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1. 发明申请

WO2007022502A2 BRIDGED N-CYCLIC SULFONAMIDO INHIBITORS OF GAMMA SECRETASE 审中-公开
标题翻译： GAMMA分泌酶的桥联N-环状磺酰胺抑制剂
公开(公告)号：WO2007022502A2
公开(公告)日：2007-02-22
申请号：PCT/US2006/032579
申请日：2006-08-18
申请人： ELAN PHARMACEUTICALS, INC. , BOWERS, Simeon , GAROFALO, Albert, W. , HOM, Roy, K. , KONRADI, Andrei, W. , MATTSON, Matthew, N. , NEITZEL, Martin, L. , SEMKO, Chris, M. , TRUONG, Anh, P. , WU, Jing , XU, Ying-zi
发明人： BOWERS, Simeon , GAROFALO, Albert, W. , HOM, Roy, K. , KONRADI, Andrei, W. , MATTSON, Matthew, N. , NEITZEL, Martin, L. , SEMKO, Chris, M. , TRUONG, Anh, P. , WU, Jing , XU, Ying-zi
IPC分类号： A61K31/4745 , A61K31/46 , C07D451/02
CPC分类号： C07D451/14 , C07D471/08 , C07D471/18 , C07D471/22 , C07D498/08
摘要： The invention provides N-cyclic sulfonamido compounds and salts of Formula (I): wherein A is as described in the specification and R 1 and R 2 combine to form a [3.3.1] or a [3.2.1] ring system, where the nitrogen is attached to the two bridgehead carbons, and the [3.3.1] or [3.2.1] ring systems are optionally fused with an heteroaryl or heterocycloalkyl ring. Compounds of Formula (I) are useful in treating or preventing cognitive disorders, such as Alzheimer's Disease. The invention also encompasses pharmaceutical compositions comprising compounds of Formula I, methods of treating cognitive disorders, such as Alzheimer's disease, and the intermediates useful in preparing the compounds of Formula (I).
摘要翻译：本发明提供N-环磺酰氨基化合物和式（I）的盐：其中A如说明书中所述，R 1和R 2结合形成[3.3 .1]或[3.2.1]环系统，其中氮连接到两个桥头堡碳上，[3.3.1]或[3.2.1]环体系任选地与杂芳基或杂环烷基环稠合。式（I）的化合物可用于治疗或预防认知障碍，例如阿尔茨海默病。本发明还包括含有式I化合物的药物组合物，治疗认知障碍的方法，例如阿尔茨海默病，以及可用于制备式（I）化合物的中间体。

2. 发明申请

WO2006113140A2 NOVEL COMPOUNDS USEFUL FOR BRADYKININ B1 RECEPTOR ANTAGONISM 审中-公开
标题翻译：用于BRADYKININ B1受体拮抗剂的新型化合物
公开(公告)号：WO2006113140A2
公开(公告)日：2006-10-26
申请号：PCT/US2006/012807
申请日：2006-04-06
申请人： ELAN PHARMACEUTICALS, INC. , YE, Xiaocong, Michael , GAROFALO, Albert, W. , LAWLER, Rose, D. , FUKUDA, Juri, Y. , KONRADI, Andrei, W. , HOLCOMB, Ryan , ROSSITER, Kassandra, I. , WONE, David, W., G. , WU, Jing
发明人： YE, Xiaocong, Michael , GAROFALO, Albert, W. , LAWLER, Rose, D. , FUKUDA, Juri, Y. , KONRADI, Andrei, W. , HOLCOMB, Ryan , ROSSITER, Kassandra, I. , WONE, David, W., G. , WU, Jing
CPC分类号： C07D277/12 , C07D209/46 , C07D333/40 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/10 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10
摘要： Disclosed are compounds that are bradykinin B 1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B 1 receptor.
摘要翻译：公开了缓激肽B 1受体拮抗剂的化合物，并且可用于治疗由缓激肽B 1受体介导的哺乳动物中疾病或与疾病状况相关的不良症状。

