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1. 发明申请

WO2013016488A1 CERTAIN KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF 审中-公开
标题翻译：某些京那奈因-3-MONOOXYGENASE抑制剂，药物组合物及其使用方法
公开(公告)号：WO2013016488A1
公开(公告)日：2013-01-31
申请号：PCT/US2012/048254
申请日：2012-07-26
申请人： DOMINGUEZ, Celia , TOLEDO-SHERMAN, Leticia, M. , COURTNEY, Stephen, Martin , PRIME, Michael , MITCHELL, William , BROWN, Christopher, John , DE AGUIAR PENA, Paula, C. , JOHNSON, Peter
发明人： DOMINGUEZ, Celia , TOLEDO-SHERMAN, Leticia, M. , COURTNEY, Stephen, Martin , PRIME, Michael , MITCHELL, William , BROWN, Christopher, John , DE AGUIAR PENA, Paula, C. , JOHNSON, Peter
IPC分类号： A01N43/54 , C07D239/42 , C07D471/04
CPC分类号： A61K31/506 , A61K31/505 , A61K31/513 , A61K31/5377 , C07D239/26 , C07D239/28 , C07D239/42 , C07D401/04 , C07D403/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D491/044 , C07D491/048 , C07D491/052
摘要： Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.
摘要翻译：本文提供了某些化学实体。还提供了包含至少一种化学实体和一种或多种药学上可接受的载体的药物组合物。描述了治疗患有对KMO活性的抑制作用的某些疾病和病症的患者的方法，其包括给予这些患者一定量的至少一种有效减少疾病或病症的体征或症状的化学实体。这些疾病包括神经变性疾病如亨廷顿氏病。还描述了治疗方法，包括给予至少一种作为单一活性剂的化学实体或与一种或多种其它治疗剂组合施用至少一种化学实体。还提供了用于筛选能够抑制KMO活性的化合物的方法。

2. 发明申请

WO2016033440A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN 审中-公开
标题翻译：用于成像蛋白质的探针
公开(公告)号：WO2016033440A1
公开(公告)日：2016-03-03
申请号：PCT/US2015/047401
申请日：2015-08-28
申请人： CHDI FOUNDATION, INC. , DOMINGUEZ, Celia , WITYAK, John , BARD, Jonathan , KISELYOV, Alex , BROWN, Christopher, John , PRIME, Michael, Edward , JOHNSON, Peter, David , CLARK-FREW, Daniel , SCHAERTL, Sabine , HERRMANN, Frank , GRIMM, Steffan, Kaspar , KAHMANN, Jan, Dirk , SCHEICH, Christoph
发明人： DOMINGUEZ, Celia , WITYAK, John , BARD, Jonathan , KISELYOV, Alex , BROWN, Christopher, John , PRIME, Michael, Edward , JOHNSON, Peter, David , CLARK-FREW, Daniel , SCHAERTL, Sabine , HERRMANN, Frank , GRIMM, Steffan, Kaspar , KAHMANN, Jan, Dirk , SCHEICH, Christoph
IPC分类号： A01N57/00
CPC分类号： C07D519/00 , A61K51/0455 , A61K51/0459 , C07D471/04
摘要： Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use. Formula (I)
摘要翻译：提供了包含式I化合物或其药学上可接受的盐的成像剂及其使用方法。式（I）

