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1. 发明申请

WO1996023010A2 'alpha'-OLEFINS AND OLEFIN POLYMERS AND PROCESSES THEREFOR 审中-公开
标题翻译： α-烯烃和烯烃聚合物及其制备方法
公开(公告)号：WO1996023010A2
公开(公告)日：1996-08-01
申请号：PCT/US1996001282
申请日：1996-01-24
申请人： E.I. DU PONT DE NEMOURS AND COMPANY , UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
发明人： E.I. DU PONT DE NEMOURS AND COMPANY , UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , JOHNSON, Lynda, Kaye , KILLIAN, Christopher, Moore , ARTHUR, Samuel, David , FELDMAN, Jerald , McCORD, Elizabeth, Forrester , McLAIN, Stephan, James , KREUTZER, Kristina, Ann , BENNETT, Margaret, Anne , COUGHLIN, Edward, Bryan , ITTEL, Steven, Dale , PARTHASARATHY, Anju , TEMPEL, Daniel, Joseph , BROOKHART, Maurice, S.
IPC分类号： C08F210/16
CPC分类号： C09J123/06 , C08F10/00 , C08F10/02 , C08F10/06 , C08F110/02 , C08F110/06 , C08F110/14 , C08F210/02 , C08F210/14 , C08F210/16 , C08F232/00 , C08L23/02 , C09J123/20 , C08F4/7006 , C08F4/64013 , C08F4/80 , C08F4/76 , C08F4/68034 , C08F4/69034
摘要： Disclosed herein are processes for polymerizing ethylene, acyclic olefins, and/or selected cyclic olefins, and optionally selected olefinic esters or carboxylic acids, and other monomers. The polymerizations are catalysed by selected transition metal compounds, and sometimes other co-catalysts. Since some of the polymerizations exhibit some characteristics of living polymerizations, block copolymers can be readily made. Many of the polymers produced are often novel, particularly in regard to their microstructure, which gives some of them unusual properties. Numerous novel catalysts are disclosed, as well as some novel processes for making them. The polymers made are useful as elastomers, molding resins, in adhesives, etc. Also described herein is the synthesis of linear alpha -olefins by the oligomerization of ethylene using as a catalyst system a combination of a nickel compound having a selected alpha -diimine ligand and a selected Lewis or Bronsted acid, or by contacting selected DOLLAR (a)-diimine nickel complexes with ethylene.
摘要翻译：本文公开了聚合乙烯，无环烯烃和/或选择的环状烯烃以及任选选择的烯属酯或羧酸和其它单体的方法。聚合反应由选择的过渡金属化合物，有时是其他助催化剂催化。由于一些聚合表现出活性聚合的一些特征，因此可以容易地制备嵌段共聚物。所生产的许多聚合物通常是新颖的，特别是关于它们的微结构，这给出了其中一些不寻常的性质。公开了许多新颖的催化剂，以及一些制备它们的新方法。制备的聚合物可用作弹性体，模塑树脂，粘合剂等。本文还描述了通过使用作为催化剂体系的乙烯低聚来合成线性α-烯烃，该组合具有选择的α-二亚胺配体或选择的Lewis或布朗斯台德酸，或通过使选择的DOLLAR（a） - 二亚镍络合物与乙烯接触。

2. 发明申请

WO1996040272A1 AAV TRANSDUCTION OF MYOBLASTS 审中-公开
标题翻译： AAV转录子
公开(公告)号：WO1996040272A1
公开(公告)日：1996-12-19
申请号：PCT/US1996009879
申请日：1996-06-05
申请人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
发明人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , XIAO, Xiao , SAMULSKI, Richard, J.
IPC分类号： A61K48/00
CPC分类号： C12N15/86 , A61K48/00 , C12N2750/14143
摘要： A method of expressing a gene product in the muscle tissue of an animal, which comprises administering a recombinant AAV vector to the muscle tissue of the animal, wherein the vector comprises a non-AAV gene of interest ligated into an AAV vector genome.
摘要翻译：一种在动物的肌肉组织中表达基因产物的方法，其包括向所述动物的肌肉组织施用重组AAV载体，其中所述载体包含连接到AAV载体基因组中的目的非AAV基因。

