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1. 发明申请

WO2007123498A8 MUTATED TRUNCATED MT-PFKA GENE FOR THE SYNTHESIS OF ACTIVE SHORTER FRAGMENT OF 6-PHOSPHOFRUCTO-l-KINASE 审中-公开
标题翻译：用于合成6-磷酸酶-L-激酶活性成分的MUTATED TRUNCATED MT-PFKA基因
公开(公告)号：WO2007123498A8
公开(公告)日：2009-07-23
申请号：PCT/SI2007000007
申请日：2007-02-27
申请人： KEMIJSKI INST , LEGISA MATIC , BENCINA MOJCA , TEVZ GREGOR , CAPUDER MAJA , MLAKAR TINA , OVEN DARIJA
发明人： LEGISA MATIC , BENCINA MOJCA , TEVZ GREGOR , CAPUDER MAJA , MLAKAR TINA , OVEN DARIJA
IPC分类号： C12N9/12 , C12N15/54
CPC分类号： C12Y207/01011 , C12N9/1205
摘要： The invention deals with mutated truncated mX-pfkA gene encoding shorter fragment of 6- phosphofructo-1 -kinase (PFKl), with no need for phosphorylation of the protein molecule for activation, that is not significantly inhibited by citric acid and/or its salts and ATP molecules. Active 49 -52 kDa fragment encoded by mt-pfltk gene, retains positive regulatory properties of the native protein and is activated in the presence of specific activators, while citric acid and ATP, important metabolites that function as feed back inhibitors in higher organisms do not reduce its activity. The invention deals with the use of modified shorter fragment in biotechnological processes for fabricating primary and secondary metabolites.
摘要翻译：本发明涉及编码6-磷酸果糖-1-激酶（PFK1）的较短片段的突变的截短的mX-pfkA基因，不需要用于激活的蛋白质分子的磷酸化，其不被柠檬酸和/或其盐显着抑制和ATP分子。由mt-pfltk基因编码的活性49-52kDa片段保留天然蛋白质的阳性调节性质，并在特定活化剂存在下活化，而柠檬酸和ATP是在高等生物体中起反馈抑制剂作用的重要代谢物减少其活动。本发明涉及在生物技术过程中使用修饰的较短的片段来制造初级和次级代谢物。

2. 发明申请

WO2009064260A2 NANOPARTICLES AND NANOWIRES OF ZNO WITH ORGANOPHILIC SURFACES AND THEIR NANOCOMPOSITES WITH POLY(METHYL METHACRYLATE) 审中-公开
标题翻译： ZNO与有机表面的纳米颗粒和纳米颗粒及其与聚（甲基丙烯酸甲酯）的纳米复合体
公开(公告)号：WO2009064260A2
公开(公告)日：2009-05-22
申请号：PCT/SI2008000055
申请日：2008-10-24
申请人： KEMIJSKI INST , ANZLOVAR ALOJZ , CRNJAK OREL ZORICA , ZIGON MAJDA
发明人： ANZLOVAR ALOJZ , CRNJAK OREL ZORICA , ZIGON MAJDA
IPC分类号： C09C1/04 , C08K3/22
CPC分类号： C09C1/043 , B82Y30/00 , C01P2004/04 , C01P2004/62 , C01P2004/64
摘要： The subject of the patent are nanoparticles and nanowires of zinc oxide - ZnO with organophilic surfaces, synthesized in various diols in the presence para - toluene sulfonic acid (p-TsOH) and their nanocomposites with polymethyl methacrylate (PMMA), prepared without additional surface modification of ZnO particles. The preparation procedure of nano ZnO proceeds by hydrolysis of the zinc compound in the presence of catalyst, para - toluene sulfonic acid, in various diols and comprises the following steps: mixing and sonication of the solution from 5 to 60 min., heating of the solution from 30 to 90 min. at temperatures from 100 to 300 °C; sedimentation of the zinc oxide compound up to 24 hours; separation of the suspension from the precipitate, washing of the suspension; drying of the compound. Preparation of nanocomposites composed of methacrylic or acrylic polymer and of unmodified nano ZnO is comprised of the following steps: preparation of the mixture of methacrylic or acrylic monomer, initiator and of zinc (II) oxide, mixing and sonication from 5 - 60 min.; optional partial polymerization of MMA; optional addition of initiator from 0.1 to 40 % once again; transfer into the mold and polymerization at temperatures between 35 and 80 °C; cooling of the polymer and separation from the mold.
摘要翻译：该专利的主题是纳米颗粒和具有亲有机表面的氧化锌 - ZnO的纳米线，其在各种二醇中在对甲苯磺酸（p-TsOH）存在下合成，并且它们与聚甲基丙烯酸甲酯（PMMA）的纳米复合材料在没有附加表面改性的情况下制备的ZnO颗粒。纳米ZnO的制备方法是在催化剂对甲苯磺酸存在下，在各种二醇中水解锌化合物，包括以下步骤：将溶液混合和超声处理5至60分钟，加热溶液从30分钟到90分钟。在100至300℃的温度; 氧化锌复合物沉淀24小时; 将悬浮液与沉淀物分离，洗涤悬浮液; 干燥该化合物。由甲基丙烯酸或丙烯酸聚合物和未改性纳米ZnO组成的纳米复合材料的制备包括以下步骤：制备甲基丙烯酸或丙烯酸单体，引发剂和氧化锌（II）的混合物，混合和超声处理5-60分钟。 MMA的任选部分聚合; 引发剂的任选添加量从0.1到40％再次; 转移到模具中并在35至80℃的温度下聚合; 冷却聚合物并与模具分离。

