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1. 发明申请

WO2004091815A3 METHOD AND SYSTEM FOR PRODUCING A MOISTURE CONTENT MAP FOR USE IN MOISTURE SORTING GREEN VENEER USING LIGHT TRANSMISSION 审中-公开
标题翻译：生产水分含量图的方法和系统，用于使用光传输的湿度分配绿色喷雾器
公开(公告)号：WO2004091815A3
公开(公告)日：2005-03-03
申请号：PCT/CA2004000608
申请日：2004-04-14
申请人： FORINTEK CANADA CORP , DAI CHUNPING , THOMAS TONY , GROVES KEVIN , XU HENG
发明人： DAI CHUNPING , THOMAS TONY , GROVES KEVIN , XU HENG
IPC分类号： B07C5/14 , B07C5/34 , G01N21/59 , G01N21/89
CPC分类号： B07C5/3416 , B07C5/14 , G01N21/59 , G01N21/8914
摘要： Disclosed is a method and system for sorting a plurality of green wood veneer sheets (10) into a plurality of subsets of sheets, the subsets including a "driest" subset, a "wettest" subset, and one or more "intermediate" subsets. The system has a light source (30) for transmitting light (32) through a sheet of veneer (10) as it passes along a conveyor system, and a light sensor (40) for sensing the light (34) passing through the sheet (10). The pattern of light is recorded by an image acquisition and processing subsystem (50) as an image, which is fed to an image analysis subsystem (60) programmed to analyse the light pattern and to produce a mathematical representation of the image. An integrated moisture content value (IMCV) is set for the particular veneer sheet (10). Based on this value, a controller (70) sends signals (65) to the conveyor system (20) to convey the particular sheet to a location storing sheets having similar IMCV values for drying.
摘要翻译：公开了一种用于将多个绿色木皮单板（10）分类成多个片材子集的方法和系统，所述子集包括“最干”子集，“最低”子集和一个或多个“中间”子集。该系统具有一个光源（30），用于在沿着传送系统通过时通过一片胶合板（10）传送光（32）;以及光传感器（40），用于感测通过该纸张的光（34） 10）。光图案由图像获取和处理子系统（50）记录为图像，该图像被馈送到图像分析子系统（60），其被编程为分析光图案并产生图像的数学表示。为特定的单板（10）设置综合水分含量值（IMCV）。基于该值，控制器（70）将信号（65）发送到输送系统（20），以将特定的纸张传送到存储具有相似IMCV值的纸张的位置用于干燥。

2. 发明申请

WO2007028163A8 BIOCOMPATIBLE FLUORESCENT IMAGING AGENTS 审中-公开
标题翻译：生物成分荧光成像剂
公开(公告)号：WO2007028163A8
公开(公告)日：2007-05-24
申请号：PCT/US2006034604
申请日：2006-09-01
申请人： VISEN MEDICAL INC , RAJOPADHYE MILIND , GROVES KEVIN
发明人： RAJOPADHYE MILIND , GROVES KEVIN
IPC分类号： C07D419/02 , A61K31/496 , A61K49/00 , C09B23/02 , G01N33/533 , G01N33/58
CPC分类号： G01N33/582 , A61K49/0032 , A61K49/0052 , C09B23/0008 , C09B23/0066 , C09B23/083 , C09B23/086 , G01N33/533
摘要： This invention relates to new fluorescent chemical entities that are designed to attach to biocompatible molecules to form in vivo optical imaging agents.
摘要翻译：本发明涉及被设计成连接到生物相容性分子以形成体内光学成像剂的新的荧光化学实体。

3. 发明申请

WO2009092062A3 FLUORESCENT IMAGING AGENTS 审中-公开
标题翻译：荧光成像剂
公开(公告)号：WO2009092062A3
公开(公告)日：2009-10-29
申请号：PCT/US2009031364
申请日：2009-01-17
申请人： VISEN MEDICAL INC , RAJOPADHYE MILIND , GROVES KEVIN , PREDA DORIN V
发明人： RAJOPADHYE MILIND , GROVES KEVIN , PREDA DORIN V
IPC分类号： A61K49/00 , A61K49/04
CPC分类号： A61K49/0032 , A61K47/65 , A61K49/0056 , C07K5/1019 , C07K7/06 , C07K7/64 , C09B23/0008 , C09B23/083 , C09B23/086
摘要： Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.
摘要翻译：提供了用于体内和体外成像的分子内骤冷成像剂家族，其包含至少一种可酶促切割的寡肽和两个荧光团或荧光团和猝灭剂。当进行蛋白水解切割时，至少一个荧光团是不淬灭的，并且在用适当波长的光激发时变得能够产生荧光信号。还提供了使用这种成像剂的体内和体外成像方法。

