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1. 发明申请

WO2011155979A2 PROCESS FOR PREPARING STABLE DISPERSIONS OF STARCH PARTICLES 审中-公开
标题翻译：制备稳定的淀粉分散体的方法
公开(公告)号：WO2011155979A2
公开(公告)日：2011-12-15
申请号：PCT/US2011/001019
申请日：2011-06-06
申请人： DOW GLOBAL TECHNOLOGIES LLC , WELSCH, Gregory, W. , NINNESS, Brian, J. , READ, Michael , YOUNG, Timothy, J. , MATTEUCCI, Michal, E. , HAMMOND, David, E. , HONG, Liang
发明人： WELSCH, Gregory, W. , NINNESS, Brian, J. , READ, Michael , YOUNG, Timothy, J. , MATTEUCCI, Michal, E. , HAMMOND, David, E. , HONG, Liang
IPC分类号： B32B9/02 , C09D103/00 , C04B16/00
CPC分类号： D21H19/12 , C08B30/02 , C08B30/04 , C08B30/06 , C08B30/08 , C08B30/12 , C08J3/05 , C08J3/12 , C08J2303/02 , C08L3/02 , C09D103/02 , C09J103/02 , C12P19/04 , D21H17/28 , D21H19/54 , D21H21/20 , Y10T428/2982 , Y10T428/31971
摘要： In one or more embodiments, the present disclosure provides for a process for preparing a dispersion of starch particles in an aqueous liquid. In one or more embodiments, the process includes introducing a feed starch and the aqueous liquid into a rotor stator mixer, maintaining the feed starch and the aqueous liquid in the rotor stator mixer at a temperature ranging from a gelation temperature to less than a solubilization temperature, and shearing the feed starch into starch particles with the rotor stator mixer to form the dispersion of starch particles in the aqueous liquid. In one or more embodiments, the starch particles produced by this process have an average particle size diameter of no larger than 2 micrometers and the dispersion has 20 to 65 weight percent of the starch particles based on a total weight of the dispersion.
摘要翻译：在一个或多个实施方案中，本公开提供了一种制备淀粉颗粒在水性液体中的分散体的方法。在一个或多个实施方案中，该方法包括将进料淀粉和含水液体引入转子定子混合器中，将进料淀粉和水性液体保持在转子定子混合器中，温度范围为凝胶化温度至小于溶解温度并用转子定子混合器将饲料淀粉剪切成淀粉颗粒，以形成淀粉颗粒在含水液体中的分散体。在一个或多个实施方案中，通过该方法生产的淀粉颗粒的平均粒度直径不大于2微米，并且基于分散体的总重量，分散体具有20至65重量％的淀粉颗粒。

2. 发明申请

WO2011119288A2 MULTILAYER MELT-EXTRUDED FILM 审中-公开
标题翻译：多层薄膜挤出膜
公开(公告)号：WO2011119288A2
公开(公告)日：2011-09-29
申请号：PCT/US2011/026230
申请日：2011-02-25
申请人： DOW GLOBAL TECHNOLOGIES LLC , HALL, Mark , COPPENS, Karen , READ, Michael , SHRESTHA, Uma
发明人： HALL, Mark , COPPENS, Karen , READ, Michael , SHRESTHA, Uma
IPC分类号： A61K9/00 , A61K9/70 , A61K47/34 , A61K45/06 , A61K31/167 , A61K31/522 , A61K47/10 , A61K47/26
CPC分类号： A61K31/522 , A61K9/0014 , A61K9/006 , A61K9/7007 , A61K31/167 , A61K47/10
摘要： High amounts of active ingredients, such as drugs, can be incorporated into a multilayer melt-extruded film which comprises i) one or more active ingredient layers produced from a melt-extruded polymer composition comprising a) a water-soluble polymer and b) an active ingredient; and ii) one or more removable protective layers which leave the active ingredient layer(s) substantially intact upon removal of the protective layer(s).
摘要翻译：可以将大量活性成分（例如药物）掺入多层熔融挤出膜中，其包括i）由熔融挤出的聚合物组合物制备的一种或多种活性成分层，其包含a）水溶性聚合物和b）有效成分; 和ii）一个或多个可移除的保护层，其在去除保护层时基本上保持活性成分层。

3. 发明申请

WO2011119289A3 A PROCESS FOR PRODUCING A MELT-EXTRUDED FILM, AND MELT-EXTRUDED FILM 审中-公开
公开(公告)号：WO2011119289A3
公开(公告)日：2011-09-29
申请号：PCT/US2011/026234
申请日：2011-02-25
申请人： DOW GLOBAL TECHNOLOGIES LLC , HALL, Mark , READ, Michael , SHRESTHA, Uma
发明人： HALL, Mark , READ, Michael , SHRESTHA, Uma
IPC分类号： B29C47/00 , A61K9/70 , B29C55/00 , B32B27/08 , B32B27/18 , C08J5/18
摘要： A melt-extruded film is produced by a process which comprises the steps of blending a) a water-soluble polymer, b) an active ingredient, and c) optional additives and subjecting the blend to melt-extrusion to produce an extruded melt and drawing the extruded melt at a draw-down ratio of from 1.5 to 20 to a film of a thickness of at least 0.04 mm.

