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1. 发明申请

WO2019140019A1 ACOUSTIC PROCESSING FOR CELL AND GENE THERAPY 审中-公开
公开(公告)号：WO2019140019A1
公开(公告)日：2019-07-18
申请号：PCT/US2019/012950
申请日：2019-01-09
申请人： FLODESIGN SONICS, INC.
发明人： LIPKENS, Bart , TOSTOES, Rui , PRESZ, JR., Walter, M. , ROSS-JOHNSRUD, Benjamin , CHITALE, Kedar , KENNEDY, III, Thomas, J. , DUTRA, Brian , MACCARTHY, Brian , SALOIO, Jack
IPC分类号： C12M1/00 , C12N5/078 , C12N13/00 , B01D21/28 , B02C19/00 , B02C19/18
摘要： A closed and modular fluidic system composed of one or more acoustic elements and cell processing reagents. The system employs a cellular manufacturing process for producing cell and gene therapy therapeutics.

2. 发明申请

WO2017193085A1 ACOUSTOPHORETIC CLARIFICATION OF PARTICLE-LADEN NON-FLOWING FLUIDS 审中-公开
标题翻译：对粒状非流动性液体的透明膜清除
公开(公告)号：WO2017193085A1
公开(公告)日：2017-11-09
申请号：PCT/US2017/031425
申请日：2017-05-05
申请人： FLODESIGN SONICS, INC. , LIPKENS, Bart , PRESZ JR, Walter, M. , CHITALE, Kedar , HATTEN, Daniel , BODNAR, Nathaniel , GHOSHAL, Goutam
发明人： LIPKENS, Bart , PRESZ JR, Walter, M. , CHITALE, Kedar , HATTEN, Daniel , BODNAR, Nathaniel , GHOSHAL, Goutam
IPC分类号： B01D43/00 , B01D21/28 , B01D49/00 , B01D51/08 , C12N3/00 , G01N1/40
CPC分类号： C12N13/00 , B01D21/283 , B01D51/08 , C12N1/02
摘要： Acoustophoretic devices for separating particles from a non-flowing host fluid are disclosed. The devices include a substantially acoustically transparent container and a separation unit, with the container being placed within the separation unit. An ultrasonic transducer in the separation unit creates a planar or multi-dimensional acoustic standing wave within the container, trapping particles disposed within the non-flowing fluid and causing them to coalesce or agglomerate, then separate due to buoyancy or gravity forces.
摘要翻译：公开了用于从不流动的主流体中分离颗粒的声泳装置。这些装置包括基本透声的透明容器和分离单元，容器放置在分离单元内。分离单元中的超声换能器在容器内产生平面或多维声驻波，捕集设置在非流动流体内的颗粒并使它们聚结或结块，然后由于浮力或重力而分离。

3. 发明申请

WO2016176663A1 ACOUSTOPHORETIC DEVICE FOR ANGLED WAVE PARTICLE DEFLECTION 审中-公开
标题翻译：用于抛物面波粒偏移的防震装置
公开(公告)号：WO2016176663A1
公开(公告)日：2016-11-03
申请号：PCT/US2016/030315
申请日：2016-04-29
申请人： FLODESIGN SONICS, INC.
发明人： LIPKENS, Bart , PRESZ, Walter M. Jr. , CHITALE, Kedar , KENNEDY, Thomas J. III
IPC分类号： B01D21/28 , B01J19/10 , A61M1/36
CPC分类号： C12N13/00 , A61M1/3678 , B01D21/283 , B01L3/502761 , B01L2300/0864 , B01L2300/0867 , B01L2400/0436 , B01L2400/0439 , C12M47/04 , G01N15/1484 , G01N2015/0053 , G01N2015/1006 , G01N2015/149
摘要： Devices for separating materials from a host fluid are disclosed. The devices 100 include a flow chamber, an ultrasonic transducer 120, and a reflector 130. The ultrasonic transducer 120 and reflector 130 create an angled acoustic standing wave oriented at an angle A relative to the direction of mean flow 116 through the flow chamber. The angled acoustic standing wave 122 results in an acoustic radiation force having an axial force component that deflects the materials, so that the materials and the host fluid can thus be separated. The angled acoustic standing wave can be oriented at an angle of about 20° to about 70° relative to the direction of mean flow through the flow chamber to deflect, collect, differentiate, or fractionate the materials from the fluid flowing through the device at flow rates of about 400 mL/min up to about 700 mL/min.
摘要翻译：公开了用于从主体流体分离材料的装置。装置100包括流动室，超声波换能器120和反射器130.超声波换能器120和反射器130产生相对于通过流动室的平均流动方向116以角度A定向的倾斜声驻波。倾斜的声驻波122导致具有使材料偏转的轴向力分量的声辐射力，从而可以分离材料和主流体。倾斜的声驻波可以相对于通过流动室的平均流动的方向以大约20°至大约70°的角度定向，从而偏离，收集，分离或分流材料与流过流过装置的流体速率约400mL / min，高达约700mL / min。