3. 发明申请

WO2007123498A3 MUTATED TRUNCATED MT-PFKA GENE FOR THE SYNTHESIS OF ACTIVE SHORTER FRAGMENT OF 6-PHOSPHOFRUCTO-l-KINASE 审中-公开
标题翻译：用于合成6-磷酸酶-L-激酶活性成分的MUTATED TRUNCATED MT-PFKA基因
公开(公告)号：WO2007123498A3
公开(公告)日：2007-12-21
申请号：PCT/SI2007000007
申请日：2007-02-27
申请人： KEMIJSKI INST , LEGISA MATIC , BENCINA MOJCA , TEVZ GREGOR , CAPUDER MAJA , MLAKAR TINA , OVEN DARIJA
发明人： LEGISA MATIC , BENCINA MOJCA , TEVZ GREGOR , CAPUDER MAJA , MLAKAR TINA , OVEN DARIJA
IPC分类号： C12N9/12 , C12N15/54
CPC分类号： C12Y207/01011 , C12N9/1205
摘要： The invention deals with mutated truncated mX-pfkA gene encoding shorter fragment of 6- phosphofructo-1 -kinase (PFKl), with no need for phosphorylation of the protein molecule for activation, that is not significantly inhibited by citric acid and/or its salts and ATP molecules. Active 49 -52 kDa fragment encoded by mt-pfltk gene, retains positive regulatory properties of the native protein and is activated in the presence of specific activators, while citric acid and ATP, important metabolites that function as feed back inhibitors in higher organisms do not reduce its activity. The invention deals with the use of modified shorter fragment in biotechnological processes for fabricating primary and secondary metabolites.
摘要翻译：本发明涉及编码6-磷酸果糖-1-激酶（PFK1）的较短片段的突变的截短的mX-pfkA基因，不需要用于激活的蛋白质分子的磷酸化，其不被柠檬酸和/或其盐显着抑制和ATP分子。由mt-pfltk基因编码的活性49-52kDa片段保留天然蛋白质的阳性调节性质，并在特定活化剂存在下活化，而柠檬酸和ATP是在高等生物体中起反馈抑制剂作用的重要代谢物减少其活动。本发明涉及在生物技术过程中使用修饰的较短的片段来制造初级和次级代谢物。

