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    • 5. 发明申请
    • SPATIAL AGGREGATION OF HOLISTICALLY-NESTED CONVOLUTIONAL NEURAL NETWORKS FOR AUTOMATED ORGAN LOCALIZATION AND SEGMENTATION IN 3D MEDICAL SCANS
    • 三维医学扫描仪自动化定位及分割的立体卷积神经网络的空间聚合
    • WO2017210690A1
    • 2017-12-07
    • PCT/US2017/035974
    • 2017-06-05
    • LU, LeROTH, HolgerNOGUES, Isabella-EmmanuellaSUMMERS, RonaldWANG, XiaosongHARRISON, Adam P.
    • LU, LeROTH, HolgerNOGUES, Isabella-EmmanuellaSUMMERS, RonaldWANG, XiaosongHARRISON, Adam P.
    • G06K9/00G06T7/00
    • G06K9/00G06K9/6273G06N3/0454G06N3/084G06N5/003G06T7/0012G06T7/11G06T7/143G06T2207/10081G06T2207/10088G06T2207/20072G06T2207/20084G06T2207/30056G06T2207/30092
    • Disclosed are systems and methods for localization and segmentation of organs (especially abnormally shaped, deformable, and/or smaller organs, such as the pancreas and lymph nodes) based on data from 3D medical imaging (e.g., CT and MRI scans) using holistically-nested convolutional neural networks ("HNNs"). Using as an example CT scan data and the pancreas, the methods can include localizing an organ from an entire 3D CT scan, providing a reliable bounding box for the more refined segmentation step. The methods can further comprise introducing a fully deep-learning approach, based on an efficient application of HNNs on the three orthogonal views. The resulting HNN per-pixel probability maps can then be fused using pooling to reliably produce a 3D bounding box of the pancreas that maximizes the recall. An introduced localizer compares favorably to both a conventional non-deep-learning method and a hybrid approach based on spatial aggregation of superpixels using random forest classification. The segmentation phase can operate within the computed bounding box and can integrate semantic mid-level cues of deeply-learned organ interior and boundary maps, obtained by two additional and separate realizations pf HNNs. By integrating these two mid-level cues, the disclosed methods are capable of generating boundary-preserving pixel-wise class label maps that result in exceptional final organ segmentations.
    • 公开了用于基于来自3D医学成像的数据定位和分割器官(特别是异常形状的,可变形的和/或更小的器官,诸如胰腺和淋巴结)的系统和方法(例如, CT和MRI扫描)使用整体嵌套卷积神经网络(“HNN”)。 以CT扫描数据和胰腺为例,这些方法可以包括从整个3D CT扫描中定位器官,为更精细的分割步骤提供可靠的边界框。 该方法可以进一步包括基于在三个正交视图上有效应用HNN来引入完全深度学习方法。 然后可以使用汇集来融合所得到的每个像素的HNN概率图,以可靠地产生胰腺的三维边界框,以最大化召回。 引入的定位器与传统的非深度学习方法和基于使用随机森林分类的​​超级像素的空间聚合的混合方法相比是有利的。 分割阶段可以在计算的边界框内运行,并且可以集成深度学习的器官内部和边界图的语义中级线索,通过两个额外的和单独的实现pN HNN获得。 通过整合这两个中级线索,所公开的方法能够生成保留边界像素类别标签映射,从而导致异常的最终器官分割。