4. 发明申请

WO2016154475A1 METHODS AND APPARATUS FOR PARTICLE AGGREGATION USING ACOUSTIC STANDING WAVES 审中-公开
标题翻译：使用声学波形的粒子聚集的方法和装置
公开(公告)号：WO2016154475A1
公开(公告)日：2016-09-29
申请号：PCT/US2016/024082
申请日：2016-03-24
申请人： FLODESIGN SONICS, INC.
发明人： PRESZ, JR., Walter M. , CHITALE, Kedar , LIPKENS, Bart
IPC分类号： B01D21/28
CPC分类号： B01D21/283 , C02F1/36 , C12M47/02
摘要： Devices for separating materials from a host fluid are disclosed. The devices include an acoustic chamber, the figure indicates the view perpendicular to an ultrasonic transducer (130), having an inlet at the bottom and an outlet at the top. The ultrasonic transducer (130) and reflector create a multi-dimensional acoustic standing wave in the acoustic chamber that traps the materials and permits a continuous separation of the materials from the host fluid (vertical flow direction 120). The materials and the host fluid can thus be separately collected. Multiple sets of trapping lines (132) are generated by the acoustic standing wave, and the transducer (130) is oriented or has a shape to minimize cross-sectional area for straight vertical channels between the trapping lines.
摘要翻译：公开了用于从主体流体分离材料的装置。这些装置包括声学室，该图表示垂直于超声换能器（130）的视图，其具有底部的入口和顶部的出口。超声波换能器（130）和反射器在声学室中产生多维声驻波，其捕获材料并允许材料与主体流体（垂直流动方向120）的连续分离。因此，可以分别收集材料和主体流体。通过声驻波产生多组捕获线（132），并且换能器（130）被定向或具有使捕集线之间的直立垂直通道的横截面积最小化的形状。

5. 发明申请

WO2016100923A1 ACOUSTIC PERFUSION DEVICES 审中-公开
标题翻译：声音佩戴装置
公开(公告)号：WO2016100923A1
公开(公告)日：2016-06-23
申请号：PCT/US2015/066884
申请日：2015-12-18
申请人： FLODESIGN SONICS, INC.
发明人： LIPKENS, Bart , MILLER, Erik , ROSS-JOHNSRUD, Benjamin , PRESZ, Walter M. Jr. , CHITALE, Kedar , KENNEDY, Thomas J. III
IPC分类号： C12M1/00 , B01D43/00
CPC分类号： C12M29/10 , C12M47/02 , C12M47/10
摘要： Acoustic perfusion devices for separating biological cells from other material in a fluid medium are disclosed. The devices include an inlet port, an outlet port, and a collection port that are connected to an acoustic chamber. An ultrasonic transducer creates an acoustic standing wave in the acoustic chamber that permits a continuous flow of fluid to be recovered through the collection port while keeping the biological cells within the acoustic chamber to be returned to the bioreactor from which the fluid medium is being drawn.
摘要翻译：公开了用于将流体介质中的生物细胞与其它材料分离的声学灌注装置。这些装置包括连接到声学室的入口端口，出口端口和收集端口。超声波换能器在声学室中产生声驻波，允许流体通过收集口连续流动，同时将声室内的生物细胞保持回流到生物反应器，流体介质从该反应器被拉出。

