identification of TEM mediators which inhibit or stimulate this process. The composition for detecting migration of cells comprises a solid layer comprising collagen gel; a first cellular layer in contact with the solid layer and comprising a first cell type; and a second cell type seeded on top of the first cellular layer. Optionally, gelatin is included in the collagen gel. A 96 well plate format is disclosed, the combination with a high throughput cellular scanner enables high throughput TEM assay.
摘要翻译：本发明提供了用于制备三维跨内皮细胞迁移（TEM）测定的组合物和方法。这些组合物和方法独特地适用于高通量TEM测定，以及用于分析和鉴定抑制或刺激该过程的TEM介质。用于检测细胞迁移的组合物包括包含胶原凝胶的固体层; 与固体层接触并包含第一细胞类型的第一细胞层; 以及种子在第一细胞层顶部的第二细胞类型。任选地，胶原凝胶中包含明胶。公开了96孔板格式，与高通量细胞扫描仪的组合可实现高通量TEM测定。

2. 发明申请

WO2007076240A3 COMPOSITIONS AND METHODS FOR LIPOPROTEIN UPTAKE ASSAYS 审中-公开
公开(公告)号：WO2007076240A3
公开(公告)日：2007-07-05
申请号：PCT/US2006/061885
申请日：2006-12-12
申请人： GENERAL ELECTRIC COMPANY , BELETSKII, Anton , YU, Liming , CASTLE, Jason, W.
发明人： BELETSKII, Anton , YU, Liming , CASTLE, Jason, W.
IPC分类号： G01N33/92 , G01N33/50 , G01N33/533 , C09B23/02
摘要： Provided herein are compositions and methods for lipoprotein uptake assay. These compositions and methods may be used for lipoprotein uptake assays, including high-throughput assays. The disclosed compositions and method may further be used to characterize the activity agents that inhibit or stimulate lipoprotein uptake.

3. 发明申请

WO2007103285A2 REAL TIME DATA QUALITY CONTROL AND DETERMINATION OF FORMATION ANGLES FROM MULTICOMPONENT INDUCTION MEASUREMENTS USING NEURAL NETWORKS 审中-公开
标题翻译：使用神经网络实时数据质量控制和确定来自多元感应测量的形成角度
公开(公告)号：WO2007103285A2
公开(公告)日：2007-09-13
申请号：PCT/US2007/005545
申请日：2007-03-02
申请人： BAKER HUGHES INCORPORATED , FANG, Sheng , TABAROVSKY, Leonty , RABINOVICH, Michael , YU, Liming
发明人： FANG, Sheng , TABAROVSKY, Leonty , RABINOVICH, Michael , YU, Liming
IPC分类号： G06F19/00
CPC分类号： G01V3/28
摘要： Neural networks may be used to determine and predict formation dip angles and perform quality assurance assessments from data collected with a multi-component induction tool used for well logging. The neural networks make use of corrected, rotated and normalized data to provide the predictions and assessments. Synthetic data using various models is used to train the neural networks. The teachings herein provide for real-time determinations with a substantial degree of accuracy in the results.
摘要翻译：可以使用神经网络来确定和预测地层倾角，并通过用于测井的多组分感应工具收集的数据进行质量保证评估。神经网络使用校正，旋转和归一化的数据来提供预测和评估。使用各种模型的合成数据用于训练神经网络。本文的教导提供了在结果中具有相当程度的准确性的实时确定。

4. 发明申请

WO2010064973A1 SYSTEM AND METHOD FOR SEPARATING CELLS FROM BODY FLUIDS 审中-公开
标题翻译：用于从体液分离细胞的系统和方法
公开(公告)号：WO2010064973A1
公开(公告)日：2010-06-10
申请号：PCT/SE2009/051327
申请日：2009-11-24
申请人： GENERAL ELECTRIC COMPANY , GE HEALTHCARE BIO-SCIENCES AB , MILLER, Peter , POLIZZOTTI, Brian, D. , SMITH, Reginald, D. , SOOD, Anup , WOOD, Nichole, L. , YU, Liming , ZHOU, Hongyi
发明人： MILLER, Peter , POLIZZOTTI, Brian, D. , SMITH, Reginald, D. , SOOD, Anup , WOOD, Nichole, L. , YU, Liming , ZHOU, Hongyi
IPC分类号： A61M1/36 , A61M1/38 , B01D36/04 , G01N33/50
CPC分类号： A61K35/14 , B01L3/502 , B01L2200/0605 , B01L2200/0631 , B01L2200/10 , B01L2300/0627
摘要： Method and systems, for processing biological material, that contain a biological material in a vessel; add an aggregating agent to the material in the vessel and allow the material to separate into two or more distinct submaterials; extract one or more of the submaterials from the vessel; automatically transport one or more of the submaterials remaining in the vessel to a filtration device; and collect a resulting target retentate into a target retentate receptacle.
摘要翻译：用于处理在容器中含有生物材料的生物材料的方法和系统; 向容器中的材料添加聚集剂，并使材料分离成两个或更多不同的子材料; 从容器中提取一种或多种副材料; 将剩余在容器中的一种或多种副材料自动输送到过滤装置; 并将得到的目标滞留物收集到目标滞留容器中。

