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1. 发明申请

WO2004018512A2 POLYMORPHISMS IN THE HUMAN GENES FOR OCT1 AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS 审中-公开
标题翻译： OCT1人类基因多态性及其在诊断和治疗应用中的应用
公开(公告)号：WO2004018512A2
公开(公告)日：2004-03-04
申请号：PCT/EP2003/009356
申请日：2003-08-22
申请人： EPIDAUROS BIOTECHNOLOGIE AG , KERB, Reinhold , KOEPSELL, Hermann , BRINKMANN, Ulrich
发明人： KERB, Reinhold , KOEPSELL, Hermann , BRINKMANN, Ulrich
IPC分类号： C07K14/47
CPC分类号： C07K14/4702 , A01K2217/05 , A61K38/00 , C12Q1/6883
摘要： The present invention relates to a polymorphic OCT1 polynucleotide. Moreover, the invention relates to genes or vectors comprising the polynucleotides of the invention and to a host cell genetically engineered with the polynucleotide or gene of the invention. Further, the invention relates to methods for producing molecular variant polypeptides or fragments thereof, methods for producing cells capable of expressing a molecular variant polypeptide and to a polypeptide or fragment thereof encoded by the polynucleotide or the gene of the invention or which is obtainable by the method or from the cells produced by the method of the invention. Furthermore, the invention relates to an antibody which binds specifically the polypeptide of the invention. Moreover, the invention relates to a transgenic non-human animal. The invention also relates to a solid support comprising one or a plurality of the above mentioned polynucleotides, genes, vectors, polypeptides, antibodies or host cells. Furthermore, methods of identifying a polymorphism, identifying and obtaining a pro-drug or drug or an inhibitor are also encompassed by the present invention. In addition, the invention relates to methods for producing of a pharmaceutical composition and to methods of diagnosing a disease. Further, the invention relates to a method of detection of the polynucleotide of the invention. Furthermore, comprised by the present invention are a diagnostic and a pharmaceutical composition. Even more, the invention relates to uses of the polynucleotides, genes, vectors, polypeptides or antibodies of the invention. Finally, the invention relates to a diagnostic kit.
摘要翻译：本发明涉及多晶型OCT1多核苷酸。此外，本发明涉及包含本发明的多核苷酸的基因或载体，并涉及用本发明的多核苷酸或基因进行遗传工程改造的宿主细胞。此外，本发明涉及用于产生分子变体多肽或其片段的方法，用于产生能够表达分子变体多肽的细胞的方法，以及由本发明的多核苷酸或基因编码的多肽或其片段，或可由方法或由本发明方法生产的细胞。此外，本发明涉及特异性结合本发明多肽的抗体。此外，本发明涉及转基因非人动物。本发明还涉及包含一种或多种上述多核苷酸，基因，载体，多肽，抗体或宿主细胞的固体支持物。此外，鉴定多态性，鉴定和获得前药或药物或抑制剂的方法也包括在本发明中。此外，本发明涉及制备药物组合物的方法和诊断疾病的方法。此外，本发明涉及本发明的多核苷酸的检测方法。此外，本发明包括诊断和药物组合物。更进一步地，本发明涉及本发明的多核苷酸，基因，载体，多肽或抗体的用途。最后，本发明涉及诊断试剂盒。