6. 发明申请

WO2019140019A8 ACOUSTIC PROCESSING FOR CELL AND GENE THERAPY 审中-公开
公开(公告)号：WO2019140019A8
公开(公告)日：2019-07-18
申请号：PCT/US2019/012950
申请日：2019-01-09
申请人： FLODESIGN SONICS, INC.
发明人： LIPKENS, Bart , TOSTOES, Rui , PRESZ, JR., Walter, M. , ROSS-JOHNSRUD, Benjamin , CHITALE, Kedar , KENNEDY, III, Thomas, J. , DUTRA, Brian , MCCARTHY, Brian , SALOIO, Jack
IPC分类号： C12M1/00 , C12N5/078 , C12N13/00 , B01D21/28 , B02C19/00 , B02C19/18
摘要： A closed and modular fluidic system composed of one or more acoustic elements and cell processing reagents. The system employs a cellular manufacturing process for producing cell and gene therapy therapeutics.

7. 发明申请

WO2017165014A1 METHODS AND APPARATUS FOR PARTICLE AGGREGATION USING ACOUSTIC STANDING WAVES 审中-公开
标题翻译：使用声学驻波的粒子聚集的方法和装置
公开(公告)号：WO2017165014A1
公开(公告)日：2017-09-28
申请号：PCT/US2017/017788
申请日：2017-02-14
申请人： FLODESIGN SONICS, INC,
发明人： PRESZ, JR, Walter M. , CHITALE, Kedar , LIPKENS, Bart
IPC分类号： B01D21/28 , B01J19/10 , C02F1/36
CPC分类号： B01D21/283 , C02F1/36 , C12M47/02
摘要： Methods for generating particulate clusters and nodal trapping lines having desired widths are disclosed. The devices include an acoustic chamber having an inlet and an outlet. An ultrasonic transducer and reflector create a multi-dimensional acoustic standing wave that generates particulate clusters separated by a channel of fluid running therebetween and creates nodal trapping lines. The frequency of the multi-dimensional acoustic standing wave can be selectively tuned so as to selectively control at least one of (a) a width of each particulate cluster, or (b) a width of each channel of fluid. The frequency of the multi-dimensional acoustic standing wave can also be selectively tuned so as to selectively control the width of each nodal trapping line. Also disclosed are particulate clusters separated by a channel of fluid, wherein a ratio of the widths of the particulate clusters and the channel of fluid can be varied as desired.
摘要翻译：公开了用于产生具有期望宽度的粒子簇和节点捕获线的方法。这些装置包括具有入口和出口的声室。超声波换能器和反射器产生多维声学驻波，其产生由在其间流动的流体通道分开的颗粒群并产生节点俘获线。可以选择性地调节多维声驻波的频率，以便选择性地控制（a）每个颗粒簇的宽度，或（b）每个流体通道的宽度中的至少一个。多维声学驻波的频率也可以被选择性地调谐，以选择性地控制每个节点陷波线的宽度。还公开了由流体通道分离的颗粒簇，其中颗粒簇的宽度与流体通道的宽度的比率可以根据需要改变。

