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1. 发明申请

WO2008066642A2 TRANSDERMAL DELIVERY SYSTEMS 审中-公开
标题翻译：变送器系统
公开(公告)号：WO2008066642A2
公开(公告)日：2008-06-05
申请号：PCT/US2007022927
申请日：2007-10-29
申请人： DURECT CORP , YUM SU II , KWON SUNG YUN , SONG XIAO PING , BROWN JAMES E
发明人： YUM SU II , KWON SUNG YUN , SONG XIAO PING , BROWN JAMES E
IPC分类号： A61L15/58 , A61K9/70 , A61L15/44
CPC分类号： A61K31/445 , A61K9/0014 , A61K9/7023 , A61K9/7053 , A61K9/7084 , A61K47/26 , A61L15/58
摘要： Disclosed are bupivacaine transdermal delivery systems, and related methods.
摘要翻译：公开了布比卡因透皮递送系统及相关方法。

2. 发明申请

WO0243800A2 DEVICES AND METHODS FOR CONTROLLED DELIVERY FROM A DRUG DELIVERY DEVICE 审中-公开
标题翻译：用于从药物递送装置进行控制的装置和方法
公开(公告)号：WO0243800A2
公开(公告)日：2002-06-06
申请号：PCT/US0143143
申请日：2001-11-21
申请人： DURECT CORP , BROWN JAMES E , CULWELL JOHN , FILICE JAMES A , GILLIS EDWARD M , THEEUWES FELIX , WICKMAN PETER , YUM SU IL
发明人： BROWN JAMES E , CULWELL JOHN , FILICE JAMES A , GILLIS EDWARD M , THEEUWES FELIX , WICKMAN PETER , YUM SU IL
IPC分类号： A61M37/00 , A61K9/00 , A61K9/22 , A61M5/142 , A61M5/168 , A61M5/36 , A61M31/00 , A61M39/00
CPC分类号： A61M5/14276 , A61K9/0004 , A61M5/168 , A61M5/16804 , A61M5/36 , A61M31/002 , A61M2205/0294
摘要： The invention features a plug for use with a drug delivery device, wherein the plug defines an expansion control channel, which accommodates thermal expansion of a formulation in a reservoir of a drug delivery device, and an exit channel. In one embodiment, the plug comprises an inner plug member and an outer plug member, which members define an expansion control channel to facilitate release of entrapped air and to accommodate thermal expansion of formulation from the sealed drug reservoir. The plug further defines an exit channel, and may optionally further comprise a frit positioned within the flow pathway just prior to the delivery outlet, or both.
摘要翻译：本发明的特征在于一种用于药物递送装置的塞子，其中塞子限定扩张控制通道，其适应制剂在药物递送装置的储存器中的热膨胀和出口通道。在一个实施例中，塞子包括内塞构件和外塞构件，这些构件限定了膨胀控制通道，以便于捕获的空气的释放和适应制剂从密封的药物储存器的热膨胀。插头进一步限定出口通道，并且可以任选地进一步包括刚刚在输送出口之前或两者位于流动通道内的玻璃料。

3. 发明申请

WO03009883B1 CATHETER FOR MODIFICATION OF AGENT FORMULATION 审中-公开
标题翻译：用于修改配方的导管
公开(公告)号：WO03009883B1
公开(公告)日：2003-10-30
申请号：PCT/US0222837
申请日：2002-07-16
申请人： DURECT CORP , CHAN TAI WAH , NELSON TIMOTHY SCOTT , BROWN JAMES E
发明人： CHAN TAI WAH , NELSON TIMOTHY SCOTT , BROWN JAMES E
IPC分类号： A61L29/16 , A61M25/00 , A61M25/16 , A61M31/00 , A61M37/00
CPC分类号： A61L29/16 , A61M25/00 , A61M25/0068 , A61M25/0082 , A61M2025/0057 , A61M2025/0073 , A61M2025/0076 , A61M2025/105 , A61M2025/1086
摘要： The present invention provides a catheter (10) for use in delivering formulation that allows modification of the formulation prior to or concomitant with its transport or at a delivery site. The catheter (10) comprises an elongate body (20), which defines an inner lumen (26) extending between the proximal (21) and distal (23) ends, and a modifying element (40), which provides for modification of one or more components of a formulation prior to or concomitant with release at the delivery site.
摘要翻译：本发明提供一种用于递送制剂的导管（10），其允许在其运输之前或伴随其运输或在递送部位改变制剂。导管（10）包括细长主体（20），其限定在近端（21）和远端（23）端部之间延伸的内腔（26）和修改元件（40），其修改一个或多个在配送地点之前或伴随释放的配方的更多组分。