2. 发明申请

WO2002099099A3 POLYMORPHISMS IN THE HUMAN GENE FOR CYTOCHROME P450 POLYPEPTIDE 2C8 AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS 审中-公开
公开(公告)号：WO2002099099A3
公开(公告)日：2002-12-12
申请号：PCT/EP2002/006000
申请日：2002-05-31
申请人： EPIDAUROS BIOTECHNOLOGIE AG , PENGER, Anja , SPRENGER, Reimund , BRINKMANN, Ulrich
发明人： PENGER, Anja , SPRENGER, Reimund , BRINKMANN, Ulrich
IPC分类号： C12N9/02
摘要： The present invention relates to a polymorphic CYP2C8-polynucleotide. Moreover, the invention relates to genes or vectors comprising the polynucleotides of the invention and to a host cell genetically engineered with the polynucleotide or gene of the invention. Further, the invention relates to methods for producing molecular variant polypeptides or fragments thereof, methods for producing cells capable of expressing a molecular variant polypeptide and to a polypeptide or fragment thereof encoded by the polynucleotide or the gene of the invention or which is obtainable by the method or from the cells produced by the method of the invention. Furthermore, the invention relates to an antibody which binds specifically the polypeptide of the invention. Moreover, the invention relates to a transgenic non-human animal. The invention also relates to a solid support comprising one or a plurality of the above mentioned polynucleotides, genes, vectors, polypeptides, antibodies or host cells. Furthermore, methods of identifying a polymorphism, identifying and obtaining a prodrug or drug or an inhibitor are also encompassed by the present invention. In addition, the invention relates to methods for producing of a pharmaceutical composition and to methods of diagnosing a disease. Further, the invention relates to a method of detection of the polynucleotide of the invention. Furthermore, comprised by the present invention are a diagnostic and a pharmaceutical composition. Even more, the invention relates to uses of the polynucleotides, genes, vectors, polypeptides or antibodies of the invention. Finally, the invention relates to a diagnostic kit.

3. 发明申请

WO2002099099A2 POLYMORPHISMS IN THE HUMAN GENE FOR CYTOCHROME P450 POLYPEPTIDE 2C8 AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS 审中-公开
标题翻译：人类基因组P450多肽2C8的多态性及其在诊断和治疗应用中的应用
公开(公告)号：WO2002099099A2
公开(公告)日：2002-12-12
申请号：PCT/EP2002/006000
申请日：2002-05-31
申请人： EPIDAUROS BIOTECHNOLOGIE AG , PENGER, Anja , SPRENGER, Reimund , BRINKMANN, Ulrich
发明人： PENGER, Anja , SPRENGER, Reimund , BRINKMANN, Ulrich
IPC分类号： C12N15/00
CPC分类号： C12N9/0077 , A01K2217/05 , C12Q1/6883 , C12Q2600/156
摘要： The present invention relates to a polymorphic CYP2C8-polynucleotide. Moreover, the invention relates to genes or vectors comprising the polynucleotides of the invention and to a host cell genetically engineered with the polynucleotide or gene of the invention. Further, the invention relates to methods for producing molecular variant polypeptides or fragments thereof, methods for producing cells capable of expressing a molecular variant polypeptide and to a polypeptide or fragment thereof encoded by the polynucleotide or the gene of the invention or which is obtainable by the method or from the cells produced by the method of the invention. Furthermore, the invention relates to an antibody which binds specifically the polypeptide of the invention. Moreover, the invention relates to a transgenic non-human animal. The invention also relates to a solid support comprising one or a plurality of the above mentioned polynucleotides, genes, vectors, polypeptides, antibodies or host cells. Furthermore, methods of identifying a polymorphism, identifying and obtaining a prodrug or drug or an inhibitor are also encompassed by the present invention. In addition, the invention relates to methods for producing of a pharmaceutical composition and to methods of diagnosing a disease. Further, the invention relates to a method of detection of the polynucleotide of the invention. Furthermore, comprised by the present invention are a diagnostic and a pharmaceutical composition. Even more, the invention relates to uses of the polynucleotides, genes, vectors, polypeptides or antibodies of the invention. Finally, the invention relates to a diagnostic kit.
摘要翻译：本发明涉及多态CYP2C8-多核苷酸。此外，本发明涉及包含本发明的多核苷酸的基因或载体，并涉及用本发明的多核苷酸或基因进行遗传工程改造的宿主细胞。此外，本发明涉及用于产生分子变体多肽或其片段的方法，用于产生能够表达分子变体多肽的细胞的方法，以及由本发明的多核苷酸或基因编码的多肽或其片段，或可由方法或由本发明方法生产的细胞。此外，本发明涉及特异性结合本发明多肽的抗体。此外，本发明涉及转基因非人动物。本发明还涉及包含一种或多种上述多核苷酸，基因，载体，多肽，抗体或宿主细胞的固体支持物。此外，鉴定多态性，鉴定和获得前药或药物或抑制剂的方法也包括在本发明中。此外，本发明涉及制备药物组合物的方法和诊断疾病的方法。此外，本发明涉及本发明的多核苷酸的检测方法。此外，本发明包括诊断和药物组合物。更进一步地，本发明涉及本发明的多核苷酸，基因，载体，多肽或抗体的用途。最后，本发明涉及诊断试剂盒。