3. 发明申请

WO2016033460A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN 审中-公开
标题翻译：用于成像蛋白质的探针
公开(公告)号：WO2016033460A1
公开(公告)日：2016-03-03
申请号：PCT/US2015/047427
申请日：2015-08-28
申请人： CHDI FOUNDATION, INC. , DOMINGUEZ, Celia , WITYAK, John , BARD, Jonathan , BROWN, Christopher, John , PRIME, Michael, Edward , WEDDELL, Derek, Alexander , WALTER, Daryl, Simon , GILES, Paul, Richard , WIGGINTON, Ian, James , TAYLOR, Malcolm, George , GALAN, Sébastien, René, Gabriel , JOHNSON, Peter, David , KRÜLLE, Thomas, Martin , MORAO, Inaki , CLARK-FREW, Daniel , SCHAERTL, Sabine , HERRMANN, Frank , GRIMM, Steffen, Kaspar , KAHMANN, Jan, Dirk , SCHEICH, Christoph
发明人： DOMINGUEZ, Celia , WITYAK, John , BARD, Jonathan , BROWN, Christopher, John , PRIME, Michael, Edward , WEDDELL, Derek, Alexander , WALTER, Daryl, Simon , GILES, Paul, Richard , WIGGINTON, Ian, James , TAYLOR, Malcolm, George , GALAN, Sébastien, René, Gabriel , JOHNSON, Peter, David , KRÜLLE, Thomas, Martin , MORAO, Inaki , CLARK-FREW, Daniel , SCHAERTL, Sabine , HERRMANN, Frank , GRIMM, Steffen, Kaspar , KAHMANN, Jan, Dirk , SCHEICH, Christoph
IPC分类号： A01N43/42
CPC分类号： C12Q1/6823 , A61K51/0419 , A61K51/0453 , A61K51/0455 , C07D253/08 , C07D401/04 , C07D473/00
摘要： Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use.
摘要翻译：提供了包含式（I）化合物或其药学上可接受的盐的成像剂及其使用方法。

4. 发明申请

WO2016033445A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN 审中-公开
标题翻译：成像探针亨廷顿蛋白
公开(公告)号：WO2016033445A1
公开(公告)日：2016-03-03
申请号：PCT/US2015/047407
申请日：2015-08-28
申请人： CHDI FOUNDATION, INC. , DOMINGUEZ, Celia , WITYAK, John , BARD, Jonathan , KISELYOV, Alex , BROWN, Christopher, John , GALAN, Sebastien, Rene Gabriel , PRIME, Michael, Edward , GILES, Paul, Richard , GADOULEAU, Elise, Luciennen Paulette , KRÜLLE, Thomas, Martin , CLARK-FREW, Daniel , JOHNSON, Peter, David , SCHAERTL, Sabine , HERRMANN, Frank , GRIMM, Steffen, Kaspar , KAHMANN, Jan, Dirk , SCHEICH, Christoph , COE, Samuel , HAYES, Sarah
发明人： DOMINGUEZ, Celia , WITYAK, John , BARD, Jonathan , KISELYOV, Alex , BROWN, Christopher, John , GALAN, Sebastien, Rene Gabriel , PRIME, Michael, Edward , GILES, Paul, Richard , GADOULEAU, Elise, Luciennen Paulette , KRÜLLE, Thomas, Martin , CLARK-FREW, Daniel , JOHNSON, Peter, David , SCHAERTL, Sabine , HERRMANN, Frank , GRIMM, Steffen, Kaspar , KAHMANN, Jan, Dirk , SCHEICH, Christoph , COE, Samuel , HAYES, Sarah
IPC分类号： C07D279/00
CPC分类号： C07D513/04 , A61K51/0455 , A61K51/0459 , A61K51/0463 , C07D263/57 , C07D405/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D471/04 , C07D498/04
摘要： Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use.
摘要翻译：提供包含式（I）化合物或其药学上可接受的盐的显像剂及其使用方法。

5. 发明申请

WO2016033436A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN 审中-公开
标题翻译：用于成像蛋白质的探针
公开(公告)号：WO2016033436A1
公开(公告)日：2016-03-03
申请号：PCT/US2015/047396
申请日：2015-08-28
申请人： CHDI FOUNDATION, INC. , DOMINGUEZ, Celia , WITYAK, John , BARD, Jonathan , BROWN, Christopher, John , KRÜLLE, Thomas, Martin , CLARK-FREW, Daniel , HAYES, Sarah , SCHAERTL, Sabine , HERRMANN, Frank , GRIMM, Steffen, Kaspar , KAHMANN, Jan, Dirk , SCHEICH, Christoph
发明人： DOMINGUEZ, Celia , WITYAK, John , BARD, Jonathan , BROWN, Christopher, John , KRÜLLE, Thomas, Martin , CLARK-FREW, Daniel , HAYES, Sarah , SCHAERTL, Sabine , HERRMANN, Frank , GRIMM, Steffen, Kaspar , KAHMANN, Jan, Dirk , SCHEICH, Christoph
IPC分类号： C07D403/02
CPC分类号： A61K51/0455 , C07B2200/05 , C07D401/04 , C07D401/14 , C07D403/04 , C07D487/04 , C07D513/04 , C07D513/14
摘要： Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.
摘要翻译：提供了包含式I化合物或其药学上可接受的盐的成像剂及其使用方法。

