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1. 发明申请

WO2020148318A1 CRYOGENIC APPLICATOR 审中-公开
公开(公告)号：WO2020148318A1
公开(公告)日：2020-07-23
申请号：PCT/EP2020/050881
申请日：2020-01-15
申请人： DUTCH RENEWABLE ENERGY B.V.
发明人： KLEVER, Diede Hendrik Paul , PELLIKAAN, Hubert Clemens
IPC分类号： A61B18/00 , A61B18/02 , A61B90/00 , A61F7/00
摘要： An applicator for applying cryogenic fluid to a treatment area is described, the applicator comprising:a reservoir (12) configured to contain a cryogenic fluid comprising a gas phase (G) and a liquid phase (L). A nozzle (20) extends from a proximal end arranged in fluid communication with the reservoir (12) to an open distal end (21) for application of fluid to a treatment area. An actuatable valve is provided to selectively allow a flow of cryogenic fluid from the reservoir (12) through the distal end of the nozzle (20). A spacer (14) extends distally beyond the distal end (21) of the nozzle (20), the spacer (14) comprising a skin contacting surface (14a) at its distal end. A porous material (16) is provided between the distal end (21) of the nozzle (20), at least between the open end of the nozzle and the skin contacting surface of the spacer.

2. 发明申请

WO2016010428A1 NEBULIZER AND SPACER FOR THE TOPICAL APPLICATION OF A LIQUID AND/OR SOLID TO A SURFACE 审中-公开
标题翻译：液体和/或固体表面局部应用的基质和间隔物
公开(公告)号：WO2016010428A1
公开(公告)日：2016-01-21
申请号：PCT/NL2015/050517
申请日：2015-07-15
申请人： DUTCH RENEWABLE ENERGY B.V.
发明人： KLEVER, Diede Hendrik Paul , PELLIKAAN, Hubert Clemens , VISSER, Rolf Lourens
IPC分类号： B05B7/04 , B65D83/30
CPC分类号： A61M11/02 , A61M35/00 , B05B1/1663 , B05B1/169 , B05B1/28 , B05B7/0416 , B05B7/0483 , B05B7/2432 , B65D83/306 , B65D83/36 , B65D83/44 , B65D83/48 , B65D83/565 , B65D83/7532
摘要： The present invention relates to a nebulizer, such as a spray can, for the topical application of a liquid and/or solid to a surface. The nebulizer is characterized by a valve comprising a mixing chamber designed for forming a colloidal mixture comprising a dispersed phase consisting of a liquid and/or a solid substance and a continuous phase consisting of a propellant gas before delivering the colloidal mixture to the nozzle. The invention also relates to a method for the topical cooling of the skin of a person or animal. In addition, the invention relates to various other uses of the device.
摘要翻译：本发明涉及用于将液体和/或固体局部施用于表面的雾化器，例如喷雾罐。雾化器的特征在于包括设计用于形成胶体混合物的混合室，所述胶体混合物包含由液体和/或固体物质组成的分散相和在将胶态混合物输送到喷嘴之前由推进剂气体组成的连续相。本发明还涉及用于局部冷却人或动物皮肤的方法。此外，本发明涉及该装置的各种其他用途。

3. 发明申请

WO2021177815A1 DISPENSING SYSTEM 审中-公开
公开(公告)号：WO2021177815A1
公开(公告)日：2021-09-10
申请号：PCT/NL2021/050135
申请日：2021-03-01
申请人： DUTCH RENEWABLE ENERGY B.V.
发明人： PELLIKAAN, Hubert Clemens , KLEVER, Diede Hendrik Paul
IPC分类号： B65D83/36
摘要： The present invention relates to a dispensing system for spraying a liquid/gas mixture, the system comprising a dispenser and a holder in which the dispenser is held, the dispenser comprising a container that is adapted for holding therein a liquid phase and a gas phase that is at a pressure of 2 bar or greater and is in direct contact with the liquid phase. The dispensing system may be used in a first orientation and a second orientation, wherein the ratio of liquid to gas in the sprayed mixture is different depending on the orientation of the system during spraying.

4. 发明申请

WO2019016105A1 DISPENSING SYSTEM FOR USE IN CRYOGENIC SKIN TREATMENT 审中-公开
公开(公告)号：WO2019016105A1
公开(公告)日：2019-01-24
申请号：PCT/EP2018/069167
申请日：2018-07-13
申请人： DUTCH RENEWABLE ENERGY B.V.
发明人： KLEVER, Diede Hendrik Paul , PELLIKAAN, Hubert Clemens
IPC分类号： A61M11/02 , B05B1/16 , A61B18/02
摘要： The invention relates to a dispensing system for use in cryogenic skin treatment that is capable of targeted delivery of a cryogen at a high rate, thereby achieving rapid freezing of targeted skin tissue. The dispensing system of the present invention uses a cryogen that contains dimethyl ether and is designed to deliver the cryogen in an accurate and very effective manner.

