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1. 发明申请

WO2008100434A1 TRANSORAL DOSAGE FORMS COMPRISING SUFENTANIL AND NALOXONE 审中-公开
标题翻译：包含SUFENTANIL和NALOXONE的转运剂型
公开(公告)号：WO2008100434A1
公开(公告)日：2008-08-21
申请号：PCT/US2008/001711
申请日：2008-02-08
申请人： DURECT CORPORATION , YUM, Su II , SHAH, Jaymin , KWON, Sung Yun , SONG, Xiaoping
发明人： YUM, Su II , SHAH, Jaymin , KWON, Sung Yun , SONG, Xiaoping
IPC分类号： A61K31/4535 , A61K9/00
CPC分类号： A61K31/4535 , A61K9/0056 , A61K9/006 , A61K9/06 , A61K9/2009 , A61K9/2063 , A61K9/7007 , A61K31/485 , A61K2300/00
摘要： The invention pertains to methods that include administering to a subject a transoral dosage form comprising a pharmaceutical carrier and sufentanil, and maintaining a mean pH ranging from about 3.5 to about 5.5 during a dosing period after administration of the transoral dosage form as determined using an in vitro donor media test. Related dosage forms are also disclosed. Also disclosed are transoral dosage forms and related methods, wherein a transoral dosage form may comprise: (1) about 5 to about 1000 micrograms of sufentanil; (2) about 50 micrograms to about 100 milligrams of naloxone; and (3) acidifying material in an amount sufficient to provide a mean pH ranging from about 3.5 to about 5.5 during a dosing period after administration of the transoral dosage form as determined using an in vitro donor media test; wherein the dosing period begins no earlier than about 1 minute after administration of the transoral dosage form, and ends no later than about 120 minutes after administration of the transoral dosage form.
摘要翻译：本发明涉及包括向受试者施用包含药物载体和舒芬太尼的经口给药形式的方法，并且在给予经口给药后的给药期间保持约3.5至约5.5的平均pH，所述给药期间使用体外供体介质试验。还公开了相关的剂型。还公开了经口给药剂型和相关方法，其中经口剂型可包含：（1）约5至约1000微克的舒芬太尼; （2）约50微克至约100毫克的纳洛酮; 和（3）足量的酸化材料，其在施用经口给药形式后的给药期间提供约3.5至约5.5的平均pH，使用体外供体培养基测试确定; 其中给药期在给予经口给药后不早于约1分钟开始，并且在给予经口给药后不迟于约120分钟结束。

2. 发明申请

WO2011014561A1 EXTRACTS OF MEDICINAL PLANT AND USES THEREOF 审中-公开
标题翻译：药用植物提取物及其用途
公开(公告)号：WO2011014561A1
公开(公告)日：2011-02-03
申请号：PCT/US2010/043542
申请日：2010-07-28
申请人： HE, Johnny, J. , PARK, In-Woo , CHEN, Guangying , HAN, Changri , SONG, Xiaoping
发明人： HE, Johnny, J. , PARK, In-Woo , CHEN, Guangying , HAN, Changri , SONG, Xiaoping
IPC分类号： A01N65/00 , A61K36/00
CPC分类号： A61K36/185 , A61K36/47
摘要： Extracts of traditional Chinese medicinal plants, Annonaceae, Artabotrys pilosus, Annonaceae, Dasymaschalon rostratum, Euphorbiaceae, Trigonostema xyphophylloides, and Dipterocarpaceae, Vatica astrotricha, are described. Pharmaceutical compositions comprising the extracts and treatment of HIV infection is described.
摘要翻译：描述了中药材提取物，芸香科，蒿科，ace科，大戟科，大戟科，三叶草叶提取物，Dipterocarpaceae，Vatica astrotricha等。描述了包含提取物和治疗HIV感染的药物组合物。

3. 发明申请

WO2015085312A1 COMPOSITIONS COMPRISING ANTIOXIDANT, FLUID DISPENSERS, AND METHODS INVOLVING THE SAME 审中-公开
标题翻译：包含抗氧化剂，流体分配剂和涉及其的方法的组合物
公开(公告)号：WO2015085312A1
公开(公告)日：2015-06-11
申请号：PCT/US2014/069135
申请日：2014-12-08
申请人： DURECT CORPORATION
发明人： SONG, Xiaoping , PEER, Clarissa , YUM, Su, Ii
IPC分类号： A61K9/00
CPC分类号： A61K9/0004 , A61K47/02 , A61K47/10 , A61K47/20 , A61K47/32 , A61K47/34 , A61K47/38 , A61M5/14276 , A61M2005/14513
摘要： A composition includes a salt; a polymer; and an antioxidant. A dispenser includes a flexible container having a closed end and an opposed open end; an osmotically-effective solute composition encapsulating at least a portion of the container, the solute composition including antioxidant in an amount of at least 0.5 wt%, based on weight of the solute composition; a semipermeable membrane encapsulating the osmotically-effective solute composition; a cap having a sealing surface adapted for sealing engagement with the open end of the container; and a port extending from an interior of the container and through the cap. Also disclosed are methods of making and using the composition and osmotic pumps.
摘要翻译：组合物包括盐; 聚合物和抗氧化剂。分配器包括具有封闭端和相对开口端的柔性容器; 包封所述容器的至少一部分的渗透有效溶质组合物，所述溶质组合物包含基于所述溶质组合物的重量为至少0.5重量％的量的抗氧化剂; 包封渗透有效的溶质组合物的半透膜; 盖，其具有适于与容器的开口端密封接合的密封表面; 以及从容器的内部延伸并穿过盖的端口。还公开了制备和使用组合物和渗透泵的方法。

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