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1. 发明申请

WO2009088414A3 ORAL PHARMACEUTICAL DOSAGE FORMS 审中-公开
公开(公告)号：WO2009088414A3
公开(公告)日：2009-07-16
申请号：PCT/US2008/013381
申请日：2008-12-05
申请人： DURECT CORPORATION , YUM, Su II
发明人： YUM, Su II , CHAO, Wendy , SU, Huey-Ching , FU, Roger , ZAMLOOT, Michael
IPC分类号： A01N43/42 , A61K9/64 , A61K31/44
摘要： Abuse-resistant oral dosage forms suitable for administration of pharmacologically active agents are provided.

2. 发明申请

WO2008066642A3 TRANSDERMAL DELIVERY SYSTEMS COMPRISING BUPIVACAINE 审中-公开
公开(公告)号：WO2008066642A3
公开(公告)日：2008-06-05
申请号：PCT/US2007/022927
申请日：2007-10-29
申请人： DURECT CORPORATION , YUM, Su II , KWON, Sung, Yun , SONG, Xiao, Ping , BROWN, James, E.
发明人： YUM, Su II , KWON, Sung, Yun , SONG, Xiao, Ping , BROWN, James, E.
IPC分类号： A61K9/70
摘要： Disclosed are bupivacaine transdermal delivery systems, and related methods.

3. 发明申请

WO2009075782A1 METHODS USEFUL FOR THE TREATMENT OF PAIN, ARTHRITIC CONDITIONS, OR INFLAMMATION ASSOCIATED WITH A CHRONIC CONDITION 审中-公开
标题翻译：用于治疗与慢性病相关的疼痛，疼痛症状或炎症的方法
公开(公告)号：WO2009075782A1
公开(公告)日：2009-06-18
申请号：PCT/US2008/013404
申请日：2008-12-05
申请人： DURECT CORPORATION , YUM, Su II
发明人： YUM, Su II , CHAO, Wendy , FU, Roger , ZAMLOOT, Michael
IPC分类号： A61K9/48 , A61K31/137 , A61K31/4402 , A61K31/485 , A61P19/00 , A61P19/02 , A61P43/00
CPC分类号： A61K9/4866 , A61K9/48 , A61K9/4858 , A61K31/137 , A61K31/4402 , A61K31/4458 , A61K31/485
摘要： Methods, including those for administering novel pharmaceutical compositions, dosage forms containing an opioid active pharmaceutical ingredient, are useful for treating pain, arthritic conditions and/or inflammation associated with a chronic condition, including pain from arthritis and inflammation.
摘要翻译：包括用于施用新药物组合物的方法，含有阿片样物质活性药物成分的剂型可用于治疗与慢性疾病相关的疼痛，关节炎病症和/或炎症，包括由关节炎和炎症引起的疼痛。

4. 发明申请

WO2008100434A1 TRANSORAL DOSAGE FORMS COMPRISING SUFENTANIL AND NALOXONE 审中-公开
标题翻译：包含SUFENTANIL和NALOXONE的转运剂型
公开(公告)号：WO2008100434A1
公开(公告)日：2008-08-21
申请号：PCT/US2008/001711
申请日：2008-02-08
申请人： DURECT CORPORATION , YUM, Su II , SHAH, Jaymin , KWON, Sung Yun , SONG, Xiaoping
发明人： YUM, Su II , SHAH, Jaymin , KWON, Sung Yun , SONG, Xiaoping
IPC分类号： A61K31/4535 , A61K9/00
CPC分类号： A61K31/4535 , A61K9/0056 , A61K9/006 , A61K9/06 , A61K9/2009 , A61K9/2063 , A61K9/7007 , A61K31/485 , A61K2300/00
摘要： The invention pertains to methods that include administering to a subject a transoral dosage form comprising a pharmaceutical carrier and sufentanil, and maintaining a mean pH ranging from about 3.5 to about 5.5 during a dosing period after administration of the transoral dosage form as determined using an in vitro donor media test. Related dosage forms are also disclosed. Also disclosed are transoral dosage forms and related methods, wherein a transoral dosage form may comprise: (1) about 5 to about 1000 micrograms of sufentanil; (2) about 50 micrograms to about 100 milligrams of naloxone; and (3) acidifying material in an amount sufficient to provide a mean pH ranging from about 3.5 to about 5.5 during a dosing period after administration of the transoral dosage form as determined using an in vitro donor media test; wherein the dosing period begins no earlier than about 1 minute after administration of the transoral dosage form, and ends no later than about 120 minutes after administration of the transoral dosage form.
摘要翻译：本发明涉及包括向受试者施用包含药物载体和舒芬太尼的经口给药形式的方法，并且在给予经口给药后的给药期间保持约3.5至约5.5的平均pH，所述给药期间使用体外供体介质试验。还公开了相关的剂型。还公开了经口给药剂型和相关方法，其中经口剂型可包含：（1）约5至约1000微克的舒芬太尼; （2）约50微克至约100毫克的纳洛酮; 和（3）足量的酸化材料，其在施用经口给药形式后的给药期间提供约3.5至约5.5的平均pH，使用体外供体培养基测试确定; 其中给药期在给予经口给药后不早于约1分钟开始，并且在给予经口给药后不迟于约120分钟结束。

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