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1. 发明申请

WO2007085992A1 OPTICAL IMAGING SYSTEM WITH EXTENDED DEPTH OF FOCUS 审中-公开
标题翻译：光学成像系统具有更广泛的聚焦深度
公开(公告)号：WO2007085992A1
公开(公告)日：2007-08-02
申请号：PCT/IB2007/050195
申请日：2007-01-20
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) , LEITGEB, Rainer , LASSER, Theo , BACHMANN, Adrian , STEINMANN, Lukas , VILLIGER, Martin
发明人： LEITGEB, Rainer , LASSER, Theo , BACHMANN, Adrian , STEINMANN, Lukas , VILLIGER, Martin
IPC分类号： G01N21/47
CPC分类号： G01N21/4795 , G01B9/02002 , G01B9/02035 , G01B9/02044 , G01B9/02091 , G01B2290/70
摘要： The invention concerns an optical imaging apparatus comprising (o) a light source (1) , (p) sample holding means, (q) an interferometer, (r) reference means, (s) an objective (8) which is adapted to have its sample side focal plane crossing a sample held in said sample holding means, (t) optical or electro-optical means (2, 3, 5, 16) adapted to produce a ring shaped or multi-spot light source in the front focal plane (17) or any conjugated plane (17') of said objective (8) , at least one detector. The invention also includes a method for using said apparatus where the sample is illuminated by an interference pattern and the depth information is obtained by using optical Coherence Tomography.
摘要翻译：本发明涉及一种光学成像设备，包括（o）光源（1），（p）样品保持装置，（q）干涉仪，（r）参考装置，（s）物镜（8）其样品侧焦平面与保持在所述样品保持装置中的样品交叉;（t）适于在前焦平面中产生环形或多点光源的光学或电光装置（2,3,5,16）（17）或所述物镜（8）的任何共轭平面（17'），至少一个检测器。本发明还包括使用所述装置的方法，其中样本被干涉图案照射，并且通过使用光学相干断层扫描获得深度信息。

2. 发明申请

WO2008087613A3 DUAL BEAM HETERODYNE FOURIER DOMAIN OPTICAL COHERENCE TOMOGRAPHY 审中-公开
公开(公告)号：WO2008087613A3
公开(公告)日：2008-07-24
申请号：PCT/IB2008/050205
申请日：2008-01-21
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) , LEITGEB, Rainer , BACHMANN, Adrian , VILLIGER, Martin , MICHAELY, Roland , LASSER, Theo
发明人： LEITGEB, Rainer , BACHMANN, Adrian , VILLIGER, Martin , MICHAELY, Roland , LASSER, Theo
IPC分类号： G01B9/02
摘要： The present invention relates to an apparatus and a method combining achromatic complex FDOCT signal reconstruction with a common path and dual beam configuration. The complex signal reconstruction allows resolving the complex ambiguity of the Fourier transform and to enhance the achievable depth range by a factor of two. The dual beam configuration shares the property of high phase stability with common path FDOCT. This is of importance for a proper complex signal reconstruction and is in particular useful in combination with handheld probes such as in endoscopy and catheter applications. The advantages of the present invention are in particular the flexibility to choose arbitrarily positioned interfaces in the sample arm as reference together with the possibility to compensate for dispersion.