4. 发明申请

WO0160738A3 A PROCESS FOR CATALYTIC, SELECTIVE OXIDATION OF CARBON MONOXIDE IN GASEOUS MIXTURES CONTAINING EXCESS HYDROGEN, A CATALYST AND A PROCESS FOR ITS PREPARATION 审中-公开
标题翻译：一种含有过氧化氢，催化剂和其制备方法的气体混合物中一氧化碳的催化选择性氧化方法
公开(公告)号：WO0160738A3
公开(公告)日：2002-02-07
申请号：PCT/SI0100005
申请日：2001-02-09
申请人： KEMIJSKI INST , FOUNDATION FOR RES AND TECHNOL , HOCEVAR STANKO , BATISTA JURKA , MATRALIS HARALAMBOS , IOANNIDES THEOPHILOS , AVGOUROPOULOS GEORGE
发明人： HOCEVAR STANKO , BATISTA JURKA , MATRALIS HARALAMBOS , IOANNIDES THEOPHILOS , AVGOUROPOULOS GEORGE
IPC分类号： B01J23/00 , B01J23/83 , B01J37/03 , C01B3/58 , C01G3/02
CPC分类号： C01G3/02 , B01J23/002 , B01J23/83 , B01J37/03 , C01B3/583 , C01B2203/044 , C01B2203/047 , C01P2002/76 , C01P2002/77
摘要： The invention refers to a process for catalytic, selective oxidation of carbon monoxide in gaseous mixtures containing excess hydrogen with stoichiometric quantity of oxygen at the temperature between 298 K and 573 K, pressure between 1 and 10 bar and at the ratio of oxygen and carbon monoxide partial pressures ( lambda = 2p02/pco) between 1.0 and 2.5, in a one-step flow reactor at contact time (W/F) between 0.03 and 0.40 g.s.cm , or at the flow rate of the gaseous mixture (F) between 0.083 cm /s and 1.67 cm /s in the presence of 0.010 to 0.100 g of the catalyst, namely the complex oxide of the formula CuxCe1-xxO2-y, where x is between 0.01 and 0.30 while y is equal or greater than x. This invention refers also to a process for the catalyst preparation and to the catalyst prepared by this process. This invention is useful in the field of fuel technology for low temperature fuel cells.
摘要翻译：本发明涉及一种用于在气体混合物中催化，选择性氧化一氧化碳的方法，所述气体混合物含有在298K和573K之间的温度以及1至10巴之间的温度和氧和一氧化碳的比例下具有化学计量的氧的过量的氢在一步流动反应器中，接触时间（W / F）在0.03至0.40gscm -3之间的分压力（λ= 2p02 / pco）为1.0至2.5，或气体混合物 F）在0.010至0.100g催化剂，即CuxCe1-xxO2-y的复合氧化物存在下，在0.083cm 3 / s和1.67cm 3 / s之间，其中x在0.01和0.30之间而y等于或大于x。本发明还涉及催化剂制备方法和通过该方法制备的催化剂。本发明在低温燃料电池的燃料技术领域是有用的。