6. 发明申请

WO2011064606A2 MILL AND METHOD OF MILLING 审中-公开
标题翻译：铣刀和铣削方法
公开(公告)号：WO2011064606A2
公开(公告)日：2011-06-03
申请号：PCT/GB2011/000094
申请日：2011-01-25
申请人： BROWN, CHRISTOPHER JOHN , BROWN, Christopher, John
发明人： BROWN, Christopher, John
CPC分类号： B02C15/16
摘要： A milling apparatus in which at least two independently driven axiaily mounted elements are eccentrically mounted one within the other so as to define a processing chamber therebetween with the minimum radial gap between the elements at one position being diametrically opposite to the maximum radial gap. Stresses are applied to the material by passing it through the minimum radial gap, which is adjustable. The elements may be rotated in the same direction to apply compressive and extensional stresses to material within the minimum gap, or in opposite directions to apply shear stresses to the material within this gap. A third element may be incorporated within the chamber to provide heat transfer and distributive mixing to the stressed material.
摘要翻译：一种铣削装置，其中至少两个独立驱动的轴向安装的元件偏心地安装在另一个中，以便在其间限定一个处理室，其中一个位置处的元件之间的最小径向间隙与最大径向间隙完全相反。通过将材料通过可调节的最小径向间隙施加应力。元件可以沿相同的方向旋转，以将压缩和拉伸应力施加在最小间隙内的材料上，或者在相反方向上施加剪切应力到该间隙内的材料。第三元件可以并入室中以提供热应力材料的热传递和分配混合。

7. 发明申请

WO2010089320A1 DISTRIBUTIVE AND DISPERSIVE MIXING APPARATUS OF THE CDDM TYPE, AND ITS USE 审中-公开
标题翻译： CDDM类型的分布式和分散混合装置及其使用
公开(公告)号：WO2010089320A1
公开(公告)日：2010-08-12
申请号：PCT/EP2010/051292
申请日：2010-02-03
申请人： UNILEVER PLC , UNILEVER N.V. , HINDUSTAN UNILEVER LIMITED , BROWN, Christopher, John , IRVING, Graeme, Neil , KOWALSKI, Adam, Jan
发明人： BROWN, Christopher, John , IRVING, Graeme, Neil , KOWALSKI, Adam, Jan
IPC分类号： B01F7/00 , B01F3/08
CPC分类号： B01F7/00775 , B01F3/0807 , B01F7/00783 , B01F7/00816 , B01F7/00825
摘要： A distributive and dispersive mixing apparatus of the CDDM type comprising two confronting surfaces as being the inner surface of shell (4) and the outer surface of fixed cage (2)) and at least one cage-like member (3) disposed between the confronting surfaces said cage-like member (3) defining passages for fluid flow adjacent at least one of the confronting surfaces CHARACTERISED IN THAT the or at least one cage-like member (3) has a relative rotational movement but is not freely rotating relative to at least one of the confronting surfaces and/or at least one other cage-like member, and the bulk fluid flow within the mixing apparatus is in the plane of the surface of the or at least one cage-like member perpendicular to the direction of relative rotational movement.
摘要翻译：一种CDDM型分布式和分散混合装置，包括两个相对的表面作为壳体（4）的内表面和固定笼（2）的外表面）和至少一个笼状构件（3）表面所述笼状构件（3）限定用于流体流动的通道，其邻近表面中的至少一个表面，其特征在于，所述或至少一个笼状构件（3）具有相对旋转运动，但不相对于自由旋转至少一个相对的表面和/或至少一个其它笼状构件，并且混合装置内的主体流体流动在垂直于相对方向的该或该至少一个笼状构件的表面的平面中旋转运动。

