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1. 发明申请

WO0236616A3 COMPOSITIONS AND METHODS RELATING TO BREAST SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与乳腺特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO0236616A3
公开(公告)日：2003-09-12
申请号：PCT/US0147739
申请日：2001-10-30
申请人： DIADEXUS INC , SUN YONGMING , RECIPON HERVE , SALCEDA SUSANA , LIU CHENGHUA , TURNER LEAH R
发明人： SUN YONGMING , RECIPON HERVE , SALCEDA SUSANA , LIU CHENGHUA , TURNER LEAH R
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , G01N33/574 , A61K38/17 , C07K16/18 , C12N5/10 , C12Q1/68
CPC分类号： C07K14/47 , A61K38/00 , G01N33/57415
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast tissue, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性乳腺细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗乳腺组织中的乳腺癌和非癌性疾病状态，鉴定乳腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程乳腺组织的生产。

2. 发明申请

WO0236807A2 COMPOSITIONS AND METHODS RELATING TO BREAST SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与乳腺特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO0236807A2
公开(公告)日：2002-05-10
申请号：PCT/US0146888
申请日：2001-10-29
申请人： DIADEXUS INC , SUN YONGMING , RECIPON HERVE , SALCEDA SUSANA , LIU CHENGHUA , TURNER LEAH R
发明人： SUN YONGMING , RECIPON HERVE , SALCEDA SUSANA , LIU CHENGHUA , TURNER LEAH R
IPC分类号： G01N33/50 , A61K39/00 , A61K39/395 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/574 , C12Q
CPC分类号： C07K14/47 , G01N33/57415
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast tissue, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides if the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性乳腺细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括鉴定，诊断，监测，分期，成像和治疗乳腺组织中的乳腺癌和非癌性疾病状态，鉴定乳腺组织，监测和/或设计多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程乳腺组织的生产。

3. 发明申请

WO02068645A8 COMPOSITIONS AND METHODS RELATING TO BREAST SPECIFIC GENES AND PROTEINS 审中-公开
公开(公告)号：WO02068645A8
公开(公告)日：2003-02-20
申请号：PCT/US0145151
申请日：2001-11-20
申请人： DIADEXUS INC , SALCEDA SUSANA , MACINA ROBERTO A , RECIPON HERVE , CAFFERKEY ROBERT , SUN YONGMING , LIU CHENGHUA , TURNER LEAH R
发明人： SALCEDA SUSANA , MACINA ROBERTO A , RECIPON HERVE , CAFFERKEY ROBERT , SUN YONGMING , LIU CHENGHUA , TURNER LEAH R
IPC分类号： C07K14/47 , C12N1/21 , C12N15/12 , C12Q1/68 , G01N33/574 , A61K31/7088 , A61K38/17 , A61K39/395 , C07K16/18
CPC分类号： G01N33/57415 , A61K2039/505 , C07K14/47 , C12Q1/6886 , C12Q2600/158
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast tissue, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.

4. 发明申请

WO2004013311A3 COMPOSITIONS AND METHODS RELATING TO OVARIAN SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与OVARIAN特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO2004013311A3
公开(公告)日：2006-05-04
申请号：PCT/US0324669
申请日：2003-08-06
申请人： DIADEXUS INC , MACINA ROBERTO A , SALCEDA SUSANA , LIU CHENGHUA , SUN YONGMING , TURNER LEAH R
发明人： MACINA ROBERTO A , SALCEDA SUSANA , LIU CHENGHUA , SUN YONGMING , TURNER LEAH R
IPC分类号： C12Q1/68 , A61K38/00 , A61K39/00 , C07H21/04 , C07K14/47
CPC分类号： C07K14/82 , A61K38/00 , A61K39/00 , C07K14/47
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and noncancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括鉴定，诊断，监测，分期，成像和治疗卵巢癌，非癌性疾病状态，鉴定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程化卵巢组织的生产。

5. 发明申请

WO0242499A2 COMPOSITIONS AND METHODS RELATING TO PROSTATE SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与前列腺特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO0242499A2
公开(公告)日：2002-05-30
申请号：PCT/US0145179
申请日：2001-11-20
申请人： DIADEXUS INC , SALCEDA SUSANA , MACINA ROBERTO A , RECIPON HERVE , CAFFERKEY ROBERT , ALI SHUJATH , SUN YONGMING , LIU CHENGHUA
发明人： SALCEDA SUSANA , MACINA ROBERTO A , RECIPON HERVE , CAFFERKEY ROBERT , ALI SHUJATH , SUN YONGMING , LIU CHENGHUA
IPC分类号： C07K14/47 , C12N15/12 , C12Q1/68
CPC分类号： C07K14/47
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic prostate cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses includes identifying, diagnosing, monitoring, staging, imaging and treating prostate cancer and non-cancerous disease states in prostate tissue, identifying prostate tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered prostate tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤前列腺细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗前列腺组织中的前列腺癌和非癌性疾病状态，鉴定前列腺组织，监测和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程前列腺组织的生产。

