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1. 发明申请

WO2009006516A1 ORALLY DISINTEGRATING TABLET COMPOSITIONS OF LAMOTRIGINE 审中-公开
标题翻译：洛伐他汀的片剂组合物的ORALLY DISINCAGE
公开(公告)号：WO2009006516A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/069000
申请日：2008-07-02
申请人： EURAND, INC. , VENKATESH, Gopi M. , VYAS, Nehal H. , GOSSELIN, Michael , LAI, Jin-wang
发明人： VENKATESH, Gopi M. , VYAS, Nehal H. , GOSSELIN, Michael , LAI, Jin-wang
IPC分类号： A01N43/64 , A61K31/53
CPC分类号： A61K31/53 , A61K9/0007 , A61K9/0056 , A61K9/2072 , A61K9/2077 , A61K9/2081 , A61K9/2095 , A61K9/5005 , A61K9/5015 , A61K9/5026 , A61K9/5031 , A61K9/5042 , A61K9/5047 , A61K9/5084 , A61K9/5089
摘要： The compositions of the present invention composition comprise a therapeutically effective amount of particles comprising lamotrigine, in combination with granules comprising a disintegrant, and a sugar alcohol and/or a saccharide. These compositions are useful in treating epilepsy and bipolar disorder, particularly for patients with dysphagia, and to improve compliance with bipolar patients.
摘要翻译：本发明组合物的组合物包含治疗有效量的包含拉莫三嗪的颗粒，以及包含崩解剂和糖醇和/或糖类的颗粒。这些组合物可用于治疗癫痫和双相障碍，特别是对于吞咽困难的患者，并改善对双相患者的依从性。

2. 发明申请

WO2011085188A1 PHARMACEUTICAL COMPOSITIONS COMPRISING ANTI-PSYCHOTIC DRUGS 审中-公开
标题翻译：包含抗精神病药物的药物组合物
公开(公告)号：WO2011085188A1
公开(公告)日：2011-07-14
申请号：PCT/US2011/020505
申请日：2011-01-07
申请人： EURAND, INC. , VENKATESH, Gopi M. , LAI, Jin-Wang , PAPP, Michelle
发明人： VENKATESH, Gopi M. , LAI, Jin-Wang , PAPP, Michelle
IPC分类号： A61K9/24
CPC分类号： A61K9/5084 , A61K9/0056 , A61K9/2081 , A61K9/5078 , A61K31/496 , A61K31/5415
摘要： This invention relates to pharmaceutical compositions comprising one or more weakly basic antipsychotic drugs, and methods of making and using such compositions.
摘要翻译：本发明涉及包含一种或多种弱碱性抗精神病药物的药物组合物，以及制备和使用该组合物的方法。