3. 发明申请

WO2006100544A1 PHASE SENSITIVE FOURIER DOMAIN OPTICAL COHERENCE TOMOGRAPHY 审中-公开
标题翻译：相敏感FOURIER域光学相干TOMOGRAPHY
公开(公告)号：WO2006100544A1
公开(公告)日：2006-09-28
申请号：PCT/IB2005/050958
申请日：2005-03-21
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) , LEITGEB, Rainer , BACHMANN, Adrian , LASSER, Theo
发明人： LEITGEB, Rainer , BACHMANN, Adrian , LASSER, Theo
IPC分类号： G01B9/02 , A61B5/00
CPC分类号： G01B9/02044 , A61B5/0066 , A61B5/0073 , A61B5/7257 , G01B9/02003 , G01B9/02069 , G01B9/02091 , G01B2290/45 , G01B2290/70
摘要： Optical Coherence Tomography (OCT) is an imaging technique with high axial resolution in the micro-meter-scale range combined with a high sensitivity allowing for example to probe weakly back-scattering structures beneath the surface of biological tissues up to several millimeters. A major improvement of this conventional technique represents Fourier Domain OCT with a further decrease in image acquisition time and additional sensitivity. The apparatus including appropriate signal processing reconstructs the depth profile from the spectrally resolved light signal generated by a broadband source and an interferometric imaging system. By frequency shifting the light fields with frequency shifting means in the reference and sample arm a phase resolved signal at high speed can be registered. Therefore the reference arm does not rely on arm length changes or delays. The beating signal generated in this way shows high phase stability. The phase of this beating signal is not wavelength dependent, as the frequency shift applied is the same for all wavelengths. Moreover this results in an additional suppression of unwanted auto-correlated distortion as well as an extended depth range.
摘要翻译：光学相干断层扫描（OCT）是一种成像技术，在微米尺度范围内具有高轴向分辨率，并具有高灵敏度，例如可以探测几毫米以下的生物组织表面之下的弱背散射结构。这种常规技术的主要改进表现为傅立叶域OCT，图像获取时间和附加灵敏度进一步降低。包括适当信号处理的装置根据由宽带源和干涉成像系统产生的光谱分辨光信号重构深度分布。通过在参考和采样臂中使用频移装置对光场进行频移，可以登记高速的相位解析信号。因此，参考臂不依赖于手臂长度的变化或延迟。以这种方式产生的跳动信号显示出高相位稳定性。这种跳动信号的相位不是波长相关的，因为施加的频移对于所有波长都是相同的。此外，这导致额外的抑制不想要的自相关失真以及扩展的深度范围。

4. 发明申请

WO2011083420A2 DARK FIELD OPTICAL COHERENCE MICROSCOPY 审中-公开
标题翻译：暗场光学相干显微镜
公开(公告)号：WO2011083420A2
公开(公告)日：2011-07-14
申请号：PCT/IB2011/050020
申请日：2011-01-04
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) , VILLIGER, Martin , PACHE, Christophe , LASSER, Theo
发明人： VILLIGER, Martin , PACHE, Christophe , LASSER, Theo
IPC分类号： G02B21/12
CPC分类号： G02B21/125 , G01B9/02002 , G01B9/02057 , G01B9/02091 , G01B2290/50 , G01B2290/70 , G01J3/453
摘要： The invention relates to an optical coherence microscopy system for fast, phase resolved imaging by means of optical coherence microscopy with decoupled illumination and detection apertures, producing a dark-field effect with an enhanced optical contrast. The setup uses a light source with an appropriate temporal coherence, an interferometer and an array detector combined with a spectrometer. The dark-field effect is produced by optical filter means in the illumination and detection paths, positioned in conjugated planes of the sample microscope objective. These optical means comprise for example refractive or diffractive elements, amplitude or phase masks, or programmable spatial light modulators. The object is scanned via a scanning unit allowing a point scan of the object.
摘要翻译：本发明涉及通过具有解耦照明和检测孔径的光学相干显微镜进行快速，相位分辨成像的光学相干显微镜系统，产生具有增强的光学对比度的暗场效应。该设置使用具有适当的时间相干性的光源，干涉仪和与光谱仪结合的阵列检测器。暗场效应由位于样品显微镜物镜的共轭平面中的照明和检测路径中的滤光器装置产生。这些光学装置包括例如折射或衍射元件，幅度或相位掩模或可编程空间光调制器。通过允许对象的点扫描的扫描单元扫描物体。