4. 发明申请

WO2012093068A1 A PHARMACEUTICAL COMPOSITION OF A COMPLEX OF AN ANTI-DIG ANTIBODY AND DIGOXIGENIN THAT IS CONJUGATED TO A PEPTIDE 审中-公开
标题翻译：复合抗生素抗体和二氢呋喃酮复合物的药物组合物与肽结合
公开(公告)号：WO2012093068A1
公开(公告)日：2012-07-12
申请号：PCT/EP2011/074273
申请日：2011-12-30
申请人： F. HOFFMANN-LA ROCHE AG , BRINKMANN, Ulrich , DZIADEK, Sebastian , HOFFMANN, Eike
发明人： BRINKMANN, Ulrich , DZIADEK, Sebastian , HOFFMANN, Eike
IPC分类号： A61K47/48 , A61K39/385 , A61K39/395 , A61P35/00 , A61P3/00 , A61P43/00
CPC分类号： A61K47/48692 , A61K39/385 , A61K47/554 , A61K47/6883
摘要： The present invention relates to a pharmaceutical composition of complex of a monospecific antibody that binds to digoxigenin, and a digoxigenin-conjugated peptide, to the isolated or recovered complex as well as to a method of producing such complex or composition. Furthermore the use of such a pharmaceutical composition as a medicament is described.
摘要翻译：本发明涉及与分离或回收的复合物结合的地高辛和单独特异性抗体与地高辛缀合的肽的复合物的药物组合物，以及生产该复合物或组合物的方法。此外，描述了使用这种药物组合物作为药物。

5. 发明申请

WO2012025530A1 BISPECIFIC ANTIBODIES COMPRISING A DISULFIDE STABILIZED - FV FRAGMENT 审中-公开
标题翻译：包含稳定的稳定抗体 - FV片段
公开(公告)号：WO2012025530A1
公开(公告)日：2012-03-01
申请号：PCT/EP2011/064476
申请日：2011-08-23
申请人： F. HOFFMANN-LA ROCHE AG , BRINKMANN, Ulrich , HAAS, Alexander , METZ, Silke , SCHANZER, Juergen Michael
发明人： BRINKMANN, Ulrich , HAAS, Alexander , METZ, Silke , SCHANZER, Juergen Michael
IPC分类号： C07K16/00 , C07K16/32 , C07K16/28
CPC分类号： C07K16/468 , C07K16/00 , C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/56 , C07K2317/624 , C07K2317/64 , C07K2319/00
摘要： The present invention relates to bispecific antibodies, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译：本发明涉及双特异性抗体，其制备方法，含有所述抗体的药物组合物及其用途。