3. 发明申请

WO1996031625A1 POLYPEPTIDES HAVING A FUNCTIONAL DOMAIN OF INTEREST AND METHODS OF IDENTIFYING AND USING SAME 审中-公开
标题翻译：具有功能性功能域的多肽及其鉴别和使用方法
公开(公告)号：WO1996031625A1
公开(公告)日：1996-10-10
申请号：PCT/US1996004454
申请日：1996-04-04
申请人： CYTOGEN CORPORATION , UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
发明人： CYTOGEN CORPORATION , UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , SPARKS, Andrew, B. , HOFFMAN, Noah , KAY, Brian, K. , FOWLKES, Dana, M. , MCCONNELL, Stephen, J.
IPC分类号： C12Q01/68
CPC分类号： C40B30/04 , A61K38/00 , C12N15/1037 , C40B40/02 , G01N33/6842 , G01N33/6845 , G01N2500/02 , G01N2500/04
摘要： Novel polypeptides having functional domains of interest are described, along with DNA sequences that encode the same. A method of identifying these polypeptides by means of a sequence-independent (that is, independent of the primary sequence of the polypeptide sought), recognition unit-based functional screen is also disclosed. Various applications of the method and of the polypeptides identified are described, including their use in assay kits for drug discovery, modification, and refinement.
摘要翻译：描述了具有目标功能结构域的新型多肽，以及编码该功能结构域的DNA序列。还公开了通过独立于序列（即，独立于所寻求的多肽的一级序列）鉴定这些多肽的方法，基于识别单元的功能屏幕也被公开。描述了鉴定的方法和多肽的各种应用，包括它们在用于药物发现，修饰和细化的测定试剂盒中的用途。

4. 发明申请

WO1995031995A1 MIMETICS OF SENESCENT CELL DERIVED INHIBITORS OF DNA SYNTHESIS 审中-公开
标题翻译： DNA合成的敏感细胞衍生抑制剂的模拟
公开(公告)号：WO1995031995A1
公开(公告)日：1995-11-30
申请号：PCT/US1995006451
申请日：1995-05-23
申请人： BAYLOR COLLEGE OF MEDICINE , UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
发明人： BAYLOR COLLEGE OF MEDICINE , UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , SMITH, James, R. , KAY, Brian, K.
IPC分类号： A61K38/04
CPC分类号： A61K31/70 , A61K9/1272 , A61K38/00 , C07H21/00 , C07K14/4703 , C07K16/18 , C07K2319/00 , C12N15/113 , C12N2310/111 , C12N2310/322
摘要： Phage display methods were used to identify mimetics of SDI-1. Such mimetics are small peptides that are capable of binding to cyclin molecules, especially CDK2. The invention is directed to the mimetics and to methods for producing them.
摘要翻译：使用噬菌体展示方法鉴定SDI-1的模拟物。这种模拟物是能够结合细胞周期蛋白分子，特别是CDK2的小肽。本发明涉及模拟物及其制备方法。

5. 发明申请

WO1993022319A1 4-BETA-AMINO PODOPHYLLOTOXIN DERIVATIVES ANTITUMOR AGENTS 审中-公开
标题翻译： 4-BETA-AMINO PODOPHYLLOTOXIN DERIVATIVES抗菌剂
公开(公告)号：WO1993022319A1
公开(公告)日：1993-11-11
申请号：PCT/US1993003830
申请日：1993-04-23
申请人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , LEE, Kuo-Hsiung , CHENG, Yung-Chi
发明人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
IPC分类号： C07D493/04
CPC分类号： C07D493/04
摘要： Novel podophyllotoxin compounds and their use in treating tumors are disclosed. In one embodiment, the compounds have general formula (I), wherein NHR is selected from the group consisting of: (a) NH-(CH2)n-NR1R2, where n=2-4, and where (1) R1 and R2 are the same or different and are H or lower alkyl groups, or (2) NR1R2 is (a1), (a2), (a3), or (a4); (b) where R3 is CH2Ph or CO2Et; and (c) including physiologically acceptable ammonium salts of (a), (b) and (c).
摘要翻译：公开了新型鬼臼毒素化合物及其在治疗肿瘤中的用途。在一个实施方案中，化合物具有通式（I），其中NHR选自：（a）NH-（CH 2）n -NR 11 R 2，其中n = 2-4，并且其中（1）R 1和R 2 相同或不同，为H或低级烷基，或（2）NR1R2为（a1），（a2），（a3）或（a4）; （b）其中R3是CH2Ph或CO2Et; 和（c）包括（a），（b）和（c）的生理上可接受的铵盐。

6. 发明申请

WO1989009791A1 DNA ENCODING ANDROGEN RECEPTOR PROTEIN 审中-公开
标题翻译： DNA编码雄激素受体蛋白
公开(公告)号：WO1989009791A1
公开(公告)日：1989-10-19
申请号：PCT/US1989001548
申请日：1989-04-13
申请人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
发明人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , FRENCH, Frank, S. , WILSON, Elisabeth, M. , JOSEPH, David, R. , LUBAHN, Dennis, B.
IPC分类号： C07K15/00
CPC分类号： C07K16/2869 , A61K38/00 , C07K14/721
摘要： DNA sequences encoding human androgen receptor protein and polypeptides and proteins having substantially the same biological activity as human androgen receptor protein and the amino acid sequences of human androgen receptor protein and polypeptides and proteins having substantially the same biological activity as human androgen receptor protein are disclosed. Methods for the production and use of such compositions are also disclosed.
摘要翻译：公开了编码人雄激素受体蛋白质的DNA序列以及与人雄激素受体蛋白基本相同的生物学活性的多肽和蛋白质以及人雄激素受体蛋白质的氨基酸序列以及与人类雄激素受体蛋白具有基本相同的生物学活性的多肽和蛋白质。还公开了生产和使用这些组合物的方法。