5. 发明申请

WO2018158234A1 INTRANASAL ADMINISTRATION OF PHYSIOLOGICALLY ACTIVE SUBSTANCES 审中-公开
公开(公告)号：WO2018158234A1
公开(公告)日：2018-09-07
申请号：PCT/EP2018/054777
申请日：2018-02-27
申请人： DUTCH RENEWABLE ENERGY B.V.
发明人： PELLIKAAN, Hubert Clemens , VISSER, Rolf Lourens
IPC分类号： A61K9/00 , A61K9/08 , A61K47/22 , A61K31/714 , A61K31/4415 , A61K38/18
摘要： The present invention relates to a method for administering water soluble physiologically active substances, said method comprising intranasally administering to a subject an aqueous composition comprising 0.001-25 wt.% of one or more fully dissolved physiologically active substances, the physiologically active substances having a water solubility in demineralized water of at least 15 mg/mL at 20°C of, 0.01-10 wt.% nicotinamide, and at least 60 wt.% water. The invention also relates to a kit comprising said composition and to the use of nicotinamide as an enhancer of intranasal absorption of a physiologically active substance from an aqueous solution, wherein the aqueous solution further comprises 0.01-10 wt.% nicotinamide.

6. 发明申请

WO2014062059A1 ENHANCED NAIL PENETRATING COMPOSITION 审中-公开
标题翻译：增强指甲组合物
公开(公告)号：WO2014062059A1
公开(公告)日：2014-04-24
申请号：PCT/NL2013/050735
申请日：2013-10-18
申请人： DUTCH RENEWABLE ENERGY B.V.
发明人： PELLIKAAN, Hubert Clemens
IPC分类号： A61K47/10 , A61K47/44 , A61P17/04 , A61K9/00
CPC分类号： A61K9/0014 , A61K47/08 , A61K47/10 , A61K47/44 , A61K47/46
摘要： The present invention relates to a composition for delivering components topically to mammal nails having enhanced nail penetration properties comprising: a water-miscible organic solvent present in an amount of more than 50% by weight of the total weight of the composition, a hydrophilic solvent present in an amount of less than 30% by weight of the total weight of the composition and a terpene and/or aetheric oil, wherein the total amount of terpene and aetheric oil is less than 20% by weight of the total weight of the composition. The present invention further relates to the use of the composition for the treatment of a nail disease, including nail infections preferably onychomycosis and a device comprising the composition for the application of the composition to a to be treated area.
摘要翻译：本发明涉及用于将组分局部递送至具有增强的指甲渗透性能的哺乳动物指甲的组合物，其包含：以组合物总重量的50重量％以上的量存在的水混溶性有机溶剂，存在的亲水溶剂其量小于组合物总重量的30重量％，萜烯和/或醚油的萜烯和醚油的总量小于组合物总重量的20重量％。本发明还涉及组合物用于治疗指甲疾病（包括指甲感染，优选甲真菌病）的用途，以及包含该组合物用于待治疗区域的组合物的装置的用途。

7. 发明申请

WO2014035246A1 ANTIMICROBIAL COMPOSITION 审中-公开
标题翻译：抗微生物组合物
公开(公告)号：WO2014035246A1
公开(公告)日：2014-03-06
申请号：PCT/NL2013/050628
申请日：2013-08-30
申请人： DUTCH RENEWABLE ENERGY B.V.
发明人： PELLIKAAN, Hubert Clemens
IPC分类号： A61K31/047 , A61K31/20 , A61K31/352 , A61K31/723 , A61P31/02 , A61K31/19 , A61K31/194
CPC分类号： A61K31/20 , A61K31/047 , A61K31/19 , A61K31/194 , A61K31/352 , A61K31/723 , Y02A50/473 , A61K2300/00
摘要： The present invention relates to an antimicrobial composition comprising at least one free fatty acid or a derivative and/or a pharmaceutically acceptable salt thereof, wherein the free fatty acid is selected from a free fatty acid having from 6 to 16 carbon atoms, at least one carboxylic acid or a pharmaceutically acceptable salt thereof and/or at least one carbohydrate or a pharmaceutically acceptable salt thereof, wherein the carbohydrate is selected from a hydrogenated carbohydrate, a monosaccharide, a disaccharide, a polysaccharide and combinations thereof. The antimicrobial composition of the present inventions provides enhanced anti-adhesion and /or disinfecting properties. The composition of the present invention can be formulated into a drink, gel or spray suitable for treating or preventing the first stage in pathogenesis.
摘要翻译：本发明涉及包含至少一种游离脂肪酸或其衍生物和/或其药学上可接受的盐的抗微生物组合物，其中游离脂肪酸选自具有6至16个碳原子的游离脂肪酸，至少一种羧酸或其药学上可接受的盐和/或至少一种碳水化合物或其药学上可接受的盐，其中所述碳水化合物选自氢化碳水化合物，单糖，二糖，多糖及其组合。本发明的抗微生物组合物提供增强的抗粘连和/或消毒性能。本发明的组合物可以配制成适合于治疗或预防发病机理中的第一阶段的饮料，凝胶或喷雾剂。

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