4. 发明申请

WO03009883A2 CATHETER FOR MODIFICATION OF AGENT FORMULATION 审中-公开
标题翻译：改性剂配方的导管
公开(公告)号：WO03009883A2
公开(公告)日：2003-02-06
申请号：PCT/US0222837
申请日：2002-07-16
申请人： DURECT CORP , CHAN TAI WAH , NELSON TIMOTHY SCOTT , BROWN JAMES E
发明人： CHAN TAI WAH , NELSON TIMOTHY SCOTT , BROWN JAMES E
IPC分类号： A61L29/16 , A61M25/00 , A61M25/16 , A61M
CPC分类号： A61L29/16 , A61M25/00 , A61M25/0068 , A61M25/0082 , A61M2025/0057 , A61M2025/0073 , A61M2025/0076 , A61M2025/105 , A61M2025/1086
摘要： The present invention provides a catheter (10) for use in delivering formulation that allows modification of the formulation prior to or concomitant with its transport or at a delivery site. The catheter (10) comprises an elongate body (20), which defines an inner lumen (26) extending between the proximal (21) and distal (23) ends, and a modifying element (40), which provides for modification of one or more components of a formulation prior to or concomitant with release at the delivery site.
摘要翻译：本发明提供了一种用于输送制剂的导管（10），该制剂允许在制剂在其运输之前或伴随其运输或在递送部位对制剂进行改性。导管10包括限定在近端21和远端23之间延伸的内腔26的细长主体20和修改元件40，在递送部位释放之前或伴随释放的制剂的更多组分。

5. 发明申请

WO9842317A2 IMPLANTABLE DELIVERY DEVICE WITH SELF ADJUSTABLE EXIT PORT 审中-公开
标题翻译：具有自由可调出口端口的可移植输送装置
公开(公告)号：WO9842317A2
公开(公告)日：1998-10-01
申请号：PCT/US9804637
申请日：1998-03-10
申请人： ALZA CORP , GUMUCIO JUAN C , DIONNE KEITH E , BROWN JAMES E
发明人： GUMUCIO JUAN C , DIONNE KEITH E , BROWN JAMES E
IPC分类号： A61K9/48 , A61K9/00 , A61K9/22 , A61K9/52
CPC分类号： A61K9/0004
摘要： A delivery device having a first chamber containing an osmotic agent, a membrane forming a wall of the first chamber through which fluid is imbibed by osmosis, a second chamber containing a beneficial agent to be delivered, and a moveable piston separating the two chambers. In fluid communiation with the second chamber is an orifice which comprises a slit valve. In the presence of pressure, the beneficial agent pushes through the slit, opening up a channel for delivery of the beneficial agent and creating flow. Because the slit remains closed in the absence of flow (or when the pressure is below the pressure required to open the slit), back diffusion of external fluids is eliminated when the slit is closed, which prevents contamination of the beneficial agent in the second chamber by external fluids. In addition, forward diffusion of the beneficial agent out of the capsule is prevented when the slit is closed. The slit valve opens only to the minimum dimension required to allow the flow generated by the osmostic pumping rate. The slit valve also allows a flow path to open around any obstruction in the slit valve to prevent clogging.
摘要翻译：一种输送装置，其具有包含渗透剂的第一室，形成第一室的壁的膜，通过渗透吸收流体的第一室;含有要输送的有益剂的第二室和分离两个室的活动活塞。在与第二室的流体通信中是包括狭缝阀的孔口。在存在压力的情况下，有益剂推动狭缝，打开用于输送有益剂并产生流动的通道。因为缝隙在没有流动的情况下保持关闭（或当压力低于打开狭缝所需的压力时），当狭缝闭合时，外部流体的反向扩散被消除，这防止有益剂在第二腔室中的污染通过外部流体。此外，当狭缝被关闭时，可以防止有益剂从胶囊中向前扩散。狭缝阀仅打开允许通过渗透泵送速率产生的流量所需的最小尺寸。狭缝阀还允许流动通道围绕狭缝阀中的任何阻塞开放以防止堵塞。

