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1. 发明申请

WO2004062595A3 ANTINEOPLASTIC ETHER LIPID COMPOUNDS WITH MODIFICATIONS AT THE SN-1 CARBON 审中-公开
标题翻译：具有SN-1碳改性的异腈橡胶醚化合物
公开(公告)号：WO2004062595A3
公开(公告)日：2004-12-09
申请号：PCT/US2004000359
申请日：2004-01-09
申请人： ELAN PHARM INC , PERKINS WALTER R
发明人： PERKINS WALTER R
IPC分类号： C07F9/10 , A61K31/685 , C07F9/09
CPC分类号： C07F9/10
摘要： Ether lipid compounds of formula (I): pharmaceutically-acceptable salts, prodrugs or isomers thereof are provided, where the variables are as defined herein. The compounds of the invention have antineoplastic activity, and accordingly have utility in treating cancer and related diseases. Enantiomers of these compounds, pharmaceutical compositions, and methods for treating cancer with the pharmaceutical compositions are also provided.
摘要翻译：提供式（I）的醚类脂质化合物：其药学上可接受的盐，前药或异构体，其中变量如本文所定义。本发明的化合物具有抗肿瘤活性，因此具有治疗癌症和相关疾病的效用。还提供了这些化合物的对映异构体，药物组合物和用药物组合物治疗癌症的方法。

2. 发明申请

WO2004062596A3 ANTINEOPLASTIC ETHER LIPID COMPOUNDS HAVING A FOUR CARBON BACKBONE 审中-公开
标题翻译：具有四个碳背景的抗微生物醚类脂质化合物
公开(公告)号：WO2004062596A3
公开(公告)日：2004-11-04
申请号：PCT/US2004000360
申请日：2004-01-09
申请人： ELAN PHARM INC , PERKINS WALTER R
发明人： PERKINS WALTER R
IPC分类号： A61K20060101 , A61K31/662 , A61K31/675 , C07F9/10 , C07F9/40 , C07F9/564 , C07F9/572 , C07F9/58 , C07F9/59 , C07F9/6533
CPC分类号： C07F9/595 , C07F9/10 , C07F9/564 , C07F9/5725 , C07F9/581 , C07F9/6533
摘要： Ether lipid compounds of formula (I), pharmaceutically-acceptable salts, prodrugs or isomers thereof are provided, where 5 the variables are as defined herein. The compounds of the invention have antineoplastic activity, and accordingly have utility in treating cancer and related diseases. Enantiomers of these compounds, pharmaceutical compositions, and methods for treating cancer with the pharmaceutical compositions are also provided.

3. 发明申请

WO2004062586A3 ANTINEOPLASTIC ETHER LIPID COMPOUNDS 审中-公开
标题翻译：抗生素醚类化合物
公开(公告)号：WO2004062586A3
公开(公告)日：2004-12-09
申请号：PCT/US2004000267
申请日：2004-01-08
申请人： ELAN PHARM INC , PERKINS WALTER R
发明人： PERKINS WALTER R
IPC分类号： A61K20060101 , A61K31/535 , A61K38/16 , C07D265/28 , C07F9/02 , C07F9/10 , C07F9/117 , C07F9/6533
CPC分类号： C07F9/6533 , C07F9/10 , C07F9/117
摘要： Ether lipid compounds of formula (I): Formula (I) pharmaceutically-acceptable salts, prodrugs or isomers thereof are provided, where the variables are as defined herein. The compounds of the invention have anti-neoplastic activity, and accordingly have utility in treating cancer and related diseases. Enantiomers of these compounds, pharmaceutical compositions, and methods for treating cancer with the pharmaceutical compositions are also provided.
摘要翻译：提供式（I）的醚类脂质化合物：式（I）其药学上可接受的盐，前药或异构体，其中变量如本文所定义。本发明的化合物具有抗肿瘤活性，因此具有治疗癌症和相关疾病的效用。还提供了这些化合物的对映异构体，药物组合物和用药物组合物治疗癌症的方法。