4. 发明申请

WO2004108902A3 BIOCOMPATIBLE FLUORESCENT SILICON NANOPARTICLES 审中-公开
标题翻译：生物成分荧光硅纳米粒子
公开(公告)号：WO2004108902A3
公开(公告)日：2005-04-21
申请号：PCT/US2004018023
申请日：2004-06-04
申请人： VISEN MEDICAL INC , POSS KIRTLAND G , MADDEN KAREN N , GROVES KEVIN , RAJOPADHYE MILIND
发明人： POSS KIRTLAND G , MADDEN KAREN N , GROVES KEVIN , RAJOPADHYE MILIND
IPC分类号： A61K49/00 , C12N20060101 , C12Q1/00 , G01N33/543
CPC分类号： G01N33/54346 , A61K49/0017 , A61K49/0052 , A61K49/0056 , A61K49/0065 , B82Y5/00
摘要： The invention features biocompatible fluorescent nanoparticle and their use in in vivo imaging methods.
摘要翻译：本发明特征在于生物相容的荧光纳米颗粒及其在体内成像方法中的应用。

5. 发明申请

WO2012154885A2 CARBONIC ANHYDRASE TARGETING AGENTS AND METHODS OF USING SAME 审中-公开
标题翻译：碳酸酐靶向剂及其使用方法
公开(公告)号：WO2012154885A2
公开(公告)日：2012-11-15
申请号：PCT/US2012037166
申请日：2012-05-09
申请人： VISEN MEDICAL INC , GROVES KEVIN , BAO BAGNA
发明人： GROVES KEVIN , BAO BAGNA
IPC分类号： C07D417/14 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K49/00 , A61P9/00 , A61P29/00 , A61P35/00 , A61P37/00 , C07D401/14
CPC分类号： C07D401/06 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K49/0002 , A61K49/0032 , A61K49/0052 , C07D209/14 , C07D209/60 , C07D401/14 , C07D417/14 , C09B23/0008 , C09B23/0033 , C09B23/083 , C09B23/086 , G01N21/6458 , G01N33/582 , G01N2333/988
摘要： The invention provides agents that target carbonic anhydrase, which can be used as imaging agents or therapeutic agents. The agents can be used to image tumor hypoxia as well as other physiological processes in a subject.
摘要翻译：本发明提供靶向碳酸酐酶的试剂，其可用作显像剂或治疗剂。这些药剂可用于成像肿瘤缺氧以及受试者中的其他生理过程。

6. 发明申请

WO2007028037A8 BIOCOMPATIBLE N, N-DISUBSTITUTED SULFONAMIDE-CONTAINING FLUORESCENT DYE LABELS 审中-公开
标题翻译：生物相容性N，N-二取代磺酰胺荧光染料标签
公开(公告)号：WO2007028037A8
公开(公告)日：2007-05-31
申请号：PCT/US2006034260
申请日：2006-09-01
申请人： VISEN MEDICAL INC , NARAYANAN NARASIMHACHARI , GROVES KEVIN , PETERSON JEFFREY D , RAJOPADHYE MILIND
发明人： NARAYANAN NARASIMHACHARI , GROVES KEVIN , PETERSON JEFFREY D , RAJOPADHYE MILIND
IPC分类号： C07D419/02 , A61K49/00 , C09B23/02 , G01N33/533 , G01N33/58
CPC分类号： C09B23/086 , A61K49/0032 , A61K49/0052 , C07D209/14 , C07D401/14 , C07D403/06 , C07D403/14 , C09B23/0066 , C09B23/083 , G01N33/533 , G01N33/537 , G01N33/582
摘要： This invention relates to new fluorescent chemical entities, especially fluorescent molecules that comprise biocompatible N, N-disubstituted sulfonamide fluorochromes. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
摘要翻译：本发明涉及新的荧光化学实体，特别是包含生物相容性N，N-二取代磺酰胺荧光染料的荧光分子。本发明还涉及这种分子的相应反应形式。本发明还涉及具有诸如肽，蛋白质，各种生物分子，碳环和杂环化合物，糖及其用途的部分的相应缀合物。