7. 发明申请

WO1997037223A1 IDENTIFICATION AND ISOLATION OF NOVEL POLYPEPTIDES HAVING WW DOMAINS AND METHODS OF USING SAME 审中-公开
标题翻译：具有WW域的新型多肽的鉴定和分离及其使用方法
公开(公告)号：WO1997037223A1
公开(公告)日：1997-10-09
申请号：PCT/US1997005547
申请日：1997-04-03
申请人： CYTOGEN CORPORATION , UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
发明人： CYTOGEN CORPORATION , UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , PIROZZI, Gregorio , KAY, Brian, K. , FOWLKES, Dana, M.
IPC分类号： G01N33/567
CPC分类号： C12N9/93 , C07K2319/00 , G01N33/68 , Y10S435/81 , Y10S435/975
摘要： Novel polypeptides having WW domains of interest are described, along with DNA sequences that encode the same. A method of identifying these polypeptides by means of a sequence-independent (that is, independent of the primary sequence of the polypeptide sought), recognition unit-based functional screen is also disclosed. Various applications of the method and of the polypeptides identified are described, including their use in assay kits for drug discovery, modification, and refinement.
摘要翻译：描述了具有WW感兴趣的WW结构域的新型多肽以及编码它们的DNA序列。还公开了通过独立于序列（即，独立于所寻求的多肽的一级序列）鉴定这些多肽的方法，基于识别单元的功能筛选。描述了鉴定的方法和多肽的各种应用，包括它们在用于药物发现，修饰和细化的测定试剂盒中的用途。

8. 发明申请

WO1997032020A3 SHC PROTEINS 审中-公开
公开(公告)号：WO1997032020A3
公开(公告)日：1997-09-04
申请号：PCT/US1997002997
申请日：1997-02-28
申请人： MOUNT SINAI HOSPITAL CORPORATION , UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , DER, Channing , O'Bryan, John , PAWSON, Anthony , SAXTON, Tracy
发明人： MOUNT SINAI HOSPITAL CORPORATION , UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
IPC分类号： C12N15/12

9. 发明申请

WO1996002560A1 OLIGONUCLEOSIDE COMPOUNDS AND METHODS FOR INHIBITING TUMOR GROWTH, INVASION AND METASTASIS 审中-公开
标题翻译：寡核苷酸化合物和抑制肿瘤生长，入侵和分化的方法
公开(公告)号：WO1996002560A1
公开(公告)日：1996-02-01
申请号：PCT/US1995009040
申请日：1995-07-18
申请人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , CANCE, William, G. , LIU, Edison, T. , OWENS, Lewis, V.
发明人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
IPC分类号： C07H21/04
CPC分类号： C12N15/1137 , A61K38/00 , C12N9/1205 , C12N2310/315
摘要： Oligonucleoside compounds useful in inhibiting expression of focal adhesion kinase protein in animals, and related methods and formulations for reducing cancer cell growth, invasion and metastasis. The compounds are selected to be complementary to a target region of a focal adhesion kinase nucleic acid sequence, preferably human FAK mRNA.
摘要翻译：用于抑制动物中粘着斑激酶蛋白表达的寡核苷酸化合物，以及用于减少癌细胞生长，侵袭和转移的相关方法和制剂。选择这些化合物与粘着斑激酶核酸序列的靶区域互补，优选人FAK mRNA。

