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1. 发明申请

WO2008053019A3 METHOD FOR REDUCING THE EXPRESSION OF A GENE IN A FILAMENTOUS FUNGAL CELL 审中-公开
标题翻译：用于减少真菌真菌细胞中基因表达的方法
公开(公告)号：WO2008053019A3
公开(公告)日：2009-01-22
申请号：PCT/EP2007061768
申请日：2007-10-31
申请人： DSM IP ASSETS BV , PEIJ VAN NOEL NICOLAAS MARIA ELISABETH , PARENICOVA LUCIE , BENCINA MOJCA , IVICAK KAROLINA
发明人： PEIJ VAN NOEL NICOLAAS MARIA EISABETH , PARENICOVA LUCIE , BENCINA MOJCA , IVICAK KAROLINA
IPC分类号： C07K14/37 , C12N15/11 , C12N15/113 , C12N15/80
CPC分类号： C12N15/80 , C07K14/37 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2320/12
摘要： The present invention relates to a method for reducing the expression of a gene in a filamentous fungal cell. The invention further relates to a modified filamentous fungal cell suitable for the production of a compound of interest, wherein, compared to the parental cell the modified cell derives from, said modified cell exhibits improved abilities for RNAi mediated reduction of gene expression of a target gene. In addition, the invention relates to a method for the production of a compound of interest in said modified filamentous fungal cell.
摘要翻译：本发明涉及一种降低丝状真菌细胞中基因表达的方法。本发明还涉及一种适用于生产目标化合物的修饰丝状真菌细胞，其中与所述修饰细胞相比，所述修饰的细胞来源的亲本细胞相比，显示改进的RNAi介导的靶基因基因表达减少的能力。此外，本发明涉及一种在所述修饰的丝状真菌细胞中生产感兴趣的化合物的方法。

2. 发明申请

WO2011119119A3 THE COMBINATION OF ANTIFUNGAL COMPOUND AND MODIFIER OF PROTON HOMEOSTASIS FOR DESTROYING OR GROWTH INHIBITION AND REPRODUCTION OF FUNGI 审中-公开
标题翻译：抗真菌化合物的组合和原子生物修复的破坏或增殖抑制和真菌繁殖
公开(公告)号：WO2011119119A3
公开(公告)日：2012-04-05
申请号：PCT/SI2010000050
申请日：2010-09-07
申请人： KEMIJSKI INST , BENCINA MOJCA , BAGAR TANJA , MEDVED NATASA
发明人： BENCINA MOJCA , BAGAR TANJA , MEDVED NATASA
IPC分类号： A01N43/04 , A01N37/06 , A61K31/19 , A61K31/4164 , A61K31/4196 , A61K31/70
CPC分类号： A61K31/4164 , A01N37/06 , A01N43/16 , A61K31/19 , A61K31/4196 , A61K31/70 , A01N43/50 , A01N43/60 , A01N43/653 , A01N43/90 , A01N2300/00
摘要： The presented invention refers to the combination of an antifungal substance and a proton homeostasis modifier for enhancing the fungicidic or fungistatic action of the antifungal substance for treating or preventing fungal infections. The invention refers to a medicament or a plant protection product, which contains the combination. The invention refers to a method for preventing and treating fungal infection and in vitro for the disinfection of surfaces and implants.
摘要翻译：本发明涉及抗真菌物质和质子稳态调节剂的组合，用于增强用于治疗或预防真菌感染的抗真菌物质的杀真菌剂或抑菌作用。本发明涉及包含该组合的药物或植物保护产品。本发明涉及一种预防和治疗真菌感染和体外消毒表面和植入物的方法。

3. 发明申请

WO2005023854A3 MODIFIED 6-PHOSPHOFRUCTO-1-KINASE OF THE FUNGUS ASPERGILLUS NIGER 审中-公开
标题翻译：真菌US US ER ER ER ER ER ER ER ER ER ER ER ER
公开(公告)号：WO2005023854A3
公开(公告)日：2005-06-09
申请号：PCT/SI2004000028
申请日：2004-08-25
申请人： KEMIJSKI INST , LEGISA MATIC , BENCINA MOJCA
发明人： LEGISA MATIC , BENCINA MOJCA
IPC分类号： C07K14/38 , C12N9/12 , C12N15/52 , C12P7/00
CPC分类号： C12N9/1205
摘要： The invention deals with the shorter fragment of 6-phosphofructo-l-kinase (PFK1) with molecular mass between 49 and 55 kDa that is not significantly inhibited by citric acid and/or its salts and is post-translationally modified. The 49-52 kDa fragment that is formed by post-translational modifications of the fungal enzyme retains positive regulatory properties and is activated by specific activators, yet is no more sensitive to inhibition by citric acid a substance that in higher organisms acts as a feed back inhibitor. The invention describes a procedure that includes the introduction of the gene coding for a shorter fragment into the eukaryotic cells with an aim to increase the metabolic flow through the glycolysis and concomitantly to increase the rate of primary and secondary metabolites synthesis. The invention describes the use of the shorter fragment in biotechnological procedures for production of primary and secondary metabolites.
摘要翻译：本发明涉及分子质量在49和55kDa之间的6-磷酸果糖-1-激酶（PFK1）的较短片段，其不被柠檬酸和/或其盐显着抑制并被翻译后修饰。通过真菌酶的翻译后修饰形成的49-52kDa片段保留阳性调节性质，并被特定的活化剂活化，但对柠檬酸的抑制没有更敏感，在高等生物体中作为反馈物质抑制剂。本发明描述了一种方法，其包括将编码较短片段的基因引入真核细胞中，目的是增加通过糖酵解的代谢流，并且伴随地增加初级和次级代谢物合成的速率。本发明描述了生物技术方法中较短片段用于生产初级和次级代谢物的用途。