5. 发明申请

WO2010004365A1 FUNCTIONAL OPTICAL COHERENT IMAGING 审中-公开
标题翻译：功能光学相干成像
公开(公告)号：WO2010004365A1
公开(公告)日：2010-01-14
申请号：PCT/IB2008/052787
申请日：2008-07-10
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) , LASSER, Theo , VAN DE VILLE, Dimitri , MARTIN-WILLIAMS, Erica , LEUTENEGGER, Marcel , MAERKI, Iwan , FRIEDRICH, Michael , VILLIGER, Martin
发明人： LASSER, Theo , VAN DE VILLE, Dimitri , MARTIN-WILLIAMS, Erica , LEUTENEGGER, Marcel , MAERKI, Iwan , FRIEDRICH, Michael , VILLIGER, Martin
IPC分类号： A61B5/00 , A61B5/026 , A61B3/12
CPC分类号： A61B5/0066 , A61B3/102 , A61B3/1233 , A61B5/0048 , A61B5/0059 , A61B5/02028 , A61B5/413 , A61B5/7203 , A61B5/726 , A61B5/7278 , A61B5/742
摘要： The present invention relates to a functional optical coherent imaging (fOCI) platform comprising at least one active camera unit (ACU) comprising a coherent and/or a partially coherent light source, and means for spectral filtering and imaging a selected body area of interest; an image processing unit (IPU) for pre-processing data received from an ACU; at least one stimulation unit (STU) transmitting a stimulation to a subject; at least one body function reference measurement unit (BFMU); a central clock and processing unit (CCU), with interconnections to the ACU, the IPU, the STU, for collecting pre-processed data from the IPU, stimuli from the STU body function reference data from the BFMU in a synchronized manner; a post-processing unit (statistical analysis unit, SAU); and an operator interface (HOI). Further the invention relates to a process for acquiring stimuli activated subject data comprising the steps of aligning a body function unit at a subject and monitoring pre-selected body function; selecting a stimulus or stimuli; imaging a body area of interest; exerting one or a series of stimuli on the subject; imaging the body area of interest synchronous with said stimuli and the preselected body functions; and transferring said synchronized image, stimuli and body function data to a statistical analysis unit (SAU) and performing calculations to generate results pertaining to body functions.
摘要翻译：功能性光学相干成像（fOCI）平台本发明涉及包括至少一个包括相干和/或部分相干光源的有源相机单元（ACU）的功能性光学相干成像（fOCI）平台，以及用于对感兴趣的所选择的身体区域进行频谱滤波和成像的装置; 用于预处理从ACU接收的数据的图像处理单元（IPU）; 向受试者传送刺激的至少一个刺激单元（STU）; 至少一个身体功能参考测量单元（BFMU）; 中央时钟和处理单元（CCU），与ACU，IPU，STU的互连，用于从IPU收集预处理的数据，以同步方式从BFMU的STU主体功能参考数据的刺激; 后处理单位（统计分析单位，SAU）; 和操作界面（HOI）。此外，本发明涉及一种用于获取刺激激活的受试者数据的方法，包括以下步骤：对准受试者的身体功能单元并监测预先选择的身体功能; 选择刺激或刺激; 成像感兴趣的身体区域; 在该主题上施加一个或一系列刺激; 对与所述刺激同步的感兴趣的身体区域和预选的身体功能进行成像; 以及将所述同步图像，刺激和身体功能数据传送到统计分析单元（SAU）并执行计算以产生与身体功能有关的结果。

