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1. 发明申请

WO2010040096A3 AGONISTS OF TOLL-LIKE RECEPTOR 5 FOR THE TREATMENT OF GRAFT-VERSUS-HOST DISEASE 审中-公开
公开(公告)号：WO2010040096A3
公开(公告)日：2010-04-08
申请号：PCT/US2009/059437
申请日：2009-10-02
申请人： EMORY UNIVERSITY , HOSSAIN, Mohammad, S. , GEWITZ, Andrew, T. , ROBACK, John, D. , WALLER, Edmund, K.
发明人： HOSSAIN, Mohammad, S. , GEWITZ, Andrew, T. , ROBACK, John, D. , WALLER, Edmund, K.
IPC分类号： A61K35/28 , A61K38/16 , A61K39/00 , A61P37/06
摘要： Methods are disclosed for treating or preventing graft versus host disease in a subject. The methods include selecting a subject in need of treatment for graft versus host disease; and administering to the subject a therapeutically effective amount of a TLR5 agonist such as a flagellin polypeptide, or a polynucleotide encoding the flagellin, thereby treating or preventing graft versus host disease in the subject. Methods are also disclosed for reducing susceptibility to an opportunistic infection in a subject who is a bone marrow transplant recipient. The methods include selecting a subject who has had a bone marrow or hematopoietic stem cell transplant; and administering to the subject a therapeutically effective amount of a TLR5 agonist such as a flagellin polypeptide or a polynucleotide encoding the polypeptide, and administering to the subject an effective amount antigen of the opportunistic infection, thereby reducing the susceptibility to the opportunistic infection in the subject.

2. 发明申请

WO2012161755A2 ANTAGONISM OF THE VIP SIGNALING PATHWAY 审中-公开
标题翻译： VIP信号路径的拮据
公开(公告)号：WO2012161755A2
公开(公告)日：2012-11-29
申请号：PCT/US2012/023268
申请日：2012-01-31
申请人： EMORY UNIVERSITY , WALLER, Edmund, K. , HOSSAIN, Mohammad, S. , LI, Jian-Ming
发明人： WALLER, Edmund, K. , HOSSAIN, Mohammad, S. , LI, Jian-Ming
IPC分类号： A61K38/16 , A61K38/17 , A61K39/395 , A61K48/00 , A61P31/16 , A61P31/12
CPC分类号： A61K39/3955 , A61K35/14 , A61K35/17 , A61K38/04 , A61K38/16 , A61K38/2278 , A61K39/245 , Y02A50/467

3. 发明申请

WO2002090510A3 REGULATING IMMINE RESPONSES USING DENDRITIC CELLS 审中-公开
公开(公告)号：WO2002090510A3
公开(公告)日：2002-11-14
申请号：PCT/US2002/014497
申请日：2002-05-08
申请人： EMORY UNIVERSITY , WALLER, Edmund, K. , ROSENTHAL, Hillary, S. , LONAIL, Sagar
发明人： WALLER, Edmund, K. , ROSENTHAL, Hillary, S. , LONAIL, Sagar
IPC分类号： A01K63/00
摘要： Disclosed within a method of altering immune responses using dendritic cells. One form of the method is a method of inducing immunological tolerance in an individual, where type 2 dendritic cells are administrated to an individual, and where the dendritic cells have been incubated with one or more antigens. Another form of the method involves altering an immune response, in which liposomes containing where liposomes containing one or more antigens are administrated to an individual, and where the liposomes are modified with surface-bound molecules that target the liposomes to type 2 dendritic cells. Another form of the method involves reducing immune responsiveness, where liposomes containing one or more antigens are administrated to an individual and where the liposomes are modified with the surface bound molecules that target the liposomes to type 1 dendritic cells or type 2 dendritic cells. Another form of the method is a method of enhancing immune responsiveness, where liposomes containing one or more antigens are administrated to an individual, and where the liposomes are modified with surface-bound molecules that target the liposomes to mature type 1 dendritic cells.

