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    • 4. 发明申请
    • COMPOSITIONS AND METHODS FOR MICRORNA EXPESSION PROFILING IN PLASMA OF COLORECTAL CANCER
    • 彩色血浆等离子体快速成像分析的组合物和方法
    • WO2011076142A1
    • 2011-06-30
    • PCT/CN2010/080233
    • 2010-12-24
    • FUDAN UNIVERSITYLI, ZhaoyongWU, YingZHU, HongguangLI, JianREN, Yiping
    • LI, ZhaoyongWU, YingZHU, HongguangLI, JianREN, Yiping
    • C12Q1/68
    • C12Q1/6886A61K31/7105B82Y5/00B82Y15/00C12Q2600/178
    • The present invention relates to compositions and methods for microRNA (miRNA) expression profiling in plasma of colorectal cancer. In particular, the invention relates to a diagnostic kit of molecular markers in blood for diagnosing colorectal cancer, monitoring the cancer therapy and/or treating colorectal cancer, the kit comprising a plurality of nucleic acid molecules, each nucleic acid molecule encoding a microRNA sequence, wherein one or more of the plurality of nucleic acid molecules are differentially expressed in plasma of colorectal cancer and healthy control plasma, and wherein the one or more differentially expressed nucleic acid molecules together represent a nucleic acid expression signature that is indicative for the presence of colorectal cancer. The invention further relates to corresponding methods using such nucleic acid expression signatures for identifying colorectal cancer as well as for preventing or treating such a condition. Finally, the invention is directed to a pharmaceutical composition for the prevention and/or treatment of colorectal cancer.
    • 本发明涉及用于结直肠癌血浆中的微小RNA(miRNA)表达谱的组合物和方法。 特别地,本发明涉及用于诊断结肠直肠癌,监测癌症治疗和/或治疗结直肠癌的血液中的分子标记物的诊断试剂盒,所述试剂盒包含多个核酸分子,编码微小RNA序列的每个核酸分子, 其中所述多个核酸分子中的一个或多个在结肠直肠癌和健康对照血浆的血浆中差异表达,并且其中所述一个或多个差异表达的核酸分子一起代表指示存在结肠直肠的核酸表达特征 癌症。 本发明还涉及使用这种核酸表达特征鉴定结肠直肠癌以及预防或治疗这种病症的相应方法。 最后,本发明涉及用于预防和/或治疗结肠直肠癌的药物组合物。
    • 6. 发明申请
    • PLASMA-BASED MICRO-RNA BIOMARKERS AND METHODS FOR EARLY DETECTION OF COLORECTAL CANCER
    • 基于血浆的微RNA生物标记物和早期检测色素性癌症的方法
    • WO2011076147A1
    • 2011-06-30
    • PCT/CN2010/080247
    • 2010-12-24
    • FUDAN UNIVERSITYLI, ZhaoyongWU, YingZHU, Hongguang
    • LI, ZhaoyongWU, YingZHU, Hongguang
    • C12Q1/68A61K31/7088A61P35/00
    • C12Q1/6886A61K31/7088C12Q2600/112C12Q2600/158C12Q2600/16C12Q2600/178
    • The present invention provides a diagnostic kit of molecular markers in blood for diagnosing colorectal cancer, and/or monitoring the therapeutic effect for treating colorectal cancer. The kit comprises a plurality of nucleic acid molecules, and each nucleic acid molecule encodes a microRNA biomarker, wherein one or more of the plurality of nucleic acid molecules are differentially expressed in plasma of patient and healthy control, and wherein the one or more differentially expressed nucleic acid molecules together represent a nucleic acid expression biomarker that is indicative for the presence of colorectal cancer. The invention further provides corresponding methods using such nucleic acid expression biomarkers for identifying colorectal cancer as well as for preventing or treating such a condition. Finally, the invention provides a pharmaceutical composition for the prevention and/or treatment of colorectal cancer.
    • 本发明提供用于诊断结肠直肠癌的血液中的分子标记物的诊断试剂盒和/或监测治疗结肠直肠癌的治疗效果。 试剂盒包含多个核酸分子,每个核酸分子编码微小RNA生物标志物,其中多个核酸分子中的一个或多个在患者和健康对照的血浆中差异表达,并且其中所述一个或多个差异表达 核酸分子一起代表指示存在结肠直肠癌的核酸表达生物标志物。 本发明还提供了使用这种核酸表达生物标志物鉴定结肠直肠癌以及预防或治疗这种病症的相应方法。 最后,本发明提供了用于预防和/或治疗结肠直肠癌的药物组合物。