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    • 10. 发明申请
    • PROCESS FOR THE MANUFACTURE OF 3,7-DIMETHYL-1-OCTEN-3-OL
    • 制备3,7-二甲基-1-戊烯-3-OL的方法
    • WO2012025559A2
    • 2012-03-01
    • PCT/EP2011/064531
    • 2011-08-24
    • DSM IP Assets B.V.BONRATH, WernerTSCHUMI, JohannesMEDLOCK, Jonathan
    • BONRATH, WernerTSCHUMI, JohannesMEDLOCK, Jonathan
    • C07C29/42
    • C07C29/17C07C29/42C07C45/62C07C33/03C07C33/042C07C49/04
    • The present invention is directed to a process for the manufacture of 3,7-dimethyl-l-octen-3-ol comprising the following steps: a) hydrogenation of 6-methyl-5-hepten-2-on to 6-methyl-2-heptanon in the presence of hydrogen and a palladium containing catalyst on a carrier selected from the group consisting of carbon, calcium carbonate and aluminum oxide. b) reaction of 6-methyl-2-heptanon with acetylene to 3,7-dimethyl-l-octin-3-ol in the presence of ammonia and potassium hydroxide and in the absence of any additional organic solvent; c) hydrogenation of 3,7-dimethyl-l -octin-3-ol to 3,7-dimethyl-l-octen-3-ol in the presence of hydrogen and a palladium containing catalyst on a carrier selected from the group consisting of calcium carbonate, aluminum oxide, silica, porous glass, carbon or graphite, and barium sulphate, with the proviso that the catalyst additionally contains lead when the carrier is calcium carbonate. The present invention is further directed to a process for the manufacture of isophytol and vitamin E, where a thus produced 3,7-dimethyl-l-octen-3-ol is used as starting material.
    • 本发明涉及制备3,7-二甲基-1-辛烯-3-醇的方法,包括以下步骤:a)将6-甲基-5-庚烯-2-酮氢化为6-甲基-1-辛烯-3-醇, 在氢气和含钯催化剂的存在下,在选自碳,碳酸钙和氧化铝的载体上存在2-庚酮。 b)在氨和氢氧化钾存在下,在不存在任何另外的有机溶剂的情况下,将6-甲基-2-庚酮与乙炔反应至3,7-二甲基-1-辛烯-3-醇; c)在氢和含钯催化剂存在下,在选自以下的载体上,将3,7-二甲基-1-辛烯-3-醇氢化为3,7-二甲基-1-辛烯-3-醇: 碳酸钙,氧化铝,二氧化硅,多孔玻璃,碳或石墨和硫酸钡,条件是当载体是碳酸钙时,催化剂另外含有铅。 本发明进一步涉及用于制造异生醇和维生素E的方法,其中使用如此制备的3,7-二甲基-1-辛烯-3-醇作为起始原料。