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1. 发明申请

WO2003070953A1 VERBINDUNG ZUR INHIBIERUNG DER SERIN-PROTEINASEN UND ZUR INHIBIERUNG VON INFEKTIONEN ODER VIRUSVERMEHRUNG: RLD 8564 审中-公开
标题翻译：连接来抑制丝氨酸蛋白酶和感染或病毒繁殖的抑制：RLD 8564
公开(公告)号：WO2003070953A1
公开(公告)日：2003-08-28
申请号：PCT/EP2003/001704
申请日：2003-02-20
申请人： IPF PHARMACEUTICALS GMBH , FORSSMANN, Wolf-Georg , KIRCHHOFF, Frank , MÜNCH, Jan , KREUTZMANN, Peter , MÄGERT, Hans-Jürgen
发明人： FORSSMANN, Wolf-Georg , KIRCHHOFF, Frank , MÜNCH, Jan , KREUTZMANN, Peter , MÄGERT, Hans-Jürgen
IPC分类号： C12N15/15
CPC分类号： C07K14/8135 , A61K38/00
摘要： Das Peptid RLD 8564 mit nachfolgender Aminosäuresequenz:GPDSEMCKDYRVLPRIGYLCPKDLKPVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKCEESSTPGTTAASMPPSDE.
摘要翻译：肽RLD 8564与随后的氨基酸序列：GPDSEMCKDYRVLPRIGYLCPKDLKPVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKCEESSTPGTTAASMPPSDE。

2. 发明申请

WO1995018228A1 HUMAN CIRCULATING CYTOKINE CC-1 审中-公开
标题翻译： HUMAN循环细胞因子CC-1
公开(公告)号：WO1995018228A1
公开(公告)日：1995-07-06
申请号：PCT/EP1994004282
申请日：1994-12-22
申请人： FORSSMANN, Wolf-Georg , SCHULZ-KNAPPE, Peter , MEYER, Markus , MÄGERT, Hans-Jürgen
IPC分类号： C12N15/19
CPC分类号： C07K14/523 , A61K38/00
摘要： A cytokine CC-1 having the following sequence of aminoacids and SEQ ID No. 6 is disclosed, as well as its biologically active fragments and/or derivatives, in particular its amidated, acetylated, phosphorylated and/or glycosylated derivatives.
摘要翻译：根据SEQ ID号细胞因子CC-1具有下列氨基酸序列 6个，以及其生物活性片段和/或衍生物，尤其是酰胺化，乙酰化，磷酸化和/或糖基化的衍生物。

3. 发明申请

WO1997041230A2 CC-TYPE CHEMOKINES 审中-公开
标题翻译：趋化因子从cc-TYPE
公开(公告)号：WO1997041230A2
公开(公告)日：1997-11-06
申请号：PCT/EP1997002217
申请日：1997-04-30
申请人： FORSSMANN, Wolf-Georg , PARDIGOL, Andreas , MÄGERT, Hans-Jürgen , SCHULZ-KNAPPE, Peter
IPC分类号： C12N15/19
CPC分类号： C07K14/523 , A61K38/00
摘要： CC-type chemokines belong to a family of polypeptides which have been shown to mediate immune reactions and have recently attracted attention because of their antiviral activity against HIV. The invention relates to the cloning and molecular characterisation of a human tandem gene which contains closely linked coding sites for two new CC-type chemokines whose sequences are similar to a high degree to those of MIP-1 alpha . The transcription of the tandem gene leads to a bicistronic mature transcript which contains the non-overlapping open reading frames for the recently described HCC-1 factor and for a hitherto unknown CC-type chemokine, named CC-2. Moreover, by alternatively splicing the primary transcript, at least one other CC-type chemokine, the CC-3 cytokine, is obtained. Within the tandem gene two functional promoter sites could be identified. The disclosed data give fundamental information about the structure and expression of the new human CC-2/HCC-1 tandem gene and describe a mechanism which could be used to regulate the co-expression of closely linked genes in higher eukaryotes.
摘要翻译：趋化因子CC类型属于一个家族，已被证明是免疫应答介质，最近吸引，因为相对于HIV的抗病毒作用关注的多肽。这是克隆和含有紧密连接的编码区域为两个新的趋化因子CC类型，其序列高度到MIP-1α的是相同的公开的人串联基因的分子表征。产生含有对于最近描述因子HCC-1和趋化因子未知CC型非重叠的开放阅读框双顺反子转录物成熟串联基因的转录中，被称为CC-2。通过初级转录物的可变剪接另一个趋化因子CC型，细胞因子CC-3也至少被产生。在串联基因启动子进行鉴定两个功能区。所公开的数据提供了结构的新的人CC-2 / HCC-1-串联基因的基本知识和表达和描述通过该共表达密切相关的基因可以在更高的真核生物中进行控制的机制。