4. 发明申请

WO2004062593A3 ANTINEOPLASTIC ETHER LIPID COMPOUNDS WITH MODIFICATIONS AT THE SN-2 CARBON 审中-公开
标题翻译：在SN-2碳上具有改性的抗菌脂质脂质化合物
公开(公告)号：WO2004062593A3
公开(公告)日：2004-12-09
申请号：PCT/US2004000357
申请日：2004-01-09
申请人： ELAN PHARM INC , PERKINS WALTER R
发明人： PERKINS WALTER R
IPC分类号： A61K20060101 , A61K31/445 , C07F9/10 , C07F9/28 , C07F9/59
CPC分类号： C07F9/10 , C07F9/591
摘要： Ether lipid compounds of formula (I), Pharmaceutically-acceptable salts, prodrugs or isomers thereof are provided, where the variables are as defined herein. The compounds of the invention have antineoplastic activity, and accordingly have utility in treating cancer and related diseases. Enantiomers of these compounds, pharmaceutical compositions, and methods for treating cancer with the pharmaceutical compositions are also provided.
摘要翻译：提供式（I）的醚脂质化合物，其药学上可接受的盐，前药或异构体，其中变量如本文所定义。本发明的化合物具有抗肿瘤活性，因此可用于治疗癌症和相关疾病。还提供了这些化合物的对映异构体，药物组合物和用该药物组合物治疗癌症的方法。

5. 发明申请

WO03059280A3 EFFICIENT LIPOSOMAL ENCAPSULATION 审中-公开
标题翻译：有效的脂质包埋
公开(公告)号：WO03059280A3
公开(公告)日：2003-10-16
申请号：PCT/US0300377
申请日：2003-01-08
申请人： ELAN PHARM INC , LI XINGONG , TONG SHANGGUAN , POLOZOVA ALLA , MEERS PAUL R , PERKINS WALTER R
发明人： LI XINGONG , TONG SHANGGUAN , POLOZOVA ALLA , MEERS PAUL R , PERKINS WALTER R
IPC分类号： A61K9/127 , B01J13/02
CPC分类号： B01J13/02 , A61K9/1277 , A61K47/6911
摘要： The present invention concerns a method for preparing liposomes, said method comprising the following steps: (I) mixing at least one liposome-forming lipid, a water-miscible organic solvent and aqueous medium Y to form a gel or liquid containing gel particles without sonication; and thereafter (II) (a) mixing the gel or liquid containing gel particles with aqueous medium Z1 to directly form the liposomes; (b) (i) mixing the gel or liquid containing gel particles with aqueous medium Z1 to form a curd or curdy substance; and (ii) mixing the curd or curdy substance with aqueous medium Z2 to directly form the liposomes; or (c) (i) cooling the gel or liquid containing gel particles to form a waxy substance; and (ii) mixing the waxy substance with aqueous medium Z1 to directly form the liposomes; wherein aqueous media Y, Z1 and Z2 are the same or different.
摘要翻译：本发明涉及一种制备脂质体的方法，所述方法包括以下步骤：（I）将至少一种形成脂质体的脂质，水混溶性有机溶剂和水性介质Y混合以形成不含超声波处理的含有凝胶颗粒的凝胶或液体 ; 然后（II）（a）将含有凝胶颗粒的凝胶或液体与水性介质Z1混合以直接形成脂质体; （b）（i）将含有凝胶颗粒的凝胶或液体与水性介质Z1混合以形成凝乳或卷曲物质; 和（ii）将凝乳或卷曲物质与水性介质Z2混合以直接形成脂质体; 或（c）（i）冷却含有凝胶颗粒的凝胶或液体以形成蜡状物质; 和（ii）将蜡状物质与水性介质Z1混合以直接形成脂质体; 其中水性介质Y，Z1和Z2相同或不同。

6. 发明申请

WO2009055568A2 LIPOSOMAL VANCOMYCIN FORMULATIONS 审中-公开
标题翻译：脂肪维生素制剂
公开(公告)号：WO2009055568A2
公开(公告)日：2009-04-30
申请号：PCT/US2008080954
申请日：2008-10-23
申请人： TRANSAVE INC , LI XINGONG , PERKINS WALTER R
发明人： LI XINGONG , PERKINS WALTER R
IPC分类号： A61K9/127 , A61K31/70 , A61P11/00
CPC分类号： A61K9/127 , A61K9/0078 , A61K9/1277 , A61K38/14
摘要： The present disclosure relates in part to liposomal vancomycin compositions having low lipid to drug ratios and high concentration of vancomycin. The present disclosure also relates in part to methods of making such compositions.
摘要翻译：本公开部分涉及具有低脂质与药物比例和高浓度万古霉素的脂质体万古霉素组合物。本公开还部分涉及制备这种组合物的方法。