10. 发明申请

WO1990000897A1 METHOD FOR THE CONTROL OF HYPERLIPIDEMIA 审中-公开
标题翻译：控制高脂血症的方法
公开(公告)号：WO1990000897A1
公开(公告)日：1990-02-08
申请号：PCT/US1989003246
申请日：1989-07-27
申请人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , NORTH CAROLINA CENTRAL UNIVERSITY
发明人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , NORTH CAROLINA CENTRAL UNIVERSITY , IZYDORE, Robert, A. , HALL, Iris, H.
IPC分类号： A61K31/53
CPC分类号： A61K31/53 , A61K31/41
摘要： The invention provides pharmaceutical compositions comprising hypolipidemically active derivatives of 1,2,4-triazolidine-3,5-diones, 1,3,5-triazabicyclo[3.1.0]hexane-2,4-diones, and 1,3,5-triazine-2,4(1H,3H)-diones in a pharmaceutically acceptable carrier for treating hyperlipidemia in mammals, particularly humans. The present invention is also directed to a method of controlling hyperlipidemia in mammals which comprises administering to a mammal an amount effective to control hyperlipidemia of a compound having hypolipidemic activity and structural formula (I), wherein R is hydrogen, a C1 to C18 alkyl or substituted alkyl, a C2 to C18 alkenyl or substituted alkenyl, a C2 to C18 alkynyl or substituted alkynyl, a C4 to C10 cycloalkyl or substituted cycloalkyl, a C4 to C10 cycloalkenyl or substituted cycloalkenyl, phenyl, a substituted phenyl, cyano, phenalkyl, -CO-R or -Y-CO-R ; R is (a), (b), (c), R and R can be the same or different and are each the same as R ; R , R and R can be the same or different and are each hydrogen, a C1 to C18 alkyl or substituted alkyl, a C2 to C18 alkenyl or substituted alkenyl, a C1 to C18 alkynyl or substituted alkynyl, a C4 to C10 cycloalkyl or substituted cycloalkyl, a C4 to C10 cycloalkenyl or substituted cycloalkenyl, phenyl or substituted phenyl, phenalkyl, -CO-R , or -Y-CO-R , with the proviso that R5 and R together cannot be so bulky as to cause the compound to decompose; R is hydrogen, a C1 to C5 alkyl, a C4 to C10 cycloalkyl, -CO-R , or -Y-CO-R ; R is hydrogen, a C1 to C5 alkyl or substituted alkyl, a C2 to C5 alkenyl or substituted alkenyl, a C2 to C5 alkynyl or substituted alkynyl, phenyl or substituted phenyl, phenoxy or substituted phenoxy, a C1 to C5 alkoxy or substituted alkoxy, a C4 to C10 cycloalkyl or substituted cycloalkyl, a C4 to C10 cycloalkenyl or substituted cycloalkenyl, -NHC6C5, -NR R wherein R and R can be the same or different and are each hydrogen, a C1 to C5 alkyl or substituted alkyl, phenyl or substituted phenyl; Y is a C1 to C10 alkylene or substituted alkylene; R is -CO, -COH, -CS, -CSH, or a C1 to C4 alkylene group; and the pharmaceutically acceptable salts, and mixtures thereof.
摘要翻译：本发明提供药物组合物，其包含1,2,4-三唑烷-3,5-二酮，1,3,5-三氮杂双环[3.1.0]己烷-2,4-二酮的降血脂活性衍生物和1,3,5 - 三嗪-2,4（1H，3H） - 二酮在用于治疗哺乳动物，特别是人类的高脂血症的药学上可接受的载体中。本发明还涉及一种控制哺乳动物高脂血症的方法，其包括向哺乳动物施用有效控制具有降血脂活性的化合物的高脂血症的量和结构式（I），其中R 1是氢，C1至 C18烷基或取代的烷基，C2至C18烯基或取代的烯基，C2至C18炔基或取代的炔基，C4至C10环烷基或取代的环烷基，C4至C10环烯基或取代的环烯基，苯基，取代的苯基，氰基，苯基烷基，-CO-R 9或-Y-CO-R 9; R 2是（a），（b），（c），R 3和R 4可以相同或不同，并且各自与R 1相同; R 5，R 6和R 7可以相同或不同，各自为氢，C1至C18烷基或取代的烷基，C2至C18烯基或取代的烯基，C1至C18炔基或取代的炔基，C4至C10环烷基或取代的环烷基，C4至C10环烯基或取代的环烯基，苯基或取代的苯基，苯基烷基，-CO-R9或-Y-CO-R9，条件是 R 5和R 6一起不能如此庞大，导致化合物分解; R 8是氢，C 1至C 5烷基，C 4至C 10环烷基，-CO-R 9或-Y-CO-R 9; R 9是氢，C 1至C 5烷基或取代的烷基，C 2至C 5烯基或取代的烯基，C 2至C 5炔基或取代的炔基，苯基或取代的苯基，苯氧基或取代的苯氧基，C 1至C 5的烷氧基或取代的烷氧基，C 4至C 10环烷基或取代的环烷基，C 4至C 10环烯基或取代的环烯基，-NHC 6 C 5，-NR 10 R 11其中R 10和R 11可以相同或不同，各自为氢，C1至C5烷基或取代的烷基，苯基或取代的苯基; Y是C1至C10亚烷基或取代的亚烷基; R 12是-CO，-COH，-CS，-CSH或C1〜C4亚烷基; 及其药学上可接受的盐及其混合物。

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