3. 发明申请

WO2004098590A1 4-BROMO-5- (2-CHLORO-BENZOYLAMINO)-1H-PYRAZOLE-3-CARBOXYLIC ACID (1-(AMINOCARBONYL) ETH-1-YL) AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES 审中-公开
标题翻译： 4-溴-5-（2-氯苯甲酰氨基）-1H-吡唑-3-羧酸（1-（氨基羰基）ETH-1-YL）酰胺衍生物及相关化合物作为治疗炎症性疾病的BRADYKININ B1受体拮抗剂
公开(公告)号：WO2004098590A1
公开(公告)日：2004-11-18
申请号：PCT/US2004/013400
申请日：2004-04-30
申请人： ELAN PHARMACEUTICALS, INC. , TUNG, Jay, S. , GAROFALO, Albert, W. , PLEISS, Michael, A. , WU, Jing , WONE, David, W., G. , GUINN, Ashley, C. , DRESSEN, Darren, B. , MARUGG, Jennifer , NEITZEL, Martin
发明人： TUNG, Jay, S. , GAROFALO, Albert, W. , PLEISS, Michael, A. , WU, Jing , WONE, David, W., G. , GUINN, Ashley, C. , DRESSEN, Darren, B. , MARUGG, Jennifer , NEITZEL, Martin
IPC分类号： A61K31/415
CPC分类号： C07D401/14 , C07D231/16 , C07D231/40 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D471/04 , C07D471/08 , C07D487/08
摘要： Disclosed are compounds of formulae (I) and (II) that are bradykinin B 1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B 1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action. Wherein Z is selected from O, S and NH; Q of formula (III) and the other substituents are as defined in claim 1.
摘要翻译：公开了缓激肽B1受体拮抗剂的式（I）和（II）化合物，并且可用于治疗由缓激肽B1受体介导的哺乳动物中疾病或与疾病相关的不良症状。某些化合物表现出增加的效力，并且还预期表现出增加的作用持续时间。其中Z选自O，S和NH; 式（III）的Q和其它取代基如权利要求1中所定义。

4. 发明申请

WO2004099155A2 SELECTED SUBSTITUTED PYRAZOLE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B1 RECEPTOR ANTAGONISTS 审中-公开
标题翻译：选择性取代的吡唑衍生物及相关化合物作为BRADYKININ B1受体拮抗剂
公开(公告)号：WO2004099155A2
公开(公告)日：2004-11-18
申请号：PCT/US2004/013655
申请日：2004-04-30
申请人： ELAN PHARMACEUTICALS, INC. , GAROFALO, Albert, W. , TUNG, Jay, S. , PLEISS, Michael, A. , WU, Jing , WONE, David, W., G. , GUINN, Ashley, C. , DRESSEN, Darren, B. , MARUGG, Jennifer , NEITZEL, Martin
发明人： GAROFALO, Albert, W. , TUNG, Jay, S. , PLEISS, Michael, A. , WU, Jing , WONE, David, W., G. , GUINN, Ashley, C. , DRESSEN, Darren, B. , MARUGG, Jennifer , NEITZEL, Martin
IPC分类号： C07D231/00
CPC分类号： C07D401/12 , C07D231/16 , C07D231/40 , C07D403/12 , C07D417/12
摘要： Disclosed are compounds that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.
摘要翻译：公开了缓激肽B1受体拮抗剂的化合物，可用于治疗由缓激肽B1受体介导的哺乳动物中疾病或与疾病状况相关的不良症状。某些化合物表现出增加的效力，并且还预期表现出增加的作用持续时间。

5. 发明申请

WO2004098589A1 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES 审中-公开
标题翻译： 4-溴 - 5-（2-氯代苯甲酰氨基） - 1H-吡唑-3-羧酸酰胺衍生物及相关化合物作为治疗炎症性疾病的BRADYKININ B1受体拮抗剂
公开(公告)号：WO2004098589A1
公开(公告)日：2004-11-18
申请号：PCT/US2004/013219
申请日：2004-04-30
申请人： ELAN PHARMACEUTICALS, INC. , TUNG, Jay, S. , GAROFALO, Albert, W. , PLEISS, Michael, A. , WU, Jing , WONE, David, W., G. , GUINN, Ashley, C. , DRESSEN, Darren, B. , NEITZ, R., Jeffrey , MARUGG, Jennifer , NEITZEL, Martin
发明人： TUNG, Jay, S. , GAROFALO, Albert, W. , PLEISS, Michael, A. , WU, Jing , WONE, David, W., G. , GUINN, Ashley, C. , DRESSEN, Darren, B. , NEITZ, R., Jeffrey , MARUGG, Jennifer , NEITZEL, Martin
IPC分类号： A61K31/415
CPC分类号： C07D401/14 , C07D231/16 , C07D231/40 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D471/04 , C07D471/08 , C07D487/08
摘要： Disclosed are compounds of formula I and II that are bradykinin B 1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B 1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.
摘要翻译：公开了作为缓激肽B1受体拮抗剂的式I和II化合物，可用于治疗由缓激肽B1受体介导的哺乳动物中疾病或与疾病相关的不良症状。某些化合物表现出增加的效力，并且还预期表现出增加的作用持续时间。