7. 发明申请

WO2008039989A3 FORMULATIONS OF DNASE AND METHODS OF USE THEREOF 审中-公开
标题翻译： DNASE的配方及其使用方法
公开(公告)号：WO2008039989A3
公开(公告)日：2008-12-04
申请号：PCT/US2007079911
申请日：2007-09-28
申请人： TRANSAVE INC , PERKINS WALTER R , MALININ VLADIMIR , MEERS PAUL R
发明人： PERKINS WALTER R , MALININ VLADIMIR , MEERS PAUL R
IPC分类号： A61K9/127
CPC分类号： A61K9/127
摘要： Compositions comprising DNase encapsulated in a liposome are provided. Additionally, provided are compositions comprising a free enzyme and empty liposomes, compositions comprising a free enzyme and an antiinfective encapsulated in a liposome, compositions comprising a free enzyme, a free-antiinfective, and empty liposomes, compositions comprising a free enzyme, a free antiinfective, and an antiinfective encapsulated in a liposome, and a composition comprising a free enzyme, empty liposomes, and an antiinfective encapsulated in a liposome, and compositions comprising a free enzyme, a free antiinfective, empty liposomes, an antiinfective encapsulated in a liposome, and pharmaceutical compositions comprising the aforementioned compositions. The Also provided are methods of treating pneumonia, bronchitis, cystic fibrosis, or emphysema comprising administering to a subject in need thereof a therapeutically effective amount of the aforementioned pharmaceutical composition.
摘要翻译：提供了包含在脂质体中的DNase的组合物。另外，提供了包含游离酶和空脂质体的组合物，包含游离酶和包封在脂质体中的抗感染剂的组合物，包含游离酶，游离抗感染性和空脂质体的组合物，包含游离酶，游离抗感染剂和包封在脂质体中的抗感染剂，以及包含游离酶，空脂质体和包封在脂质体中的抗感染药的组合物，以及包含游离酶，游离抗感染剂，空脂质体，包封在脂质体中的抗感染剂的组合物和包含上述组合物的药物组合物。还提供了治疗肺炎，支气管炎，囊性纤维化或肺气肿的方法，其包括向有需要的受试者施用治疗有效量的上述药物组合物。

8. 发明申请

WO2008022189A3 ADMINISTRATION OF HIGH POTENCY PLATINUM COMPOUND FORMULATIONS BY INHALATION 审中-公开
标题翻译：吸入高浓度铂复方制剂的管理
公开(公告)号：WO2008022189A3
公开(公告)日：2008-11-13
申请号：PCT/US2007075995
申请日：2007-08-15
申请人： TRANSAVE INC , PILKIEWICZ FRANK G , PERKINS WALTER R , METZHEISER BETH
发明人： PILKIEWICZ FRANK G , PERKINS WALTER R , METZHEISER BETH
IPC分类号： A61K33/24 , A01N55/02 , A61K9/00 , A61K9/127 , A61P37/00
CPC分类号： A61K33/24 , A61K9/0078 , A61K9/127
摘要： Provided is a method for treating a patient having cancer. The method includes administering high potency lipid-platinum compound formulations to the patient's respiratory tract. Also provided is a method of reducing treatment times for administering platinum compound formulations to a patient in need thereof by administering high potency lipid-platinum compound formulations to the patient.
摘要翻译：提供了治疗患有癌症的患者的方法。该方法包括将高效脂质 - 铂化合物制剂给予患者的呼吸道。还提供了通过向患者施用高效脂质 - 铂化合物制剂来减少用于向需要其的患者施用铂化合物制剂的治疗时间的方法。

9. 发明申请

WO2008039987A2 METHODS OF TREATING PULMONARY DISTRESS 审中-公开
标题翻译：治疗肺部疾病的方法
公开(公告)号：WO2008039987A2
公开(公告)日：2008-04-03
申请号：PCT/US2007079905
申请日：2007-09-28
申请人： TRANSAVE INC , PERKINS WALTER R
发明人： PERKINS WALTER R
IPC分类号： A61K9/127 , A61K31/7036 , A61P11/00
CPC分类号： A61K31/7036 , A61K9/0014
摘要： Provided is a method of increasing the forced expiratory volume in one second (FEV1) in a subject comprising administering to the subject in need thereof a therapeutically effective amount of a liposomal formulation. In some embodiments, the liposomal formulation comprises empty liposomes. Also provided is a method of increasing FEV1 in a subject consisting essentially of administering to the subject a therapeutically effective amount of empty liposomes and pharmaceutical carrier. Additionally, provided is a method of treating cystic fibrosis in a subject comprising administering to the subject a therapeutically effective amount of empty liposomes.
摘要翻译：提供了增加受试者中一秒钟（FEV1）中的呼气量的方法，包括向有需要的受试者施用治疗有效量的脂质体制剂。在一些实施方案中，脂质体制剂包含空脂质体。还提供了一种在受试者中增加FEV1的方法，其基本上包括向受试者施用治疗有效量的空脂质体和药物载体。另外，提供了一种治疗受试者的囊性纤维化的方法，包括向受试者施用治疗有效量的空脂质体。

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