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1. 发明申请

WO2009088414A3 ORAL PHARMACEUTICAL DOSAGE FORMS 审中-公开
公开(公告)号：WO2009088414A3
公开(公告)日：2009-07-16
申请号：PCT/US2008/013381
申请日：2008-12-05
申请人： DURECT CORPORATION , YUM, Su II
发明人： YUM, Su II , CHAO, Wendy , SU, Huey-Ching , FU, Roger , ZAMLOOT, Michael
IPC分类号： A01N43/42 , A61K9/64 , A61K31/44
摘要： Abuse-resistant oral dosage forms suitable for administration of pharmacologically active agents are provided.

2. 发明申请

WO2018026837A1 COMPOSITIONS COMPRISING OXYGENATED CHOLESTEROL SULFATE AND AT LEAST ONE OF POLYALKYLENE GLYCOL, CARBOXYMETHYL CELLULOSE AND POLYOXYLGLYCERIDE 审中-公开
标题翻译：包含氧化胆固醇硫酸酯和至少一种聚烷基二醇，羧甲基纤维素和聚氧化甘油的组合物
公开(公告)号：WO2018026837A1
公开(公告)日：2018-02-08
申请号：PCT/US2017/044934
申请日：2017-08-01
申请人： DURECT CORPORATION
发明人： MIKSZTAL, Andrew R. , LIN, WeiQi , KIM, Mee Jean , WU, Hongwei , LEE, Min L. , CHAO, Wendy
IPC分类号： A61K31/575 , A61K35/12 , C07J31/00 , C07J9/00
摘要： Compositions comprising oxygenated cholesterol sulfates (OCS) are provided. The OCS is, for example, 5-cholesten-3, 25-diol, 3-sulfate (25HC3S) or 5-cholesten, 3, 25-diol, disulfate (25HCDS). The compositions may be used to prevent and/or treat a variety of diseases and conditions, including organ failure (e.g. acute liver failure due to acetaminophen), high cholesterol/high lipids, and various inflammatory diseases and conditions.
摘要翻译：提供了包含氧化胆固醇硫酸盐（OCS）的组合物。 OCS例如是5-胆甾烯-3,25-二醇，3-硫酸盐（25HCl 3 S）或5-胆甾烯-3,25-二醇，二硫酸盐（25HCDS）。该组合物可用于预防和/或治疗多种疾病和病症，包括器官衰竭（例如由于对乙酰氨基酚导致的急性肝衰竭），高胆固醇/高脂质和各种炎性疾病和病症。

3. 发明申请

WO2014144984A1 COMPOSITIONS WITH THIXOTROPY AND ENHANCED DISSOLUTION REPRODUCIBILITY AND STABILITY 审中-公开
标题翻译：组合物与噻唑和增强的溶解可重复性和稳定性
公开(公告)号：WO2014144984A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/029617
申请日：2014-03-14
申请人： DURECT CORPORATION
发明人： ZAMLOOT, Michael S. , FU, Roger , YUM, Su Il , CHAO, Wendy , SU, Huey-Ching
IPC分类号： C07D471/00
CPC分类号： A61K31/485 , A61K9/48 , A61K9/4816 , A61K9/485 , A61K9/4858 , A61K9/4866
摘要： The present disclosure provides extended release compositions including, formulations that comprise such compositions, which exhibit desirable dissolution of an active agent while maintaining its physical stability in a dosage form including, for example, providing reduced sample variability, e.g., in the form of reduced inter-capsule variability and/or a reduction in storage-time dependent change in mean release of the active agent from the composition. Related methods of making and administering the disclosed compositions and formulations are also provided.
摘要翻译：本公开内容提供了延长释放组合物，包括包含这样的组合物的制剂，其表现出活性剂的理想溶解，同时保持其剂型的物理稳定性，包括例如提供降低的样品变异性，例如以减少的间隔 - 胶囊变异性和/或活性剂从组合物的平均释放的储存时间依赖性变化的降低。还提供了制备和施用所公开的组合物和制剂的相关方法。