4. 发明申请

WO1997035877A1 ANTIBIOTIC PEPTIDES FROM BOVINE MILK 审中-公开
标题翻译：来自牛奶牛奶的抗菌肽
公开(公告)号：WO1997035877A1
公开(公告)日：1997-10-02
申请号：PCT/EP1996001296
申请日：1996-03-25
申请人： HAEMOPEP PHARMA GMBH , FORSSMANN, Wolf-Georg , ZUCHT, Hans-Dieter , RAIDA, Manfred , ADERMANN, Knut , MÄGERT, Hans-Jürgen
发明人： HAEMOPEP PHARMA GMBH
IPC分类号： C07K14/47
CPC分类号： C07K14/4732 , A23L3/3463 , A61K38/00 , Y02A50/411
摘要： A peptide having the amino acid sequence of formula (I) H2N-X1-R-X3-X2-COOH wherein X1 is either zero or X1 and/or X2 are a residue representing at least five amino acid residues (symbolized in the one letter amino acid code), preferably naturally occurring amino acids, with the proviso that X1 and/or X2 contain at least one basic amino acid residue immediately followed by a hydrophobic amino acid residue and X1 and/or X2 contain at least one glutamine residue.
摘要翻译：具有式（I）的氨基酸序列的肽，其中X 1为零或X 1和/或X 2为代表至少5个氨基酸残基的残基（在一个字母中为符号氨基酸代码），优选天然存在的氨基酸，条件是X1和/或X2含有至少一个碱性氨基酸残基，紧接着是疏水性氨基酸残基，X1和/或X2含有至少一个谷氨酰胺残基。

5. 发明申请

WO1995003410A3 GUANYLATCYCLASE ACTIVATING PEPTIDE I (GCAP-I) CODING GENE 审中-公开
公开(公告)号：WO1995003410A3
公开(公告)日：1995-02-02
申请号：PCT/EP1994002391
申请日：1994-07-20
申请人： FORSSMANN, Wolf-Georg , HILL, Oliver , ZUCHT, Hans-Dieter , KUHN, Michaela , MÄGERT, Hans-Jürgen , ADERMANN, Knut , RAIDA, Manfred , SCHULZ-KNAPPE, Peter , PARDIGOL, Andreas
IPC分类号： C12N15/16

6. 发明申请

WO2002066513A2 HUMANE ZIRKULIERENDE LEKTI FRAGMENTE HF7072, HF7638 UND HF14448 SOWIE IHRE VERWENDUNG 审中-公开
标题翻译：人文循环LEKTI FRAGMENTS HF7072，HF7638和HF14448及其用途
公开(公告)号：WO2002066513A2
公开(公告)日：2002-08-29
申请号：PCT/EP2002/001720
申请日：2002-02-19
申请人： IPF PHARMACEUTICALS GMBH , WALDEN, Michael , MÄGERT, Hans-Jürgen , KREUTZMANN, Peter , JOHN, Harald , STÄNDKER, Ludger , FORSSMANN, Wolf-Georg
发明人： WALDEN, Michael , MÄGERT, Hans-Jürgen , KREUTZMANN, Peter , JOHN, Harald , STÄNDKER, Ludger , FORSSMANN, Wolf-Georg
IPC分类号： C07K14/81
CPC分类号： C07K14/8135 , A61K38/00
摘要： Peptide HF7072, HF7638 oder HF14448 sowie deren biologisch aktive Fragmente, Analoga und/oder Derivate.
摘要翻译：肽HF7072，HF7638或HF14448以及它们的生物活性片段，类似物和/或衍生物。