4. 发明申请

WO2002090510A2 REGULATING IMMINE RESPONSES USING DENDRITIC CELLS 审中-公开
标题翻译：使用感染细胞调节反应
公开(公告)号：WO2002090510A2
公开(公告)日：2002-11-14
申请号：PCT/US2002/014497
申请日：2002-05-08
申请人： EMORY UNIVERSITY , WALLER, Edmund, K. , ROSENTHAL, Hillary, S. , LONAIL, Sagar
发明人： WALLER, Edmund, K. , ROSENTHAL, Hillary, S. , LONAIL, Sagar
IPC分类号： C12N
CPC分类号： A61K39/0011 , A61K9/1271 , A61K39/0008 , A61K39/001 , A61K2039/5158 , A61K2039/55555
摘要： Disclosed within a method of altering immune responses using dendritic cells. One form of the method is a method of inducing immunological tolerance in an individual, where type 2 dendritic cells are administrated to an individual, and where the dendritic cells have been incubated with one or more antigens. Another form of the method involves altering an immune response, in which liposomes containing where liposomes containing one or more antigens are administrated to an individual, and where the liposomes are modified with surface-bound molecules that target the liposomes to type 2 dendritic cells. Another form of the method involves reducing immune responsiveness, where liposomes containing one or more antigens are administrated to an individual and where the liposomes are modified with the surface bound molecules that target the liposomes to type 1 dendritic cells or type 2 dendritic cells. Another form of the method is a method of enhancing immune responsiveness, where liposomes containing one or more antigens are administrated to an individual, and where the liposomes are modified with surface-bound molecules that target the liposomes to mature type 1 dendritic cells.
摘要翻译：在使用树突状细胞改变免疫应答的方法中公开。该方法的一种形式是在个体中诱导免疫耐受的方法，其中向个体施用2型树突状细胞，并且其中树突状细胞已经与一种或多种抗原一起孵育。该方法的另一种形式涉及改变免疫应答，其中含有含有一种或多种抗原的脂质体的脂质体被施用于个体，并且其中脂质体用靶向脂质体的表面结合分子修饰为2型树突状细胞。该方法的另一种形式涉及降低免疫反应性，其中含有一种或多种抗原的脂质体被施用于个体，并且其中脂质体用靶向脂质体的表面结合分子修饰为1型树突状细胞或2型树突状细胞。该方法的另一种形式是增强免疫反应性的方法，其中将含有一种或多种抗原的脂质体施用于个体，并且其中脂质体用靶向脂质体的表面结合分子修饰成熟1型树突状细胞。

5. 发明申请

WO2002058729A2 METHODS OF INDUCING ORGAN TRANSPLANT TOLERANCE AND CORRECTING HEMOGLOBINOPATHIES 审中-公开
标题翻译：诱导机体耐受性和改善肝细胞病变的方法
公开(公告)号：WO2002058729A2
公开(公告)日：2002-08-01
申请号：PCT/US2002/003780
申请日：2002-01-25
申请人： EMORY UNIVERSITY , LARSEN, Christian, P. , PEARSON, Thomas, C. , WALLER, Edmund, K. , ADAMS, Andrew, B.
发明人： LARSEN, Christian, P. , PEARSON, Thomas, C. , WALLER, Edmund, K. , ADAMS, Andrew, B.
IPC分类号： A61K39/395
CPC分类号： C07K14/70521 , A61K35/28 , A61K39/39541 , C07K2319/00 , C07K2319/30 , A61K2300/00

6. 发明申请

WO2022245820A1 VASOACTIVE INTESTINAL PEPTIDE (VIP) RECEPTOR ANTAGONISTS 审中-公开
公开(公告)号：WO2022245820A1
公开(公告)日：2022-11-24
申请号：PCT/US2022/029628
申请日：2022-05-17
申请人： EMORY UNIVERSITY , CAMBIUM ONCOLOGY LLC , RAVINDRANATHAN, Sruthi
发明人： WALLER, Edmund, K. , LI, Jian-Ming , FNU, Passang, Tensing , MAJUMDAR, Anish, Sen
IPC分类号： C07K14/47 , A61K38/16
摘要： Disclosed are VIP-R antagonists for uses in managing the treatment or prevention of cancer and viral infections. In certain embodiments, this disclosure relates to chimeric variants of VIP-R antagonists, as peptides disclosed herein, and pharmaceutical composition comprising the same. In certain embodiments, this disclosure contemplates methods of treating subjects with cancer or infection with VIP-R antagonists or stimulating immune cells to target cancer by mixing immune cells in vitro with peptides disclosed herein and further administering an effective amount of stimulated immune cells to a subject in need of cancer treatment.

7. 发明申请

WO1997006249A1 A MOUSE MODEL WITH HUMAN IMMUNE SYSTEM 审中-公开
标题翻译：一种具有人体免疫系统的鼠模型
公开(公告)号：WO1997006249A1
公开(公告)日：1997-02-20
申请号：PCT/US1996012609
申请日：1996-08-01
申请人： EMORY UNIVERSITY
发明人： EMORY UNIVERSITY , FLEMING, William, H. , WALLER, Edmund, K. , TURNER, Curtis, W.
IPC分类号： C12N15/00
CPC分类号： A01K67/0271
摘要： The present invention provides a non-human genetically immunodeficient mammal the peripheral blood of which contains at least 10 % T cells of human origin.
摘要翻译：本发明提供一种非人基因免疫缺陷的哺乳动物，其外周血含有至少10％人源的T细胞。

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