4. 发明申请

WO2018009566A1 ORAL DOSAGE FORM WITH DRUG COMPOSITION, BARRIER LAYER AND DRUG LAYER 审中-公开
标题翻译：口服剂型与药物组合物，屏障层和药物层
公开(公告)号：WO2018009566A1
公开(公告)日：2018-01-11
申请号：PCT/US2017/040750
申请日：2017-07-05
申请人： DURECT CORPORATION
发明人： YUM, Su IL , CHAO, Wendy , SU, Huey-Ching , CHEN, Yen-Fei , CHIANG, Chin-Chih
IPC分类号： A61K9/48 , A61K9/52 , A61K9/56 , A61K47/14 , A61K31/4458 , A61K47/26 , A61K47/32 , A61K47/38
摘要： The present disclosure provides dosage forms designed to deliver active pharmaceutical ingredients (APIs) in a controlled release manner. For instance, the present disclosure includes dosage forms with adequate time of onset of action and reduced lag times in the fed state. Such dosage forms find use in a variety of conditions where a rapid onset of action is desired followed by an extended release phase for the active agent, for example in the treatment of ADHD, pain or anxiety. In some cases, the dosage form includes a drug composition including a pharmacologically active agent, a barrier layer covering at least a portion of the drug composition, and a drug layer covering at least a portion of the barrier layer, wherein the drug layer includes the pharmacologically active agent. Related methods of making and administering the disclosed dosage forms are also provided.
摘要翻译：本公开提供了设计成以控释方式递送活性药物成分（API）的剂型。例如，本公开包括具有足够的作用时间和在进食状态下减少的滞后时间的剂型。这种剂型可用于需要快速起效的各种病症，随后是活性剂的缓释阶段，例如用于治疗ADHD，疼痛或焦虑。在一些情况下，所述剂型包括药物组合物，所述药物组合物包含药理学活性剂，覆盖所述药物组合物的至少一部分的阻挡层以及覆盖所述阻挡层的至少一部分的药物层，其中所述药物层包含药理活性剂。还提供了制备和给药所公开的剂型的相关方法。

5. 发明申请

WO2014144975A1 COMPOSITIONS WITH A RHEOLOGICAL MODIFIER TO REDUCE DISSOLUTION VARIABILITY 审中-公开
标题翻译：具有降解溶解变异性的流变学改性剂的组合物
公开(公告)号：WO2014144975A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/029607
申请日：2014-03-14
申请人： DURECT CORPORATION
发明人： YUM, Su Il , CHAO, Wendy , SU, Huey-Ching , FU, Roger , ZAMLOOT, Michael S. , BRATIN, Karl , SHANKER, Ravi M.
IPC分类号： A01N25/00
CPC分类号： A61K47/02 , A61K9/4816 , A61K9/485 , A61K31/485 , A61K47/14 , A61K47/26 , A61K47/38
摘要： The present disclosure provides compositions (e.g., extended release compositions) which exhibit a desirable pharmacokinetic profile of an active agent while providing reduced dissolution sample variability, e.g., in the form of reduced inter-capsule variability and/or a reduction in storage-time dependent change in mean release of the active agent from the composition. Related methods of making and administering the disclosed compositions are also provided.
摘要翻译：本公开提供了组合物（例如延长释放组合物），其表现出活性剂所需的药代动力学特征，同时提供降低的溶解样品变异性，例如以减少的胶囊间变异性和/或减少存储时间依赖性活性剂从组合物中平均释放的变化。还提供了制备和施用所公开的组合物的相关方法。

6. 发明申请

WO2009075782A1 METHODS USEFUL FOR THE TREATMENT OF PAIN, ARTHRITIC CONDITIONS, OR INFLAMMATION ASSOCIATED WITH A CHRONIC CONDITION 审中-公开
标题翻译：用于治疗与慢性病相关的疼痛，疼痛症状或炎症的方法
公开(公告)号：WO2009075782A1
公开(公告)日：2009-06-18
申请号：PCT/US2008/013404
申请日：2008-12-05
申请人： DURECT CORPORATION , YUM, Su II
发明人： YUM, Su II , CHAO, Wendy , FU, Roger , ZAMLOOT, Michael
IPC分类号： A61K9/48 , A61K31/137 , A61K31/4402 , A61K31/485 , A61P19/00 , A61P19/02 , A61P43/00
CPC分类号： A61K9/4866 , A61K9/48 , A61K9/4858 , A61K31/137 , A61K31/4402 , A61K31/4458 , A61K31/485
摘要： Methods, including those for administering novel pharmaceutical compositions, dosage forms containing an opioid active pharmaceutical ingredient, are useful for treating pain, arthritic conditions and/or inflammation associated with a chronic condition, including pain from arthritis and inflammation.
摘要翻译：包括用于施用新药物组合物的方法，含有阿片样物质活性药物成分的剂型可用于治疗与慢性疾病相关的疼痛，关节炎病症和/或炎症，包括由关节炎和炎症引起的疼痛。

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