7. 发明申请

WO2009092062A2 FLUORESCENT IMAGING AGENTS 审中-公开
公开(公告)号：WO2009092062A2
公开(公告)日：2009-07-23
申请号：PCT/US2009031364
申请日：2009-01-17
申请人： VISEN MEDICAL INC , RAJOPADHYE MILIND , GROVES KEVIN , PREDA DORIN V
发明人： RAJOPADHYE MILIND , GROVES KEVIN , PREDA DORIN V
IPC分类号： A61K49/00 , C07K5/06 , C07K5/08 , C07K5/10 , C07K5/12 , C07K7/06 , C07K7/08 , G01N33/53
CPC分类号： A61K49/0032 , A61K47/65 , A61K49/0056 , C07K5/1019 , C07K7/06 , C07K7/64 , C09B23/0008 , C09B23/083 , C09B23/086
摘要： Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.

8. 发明申请

WO2007136413A3 BIOCOMPATIBLE FLUORESCENT METAL OXIDE NANOPARTICLES 审中-公开
标题翻译：生物易燃荧光金属氧化物纳米颗粒
公开(公告)号：WO2007136413A3
公开(公告)日：2008-10-30
申请号：PCT/US2006049222
申请日：2006-12-22
申请人： VISEN MEDICAL INC , GROVES KEVIN , RAJOPADHYE MILIND
发明人： GROVES KEVIN , RAJOPADHYE MILIND
IPC分类号： A61K49/00 , A61K49/18
CPC分类号： A61K49/1866 , A61K49/0002 , A61K49/0032 , A61K49/0056 , A61K49/0093 , A61K49/1833 , A61K49/186 , B82Y5/00
摘要： The present invention provides fluorescent metal oxide nanopartic.es that are exceptionally fluorescent or have very high fluorescent brightness and can be used in a variety of in vitro and vivo applications. The fluorescent metal oxide nansparticles are particularly useful as imaging agents that can be used for in vivo imaging. The fluorescent metal oxide nanoparticles may also have magnetic properties and, therefore, can be used for MRI, thus providing a multi-modality imaging agent. Specifically, the design of the agents of the present invention provide fluorescent metal oxide nanoparticles with one or more of the following features: (I) a polymer coating suitable for attaching a plurality of fhiorochromes thereby achieving large extinction coefficients (in excess of 1,000,000 M -1 cm -1 ), (2) a non-crosslinked polymer coating suitable for attaching from about 10 to about 300 fluorochromes per particle, (3) a polymer coating suitable for attaching a plurality of fluorochromes in a manner that does not significantly compromise tht; quantum yield of the fluorochromes (e.g., the nanoparticles retain at least 50% of the fluorescent signal that is created by substantially the same number of free fluorochromes when tested under the same conditions), and (4) a polymer coating that is amenable to efficient chemical linking of biomolecules with retention of their biological properties to yield molecuSar imaging agents. The fluorescent metal oxide nanoparticles are highly stable molecular imaging agents in vitro, both before and after chemical Sinking of fluorochromes and biomolecules, but yet are labile and/or degradable in vivo.
摘要翻译：本发明提供荧光金属氧化物纳米颗粒，其是特别荧光的或具有非常高的荧光亮度，并且可以用于各种体外和体内应用。荧光金属氧化物纳米粒子特别可用作可用于体内成像的成像剂。荧光金属氧化物纳米颗粒也可以具有磁性，因此可以用于MRI，从而提供多模态成像剂。具体地，本发明的试剂的设计提供具有以下特征中的一个或多个的荧光金属氧化物纳米颗粒：（I）适合于附着多个荧光体的聚合物涂层，从而实现大的消光系数（超过1,000,000M，（2）适用于每颗颗粒附着约10至约300个荧光染料的非交联聚合物涂层，（3）适用于以不显着损害的方式附着多个荧光染料; 荧光染料的量子产率（例如，当在相同条件下测试时，纳米颗粒保留由基本上相同数量的游离荧光染料产生的荧光信号的至少50％），和（4）适合于有效的聚合物涂层生物分子的化学连接和保留其生物学特性以产生分子显像剂。荧光金属氧化物纳米颗粒是体外高度稳定的分子显像剂，在染料和生物分子的化学沉淀之前和之后，但在体内是不稳定和/或可降解的。

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