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1. 发明申请

WO2010044801A1 SYSTEMS AND METHODS FOR PREVENTING MISTRANSFUSION 审中-公开
标题翻译：用于防止误报的系统和方法
公开(公告)号：WO2010044801A1
公开(公告)日：2010-04-22
申请号：PCT/US2008/080293
申请日：2008-10-17
申请人： EMORY UNIVERSITY , HILLLYER, Christopher, D. , ROBACK, John, D. , ZIMRING, James, C.
发明人： HILLLYER, Christopher, D. , ROBACK, John, D. , ZIMRING, James, C.
IPC分类号： A61M5/168 , A61M5/00
CPC分类号： A61M5/16827 , A61M5/1723 , A61M2202/0413
摘要： In some embodiments, a system and a method for preventing mistransfusion of a patient pertain to obtaining a sample of the patient's blood, obtaining a sample of blood that is about to be infused into the patient, mixing the samples together, determining whether the samples are compatible, and if the samples are not compatible, automatically preventing infusion of the blood into the patient.
摘要翻译：在一些实施例中，用于防止患者错误输注的系统和方法涉及获得患者血液样本，获得将要输入患者的血液样本，将样本混合在一起，确定样品是否为兼容，并且如果样品不兼容，则自动防止将血液输注到患者体内。

2. 发明申请

WO2010040096A3 AGONISTS OF TOLL-LIKE RECEPTOR 5 FOR THE TREATMENT OF GRAFT-VERSUS-HOST DISEASE 审中-公开
公开(公告)号：WO2010040096A3
公开(公告)日：2010-04-08
申请号：PCT/US2009/059437
申请日：2009-10-02
申请人： EMORY UNIVERSITY , HOSSAIN, Mohammad, S. , GEWITZ, Andrew, T. , ROBACK, John, D. , WALLER, Edmund, K.
发明人： HOSSAIN, Mohammad, S. , GEWITZ, Andrew, T. , ROBACK, John, D. , WALLER, Edmund, K.
IPC分类号： A61K35/28 , A61K38/16 , A61K39/00 , A61P37/06
摘要： Methods are disclosed for treating or preventing graft versus host disease in a subject. The methods include selecting a subject in need of treatment for graft versus host disease; and administering to the subject a therapeutically effective amount of a TLR5 agonist such as a flagellin polypeptide, or a polynucleotide encoding the flagellin, thereby treating or preventing graft versus host disease in the subject. Methods are also disclosed for reducing susceptibility to an opportunistic infection in a subject who is a bone marrow transplant recipient. The methods include selecting a subject who has had a bone marrow or hematopoietic stem cell transplant; and administering to the subject a therapeutically effective amount of a TLR5 agonist such as a flagellin polypeptide or a polynucleotide encoding the polypeptide, and administering to the subject an effective amount antigen of the opportunistic infection, thereby reducing the susceptibility to the opportunistic infection in the subject.

3. 发明申请

WO2005003729A2 IMMUNOLOGICAL ASSAY SYSTEM AND METHOD 审中-公开
标题翻译：免疫测定系统和方法
公开(公告)号：WO2005003729A2
公开(公告)日：2005-01-13
申请号：PCT/US2004/020380
申请日：2004-06-24
申请人： EMORY UNIVERSITY , ROBACK, John, D. , HILLYER, Christopher, D.
发明人： ROBACK, John, D. , HILLYER, Christopher, D.
IPC分类号： G01N
CPC分类号： G01N35/028 , B01L3/5025 , B01L3/50255 , B01L2200/16 , B01L2300/0829 , B01L2300/0851 , G01N2035/00356 , G01N2035/00485 , G01N2035/0097
摘要： An immunological or immunohematological assay system is disclosed that includes a vessel capable of containing an assay sample, an incubator, a sample separation system, an image acquisition system, and a pipettor. The immunological assay system may also include a washer. Also disclosed is an immunological assay method that includes the steps of placing a immunological assay sample in a vessel, which may include a filter; adding testing reagents to the vessel; incubating the sample and reagent mixture in the vessel; separating the sample and reagent mixture in the vessel into components that have and have not reacted; and analyzing the vessel to determine the presence of interactions between the sample and reagents. The bottom of the vessel is preferably of a material that aids in spreading out the reacted components of the sample evenly over the bottom of the vessel so that interactions can more easily be analyzed.
摘要翻译：公开了免疫或免疫血液学测定系统，其包括能够包含测定样品，培养箱，样品分离系统，图像采集系统和移液器的容器。免疫测定系统还可以包括洗衣机。还公开了一种免疫测定方法，其包括将免疫测定样品置于容器中的步骤，容器可以包括过滤器; 向该容器加入测试试剂; 将样品和试剂混合物孵育在容器中; 将容器中的样品和试剂混合物分离成具有且没有反应的组分; 并分析血管以确定样品和试剂之间的相互作用的存在。容器的底部优选是有助于将样品的反应组分均匀地扩散到容器底部的材料，使得可以更容易地分析相互作用。

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