6. 发明申请

WO2012172440A1 CUMULANT MICROSCOPY 审中-公开
公开(公告)号：WO2012172440A1
公开(公告)日：2012-12-20
申请号：PCT/IB2012/051581
申请日：2012-03-31
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) , GEISSBUEHLER, Stefan , DELLAGIACOMA, Claudio , LEUTENEGGER, Marcel , GEISSBUEHLER, Matthias , LASSER, Theo
发明人： GEISSBUEHLER, Stefan , DELLAGIACOMA, Claudio , GEISSBUEHLER, Matthias , LASSER, Theo
IPC分类号： G02B21/16 , G02B21/36 , G01N21/64 , G02B27/58
CPC分类号： G02B21/365 , G01N21/6408 , G01N21/6458 , G02B21/16 , G02B21/367 , G02B27/58
摘要： The invention describes a method and a microscopy system for imaging and analysing stochastically and independently blinking point-like emitters. A multiple-order cumulants analysis in conjunction with an established blinking model enables the extraction of super-resolved environment-related parameter maps, such as molecular state lifetimes, concentration and brightness distributions of the emitter. In addition, such parameter maps can be used to compensate for the non-linear brightness and blinking response of higher-order cumulant images - used for example in Super-resolution Optical Fluctuation Imaging (SOFI) - to generate a balanced image contrast. Structures that otherwise would be masked by brighter regions in the conventional cumulant image become visible in the balanced cumulant image. The invention furthermore provides a method for the spectral unmixing of multi- colour samples using spectral cross-cumulants.
摘要翻译：本发明描述了用于成像和分析随机和独立地闪烁点状发射体的方法和显微镜系统。结合建立的闪烁模型进行多阶累积分析，可以提取超分辨环境参数图，如分子状态寿命，发射体的浓度和亮度分布。此外，这样的参数图可以用于补偿例如在超分辨率光学波动成像（SOFI）中使用的高阶累积图像的非线性亮度和闪烁响应，以产生平衡的图像对比度。否则将被传统累积图像中较亮区域掩蔽的结构在平衡累积图像中变得可见。本发明还提供了使用光谱交叉累积量的多色样品的光谱解混合的方法。

7. 发明申请

WO2011107916A1 APPARATUS AND METHOD FOR DETECTING AND MEASURING BIOMOLECULAR INTERACTIONS 审中-公开
标题翻译：用于检测和测量生物分子相互作用的装置和方法
公开(公告)号：WO2011107916A1
公开(公告)日：2011-09-09
申请号：PCT/IB2011/050808
申请日：2011-02-25
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) , DURAND, Nicolas , MÄRKI, Iwan , LASSER, Theo
发明人： DURAND, Nicolas , MÄRKI, Iwan , LASSER, Theo
IPC分类号： G01N35/00 , G01N21/64
CPC分类号： G01N21/6452 , G01N21/6428 , G01N2035/00158
摘要： A method and system for the rapid detection of biomolecular interactions, the system comprising a sensing platform which comprises a primary support structure including recesses designed to be located in front of a detection unit, said recesses containing one or several arrays of biosensors, said system furthermore comprising a reader unit for optical excitation and detection.
摘要翻译：一种用于快速检测生物分子相互作用的方法和系统，该系统包括感测平台，该感测平台包括主要支撑结构，其包括设计成位于检测单元前面的凹槽，所述凹部包含一个或多个生物传感器阵列，所述系统进一步包括用于光学激发和检测的读取器单元。

8. 发明申请

WO2011064701A1 NANOFLUIDIC BIOSENSOR AND ITS USE FOR RAPID MEASUREMENT OF BIOMOLECULAR INTERACTIONS IN SOLUTION AND METHODS 审中-公开
标题翻译：南非生物传感器及其在解决方案和方法中快速测量生物分子相互作用的用途
公开(公告)号：WO2011064701A1
公开(公告)日：2011-06-03
申请号：PCT/IB2010/055305
申请日：2010-11-19
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) , DURAND, Nicolas , FOURNIER, Yannick , LASSER, Theo , MÄRKI, Iwan
发明人： DURAND, Nicolas , FOURNIER, Yannick , LASSER, Theo , MÄRKI, Iwan
IPC分类号： G01N21/05 , G01N21/64
CPC分类号： B82Y15/00 , B01L3/5027 , B82Y35/00 , G01N21/6452
摘要： A method and device for the rapid detection of biomolecules (320) diffusing in a nanometer-confined slit (204) is claimed. In particular, the present invention relates to a novel concept of fluidic side apertures (205) that facilitates the filling of the device, the surface coating with biomolecules and that measures the affinity between fluorescently labeled biomolecules in aqueous solution with other biomolecules immobilized on surfaces.
摘要翻译：要求保护用于在纳米限制狭缝（204）中扩散的生物分子（320）的快速检测的方法和装置。特别地，本发明涉及流体侧孔（205）的新颖概念，其有利于装置的填充，用生物分子进行表面涂层，并且测量水溶液中荧光标记的生物分子与固定在表面上的其它生物分子之间的亲和力。