6. 发明申请

WO2011003780A1 BI-SPECIFIC DIGOXIGENIN BINDING ANTIBODIES 审中-公开
标题翻译：双特异性抗体结合抗体
公开(公告)号：WO2011003780A1
公开(公告)日：2011-01-13
申请号：PCT/EP2010/059243
申请日：2010-06-30
申请人： F. HOFFMANN-LA ROCHE AG , BRAMLAGE, Birgit , BRINKMANN, Ulrich , CROASDALE, Rebecca , DILL, Simone , DORMEYER, Wilma , GEORGES, Guy , GROTE, Michael , HAAS, Alexander , HOFFMANN, Eike , ICKENSTEIN, Ludger Markus , JAHN-HOFMANN, Kerstin , JOHN, Matthias , METZ, Silke , MUNDIGL, Olaf , SCHEUER, Werner , STRACKE, Jan Olaf
发明人： BRAMLAGE, Birgit , BRINKMANN, Ulrich , CROASDALE, Rebecca , DILL, Simone , DORMEYER, Wilma , GEORGES, Guy , GROTE, Michael , HAAS, Alexander , HOFFMANN, Eike , ICKENSTEIN, Ludger Markus , JAHN-HOFMANN, Kerstin , JOHN, Matthias , METZ, Silke , MUNDIGL, Olaf , SCHEUER, Werner , STRACKE, Jan Olaf
IPC分类号： A61K39/395 , A61K47/48 , C07K16/16 , C07K16/28 , C07K16/32 , C07K16/44 , C07K16/46 , C12N15/113
CPC分类号： C07K16/44 , A61K31/704 , A61K39/39533 , A61K47/6879 , A61K47/6897 , A61K49/0045 , A61K49/0058 , A61K2039/505 , B82Y5/00 , C07K16/16 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , A61K2300/00
摘要： This invention relates to bispecific antibodies and antibody fragments against a target protein and a hapten, wherein the hapten is PEG or biotin, most preferably digoxigenin, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical 5 compositions containing said antibodies, and uses thereof.
摘要翻译：本发明涉及针对靶蛋白和半抗原的双特异性抗体和抗体片段，其中半抗原是PEG或生物素，最优选地高辛，其制备方法，它们作为治疗或诊断剂的递送平台的用途，含有所述抗体及其用途。

7. 发明申请

WO2011117330A1 BISPECIFIC ANTIBODIES 审中-公开
标题翻译：双重抗体
公开(公告)号：WO2011117330A1
公开(公告)日：2011-09-29
申请号：PCT/EP2011/054505
申请日：2011-03-24
申请人： ROCHE GLYCART AG , BRINKMANN, Ulrich , CROASDALE, Rebecca , DUERR, Harald , KLEIN, Christian , KOPETZKI, Erhard , LAU, Wilma , REGULA, Joerg, Thomas , SCHANZER, Juergen, Michael , UMANA, Pablo , WARTHA, Katharina
发明人： BRINKMANN, Ulrich , CROASDALE, Rebecca , DUERR, Harald , KLEIN, Christian , KOPETZKI, Erhard , LAU, Wilma , REGULA, Joerg, Thomas , SCHANZER, Juergen, Michael , UMANA, Pablo , WARTHA, Katharina
IPC分类号： A61K39/395 , A61P35/00 , C07K16/22 , C07K16/28 , C07K16/46
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/2863 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/526 , C07K2317/56 , C07K2317/622 , C07K2317/624 , C07K2317/64 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to bispecific antibodies, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译：本发明涉及双特异性抗体，其制备方法，含有所述抗体的药物组合物及其用途。