5. 发明申请

WO2015009248A3 PREPARATION OF ZEOLITE ZSM-5 GRANULATES FREE FROM INORGANIC BINDERS 审中-公开
标题翻译：无机ZSM-5颗粒的制备无机粘结剂
公开(公告)号：WO2015009248A3
公开(公告)日：2015-06-04
申请号：PCT/SI2014000042
申请日：2014-07-10
申请人： KEMIJSKI INST , SILKEM D O O
发明人： FAKIN, TOMAŽ , RISTIĆ, ALENKA , KAUČIČ, VENČESLAV , ZABUKOVEC LOGAR, NATAŠA , GOZNIK IVAN , HORVAT ANDREJ
IPC分类号： B01J29/40 , C01B39/38
CPC分类号： B01J29/40 , B01J2229/62 , C01B39/38
摘要： The invention of the preparation of zeolite ZSM-5 granulates free from inorganic binder provides a synthetic process for the preparation of highly crystalline zeolite granulates without using inorganic binder from amorphous sodium aluminosilicate granules. This invention falls within the scope of the inorganic chemical technology. Granules were prepared from the powdered dried amorphous sodium aluminosilicate gel without containing organic structure directing agent. The proposed synthesis process provides the preparation of the amorphous sodium aluminosilicate gel from sodium water-glass, sodium aluminate using less than 5% of zeolite ZSM-5 seed crystals. The pH value of the gel is adjusted using dilute sulfuric (VI) acid. Dried amorphous sodium aluminosilicate gel is granulated using sodium water-glass. Thermally treated amorphous sodium aluminosilicate granulate is transformed in the alkaline solution into crystalline zeolite ZSM-5 granulate by the hydrothermal synthesis from 22 to 28 hours at a temperature from 170 to 190°C.
摘要翻译：不含无机粘结剂的沸石ZSM-5颗粒的制备的发明提供了制备高结晶沸石颗粒的合成方法，而不使用无定形硅铝酸盐颗粒的无机粘合剂。本发明属于无机化学技术的范围。从粉末状干燥的无定形硅铝酸钠凝胶制备颗粒，不含有机结构导向剂。所提出的合成方法提供了使用少于5％沸石ZSM-5晶种的钠水玻璃铝酸钠制备无定形硅铝酸钠凝胶。使用稀硫酸（VI）酸调节凝胶的pH值。干燥的无定形硅铝酸钠凝胶用钠水玻璃造粒。将热处理的无定形硅铝酸钠颗粒在170至190℃的温度下通过水热合成在22至28小时内在碱溶液中转化成结晶沸石ZSM-5颗粒。

6. 发明申请

WO2007030083A2 COMPOUNDS FOR COVALENT BINDING TO MD-2 AND EFFECT ON THE IMMUNE RESPONSE 审中-公开
标题翻译：用于与MD-2结合的化合物和对免疫反应的影响
公开(公告)号：WO2007030083A2
公开(公告)日：2007-03-15
申请号：PCT/SI2006000028
申请日：2006-08-23
申请人： KEMIJSKI INST , JERALA ROMAN , MANCEK KEBER MATEJA , BREMSAK ROBERT
发明人： JERALA ROMAN , MANCEK KEBER MATEJA , BREMSAK ROBERT
IPC分类号： A61K49/00 , A61K31/185
CPC分类号： A61K49/0021 , A61K31/185 , A61K49/0041
摘要： The invention presents the applications of compounds, which contain a combination of a hydrophobic group with a group, which is reactive with the cysteine residue for the binding to protein MD-2. The compounds are covalently linked to MD-2, which is either free or in the complex with other molecules. The said compounds replace or prevent binding of other ligands, especially bacterial endotoxin (lipopolysaccharide-LPS), which can otherwise lead towards unwanted activation of the immune response and acute or chronic inflammatory diseases.
摘要翻译：本发明提出了含有与半胱氨酸残基反应以结合蛋白质MD-2的疏水基团与基团组合的化合物的应用。这些化合物与MD-2共价连接，MD-2是游离的或与其他分子的复合物。所述化合物替代或防止其它配体，特别是细菌内毒素（脂多糖-DLL）的结合，否则可能导致免疫反应和急性或慢性炎性疾病的不期望的激活。