4. 发明申请

WO2011119287A1 MELT-EXTRUDED FILM 审中-公开
标题翻译：熔融挤出膜
公开(公告)号：WO2011119287A1
公开(公告)日：2011-09-29
申请号：PCT/US2011/026225
申请日：2011-02-25
申请人： DOW GLOBAL TECHNOLOGIES LLC , HALL, Mark , READ, Michael , SHRESTHA, Uma
发明人： HALL, Mark , READ, Michael , SHRESTHA, Uma
IPC分类号： C08J5/18 , A61K9/70 , C08L1/26 , C08L71/02
CPC分类号： A61K31/192 , A61K9/0056 , C08J5/18 , C08J2301/26 , C08J2371/02
摘要： A mono-layer or multi-layer film wherein at least one of the layers has a thickness of at least 0.125 mm is produced from a melt-extruded polymer composition comprising a) a water-soluble polymer, b) an active ingredient and c) an adjuvant selected from the group consisting of mono- and disaccharides, sugar alcohols, low molecular weight water soluble polymers, and salts of cross-linked carboxymethylcellulose, with the proviso that the adjuvant c) is different from the water-soluble polymer a).
摘要翻译：一层或多层薄膜，其中至少一层的厚度至少为0.125毫米，由熔体挤出的聚合物组合物制成，该组合物包含a）水溶性聚合物，b）活性成分和c）选自单糖和二糖，糖醇，低分子量水溶性聚合物和交联羧甲基纤维素盐的佐剂，条件是佐剂c）不同于水溶性聚合物a）。

5. 发明申请

WO2014089788A1 HARDENER COMPOUND FOR EPOXY SYSTEM 审中-公开
标题翻译：环氧化合物硬化剂
公开(公告)号：WO2014089788A1
公开(公告)日：2014-06-19
申请号：PCT/CN2012/086470
申请日：2012-12-12
申请人： DOW GLOBAL TECHNOLOGIES LLC , ZHANG, Chao , XIONG, Jiawen , CHEN, Hongyu , CHIOU, Nan-Rong
发明人： ZHANG, Chao , XIONG, Jiawen , CHEN, Hongyu , CHIOU, Nan-Rong , MULLINS, Michael J. , READ, Michael , STORER, Joey W.
IPC分类号： C08F212/08 , C08F222/08 , C08F267/04
CPC分类号： C08L83/06 , C08F8/30 , C08F8/42 , C08F212/08 , C08F222/08 , C08G59/4007 , C08G59/4085 , C08G59/42 , C08G77/80 , C08L2312/08 , C08F222/06 , C08F2222/408
摘要： Embodiments of the present disclosure include a hardener compound for curing with an epoxy resin, where the hardener compound includes a copolymer having a first constitutional unit of the formula (I), a second constitutional unit of the formula (II), and a third constitutional unit of the formula (III), where each q, n and m is independently a positive integer; each b is independently selected from the group of 6, 8, 10 and 12; each Y is independently an organic group; and each R is independently selected from the group of a hydrogen, an organic group and a halogen. Embodiments of the present disclosure include an epoxy system that includes the hardener compound and an epoxy resin.
摘要翻译：本公开的实施方案包括用于用环氧树脂固化的固化剂化合物，其中所述固化剂化合物包括具有式（I）的第一结构单元的共聚物，式（II）的第二结构单元和第三结构式式（III）的单元，其中每个q，n和m独立地为正整数; 每个b独立地选自6,8,10和12组; 每个Y独立地是有机基团; 并且每个R独立地选自氢，有机基团和卤素。本公开的实施方案包括包含固化剂化合物和环氧树脂的环氧体系。