6. 发明申请

WO2008043057A3 SYSTEMS AND METHODS FOR CONTRACTING WITH MULTIPLE PARTIES 审中-公开
标题翻译：与多个缔约方缔结的系统和方法
公开(公告)号：WO2008043057A3
公开(公告)日：2008-11-27
申请号：PCT/US2007080526
申请日：2007-10-05
申请人： INFILCO DEGREMONT INC , BROWN JAMES E , UBALDI RICHARD A
发明人： BROWN JAMES E , UBALDI RICHARD A
IPC分类号： H04L9/00
CPC分类号： G06Q10/10 , G06Q10/06
摘要： Systems and methods for contracting with multiple parties, by which the multiple parties agree to a single contracting instrument, are presented. The systems generally comprise one or more computing devices connected to a data source, each of which are controlled by one or more entities interested in initiating a project. The data source has stored thereon a contracting instrument adapted for designating multiple parties. The systems also include a means for receiving the contracting instrument. The methods generally include the steps of identifying two or more contractors and identifying an owner interested in engaging the plurality of contractors to work on a project. After the contractors and owner have been identified, a single contracting instrument is prepared designating the contractors and the owner as executing parties to the single contracting instrument, which may then be executed.
摘要翻译：提出了与多方签订合同的方式和方式，多方同意订立单一的合同文书。系统通常包括连接到数据源的一个或多个计算设备，每个计算设备由有意启动项目的一个或多个实体控制。数据源已经存储有适于指定多方的订约工具。这些系统还包括接收订约工具的手段。方法通常包括识别两个或多个承包商并识别有兴趣使多个承包商参与项目工作的所有者的步骤。在确认承包商和业主之后，准备一份单一的订约工具，指定承包商和所有者作为单一订约工具的执行方，然后执行。

7. 发明申请

WO2004035109A2 APPARATUS AND METHODS FOR ACTIVATING A DELIVERY DEVICE 审中-公开
标题翻译：用于激活交付设备的装置和方法
公开(公告)号：WO2004035109A2
公开(公告)日：2004-04-29
申请号：PCT/US0332566
申请日：2003-10-15
申请人： DURECT CORP
发明人： BROWN JAMES E , GILLIS EDWARD M , POUTIATINE ANDREW I , KOLOSI WILLIAM D , FLOM JAMES R , THEEUWES FELIX
IPC分类号： A61B17/34 , A61K9/00 , A61M20060101 , A61M5/00 , A61M31/00 , A61M
CPC分类号： A61B17/3468 , A61K9/0024 , A61M37/0069
摘要： Devices and methods of actuating/activating agent delivery systems are provided. The subject devices include a trocar into which an agent delivery device is loaded in preparation for implantation of the agent delivery device into a patient. The action of loading the agent delivery device into the trocar serves to actuate or activate the device for the delivery of the agent which will commence upon implantation of the device. The methods include use of the trocar to actuate/activate the agent delivery device.
摘要翻译：提供了致动/激活剂递送系统的装置和方法。主体装置包括套管针，其中加载了药剂输送装置以准备将药剂输送装置植入患者体内。将药剂输送装置加载到套管针中的作用用于致动或激活装置，用于递送将在植入装置时开始的药剂。所述方法包括使用套管针来致动/激活药剂递送装置。

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