7. 发明申请

WO2012150043A8 CELLULOSE TREATMENT BY USING A MIXTURE CONTAINING GLYCOLE, GLYCEROLE AND P-TOLUENE SULFONIC ACID 审中-公开
标题翻译：通过使用含有甘油，甘油和对硝基苯磺酸的混合物进行纤维素处理
公开(公告)号：WO2012150043A8
公开(公告)日：2013-01-24
申请号：PCT/EP2012001929
申请日：2012-05-04
申请人： CT OF EXCELLENCE POLYMER MATERIALS AND TECHNOLOGIES POLIMAT , GGP GOZDNO GOSPODARSTVO POSTOJNA D O O , KEMIJSKI INST , KUNAVER MATJAZ , CUK NATASA , JASIUKAITYTE EDITA , KOVAC FRENK , OPRESNIK SAMUEL RODMAN , KATRASNIK TOMAZ
发明人： KUNAVER MATJAZ , CUK NATASA , JASIUKAITYTE EDITA , KOVAC FRENK , OPRESNIK SAMUEL RODMAN , KATRASNIK TOMAZ
IPC分类号： C10G2/00 , C12P5/00
CPC分类号： C10L1/02 , C10G1/002 , C10G2300/1014 , C10G2300/44 , Y02P30/20
摘要： A method for the production of a liquid fuel from a cellulose-containing solid starting material, said method comprising contacting said solid starting material with a mixture comprising diethylene glycol, glycerol and p-toluene sulfonic acid in relative amounts resulting in fuel suitable for use in combustion engines.
摘要翻译：一种用于从含纤维素的固体原料生产液体燃料的方法，所述方法包括使所述固体原料与包含二甘醇，甘油和对甲苯磺酸的混合物相互接触，所述混合物的相对量导致适合用于内燃机

8. 发明申请

WO2006118550A3 HIGHLY PRODUCTIVE RECOMBINANT YEAST STRAINS WITH MODIFIED GALACTOSE-REGULATED TRANSCRIPTION 审中-公开
标题翻译：具有改性的水杨酸酯调节转录物的高生产性重组酵母菌株
公开(公告)号：WO2006118550A3
公开(公告)日：2007-02-01
申请号：PCT/SI2006000011
申请日：2006-04-14
申请人： KEMIJSKI INST , NOVAK STAGOJ MATEJA , COMINO SASA , KOMEL RADOVAN
发明人： NOVAK STAGOJ MATEJA , COMINO SASA , KOMEL RADOVAN
IPC分类号： C12N15/81 , C12P21/00 , C12R1/85
CPC分类号： C12N1/18 , C12N15/81 , C12P21/02
摘要： Highly productive recombinant yeast strains with modified galactose-regulated transcription, and use thereof . The object of this invention are highly-productive recombinant organisms with galactose-regulation, in which on chromosomes the gene encoding the enzyme for the metabolic conversion of the transcription inductor into an inactive product is replaced with a gene encoding the transcription factor for the galactose-inducible promoter. The isogenic strain is preferably chosen from Saccharomycetaceae or Cryptococcaceae families, more preferably the Saccharomyces genus. TheGAL1 gene encodes the enzyme for the galactose metabolism, and the GAL4 gene encodes the transcription factor. The galactose-inducible promoter is regulated by the Gal4 transcription factor, and regulates the transcription of GAL1, GAL2, GAL7, GAL10 or MEL1. The claimed strains are hosts for plasmids applicable in heterologous gene expression from the galactose-inducible promoter, and are used in the production of bioactive substances, and other products of biotechnology. The object of this invention is the production of bioactive substances, and other products of biotechnology, using above described strains.
摘要翻译：具有修饰的半乳糖调节转录的高效重组酵母菌株及其用途。本发明的目的是具有半乳糖调节的高生产性重组体生物，其中染色体上编码用于将转录感应器代谢转化为酶的基因的基因被编码半乳糖转运酶转录因子的基因所取代，诱导型启动子。等原生菌株优选选自酵母科或隐球藻科，更优选选自酵母属（Saccharomyces）属。 GAL1基因编码半乳糖代谢酶，GAL4基因编码转录因子。半乳糖诱导型启动子由Gal4转录因子调节，调节GAL1，GAL2，GAL7，GAL10或MEL1的转录。所要求的菌株是适用于来自半乳糖诱导型启动子的异源基因表达的质粒的宿主，并且用于生物活性物质和其他生物技术产品的生产。本发明的目的是使用上述菌株生产生物活性物质和其他生物技术产品。

