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1. 发明申请

WO2015070262A1 APPARATUS AND METHODS FOR DISINTEGRATION TESTING 审中-公开
标题翻译：装置和方法进行消毒试验
公开(公告)号：WO2015070262A1
公开(公告)日：2015-05-14
申请号：PCT/US2014/065331
申请日：2014-11-12
申请人： DISTEK, INC. , BRINKER, Jeffrey , CRAIG, Shawn , WANG, Wenyu
发明人： BRINKER, Jeffrey , CRAIG, Shawn , WANG, Wenyu
IPC分类号： G01N33/15 , G01N21/95
CPC分类号： G01N33/15 , G01N13/00 , G01N21/49 , G01N21/8507 , G01N21/9508 , G01N2013/006
摘要： In one embodiment, a disintegration or dissolution testing apparatus (100) including at least one area for a compartment (205) to hold a dosage form during disintegration testing, and at least one light emitter (302) and at least one light detector (303) arranged around each of the areas so as to face the area. The light detector (303) is adapted to provide, when a compartment (205) is disposed within the area, a signal indicative of the amount of detected light provided by the light emitter (302). In another embodiment, a bottom flange (202) for disintegration test apparatus (100) is encapsulated in a material that (i) permits the bottom flange (202) to be immersed in a liquid medium during disintegration testing without the liquid contacting any of the light emitters (302) or detectors (303), and (ii) permits light from the emitter (302) to pass through the material and be received by the light detector (303). The apparatus (100) comprises as well a drive assembly for driving the compartment (205) between a lowered position immersing the dosage form in the liquid medium and a raised postion.
摘要翻译：在一个实施方案中，一种崩解或溶解测试装置（100）包括至少一个用于在分解测试期间保持剂型的隔室（205）的区域，以及至少一个光发射器（302）和至少一个光检测器（303））布置在每个区域周围以面对该区域。光检测器（303）适于在隔室（205）设置在区域内时提供指示由光发射器（302）提供的检测光量的信号。在另一个实施例中，用于分解测试装置（100）的底部凸缘（202）被封装在以下材料中：（i）允许底部凸缘（202）在分解测试期间浸没在液体介质中，而液体接触任何光发射器（302）或检测器（303），和（ii）允许来自发射器（302）的光通过材料并被光检测器（303）接收。装置（100）还包括用于在将剂型浸入液体介质中的降低位置和升高的位置之间驱动隔室（205）的驱动组件。

2. 发明申请

WO2017151624A1 SAMPLE PROBE FOR DISSOLUTION TESTING AND THE LIKE 审中-公开
标题翻译：样品探针溶解试验等
公开(公告)号：WO2017151624A1
公开(公告)日：2017-09-08
申请号：PCT/US2017/019963
申请日：2017-02-28
申请人： DISTEK, INC.
发明人： BRINKER, Jeffrey , CRAIG, Shawn , SCHUTZ, Peter K. , NADOLSKI, Timothy, John
IPC分类号： B01L3/00
CPC分类号： G01N1/10 , B01L3/50825 , B01L3/561 , B01L3/563 , B01L2200/026 , B01L2300/042 , B01L2300/046 , B01L2300/0681 , B01L2300/0832 , B01L2300/0838 , G01N2001/1025
摘要： In one embodiment, a sample probe has a cap and a base, wherein the cap includes a grip portion and a projection portion. The projection portion fits within a hollow portion of a filter such that the filter is disposed on the outside of the projection portion and the filter and the cap form a cap assemblage. The base comprises a base recess that receives a portion of the cap assemblage including the filter. The cap and base include corresponding media transfer regions adjacent and connected to the filter that reduces flow resistance and chances of blockage and/or contamination during dissolution-testing sampling using the sample probe.
摘要翻译：在一个实施例中，样本探针具有帽和基部，其中帽包括抓握部分和突出部分。突起部分配合在过滤器的中空部分内，使得过滤器设置在突起部分的外侧，并且过滤器和帽形成帽组合件。基座包括基座凹槽，该基座凹座容纳包括过滤器的盖组件的一部分。盖子和底座包括与过滤器相邻并连接到过滤器的相应介质传输区域，以减少在使用样品探针进行溶解 - 测试取样期间的流动阻力和堵塞和/或污染的可能性。

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