8. 发明申请

WO2011048111A1 COMPOUNDS 审中-公开
标题翻译：化合物
公开(公告)号：WO2011048111A1
公开(公告)日：2011-04-28
申请号：PCT/EP2010/065746
申请日：2010-10-19
申请人： RESPIVERT LIMITED , KING-UNDERWOOD, John , ITO, Kazuhiro , MURRAY, Peter, John , HARDY, George , BROOKFIELD, Frederick, Arthur , BROWN, Christopher, John
发明人： KING-UNDERWOOD, John , ITO, Kazuhiro , MURRAY, Peter, John , HARDY, George , BROOKFIELD, Frederick, Arthur , BROWN, Christopher, John
IPC分类号： C07D487/04 , A61K31/519 , A61P11/00 , A61P11/06 , A61P17/00 , A61P19/02 , A61P35/00
CPC分类号： C07D487/04 , A61K31/4965
摘要： The present invention relates to compounds of formula (I) and to compositions comprising the same and to the use of the compounds and their 10 compositions in treatment, for example in the treatment of inflammatory diseases, in particular respiratory inflammatory disease. The invention also extends to methods of making said compounds.
摘要翻译：本发明涉及式（I）化合物和包含其的组合物，以及该化合物及其10种组合物在治疗中的用途，例如治疗炎性疾病，特别是呼吸道炎性疾病。本发明还涉及制备所述化合物的方法。

9. 发明申请

WO2010091983A1 MIXING APPARATUS OF THE CDDM- AND/OR CTM-TYPE, AND ITS USE 审中-公开
标题翻译： CDDM-和/或CTM型混合装置及其用途
公开(公告)号：WO2010091983A1
公开(公告)日：2010-08-19
申请号：PCT/EP2010/051295
申请日：2010-02-03
申请人： UNILEVER PLC , UNILEVER N.V. , HINDUSTAN UNILEVER LIMITED , BROWN, Christopher, John , IRVING, Graeme, Neil , KOWALSKI, Adam, Jan
发明人： BROWN, Christopher, John , IRVING, Graeme, Neil , KOWALSKI, Adam, Jan
IPC分类号： B01F7/00 , B01F3/08
CPC分类号： B01F7/00775 , B01F3/08 , B01F7/00816
摘要： A distributive and dispersive mixing apparatus comprising two confronting surfaces (1,2) having cavities (3) therein which on relative motion of the surfaces function as a cavity transfer mixer (CTM) or controlled deformation dynamic mixer (CDDM) or both, CHARACTERISED IN THAT the normal separation of the confronting surfaces varies in the direction of bulk flow, so as to define a plurality of regions of successive closer and wider spacing of the confronting surfaces.
摘要翻译：一种分布式和分散混合装置，包括其中具有空腔（3）的两个相对表面（1,2），其中表面的相对运动用作腔转移混合器（CTM）或受控变形动态混合器（CDDM）或两者，其特征在于面对面的正常分离在主体流动的方向上变化，从而限定面对面的连续更近和更宽间隔的多个区域。

10. 发明申请

WO2010089322A1 MIXING APPARATUS OF THE CDDM- OR CTM-TYPE, AND ITS USE 审中-公开
标题翻译： CDDM或CTM型混合装置及其用途
公开(公告)号：WO2010089322A1
公开(公告)日：2010-08-12
申请号：PCT/EP2010/051294
申请日：2010-02-03
申请人： UNILEVER PLC , UNILEVER N.V. , HINDUSTAN UNILEVER LIMITED , BROWN, Christopher, John , IRVING, Graeme, Neil , KOWALSKI, Adam, Jan
发明人： BROWN, Christopher, John , IRVING, Graeme, Neil , KOWALSKI, Adam, Jan
IPC分类号： B01F7/00 , B01F3/08
CPC分类号： B01F7/00766 , B01F3/08 , B01F7/00808
摘要： The invention provides a distributive and dispersive mixing apparatus of the CDDM or CTM type comprising two spaced-apart mutually rotatable confronting surfaces (1, 2) having cavities (3) therein. The surfaces have preferably relatively widely-spaced, axially-disposed confronting surfaces which alternate with preferably relatively narrowly-spaced, radially-disposed confronting surfaces, thereby preventing any leakage flow through the mixer and allowing expansion during operation with reduced danger of contact of the radially-disposed confronting surfaces.
摘要翻译：本发明提供了一种CDDM或CTM类型的分布式和分散混合装置，其包括在其中具有空腔（3）的两个间隔开的可相互旋转的相对表面（1,2）。这些表面具有优选地相对宽的间隔开的轴向设置的相对表面，其优选地相对狭窄间隔开的径向对置的表面交替，从而防止任何泄漏流过混合器，并允许在操作期间膨胀，同时减小径向接触的危险 - 面对面。

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