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1. 发明申请

WO03059280A3 EFFICIENT LIPOSOMAL ENCAPSULATION 审中-公开
标题翻译：有效的脂质包埋
公开(公告)号：WO03059280A3
公开(公告)日：2003-10-16
申请号：PCT/US0300377
申请日：2003-01-08
申请人： ELAN PHARM INC , LI XINGONG , TONG SHANGGUAN , POLOZOVA ALLA , MEERS PAUL R , PERKINS WALTER R
发明人： LI XINGONG , TONG SHANGGUAN , POLOZOVA ALLA , MEERS PAUL R , PERKINS WALTER R
IPC分类号： A61K9/127 , B01J13/02
CPC分类号： B01J13/02 , A61K9/1277 , A61K47/6911
摘要： The present invention concerns a method for preparing liposomes, said method comprising the following steps: (I) mixing at least one liposome-forming lipid, a water-miscible organic solvent and aqueous medium Y to form a gel or liquid containing gel particles without sonication; and thereafter (II) (a) mixing the gel or liquid containing gel particles with aqueous medium Z1 to directly form the liposomes; (b) (i) mixing the gel or liquid containing gel particles with aqueous medium Z1 to form a curd or curdy substance; and (ii) mixing the curd or curdy substance with aqueous medium Z2 to directly form the liposomes; or (c) (i) cooling the gel or liquid containing gel particles to form a waxy substance; and (ii) mixing the waxy substance with aqueous medium Z1 to directly form the liposomes; wherein aqueous media Y, Z1 and Z2 are the same or different.
摘要翻译：本发明涉及一种制备脂质体的方法，所述方法包括以下步骤：（I）将至少一种形成脂质体的脂质，水混溶性有机溶剂和水性介质Y混合以形成不含超声波处理的含有凝胶颗粒的凝胶或液体 ; 然后（II）（a）将含有凝胶颗粒的凝胶或液体与水性介质Z1混合以直接形成脂质体; （b）（i）将含有凝胶颗粒的凝胶或液体与水性介质Z1混合以形成凝乳或卷曲物质; 和（ii）将凝乳或卷曲物质与水性介质Z2混合以直接形成脂质体; 或（c）（i）冷却含有凝胶颗粒的凝胶或液体以形成蜡状物质; 和（ii）将蜡状物质与水性介质Z1混合以直接形成脂质体; 其中水性介质Y，Z1和Z2相同或不同。

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