8. 发明申请

WO2011003557A1 A COMPLEX OF BI-SPECIFIC ANTIBODY AND DIGOXIGENIN CONJUGATED TO A THERAPEUTIC OR DIAGNOSTIC AGENT 审中-公开
标题翻译：复合物与特异性抗体和联合治疗或诊断代谢的二氢吉他宁
公开(公告)号：WO2011003557A1
公开(公告)日：2011-01-13
申请号：PCT/EP2010/004051
申请日：2010-07-05
申请人： F. HOFFMANN-LA ROCHE AG , BRINKMANN, Ulrich , CROASDALE, Rebecca , DORMEYER, Wilma , GEORGES, Guy , HAAS, Alexander , HOFFMANN, Eike , METZ, Silke , MUNDIGL, Olaf , SCHEUER, Werner , STRACKE, Jan Olaf
发明人： BRINKMANN, Ulrich , CROASDALE, Rebecca , DORMEYER, Wilma , GEORGES, Guy , HAAS, Alexander , HOFFMANN, Eike , METZ, Silke , MUNDIGL, Olaf , SCHEUER, Werner , STRACKE, Jan Olaf
IPC分类号： A61K39/395 , A61K47/48 , C07K16/16 , C07K16/28 , C07K16/32 , C07K16/44 , C07K16/46 , C12N15/113
CPC分类号： C07K16/44 , A61K31/704 , A61K39/39533 , A61K47/6879 , A61K47/6897 , A61K49/0045 , A61K49/0058 , A61K2039/505 , B82Y5/00 , C07K16/16 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , A61K2300/00
摘要： The present invention relates to complexes of a) bi-specific antibodies and antibody fragments against a target protein and b) a digoxigenin conjugated to a therapeutic or diagnostic agent, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译：本发明涉及a）针对靶蛋白的双特异性抗体和抗体片段的复合物，和b）与治疗或诊断试剂缀合的地高辛，其生产方法，它们作为治疗或诊断试剂的递送平台的用途，含有所述抗体的药物组合物及其用途。

9. 发明申请

WO2010115552A8 BISPECIFIC ANTI-ERBB-3/ANTI-C-MET ANTIBODIES 审中-公开
公开(公告)号：WO2010115552A8
公开(公告)日：2010-10-14
申请号：PCT/EP2010/002005
申请日：2010-03-30
申请人： ROCHE GLYCART AG , BOSSENMAIER, Birgit , BRINKMANN, Ulrich , LAU, Wilma , HOFFMANN, Eike , KLEIN, Christian , NIEDERFELLNER, Gerhard , SCHANZER, Juergen, Michael , STRACKE, Jan, Olaf , SUSTMANN, Claudio , UMANA, Pablo
发明人： BOSSENMAIER, Birgit , BRINKMANN, Ulrich , LAU, Wilma , HOFFMANN, Eike , KLEIN, Christian , NIEDERFELLNER, Gerhard , SCHANZER, Juergen, Michael , STRACKE, Jan, Olaf , SUSTMANN, Claudio , UMANA, Pablo
IPC分类号： C07K16/28 , C07K16/32 , C07K16/46
摘要： The present invention relates to bispecific antibodies against human ErbB-3 and against human c-Met, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.

10. 发明申请

WO2010034441A1 BISPECIFIC ANTI-EGFR/ANTI-IGF-1R ANTIBODIES 审中-公开
标题翻译： BISPECIFIC抗EGFR /抗IGF-1R抗体
公开(公告)号：WO2010034441A1
公开(公告)日：2010-04-01
申请号：PCT/EP2009/006782
申请日：2009-09-21
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE GLYCART AG , BRINKMANN, Ulrich , CROASDALE, Rebecca , DORMEYER, Wilma , GERDES, Christian , HOFFMANN, Eike , KLEIN, Christian , KUENKELE, Klaus-Peter , SCHAEFER, Wolfgang , STRACKE, Jan Olaf , UMANA, Pablo
发明人： BRINKMANN, Ulrich , CROASDALE, Rebecca , DORMEYER, Wilma , GERDES, Christian , HOFFMANN, Eike , KLEIN, Christian , KUENKELE, Klaus-Peter , SCHAEFER, Wolfgang , STRACKE, Jan Olaf , UMANA, Pablo
IPC分类号： C07K16/28 , C07K16/46
CPC分类号： C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： Bispecific antibodies against EGFR and against IGF-1R, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译：针对EGFR和针对IGF-1R的双特异性抗体，其制备方法，含有所述抗体的药物组合物及其用途。

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