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1. 发明申请

WO2007112330A3 COMPOSITIONS AND METHODS FOR DETECTION, PROGNOSIS AND TREATMENT OF COLON CANCER 审中-公开
标题翻译：用于检测，预防和治疗结肠癌的组合物和方法
公开(公告)号：WO2007112330A3
公开(公告)日：2008-05-02
申请号：PCT/US2007064876
申请日：2007-03-26
申请人： DIADEXUS INC , MACINA ROBERTO A
发明人： MACINA ROBERTO A
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118
摘要： The present invention relates to methods of detection, prognosis and treatment of colon cancer using a plurality genes or gene products present in normal and neoplastic cells, tissues and bodily fluids. Additional uses include identifying, monitoring, staging, imaging and treating colon cancer and non-cancerous diseases of the colon as well as determining the effectiveness of therapies alone or in combination for an individual.
摘要翻译：本发明涉及使用存在于正常和肿瘤细胞，组织和体液中的多个基因或基因产物来检测，预后和治疗结肠癌的方法。额外的用途包括识别，监测，分期，成像和治疗结肠癌和非癌性疾病的结肠，以及确定治疗单独或组合的个人的疗效。

2. 发明申请

WO2006121991A2 COMPOSITIONS AND METHODS FOR DETECTION, PROGNOSIS AND TREATMENT OF BREAST CANCER 审中-公开
标题翻译：用于乳腺癌检测，预防和治疗的组合物和方法
公开(公告)号：WO2006121991A2
公开(公告)日：2006-11-16
申请号：PCT/US2006/017653
申请日：2006-05-08
申请人： DIADEXUS, INC. , MACINA, Roberto, A.
发明人： MACINA, Roberto, A.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118
摘要： The present invention relates to methods of detection, prognosis and treatment of breast cancer using a plurality genes or gene products present in normal and neoplastic cells, tissues and bodily fluids. Gene products relate to compositions comprising the nucleic acids, polypeptides, antibodies, post translational modifications (PTMs), variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. Additional uses include identifying, monitoring, staging, imaging and treating cancer and non-cancerous disease states in breast as well as determining the effectiveness of therapies alone or in combination for an individual. Therapies include gene therapy, therapeutic molecules including but not limited to antibodies, small molecules and antisense molecules.
摘要翻译：本发明涉及使用存在于正常和肿瘤细胞，组织和体液中的多个基因或基因产物来检测，预测和治疗乳腺癌的方法。基因产物涉及包含本发明的核酸，多肽，抗体，翻译后修饰（PTM），变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。其他用途包括识别，监测，分期，成像和治疗乳腺癌和非癌性疾病状态，以及确定单独或组合使用个体的疗法的有效性。治疗方法包括基因治疗，治疗分子，包括但不限于抗体，小分子和反义分子。

3. 发明申请

WO2005044075A2 COMPOSITIONS, SPLICE VARIANTS AND METHODS RELATING TO BREAST SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：组合物，与乳腺特异性基因和蛋白相关的差异变异和方法
公开(公告)号：WO2005044075A2
公开(公告)日：2005-05-19
申请号：PCT/US2004/030719
申请日：2004-09-20
申请人： DIADEXUS, INC. , MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming
发明人： MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming
IPC分类号： A61B
CPC分类号： C07K14/47 , C12Q1/6876
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性乳腺细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括鉴定诊断，监测，分期，成像和治疗乳腺癌和非癌性疾病状态，识别乳腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程乳腺组织的生产。

4. 发明申请

WO2004092338A2 COMPOSITIONS, SPLICE VARIANTS AND METHODS RELATING TO CANCER SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：组合物，SPLICE变量和与癌症特异性基因和蛋白质相关的方法
公开(公告)号：WO2004092338A2
公开(公告)日：2004-10-28
申请号：PCT/US2004/011104
申请日：2004-04-12
申请人： DIADEXUS, INC. , MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming , TAM, Albert
发明人： MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming , TAM, Albert
IPC分类号： C12N
CPC分类号： C07K14/82 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N33/57449
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast, colon, lung, ovarian or prostate cancer and non-cancerous disease states in breast, colon, lung, ovarian or prostate, identifying breast, colon, lung, ovarian or prostate tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered normal or cancerous breast, colon, lung, ovarian or prostate tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗乳腺，结肠，肺，卵巢或前列腺中的乳腺癌，结肠癌，肺癌，卵巢癌或前列腺癌和非癌性疾病状态，鉴别乳腺癌，结肠癌，肺癌，卵巢癌或卵巢癌前列腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的产生，以及生产工程化的正常或癌性乳腺癌，结肠癌，肺癌，卵巢癌或前列腺组织用于治疗和研究。

5. 发明申请

WO2004013311A2 COMPOSITIONS AND METHODS RELATING TO OVARIAN SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与OVARIAN特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO2004013311A2
公开(公告)日：2004-02-12
申请号：PCT/US2003/024669
申请日：2003-08-06
申请人： DIADEXUS, INC. , MACINA, Roberto, A. , SALCEDA, Susana , LIU, Chenghua , SUN, Yongming , TURNER, Leah, R.
发明人： MACINA, Roberto, A. , SALCEDA, Susana , LIU, Chenghua , SUN, Yongming , TURNER, Leah, R.
IPC分类号： C12N
CPC分类号： C07K14/82 , A61K38/00 , A61K39/00 , C07K14/47
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and noncancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括在卵巢中识别，诊断，监测，分期，成像和治疗卵巢癌和非癌性疾病状态，鉴定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程化卵巢组织的生产。