9. 发明申请

WO2013012398A3 ELECTROCATALYTIC COMPOSITE(S), ASSOCIATED COMPOSITION(S), AND ASSOCIATED PROCESS(ES) 审中-公开
标题翻译：电解质组合物，相关组合物和相关方法（ES）
公开(公告)号：WO2013012398A3
公开(公告)日：2013-04-25
申请号：PCT/SI2012000047
申请日：2012-07-18
申请人： KEMIJSKI INST , BELE MARJAN , GABERSCEK MIRAN , KAPUN GREGOR , HODNIK NEJC , HOCEVAR STANKO
发明人： BELE MARJAN , GABERSCEK MIRAN , KAPUN GREGOR , HODNIK NEJC , HOCEVAR STANKO
IPC分类号： H01M4/92 , B01J23/42 , B01J37/08 , C22C5/04
CPC分类号： H01M4/921 , B22F1/0018 , B22F1/025 , B22F9/22 , B22F9/30 , B22F2999/00 , B82Y30/00 , C22C1/05 , C22C5/04 , C22C9/00 , C22C9/06 , C22C19/03 , H01M4/926 , Y02E60/50 , Y02E60/523 , B22F2201/013 , B22F2201/11
摘要： Compositions having electrocatalytic activity and composites having electrocatalytic activity, as well as processes for making compositions and composites are described. Also process for using such compositions and/or composites, such as, for example, a machine or equipment are described Some aspects of embodiments and/or embodiments of the present invention are directed to a nanosize transition metal alloy (such as for example an alloy comprising copper, cobalt, nickel, palladium, platinum, ruthenium, the like, and combinations thereof) that is electrocatalytically active. Some other aspects of embodiments and/or embodiments of the present invention are directed to a composite material comprising a nanosize transition metal alloy and a carbonaceous matrix.
摘要翻译：描述了具有电催化活性的组合物和具有电催化活性的复合材料，以及制备组合物和复合材料的方法。还描述了使用这种组合物和/或复合材料（例如机器或设备）的方法。本发明的实施方式和/或实施方式的一些方面涉及纳米尺寸过渡金属合金（诸如例如合金包括铜，钴，镍，钯，铂，钌等，以及它们的组合），其具有电催化活性。本发明的实施方案和/或实施方案的一些其他方面涉及包含纳米尺寸过渡金属合金和含碳基质的复合材料。

10. 发明申请

WO2011119119A3 THE COMBINATION OF ANTIFUNGAL COMPOUND AND MODIFIER OF PROTON HOMEOSTASIS FOR DESTROYING OR GROWTH INHIBITION AND REPRODUCTION OF FUNGI 审中-公开
标题翻译：抗真菌化合物的组合和原子生物修复的破坏或增殖抑制和真菌繁殖
公开(公告)号：WO2011119119A3
公开(公告)日：2012-04-05
申请号：PCT/SI2010000050
申请日：2010-09-07
申请人： KEMIJSKI INST , BENCINA MOJCA , BAGAR TANJA , MEDVED NATASA
发明人： BENCINA MOJCA , BAGAR TANJA , MEDVED NATASA
IPC分类号： A01N43/04 , A01N37/06 , A61K31/19 , A61K31/4164 , A61K31/4196 , A61K31/70
CPC分类号： A61K31/4164 , A01N37/06 , A01N43/16 , A61K31/19 , A61K31/4196 , A61K31/70 , A01N43/50 , A01N43/60 , A01N43/653 , A01N43/90 , A01N2300/00
摘要： The presented invention refers to the combination of an antifungal substance and a proton homeostasis modifier for enhancing the fungicidic or fungistatic action of the antifungal substance for treating or preventing fungal infections. The invention refers to a medicament or a plant protection product, which contains the combination. The invention refers to a method for preventing and treating fungal infection and in vitro for the disinfection of surfaces and implants.
摘要翻译：本发明涉及抗真菌物质和质子稳态调节剂的组合，用于增强用于治疗或预防真菌感染的抗真菌物质的杀真菌剂或抑菌作用。本发明涉及包含该组合的药物或植物保护产品。本发明涉及一种预防和治疗真菌感染和体外消毒表面和植入物的方法。

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