6. 发明申请

WO02055735A3 COMPOSITIONS AND METHODS RELATING TO PROSTATE SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与前列腺特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO02055735A3
公开(公告)日：2003-08-14
申请号：PCT/US0144363
申请日：2001-11-27
申请人： DIADEXUS INC , SALCEDA SUSANA , MACINA ROBERTO A , RECIPON HERVE , CAFFERKEY ROBERT , ALI SHUJATH , SUN YONGMING , LIU CHENGHUA , CHEN SEI-YU
发明人： SALCEDA SUSANA , MACINA ROBERTO A , RECIPON HERVE , CAFFERKEY ROBERT , ALI SHUJATH , SUN YONGMING , LIU CHENGHUA , CHEN SEI-YU
IPC分类号： C07H21/04 , C07K16/30 , C12N15/12 , C12Q1/68 , G01N33/574 , A61K39/00 , C07K14/47 , C07K16/18 , G01N33/53
CPC分类号： C07K16/3069 , C12Q1/6886 , C12Q2600/158
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic prostate cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating prostate cancer and non-cancerous disease states in prostate tissue, identifying prostate tissue, monitoring and identifying and/or designing agonists and antagonists of the invention. The use also include gene therapy, production of transgenic animals and cells, and production of engineered prostate tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤前列腺细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗前列腺组织中的前列腺癌和非癌性疾病状态，鉴定前列腺组织，监测和/或设计本发明的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程前列腺组织的生产。

7. 发明申请

WO0238606A3 COMPOSITIONS AND METHODS RELATING TO OVARY SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：有关卵巢特异性基因和蛋白质的组合物和方法
公开(公告)号：WO0238606A3
公开(公告)日：2003-05-15
申请号：PCT/US0146459
申请日：2001-11-07
申请人： DIADEXUS INC , SUN YONGMING , RECIPON HERVE , SALCEDA SUSANA , LIU CHENGHUA
发明人： SUN YONGMING , RECIPON HERVE , SALCEDA SUSANA , LIU CHENGHUA
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , A61K39/00 , C07K16/18 , C12N15/10 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic ovary cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and non-cancerous disease states in ovary tissue, identifying ovary tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovary tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤卵巢细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂的组合物以及使用这些组合物的方法。这些用途包括鉴定，诊断，监测，分期，成像和治疗卵巢组织中的卵巢癌和非癌性疾病状态，鉴定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。这些用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程卵巢组织的生产。

8. 发明申请

WO02064741A2 COMPOSITIONS AND METHODS RELATING TO BREAST SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与乳腺特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO02064741A2
公开(公告)日：2002-08-22
申请号：PCT/US0204134
申请日：2002-02-12
申请人： DIADEXUS INC , SALCEDA SUSANA , MACINA ROBERTO A , HU PING , RECIPON HERVE , KARRA KALPANA , CAFFERKEY ROBERT , LIU CHENGHUA , SUN YONGMING
发明人： SALCEDA SUSANA , MACINA ROBERTO A , HU PING , RECIPON HERVE , KARRA KALPANA , CAFFERKEY ROBERT , LIU CHENGHUA , SUN YONGMING
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , C07H21/02 , C07H21/04 , C07K14/47 , C12N
CPC分类号： C07K14/47 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/53 , C07K2319/00
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention, The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast tissue, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性乳腺细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂的组合物本发明和使用这些组合物的方法。这些用途包括鉴定诊断，监测，分期，成像和治疗乳腺组织中的乳腺癌和非癌性疾病状态，鉴定乳腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程乳腺组织的生产。

9. 发明申请

WO0240535A3 COMPOSITIONS AND METHODS RELATING TO OVARY SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO0240535A3
公开(公告)日：2003-08-21
申请号：PCT/US0145011
申请日：2001-11-20
申请人： DIADEXUS INC , SALCEDA SUSANA , MACINA ROBERTO A , RECIPON HERVE , CAFFERKEY ROBERT , SUN YONGMING , LIU CHENGHUA
发明人： SALCEDA SUSANA , MACINA ROBERTO A , RECIPON HERVE , CAFFERKEY ROBERT , SUN YONGMING , LIU CHENGHUA
IPC分类号： G01N33/53 , A61K39/00 , A61K39/395 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/566 , G01N33/574 , G01N33/68 , G01N33/50
CPC分类号： C07K14/47 , A61K39/00 , A61K2039/505 , A61K2039/53 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , G01N33/57449 , G01N33/68
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic ovary cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and non-cancerous disease states in ovary tissue, identifying ovary tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovary tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗卵巢组织中的卵巢癌和非癌性疾病状态，鉴定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程化卵巢组织的生产。

10. 发明申请

WO0242329A3 COMPOSITIONS AND METHODS RELATING TO PROSTATE SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：有关前列腺特异性基因和蛋白质的组合物和方法
公开(公告)号：WO0242329A3
公开(公告)日：2003-06-26
申请号：PCT/US0145177
申请日：2001-11-20
申请人： DIADEXUS INC , SALCEDA SUSANA , MACINA ROBERTO A , RECIPON HERVE , SUN YONGMING , LIU CHENGHUA
发明人： SALCEDA SUSANA , MACINA ROBERTO A , RECIPON HERVE , SUN YONGMING , LIU CHENGHUA
IPC分类号： A61K38/00 , A61K39/00 , C07K14/47 , A61K31/7088 , A61K38/17 , C07K16/18 , C12Q1/68 , G01N33/577
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K2039/53
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic prostate cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating prostate cancer and non-cancerous disease states in prostate tissue, identifying prostate tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered prostate tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤前列腺细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂的组合物以及使用这些组合物的方法。这些用途包括在前列腺组织中鉴定，诊断，监测，分期，成像和治疗前列腺癌和非癌性疾病状态，鉴定前列腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。这些用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程化前列腺组织的生产。

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