9. 发明申请

WO2015044819A1 OPTICAL PRISM FOR CREATING MULTIPLE VIEWS OF AN IMAGE 审中-公开
标题翻译：用于创建图像的多个视图的光学原理
公开(公告)号：WO2015044819A1
公开(公告)日：2015-04-02
申请号：PCT/IB2014/064429
申请日：2014-09-11
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
发明人： LEUTENEGGER, Marcel , GEISSBUEHLER, Stefan , LASSER, Theo
IPC分类号： G02B27/10 , G02B27/14 , G02B21/00 , G02B21/36 , G02B21/16 , G02B27/40
CPC分类号： G02B27/148 , G02B21/006 , G02B21/16 , G02B21/367 , G02B27/1013 , G02B27/106 , G02B27/1066 , G02B27/141 , G02B27/143 , G02B27/144
摘要： Optical prism comprising two external parallel and reflecting surfaces, one internal interface, parallel to said surfaces and acting as light splitter; said prism furthermore comprising an entrance side forming an angle β with respect to said interface and at least two exit sides forming an angle γ with respect to said interface, said external surfaces being located at different distances from said interface, the lengths and the thicknesses of the prism are chosen such that at least one beam entering through said entrance side may cross said interface at least twice and exits through said exit sides.
摘要翻译：光学棱镜包括两个外部平行和反射表面，一个内部接口，平行于所述表面并用作光分离器; 所述棱镜还包括形成角度的入口侧; 相对于所述界面和至少两个出射侧相对于所述界面形成角度γ，所述外表面位于与所述界面不同的距离处，棱镜的长度和厚度被选择为使得至少一个光束进入通过所述入口侧可以穿过所述界面至少两次并且通过所述出口侧离开。

10. 发明申请

WO2016110768A1 GASTRO-INTESTINAL BIOMARKERS FOR DIAGNOSIS AND THERAPIES OF PROTEINOPATHIES 审中-公开
标题翻译：胃肠道生物标志物诊断和治疗病史
公开(公告)号：WO2016110768A1
公开(公告)日：2016-07-14
申请号：PCT/IB2015/059945
申请日：2015-12-23
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
发明人： LASSER, Theo , BOLMONT, Tristan , HARACH, Taoufiq , HANNA, Walid , FAK, Frida , MARUNGRUANG, Nittaya
IPC分类号： A61K35/74 , A61P25/28
CPC分类号： A61K35/747 , A61K35/74 , G01N33/5008 , G01N33/53 , G01N2333/90 , G01N2500/10
摘要： Pharmaceutical composition for the treatment of proteinopathies comprising products which are able to stimulate growth or inhibition of at least one of Odoribacter, Oscillospira, Dehalobacterium, Alistipes, Parabacteroides, Lactobacillus and Sutterella, Firmicutes, Bacteroidetes, Allobaculum and Akkermansia bacteria population in the gut of individuals.
摘要翻译：用于治疗蛋白质病症的药物组合物，其包含能够刺激个体肠道中的肠杆菌，Oscillospira，Dehalobacterium，Alistipes，Parabacteroides，Lactobacillus和Sutterella，Firmicutes，Bacteroidetes，Allobaculum和Akkermansia细菌群体中的至少一种的生长或抑制的产物。

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