8. 发明申请

WO2017040325A1 LARGE SCALE ACOUSTIC SEPARATION DEVICE 审中-公开
标题翻译：大规模声学分离装置
公开(公告)号：WO2017040325A1
公开(公告)日：2017-03-09
申请号：PCT/US2016/049088
申请日：2016-08-26
申请人： FLODESIGN SONICS, INC.
发明人： LIPKENS, Bart , PRESZ JR, Walter M. , KING, Jeffrey , BARNES, Jason , MEALEY, Dane , MCCARTHY, Brian , ROSS-JOHNSRUD, Benjamin , CHITALE, Kedar
IPC分类号： B01D21/28 , C02F1/36 , B06B1/06 , G01N33/15 , A61M1/36
CPC分类号： B01D21/283 , A61M1/3678 , B06B1/0622 , G10K15/00
摘要： Devices (100) for separating a host fluid from a second fluid or particulate are disclosed. The devices include an acoustic chamber (107), a fluid outlet at a top end of the acoustic chamber (114), a concentrate outlet at a bottom end of the acoustic chamber (116), and an inlet (112) on a first side end (122) of the acoustic chamber (107). An ultrasonic transducer (106) on a side wall of the acoustic chamber and reflector at the opposite side wall create a multi-dimensional acoustic standing wave in the acoustic chamber (107) that traps and separates particulates (e.g. cells) from a host fluid. The host fluid is collected via the fluid outlet (114), and the particulates are collected via the concentrate outlet (116). The device is a large-scale device that is able to process liters/hour, and has a large interior volume.
摘要翻译：公开了用于将主流体与第二流体或颗粒分离的装置（100）。这些装置包括声室（107），在声室（114）的顶端处的流体出口，在声室（116）的底端处的浓缩物出口，以及在第一侧声室（107）的端部（122）。声腔室的侧壁上的超声波换能器（106）和相对侧壁处的反射器在声室（107）中形成多个立体声波驻波，其将微粒（例如电池）与主流体捕获并分离。主流体经由流体出口（114）收集，并且经由浓缩物出口（116）收集微粒。该装置是能够处理升/小时，并具有大的内部容积的大型装置。

9. 发明申请

WO2016004398A2 ACOUSTOPHORETIC DEVICE WITH UNIFORM FLUID FLOW 审中-公开
标题翻译：具有均匀流体流动的ACOUSTOPHORETIC装置
公开(公告)号：WO2016004398A2
公开(公告)日：2016-01-07
申请号：PCT/US2015/039125
申请日：2015-07-02
申请人： FLODESIGN SONICS, INC.
发明人： LIPKENS, Bart , MCCARTHY, Brian , BARNES, Jason , MEALEY, Dane , ROSS-JOHNSRUD, Ben , PRESZ JR, Walter M. , CHITALE, Kedar
IPC分类号： C02F1/36
CPC分类号： B01D21/283 , B01D21/0045
摘要： An acoustophoresis device which includes a substantially vertical flow path of the fluid mixture in order to improve separation of particles / secondary fluid from a primary fluid is disclosed. The vertical flow path reduces velocity non-uniformities in the acoustic chamber resulting from gravity forces. The device includes an acoustic chamber in which multidimensional acoustic standing waves are generated. The fluid can be introduced into the acoustic chamber using a dump diffuser in which a plurality of inlets enter near the bottom of the acoustic chamber such that flow symmetry reduces both, gravity driven flow non-uniformities, and any flow interference effects between inlet mixture flow into the acoustic chamber and the continuous gravity driven particle cluster drop out.
摘要翻译：为了改善颗粒/次级流体与主流体的分离，公开了一种包括流体混合物的基本上垂直的流动路径的声波传导装置。垂直流动路径减小了由重力引起的声室中的速度不均匀性。该装置包括其中产生多维声驻波的声室。可以使用倾倒扩散器将流体引入声学腔室，其中多个入口进入声学腔室的底部附近，使得流动对称性降低重力驱动的流动不均匀性和入口混合物流动之间的任何流动干涉效应进入声室并且连续重力驱动的粒子簇脱落。

10. 发明申请

WO2019173800A1 CELL THERAPY PROCESSES UTILIZING ACOUSTOPHORESIS 审中-公开
公开(公告)号：WO2019173800A1
公开(公告)日：2019-09-12
申请号：PCT/US2019/021492
申请日：2019-03-08
申请人： FLODESIGN SONICS, INC.
发明人： LIPKENS, Bart , TOSTOES, Rui , DUTRA, Brian , GILMANSHIN, Rudolf , DIONNE, Jason , PRESZ, Walter, M., Jr. , ROSS-JOHNSRUD, Benjamin , GHOSHAL, Goutam , CHITALE, Kedar
IPC分类号： C12N5/0783 , C12N5/00 , C12N13/00 , C12M1/00
摘要： A closed and modular fluidic system composed of one or more acoustic elements and cell processing reagents. The system employs a cellular manufacturing process for producing cell and gene therapy therapeutics.

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