6. 发明申请

WO2010111418A2 PROCESS FOR THE PRODUCTION OF FUSED, TRICYCLIC SULFONAMIDES 审中-公开
标题翻译：生产熔融型三氯硅烷的方法
公开(公告)号：WO2010111418A2
公开(公告)日：2010-09-30
申请号：PCT/US2010/028535
申请日：2010-03-24
申请人： ELAN PHARMACEUTICALS, INC. , DAPPEN, Michael S. , JAGODZINSKI, Jacek J. , LATIMER, Lee H. , WU, Jing , GODFREY, Jollie Duaine, Jr. , MATUNAS, Robert M. , DRABB, Thomas W.
发明人： DAPPEN, Michael S. , JAGODZINSKI, Jacek J. , LATIMER, Lee H. , WU, Jing , GODFREY, Jollie Duaine, Jr. , MATUNAS, Robert M. , DRABB, Thomas W.
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D231/12 , C07D471/04
摘要： The present invention provides methods, i.e., scalable or large-scale processes for the production of fused, tricyclic sulfonamido analogs, such as substituted or unsubstituted 5- (aryl-sulfonyl)-4,5-dihydro- 1 H -pyrazolo[4,3-c]quinolines and 5-(heteroaryl-sulfonyl)-4,5- dihydro-1 H -pyrazolo[4,3-c]quinolines. Exemplary methods of the invention include an intra-molecular cyclization step, in which a carbon-nitrogen bond is formed, and which employs a copper-based catalyst that contains at least one organic ligand, such as DMEDA. The invention further provides compounds, which are useful as intermediates in the methods of the invention.
摘要翻译：本发明提供方法，即用于生产稠合的三环磺酰氨基类似物的可缩放或大规模方法，例如取代或未取代的5-（芳基 - 磺酰基）-4,5-二氢-1H-吡唑并[4,3 -c]喹啉和5-（杂芳基 - 磺酰基）-4,5-二氢-1H-吡唑并[4,3-c]喹啉。本发明的示例性方法包括分子内环化步骤，其中形成碳 - 氮键，并且使用含有至少一种有机配体如DMEDA的铜基催化剂。本发明还提供了可用作本发明方法中的中间体的化合物。

7. 发明申请

WO2018191939A1 CABLE PROTECTOR FOR INDUSTRIAL ROBOT, AND INDUSTRIAL ROBOT 审中-公开
公开(公告)号：WO2018191939A1
公开(公告)日：2018-10-25
申请号：PCT/CN2017/081382
申请日：2017-04-21
申请人： ABB SCHWEIZ AG , WU, Jing
发明人： WU, Jing
IPC分类号： B25J19/00
CPC分类号： B25J19/0025 , H02G3/0481 , H02G11/00
摘要： An industrial robot, and a cable protector for the industrial robot are described. The industrial robot comprises a base (101), an arm (103) and a cable (104), wherein the cable (104) is located outside the robot and connects the base (101) with the arm (103). The cable protector comprises a hollow conduit (201), a connection part (202) and a rotation part (203), the cable (104) traversing the hollow conduit (201), the hollow conduit (201) passing through the connection part (202) and the rotation part (203) in this order so as to be connected inside the arm (103), the connection part (202) being roughly L-shaped, the rotation part (203) comprising a first adapter part (2031) that is securely connected with the connection part (202) and a second adapter part (2032) that is securely connected with the arm (103), the first adapter part (2031) being rotatable relative to the second adapter part (2032).