3. 发明申请

WO2012075455A2 RAPIDLY DISPERSING GRANULES, ORALLY DISINTEGRATING TABLETS AND METHODS 审中-公开
标题翻译：快速分散颗粒，ORALLY DISPATTING DISPATTING AND METHODS
公开(公告)号：WO2012075455A2
公开(公告)日：2012-06-07
申请号：PCT/US2011/063172
申请日：2011-12-02
申请人： APTALIS PHARMATECH, INC. , VENKATESH, Gopi M. , SWAMINATHAN, Vijaya , LAI, Jin-Wang , CLEVENGER, James M.
发明人： VENKATESH, Gopi M. , SWAMINATHAN, Vijaya , LAI, Jin-Wang , CLEVENGER, James M.
IPC分类号： A61K9/16
CPC分类号： A61K9/2077 , A61K9/0056 , A61K9/167 , A61K9/2018 , A61K9/2027 , A61K9/205 , A61K9/2054 , A61K9/2095 , A61K31/137 , A61K31/167 , A61K31/351 , A61K31/4453 , A61K31/485 , A61K31/53 , A61K31/5513
摘要： This invention relates to rapidly dispersing microgranules comprising at least one sugar alcohol or saccharide, at least one super disintegrant, and a pharmaceutically acceptable additive with multi-functionality (e.g., starch acting as a binder, disintegrant, diluent/filler, glidant, etc) at a low level, which can be formed by not only eliminating a wet milling step but also avoiding an extensive dry milling step. Furthermore, such rapidly dispersing microgranules could also comprise a pharmaceutically active agent thereby providing for a pharmaceutical composition, or the rapidly dispersing microgranules thus produced are suitable for blending with a pharmaceutically active agent that is optionally taste-masked and/or controlled release coated microparticles to also provide for a pharmaceutical composition and the invention is also directed to a method for manufacturing such rapidly dispersing microgranules in a high useable yield, as well as orally disintegrating tablets comprising such rapidly dispersing microgranules. The rapidly dispersing microgranules are also free flowing.
摘要翻译：本发明涉及快速分散包含至少一种糖醇或糖，至少一种超级崩解剂和具有多官能度的药学上可接受的添加剂（例如，作为粘合剂的淀粉，崩解剂，稀释剂/填充剂，助流剂等）的微粒体，在低水平，其可以通过不仅消除湿磨步骤而且可以避免广泛的干磨步骤形成。此外，这种快速分散的微粒还可以包含药物活性剂，从而提供药物组合物，或由此制备的快速分散的微粒适合于与任选地掩蔽和/或控释的微粒的药物活性剂混合，还提供药物组合物，并且本发明还涉及以高可用产率制造这种快速分散的微粒的方法，以及包含这种快速分散的微粒的口腔崩解片剂。快速分散的微粒也是自由流动的。

4. 发明申请

WO2011005671A1 METHODS OF TREATING PDNV AND PONV WITH EXTENDED RELEASE ONDANSETRON COMPOSITIONS 审中-公开
标题翻译：用扩展释放的ONDANSETRON组合物处理PDNV和PONV的方法
公开(公告)号：WO2011005671A1
公开(公告)日：2011-01-13
申请号：PCT/US2010/040868
申请日：2010-07-02
申请人： EURAND, INC. , VENKATESH, Gopi M. , PERRETT, Stephen , THIEROFF-EKERDT, Ruth
发明人： VENKATESH, Gopi M. , PERRETT, Stephen , THIEROFF-EKERDT, Ruth
IPC分类号： A01N43/50 , A61K31/415
CPC分类号： A61K31/4178 , A61K9/5073 , A61K9/5078 , A61K31/00 , A61K45/06 , A61K2300/00
摘要： Extended release ondansetron compositions of the present invention are useful for treating postoperative nausea and vomiting (PONV) and/or postdischarge nausea and vomiting (PDNV).
摘要翻译：本发明的延长释放昂丹司琼组合物可用于治疗术后恶心呕吐（PONV）和/或放电后恶心呕吐（PDNV）。

5. 发明申请

WO2011041509A1 ORALLY ADMINISTERED CORTICOSTEROID COMPOSITIONS 审中-公开
公开(公告)号：WO2011041509A1
公开(公告)日：2011-04-07
申请号：PCT/US2010/050860
申请日：2010-09-30
申请人： EURAND, INC. , VENKATESH, Gopi M. , PERRETT, Stephen , COHEN, Fredric Jay
发明人： VENKATESH, Gopi M. , PERRETT, Stephen , COHEN, Fredric Jay
IPC分类号： A61K31/56
CPC分类号： A61K9/0065 , A61K9/0053 , A61K9/0056 , A61K9/006 , A61K9/06 , A61K9/08 , A61K31/56 , A61K31/569 , A61K31/58 , A61K45/06 , A61K47/38 , A61K2300/00
摘要： Orally administered corticosteroid compositions and methods for treating a condition associated with inflammation of the gastrointestinal tract in an individual, comprising administering to an individual said orally administered corticosteriod composition are disclosed.
摘要翻译：口服给药皮质类固醇组合物和治疗与个体中胃肠道炎症有关的病症的方法，包括给予个体所述口服给药的皮质类固醇组合物。