6. 发明申请

WO2002068633A2 COMPOSITIONS AND METHODS RELATING TO LUNG SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与肺特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO2002068633A2
公开(公告)日：2002-09-06
申请号：PCT/US2001/043612
申请日：2001-11-21
申请人： DIADEXUS, INC. , MACINA, Roberto, A. , RECIPON, Herve , CHEN, Sei-Yu , SUN, Yongming , LIU, Chenghua
发明人： MACINA, Roberto, A. , RECIPON, Herve , CHEN, Sei-Yu , SUN, Yongming , LIU, Chenghua
IPC分类号： C12N15/09
CPC分类号： C07K14/4748 , A61K48/00 , C12Q1/6886 , C12Q2600/158 , G01N33/57423 , G01N33/6884 , G01N2800/12
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic lung cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating lung cancer and non-cancerous disease states in lung, identifying lung tissue, monitoring and identifying and/or designing and antagonists of polypeptide of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered lung tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性肺细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗肺中的肺癌和非癌性疾病状态，鉴定肺组织，监测和鉴定和/或本发明多肽的设计和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程化肺组织的生产。

7. 发明申请

WO2002064788A3 COMPOSITIONS AND METHODS RELATING TO LUNG SPECIFIC GENES AND PROTEINS 审中-公开
公开(公告)号：WO2002064788A3
公开(公告)日：2002-08-22
申请号：PCT/US2001/045080
申请日：2001-11-20
申请人： DIADEXUS, INC. , MACINA, Roberto, A. , RECIPON, Herve , CHEN, Sei-Yu , SUN, Yongming , LIU, Chenghua
发明人： MACINA, Roberto, A. , RECIPON, Herve , CHEN, Sei-Yu , SUN, Yongming , LIU, Chenghua
IPC分类号： C12N15/12
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic lung cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating lung cancer and non-cancerous disease states in lung, identifying lung tissue, monitoring and identifying and/or designing agonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered lung tissue for treatment and research.

8. 发明申请

WO2002064788A2 COMPOSITIONS AND METHODS RELATING TO LUNG SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与肺特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO2002064788A2
公开(公告)日：2002-08-22
申请号：PCT/US2001/045080
申请日：2001-11-20
申请人： DIADEXUS, INC. , MACINA, Roberto, A. , RECIPON, Herve , CHEN, Sei-Yu , SUN, Yongming , LIU, Chenghua
发明人： MACINA, Roberto, A. , RECIPON, Herve , CHEN, Sei-Yu , SUN, Yongming , LIU, Chenghua
IPC分类号： C12N15/12
CPC分类号： C07K14/47
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic lung cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating lung cancer and non-cancerous disease states in lung, identifying lung tissue, monitoring and identifying and/or designing agonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered lung tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性肺细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗肺中的肺癌和非癌性疾病状态，鉴定肺组织，监测和鉴定和/或设计本发明多肽的激动剂。用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程化肺组织的生产。

9. 发明申请

WO2002064744A3 COMPOSITIONS AND METHODS RELATING TO COLON SPECIFIC GENES AND PROTEINS 审中-公开
公开(公告)号：WO2002064744A3
公开(公告)日：2002-08-22
申请号：PCT/US2002/004240
申请日：2002-02-12
申请人： DIADEXUS, INC. , PIDERIT, Alejandra , MACINA, Roberto, A. , SUN, Yongming , LIU, Chenghua
发明人： PIDERIT, Alejandra , MACINA, Roberto, A. , SUN, Yongming , LIU, Chenghua
IPC分类号： A01N43/04 , C07H21/04 , C12P15/00
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic colon cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. Their uses include identifying, diagnosing, monitoring, staging, imaging and treating colon cancer and non-cancerous disease states in colon tissue, identifying colon tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered colon tissue for treatment and research.

10. 发明申请

WO2002064744A2 COMPOSITIONS AND METHODS RELATING TO COLON SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：关于特定基因和蛋白质的组成和方法
公开(公告)号：WO2002064744A2
公开(公告)日：2002-08-22
申请号：PCT/US2002/004240
申请日：2002-02-12
申请人： DIADEXUS, INC. , PIDERIT, Alejandra , MACINA, Roberto, A. , SUN, Yongming , LIU, Chenghua
发明人： PIDERIT, Alejandra , MACINA, Roberto, A. , SUN, Yongming , LIU, Chenghua
IPC分类号： C12N
CPC分类号： C07K14/47 , A01K2217/05 , C07K2319/02
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic colon cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating colon cancer and non-cancerous disease states in colon tissue, identifying colon tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered colon tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性结肠细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括鉴定，诊断，监测，分期，成像和治疗结肠组织中的结肠癌和非癌性疾病状态，鉴定结肠组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程结肠组织的生产。

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