5. 发明申请

WO2010051142A1 POLYSULFONE MEMBRANES METHODS AND APPARATUSES 审中-公开
标题翻译：聚砜膜的方法和装置
公开(公告)号：WO2010051142A1
公开(公告)日：2010-05-06
申请号：PCT/US2009/059808
申请日：2009-10-07
申请人： GENERAL ELECTRIC COMPANY , YEAGER, Gary, William , YU, Liming , STEIGER, Daniel , ZHANG, Yanshi
发明人： YEAGER, Gary, William , YU, Liming , STEIGER, Daniel , ZHANG, Yanshi
IPC分类号： B01D71/68 , C08L81/06 , C08G75/23
CPC分类号： B01D71/68 , B01D2323/02 , B01D2325/36 , C08L39/08 , C08L81/06 , C08L2666/04
摘要： The present invention relates to methods and apparatuses for water filtration comprising contacting a water stream with a membrane comprising a polysulfone having structural units of Formula I wherein X is OH, NR 1 R 2 , or OR 3 ; R 1 and R 2 are independently at each occurrence hydrogen, a C 1 -C 5000 aliphatic radical, a C 3 -C 12 cycloaliphatic radical, a C 3 -C 12 aromatic radical, a polypeptide, a combination thereof, or R 1 and R 2 taken together form a 5- or 6- membered aliphatic ring or a 5-membered aromatic ring; R 3 is a C 1 -C 20 aliphatic radical, C 3 -C 12 cycloaliphatic radical, C 3 -C 12 aromatic radical, or a combination thereof; B' and C' are independently at each occurrence a nitro group, C 1 -C 20 aliphatic radical, C 3 -C 12 cycloaliphatic radical, C 3 -C 12 aromatic radical, or a combination thereof; and q and r are independently at each occurrence 0 to 4. The present invention also relates to a method and apparatus for gas separation, the method comprising contacting a gas stream with a membrane comprising a polysulfone having structural units of Formula I.
摘要翻译：本发明涉及水过滤的方法和装置，包括使水流与包含具有式I结构单元的聚砜的膜接触，其中X是OH，NR1R2或OR3; R1和R2各自独立地为氢，C1-C5000脂族基团，C3-C12脂环族基团，C3-C12芳族基团，多肽，其组合，或者R 1和R 2一起形成5-或6 - 元脂环或5元芳环; R3是C1-C20脂族基团，C3-C12脂环族基团，C3-C12芳族基团或其组合; B'和C'在每次出现时独立地为硝基，C 1 -C 20脂族基，C 3 -C 12脂环族基，C 3 -C 12芳族基或其组合; 并且q和r在每次出现时独立地为0至4.本发明还涉及一种用于气体分离的方法和装置，所述方法包括使气流与包含具有式I结构单元的聚砜的膜接触。

6. 发明申请

WO2007103285A3 REAL TIME DATA QUALITY CONTROL AND DETERMINATION OF FORMATION ANGLES FROM MULTICOMPONENT INDUCTION MEASUREMENTS USING NEURAL NETWORKS 审中-公开
公开(公告)号：WO2007103285A3
公开(公告)日：2007-09-13
申请号：PCT/US2007/005545
申请日：2007-03-02
申请人： BAKER HUGHES INCORPORATED , FANG, Sheng , TABAROVSKY, Leonty , RABINOVICH, Michael , YU, Liming
发明人： FANG, Sheng , TABAROVSKY, Leonty , RABINOVICH, Michael , YU, Liming
IPC分类号： G01V1/28 , G01V3/18
摘要： Neural networks may be used to determine and predict formation dip angles and perform quality assurance assessments from data collected with a multi-component induction tool used for well logging. The neural networks make use of corrected, rotated and normalized data to provide the predictions and assessments (520). Synthetic data using various models is used to train the neural networks. The teachings herein provide for real-time determinations with a substantial degree of accuracy in the results.

7. 发明申请

WO2004022088A1 INTERFERON AND IMMUNOGLOBULIN FC FRAGMENT HYBRID 审中-公开
标题翻译：干扰素和免疫球蛋白FC片段杂交
公开(公告)号：WO2004022088A1
公开(公告)日：2004-03-18
申请号：PCT/US2002/025154
申请日：2002-08-07
申请人： TANOX, INC. , CHANG, Tse, Wen , YU, Liming
发明人： CHANG, Tse, Wen , YU, Liming
IPC分类号： A61K38/21
CPC分类号： C07K14/555 , A61K38/00 , A61K2039/505 , C07K2319/00 , C07K2319/30
摘要： The present invention provides interferon-immunoglobulin Fc fusion proteins ("IFN-Fc hybrids") that are useful for removing or regressing tumors or delaying tumor development. The IFN-Fc hybrids preferably include peptide linkers between the IFN and the Fc fragment. These linkers are T cell inert sequences or any non-immunogenic sequence, preferably Gly-Ser repeat units. The preferred Fc fragment is a human immunoglobulin Fc fragment, preferably the γ4 chain.
摘要翻译：本发明提供可用于去除或回归肿瘤或延缓肿瘤发展的干扰素 - 免疫球蛋白Fc融合蛋白（“IFN-Fc杂合体”）。 IFN-Fc杂交体优选包括IFN和Fc片段之间的肽接头。这些接头是T细胞惰性序列或任何非免疫原性序列，优选Gly-Ser重复单元。优选的Fc片段是人免疫球蛋白Fc片段，优选γ4链。

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