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    • 3. 发明申请
    • DNA CODING FOR APHRODISIN
    • APHRODISIN的DNA编码
    • WO1993019173A1
    • 1993-09-30
    • PCT/EP1993000621
    • 1993-03-18
    • FORSSMANN, Wolf-GeorgMÄGERT, Hans-Jürgen
    • FORSSMANN, Wolf-Georg
    • C12N15/11
    • C07K14/575A61K38/00C07K2319/02
    • The description relates to a DNA coding for aphrodisin with N-terminal signal peptide, a polypeptide stimulating the copulation behaviour of small mammals. It is possible to obtain therefrom DNA fragments which can be used as nucleic acid probes for the analytical detection of corresponding genes or complementary nucleic acids. The description also relates to a polypeptide obtainable by expressing the nucleic acid of the invention and its suitability as a medicament. Diagnostic means are also described which are based on polypeptides or polypeptide fragments or corresponding antibodies against these polypeptides or fragments. The nucleic acids or their fragments which code for aphrodisin, are also possible means of diagnosis.
    • 该描述涉及编码具有N-末端信号肽的aphrodisin的DNA,其是刺激小哺乳动物的交配行为的多肽。 可以从其获得可用作核酸探针的DNA片段,用于分析检测相应的基因或互补核酸。 该描述还涉及通过表达本发明的核酸及其作为药物的适用性可获得的多肽。 还描述了基于多肽或多肽片段或针对这些多肽或片段的相应抗体的诊断手段。 编码aphrodisin的核酸或其片段也是诊断的可能手段。