8. 发明申请

WO2009085974A2 LOW WET ETCH RATE SILICON NITRIDE FILM 审中-公开
标题翻译：低湿蚀刻硅氮化硅膜
公开(公告)号：WO2009085974A2
公开(公告)日：2009-07-09
申请号：PCT/US2008/087465
申请日：2008-12-18
申请人： APPLIED MATERIALS, INC. , WANG, Anchuan , MUNGEKAR, Hemant, P. , WU, Jing , LEE, Young, S.
发明人： MUNGEKAR, Hemant, P. , WU, Jing , LEE, Young, S.
IPC分类号： C23C16/24 , C23C16/34 , H01L21/20
CPC分类号： H01L21/3185 , C23C16/345 , C23C16/505 , H01L21/0217 , H01L21/02211 , H01L21/02274 , H01L21/31111
摘要： The present invention pertains to methods of depositing low wet etch rate silicon nitride films on substrates using high-density plasma chemical vapor deposition techniques at substrate temperatures below 600°C. The method additionally involves the maintenance of a relatively high ratio of nitrogen to silicon in the plasma and a low process pressure.
摘要翻译：本发明涉及在低于600℃的衬底温度下使用高密度等离子体化学气相沉积技术在衬底上沉积低湿蚀刻速率氮化硅膜的方法。该方法还涉及在等离子体中维持相对高的氮与硅的比例以及较低的工艺压力。

9. 发明申请

WO2016193872A2 ANTIBODIES TARGETING BONE MORPHOGENETIC PROTEIN 9 (BMP9) AND METHODS THEREFOR 审中-公开
标题翻译：靶向骨形态蛋白9（BMP9）的抗体及其方法
公开(公告)号：WO2016193872A2
公开(公告)日：2016-12-08
申请号：PCT/IB2016/053095
申请日：2016-05-26
申请人： NOVARTIS AG , CHEN, Zijun , DENG, Sujun , HE, Yun , HUANG, Dagang , KUGLER, Markus , LI, Qian , LU, Chris Xiangyang , LUO, Xiao , SHAN, Yongqiang , TISSOT-DAGUETTE, Kathrin Ulrike , WU, Jing
发明人： CHEN, Zijun , DENG, Sujun , HE, Yun , HUANG, Dagang , KUGLER, Markus , LI, Qian , LU, Chris Xiangyang , LUO, Xiao , SHAN, Yongqiang , TISSOT-DAGUETTE, Kathrin Ulrike , WU, Jing
IPC分类号： C07K16/22 , A61K39/00
CPC分类号： C07K16/22 , A61K31/155 , A61K31/355 , A61K31/4439 , A61K31/4725 , A61K31/497 , A61K31/513 , A61K31/522 , A61K31/575 , A61K31/675 , A61K31/7072 , A61K38/1875 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94 , C12N15/09 , C12N15/63 , A61K2300/00
摘要： The present invention relates to isolated antibodies and antigen-binding fragments thereof which bind human BMP9 and compositions and methods of use thereof.
摘要翻译：本发明涉及结合人BMP9的分离的抗体及其抗原结合片段及其组合物及其使用方法。

10. 发明申请

WO2011156031A2 METHOD AND SYSTEM FOR PROVIDING INVERTED DUAL MAGNETIC TUNNELING JUNCTION ELEMENTS 审中-公开
标题翻译：用于提供反转双磁性连接元件的方法和系统
公开(公告)号：WO2011156031A2
公开(公告)日：2011-12-15
申请号：PCT/US2011/028254
申请日：2011-03-13
申请人： GRANDIS, INC. , TANG, Xueti , WU, Jing
发明人： TANG, Xueti , WU, Jing
IPC分类号： G06F7/40
CPC分类号： G11C11/1675 , G11C11/16 , G11C11/161 , H01L43/12
摘要： A method and system for providing a magnetic junction residing on a substrate and usable in a magnetic device are described. The magnetic junction includes a first pinned layer, a first nonmagnetic spacer layer having a first thickness, a free layer, a second nonmagnetic spacer layer having a second thickness greater than the first thickness, and a second pinned layer. The first nonmagnetic spacer layer resides between the pinned layer and the free layer. The first pinned layer resides between the free layer and the substrate. The second nonmagnetic spacer layer is between the free layer and the second pinned layer. Further, the magnetic junction is configured such that the free layer is switchable between a plurality of stable magnetic states when a write current is passed through the magnetic junction.
摘要翻译：描述了一种用于提供驻留在基板上并可用于磁性装置中的磁性结的方法和系统。磁结包括第一被钉扎层，具有第一厚度的第一非磁性间隔层，具有大于第一厚度的第二厚度的自由层，第二非磁性间隔层，以及第二钉扎层。第一非磁性间隔层位于被钉扎层和自由层之间。第一被钉扎层位于自由层和基底之间。第二非磁性间隔层位于自由层和第二被钉扎层之间。此外，磁结被配置为使得当写入电流通过磁结时，自由层可在多个稳定磁状态之间切换。

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