6. 发明申请

WO2005092065A2 NOVEL TRICYCLIC COMPOUNDS AND RELATED METHODS OF TREATMENT 审中-公开
标题翻译：新型三环化合物及相关治疗方法
公开(公告)号：WO2005092065A2
公开(公告)日：2005-10-06
申请号：PCT/US2005/009681
申请日：2005-03-24
申请人： TRANSFORM PHARMACEUTICALS, INC. , MORISSETTE, Sherry , READ, Michael
发明人： MORISSETTE, Sherry , READ, Michael
CPC分类号： C07D498/04
摘要： The invention provides novel lipid soluble forms of tricyclic antineoplastic compounds. These forms include salts, co-crystals, and solvates of the tricyclic antineoplastic compounds. The invention also provides novel pharmaceutical compositions comprising these novel lipid soluble forms and related methods of treatment. Compositions and methods of the invention are useful in the treatment of neoplasms, including MRP-1-related resistant neoplasms.
摘要翻译：本发明提供三环抗肿瘤化合物的新型脂溶性形式。这些形式包括三环抗肿瘤化合物的盐，共晶和溶剂合物。本发明还提供包含这些新型脂溶性形式和相关治疗方法的新型药物组合物。本发明的组合物和方法可用于治疗包括MRP-1相关抗性肿瘤在内的肿瘤。

7. 发明申请

WO2004076403A1 SUMATRIPTAN CRYSTALLINE FORMS, PHARMACEUTICAL COMPOSITIONS AND METHODS 审中-公开
标题翻译： SUMATRIPTAN结晶形式，药物组合物和方法
公开(公告)号：WO2004076403A1
公开(公告)日：2004-09-10
申请号：PCT/US2004/005560
申请日：2004-02-23
申请人： TRANSFORM PHARMACEUTICALS, INC. , MORISSETTE, Sherry, L. , ALMARSSON, Örn , READ, Michael
发明人： MORISSETTE, Sherry, L. , ALMARSSON, Örn , READ, Michael
IPC分类号： C07C303/40
CPC分类号： B01F3/18 , B01F7/00258 , B01F7/18 , B01F11/0065 , B01F13/0059 , B01F13/0272 , B01L3/0217 , G01G19/00 , G01N1/286
摘要： The invention provides novel soluble sumatriptan crystalline forms that include polymorphs, salts, co-crystals and related solvates useful as pharmaceuticals. The invention also provides pharmaceutical compositions comprising, and processes for making, these sumatriptan crystalline forms. Methods of using such compositions for the treatment or prevention of migraine headaches and related neurological disorders are also provided.
摘要翻译：本发明提供了可溶性舒马普坦结晶形式，其包括可用作药物的多晶型物，盐，共晶体和相关溶剂合物。本发明还提供包含这些舒马曲坦结晶形式的药物组合物和制备方法。还提供了使用这些组合物治疗或预防偏头痛和相关神经系统疾病的方法。

8. 发明申请

WO2004075241A1 NOZZLES FOR ELECTROSPRAY IONIZATION AND METHODS OF FABRICATING THEM 审中-公开
标题翻译：静电放电喷嘴及其制作方法
公开(公告)号：WO2004075241A1
公开(公告)日：2004-09-02
申请号：PCT/SE2004/000229
申请日：2004-02-19
申请人： ÅMIC AB , LARSSON, Olle , SIGMUNDSSON, Toni , READ, Michael , ÖHMAN, Ove
发明人： LARSSON, Olle , SIGMUNDSSON, Toni , READ, Michael , ÖHMAN, Ove
IPC分类号： H01J49/04
CPC分类号： H01J49/167 , H01J49/0018
摘要： A nozzle chip (3') for ejecting a liquid such as in an electrospray device is built from a substrate chip having grooves (5, 7) on a top surface. A lid (25) is attached to the top surface closing the grooves to form channels one of which has an open outlet end (9). At the outlet end a nozzle is formed at or attached and it has an outlet opening from which the liquid is to be ejected. Alignment recesses (13, 15) are made at edges of the substrate chip and they are accurately positioned in relation to the outlet opening, the alignment recesses allowing an accurate mounting of nozzle chip giving the outlet opening of the nozzle a reproducible position in the device where it is to be used. At the outlet end a recess (17) in the substrate chip can be provided and the nozzle can then be located in the recess to mechanically protect it.
摘要翻译：用于喷射诸如电喷雾装置中的液体的喷嘴芯片（3'）从在顶表面上具有凹槽（5,7）的衬底芯片构建。盖（25）附接到顶表面，封闭沟槽以形成通道，其中一个具有开放的出口端（9）。在出口处，喷嘴形成在或附接并且具有出口，液体从该出口开始喷出。对准凹槽（13,15）在基片的边缘处形成，并且它们相对于出口开口精确地定位，所述对准凹槽允许精确地安装喷嘴芯片，使得喷嘴的出口开口在装置中是可再现的位置在哪里使用。在出口端，可以设置衬底芯片中的凹部（17），然后可以将喷嘴定位在凹部中以机械地保护其。

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