4. 发明申请

WO2007123498A8 MUTATED TRUNCATED MT-PFKA GENE FOR THE SYNTHESIS OF ACTIVE SHORTER FRAGMENT OF 6-PHOSPHOFRUCTO-l-KINASE 审中-公开
标题翻译：用于合成6-磷酸酶-L-激酶活性成分的MUTATED TRUNCATED MT-PFKA基因
公开(公告)号：WO2007123498A8
公开(公告)日：2009-07-23
申请号：PCT/SI2007000007
申请日：2007-02-27
申请人： KEMIJSKI INST , LEGISA MATIC , BENCINA MOJCA , TEVZ GREGOR , CAPUDER MAJA , MLAKAR TINA , OVEN DARIJA
发明人： LEGISA MATIC , BENCINA MOJCA , TEVZ GREGOR , CAPUDER MAJA , MLAKAR TINA , OVEN DARIJA
IPC分类号： C12N9/12 , C12N15/54
CPC分类号： C12Y207/01011 , C12N9/1205
摘要： The invention deals with mutated truncated mX-pfkA gene encoding shorter fragment of 6- phosphofructo-1 -kinase (PFKl), with no need for phosphorylation of the protein molecule for activation, that is not significantly inhibited by citric acid and/or its salts and ATP molecules. Active 49 -52 kDa fragment encoded by mt-pfltk gene, retains positive regulatory properties of the native protein and is activated in the presence of specific activators, while citric acid and ATP, important metabolites that function as feed back inhibitors in higher organisms do not reduce its activity. The invention deals with the use of modified shorter fragment in biotechnological processes for fabricating primary and secondary metabolites.
摘要翻译：本发明涉及编码6-磷酸果糖-1-激酶（PFK1）的较短片段的突变的截短的mX-pfkA基因，不需要用于激活的蛋白质分子的磷酸化，其不被柠檬酸和/或其盐显着抑制和ATP分子。由mt-pfltk基因编码的活性49-52kDa片段保留天然蛋白质的阳性调节性质，并在特定活化剂存在下活化，而柠檬酸和ATP是在高等生物体中起反馈抑制剂作用的重要代谢物减少其活动。本发明涉及在生物技术过程中使用修饰的较短的片段来制造初级和次级代谢物。

5. 发明申请

WO2007123498A3 MUTATED TRUNCATED MT-PFKA GENE FOR THE SYNTHESIS OF ACTIVE SHORTER FRAGMENT OF 6-PHOSPHOFRUCTO-l-KINASE 审中-公开
标题翻译：用于合成6-磷酸酶-L-激酶活性成分的MUTATED TRUNCATED MT-PFKA基因
公开(公告)号：WO2007123498A3
公开(公告)日：2007-12-21
申请号：PCT/SI2007000007
申请日：2007-02-27
申请人： KEMIJSKI INST , LEGISA MATIC , BENCINA MOJCA , TEVZ GREGOR , CAPUDER MAJA , MLAKAR TINA , OVEN DARIJA
发明人： LEGISA MATIC , BENCINA MOJCA , TEVZ GREGOR , CAPUDER MAJA , MLAKAR TINA , OVEN DARIJA
IPC分类号： C12N9/12 , C12N15/54
CPC分类号： C12Y207/01011 , C12N9/1205
摘要： The invention deals with mutated truncated mX-pfkA gene encoding shorter fragment of 6- phosphofructo-1 -kinase (PFKl), with no need for phosphorylation of the protein molecule for activation, that is not significantly inhibited by citric acid and/or its salts and ATP molecules. Active 49 -52 kDa fragment encoded by mt-pfltk gene, retains positive regulatory properties of the native protein and is activated in the presence of specific activators, while citric acid and ATP, important metabolites that function as feed back inhibitors in higher organisms do not reduce its activity. The invention deals with the use of modified shorter fragment in biotechnological processes for fabricating primary and secondary metabolites.
摘要翻译：本发明涉及编码6-磷酸果糖-1-激酶（PFK1）的较短片段的突变的截短的mX-pfkA基因，不需要用于激活的蛋白质分子的磷酸化，其不被柠檬酸和/或其盐显着抑制和ATP分子。由mt-pfltk基因编码的活性49-52kDa片段保留天然蛋白质的阳性调节性质，并在特定活化剂存在下活化，而柠檬酸和ATP是在高等生物体中起反馈抑制剂作用的重要代谢物减少其活动。本发明涉及在生物技术过程中使用修饰的较短的片段来制造初级和次级代谢物。

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