6. 发明申请

WO2011035079A1 PANCREATIC ENZYME COMPOSITIONS AND METHODS FOR TREATING PANCREATITIS AND PANCREATIC INSUFFICIENCY 审中-公开
标题翻译：胰蛋白酶组合物和治疗胰腺癌和胰腺癌的方法
公开(公告)号：WO2011035079A1
公开(公告)日：2011-03-24
申请号：PCT/US2010/049203
申请日：2010-09-17
申请人： EURAND, INC. , VENKATESH, Gopi M. , PERRETT, Stephen , THIEROFF-EKERDT, Ruth , EFTHYMIOPOULOS, Konstantino
发明人： VENKATESH, Gopi M. , PERRETT, Stephen , THIEROFF-EKERDT, Ruth , EFTHYMIOPOULOS, Konstantino
IPC分类号： A61K38/43
CPC分类号： A61K9/16 , A61K9/2813 , A61K9/2866 , A61K9/4808 , A61K9/5084 , A61K38/00 , A61K38/465 , A61K38/48
摘要： Compositions of the present invention, comprising the combination of enterically coated and uncoated pancreatic enzyme-containing beads are useful for treating or preventing pancreatitis pain, and optionally disorders associated with digestive enzyme deficiencies.
摘要翻译：包含肠溶包衣和未包被胰酶的珠的组合的本发明的组合物可用于治疗或预防胰腺炎疼痛，以及任选与消化酶缺陷相关的病症。

7. 发明申请

WO2011066289A1 ONDANSETRON ORALLY DISINTEGRATING TABLET COMPOSITIONS FOR PREVENTION OF NAUSEA AND VOMITING 审中-公开
标题翻译： ONDANSETRON ORALLYRON OR DISETEGATING TABLET COMPOSITIONS FOR EVEREN NAUSEA AND VOMITING
公开(公告)号：WO2011066289A1
公开(公告)日：2011-06-03
申请号：PCT/US2010/057813
申请日：2010-11-23
申请人： EURAND, INC. , VENKATESH, Gopi M.
发明人： VENKATESH, Gopi M.
IPC分类号： A01N43/50
CPC分类号： A61K31/4178 , A61K9/0056 , A61K9/2077 , A61K9/2081 , A61K9/5026 , A61K9/5031 , A61K9/5047 , A61K9/5078
摘要： This invention is related to a pharmaceutical composition in the patient-friendly orally disintegrating tablet form comprising a weakly basic, selective serotonin 5-HT3 blocking agent for the prevention of nausea and/or vomiting for up to 24 hrs postdosing in cancer patients prior to undergoing moderately emetogenic chemotherapy or partial or whole body radiotherapy or in subjects at moderate to high risk of postoperative or postdischarge nausea and/or vomiting prior to inpatient or outpatient ambulatory surgery. The unit dosage form comprising a multitude of immediate-release drug particles providing dissolution profiles similar to that of reference drug product, and one or more timed, pulsatile-release bead populations, comprising at least one organic acid, which solubilizes said weakly basic selective serotonin 5-HT3 blocking agent prior to releasing it into the hostile intestinal environment.
摘要翻译：本发明涉及一种患者友好的口腔崩解片形式的药物组合物，其包含弱碱性选择性5-羟色胺5-HT 3阻断剂，用于预防恶心和/或呕吐在癌症患者之前多达24小时后进行中度排卵化疗或部分或全身放射治疗或中度至高风险的患者术后或出院后恶心和/或呕吐在住院或门诊门诊手术之前。所述单位剂量形式包含大量立即释放的药物颗粒，其提供类似于参考药物产品的溶出曲线，以及一个或多个定时的脉冲释放珠粒群，其包含至少一种有机酸，其溶解所述弱碱性选择性5-羟色胺 5-HT3阻断剂在将其释放到敌对肠道环境中之前。