7. 发明申请

WO1997006258A2 cDNA SEQUENCE, AMINO-ACID SEQUENCE, DERIVED FROM THE cDNA SEQUENCE, OF THE PRECURSOR PROTEIN OF HUMAN GCAP-II/UROGUANYLINE, AND AMINO-ACID SEQUENCE OF THE FRAGMENT CIRCULATING IN HUMAN BLOOD 审中-公开
标题翻译：的cDNA序列和人GCAP-II /尿鸟苷素及序列人体血液循环AMINO片段的前体蛋白的推导的氨基酸序列
公开(公告)号：WO1997006258A2
公开(公告)日：1997-02-20
申请号：PCT/EP1996003429
申请日：1996-08-03
申请人： FORSSMANN, Wolf-Georg , HILL, Oliver , HESS, Rüdiger , ADERMANN, Knut , RAIDA, Manfred , MÄGERT, Hans-Jürgen , MEYER, Markus , SCHULZ-KNAPPE, Peter
IPC分类号： C12N15/16
CPC分类号： C07K14/4705 , A61K38/00 , A61K48/00
摘要： The invention concerns a peptide from human blood, designated GCAP-II (guanylate cyclase activating peptide), the structure of which has been elucidated for the use of the substance as a drug for diagnostic, medical and industrial purposes. The isolation of the GCAP-II peptide proves its existence. The removal of certain amino acids from GCAP-II reduces its biological effectiveness. The GCAP-II circulating in human blood is identical to the synthetic GCAP-II reference substance, but not to other peptides or its fragments. The molecular formula of GCAP-II has been found using mass spectrometry. A different biological activity and differences in the three-dimensional peptide structure of GCAP-II compared with other GCAP-II fragments show that this GCAP-II fragment is a high-quality natural peptide belonging to a family with a peptide group which is suitable for use in treating numerous conditions which progress hand in hand with electrolyte-transport disorders in cells as well as for use in treating, in particular, diseases of endocrine organs. In addition, GCAP-II can be used industrially as the natural raw extract, or in purified form, for research into new cell functions. These discoveries concerning the structure of the cDNA and gene structure of GCAP-II can be used for future diagnostic and therapeutic concepts based on the invention.
摘要翻译：本发明涉及从人血液来源的肽，所述GCAP-II（鸟苷酸环化酶激活肽），其已经阐明了作为在其结构中医学诊断，医疗和商业用途的目的。这个新的肽GCAP-II的分离证明GCAP-II的存在。在GCAP-II的某些氨基酸去除降低其生物学活性。在血液GCAP-II的循环是相同的合成参考物质合成GCAP-II，但不与其它肽或它的片段。所述GCAP-II的分子形式通过质谱证实。不同证明生物活性和在GCAP-II比其它GCAP-II的空间肽结构的差异片段此GCAP-II片段表示家族的肽基，的优良的天然肽，其用于治疗各种疾病与病症相关的治疗伴随着在电池中的电解质输送，和内分泌器官应专门用于治疗疾病。此外，GCAP-II（鸟苷酸环化酶激活肽）可以在一个形式或作为用于新细胞功能的研究商业目的天然粗提取物一起使用。上GCAP-II的cDNA和基因结构的发现可用于诊断和治疗方面的考虑到基于所提出的分析的创新价值未来概念。

8. 发明申请

WO1993019173A1 DNA CODING FOR APHRODISIN 审中-公开
标题翻译： APHRODISIN的DNA编码
公开(公告)号：WO1993019173A1
公开(公告)日：1993-09-30
申请号：PCT/EP1993000621
申请日：1993-03-18
申请人： FORSSMANN, Wolf-Georg , MÄGERT, Hans-Jürgen
发明人： FORSSMANN, Wolf-Georg
IPC分类号： C12N15/11
CPC分类号： C07K14/575 , A61K38/00 , C07K2319/02
摘要： The description relates to a DNA coding for aphrodisin with N-terminal signal peptide, a polypeptide stimulating the copulation behaviour of small mammals. It is possible to obtain therefrom DNA fragments which can be used as nucleic acid probes for the analytical detection of corresponding genes or complementary nucleic acids. The description also relates to a polypeptide obtainable by expressing the nucleic acid of the invention and its suitability as a medicament. Diagnostic means are also described which are based on polypeptides or polypeptide fragments or corresponding antibodies against these polypeptides or fragments. The nucleic acids or their fragments which code for aphrodisin, are also possible means of diagnosis.
摘要翻译：该描述涉及编码具有N-末端信号肽的aphrodisin的DNA，其是刺激小哺乳动物的交配行为的多肽。可以从其获得可用作核酸探针的DNA片段，用于分析检测相应的基因或互补核酸。该描述还涉及通过表达本发明的核酸及其作为药物的适用性可获得的多肽。还描述了基于多肽或多肽片段或针对这些多肽或片段的相应抗体的诊断手段。编码aphrodisin的核酸或其片段也是诊断的可能手段。

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