8. 发明申请

WO2008119033A1 PHARMACEUTICAL COMPOSITIONS COMPRISING AN ACTIVE SUBSTANCE FROM THE SUBSTITUTED BENZHYDRYLPIPERAZINE FAMILY 审中-公开
标题翻译：包含活性物质的药物组合物从取代的苯甲酰胺家族
公开(公告)号：WO2008119033A1
公开(公告)日：2008-10-02
申请号：PCT/US2008/058470
申请日：2008-03-27
申请人： EURAND, INC. , VENKATESH, Gopi M.
发明人： VENKATESH, Gopi M.
IPC分类号： A61K9/24
CPC分类号： A61K9/0056 , A61K9/2077 , A61K9/5026 , A61K9/5047 , A61K9/5078
摘要： The present invention is directed to compositions of taste-masked microparticles comprising a substituted benzhydrylpiperazine coated and a taste-masking layer comprising a water-insoluble polymer and a gastrosoluble polymer, and methods of making such taste-masked microparticles. The present invention is also directed to stable orally disintegrating compositions comprising taste-masked microparticles of a substituted benzhydrylpiperazine and rapidly dispersing granules, and methods of making such orally disintegrating compositions.
摘要翻译：本发明涉及包含取代的二苯甲基哌嗪涂层和包含水不溶性聚合物和胃溶性聚合物的掩味层的掩味微粒的组合物，以及制备这种掩味微粒的方法。本发明还涉及包含取代的二苯甲基哌嗪和快速分散颗粒的掩味微粒的稳定的口腔崩解组合物，以及制备这种口腔崩解组合物的方法。

9. 发明申请

WO2011140106A1 MICROPELLET COMPOSITIONS COMPRISING PANCREATIN CONTAINING DIGESTIVE ENZYME MIXTURES 审中-公开
标题翻译：含有包含消化酶混合物的胰蛋白酶的麦克风组合物
公开(公告)号：WO2011140106A1
公开(公告)日：2011-11-10
申请号：PCT/US2011/035023
申请日：2011-05-03
申请人： EURAND PHARMACEUTICALS LIMITED , VENKATESH, Gopi M. , KRAMER, Craig , FABIANI, Flavio , MAPELLI, Luigi , ORTENZI, Giovanni , LATINO, Massimo
发明人： VENKATESH, Gopi M. , KRAMER, Craig , FABIANI, Flavio , MAPELLI, Luigi , ORTENZI, Giovanni , LATINO, Massimo
IPC分类号： A61K9/26
CPC分类号： A61K9/5078 , A61K9/0056 , A61K9/1641 , A61K9/1652 , A61K9/5042 , A61K9/5047 , A61K9/5089 , A61K38/465 , A61K38/47 , A61K38/48 , A61K2300/00
摘要： The present invention relates to a small particle size composition comprising pancreatin containing digestive enzymes for use in patients in need, including pediatric, geriatric, and adult patients, particularly those patients with dysphagia or wherein enteral administration using such composition would be suitable. In addition, the invention is directed to the composition as particles, such as micropellets or microgranules having a high potency, high useable yield and at least 10% - 90% of 400-800 µm. Furthermore, the composition optionally has an improved enteric coating and concomitant improved stability and enzyme activity compared to conventional prepared enterically coated pancreatic enzyme particles.
摘要翻译：本发明涉及一种小粒径组合物，其包含用于需要的患者的含有胰酶的消化酶，包括儿科，老年和成年患者，特别是那些吞咽困难的患者或其中使用这种组合物的肠内施用是合适的。此外，本发明涉及作为颗粒的组合物，例如具有高效力，高可用收率和400-800μm的至少10％至90％的微丸或微粒。此外，与常规制备的肠溶包衣胰酶颗粒相比，组合物任选地具有改善的肠溶衣并伴随改善的稳定性和酶活性。

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