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1. 发明申请

WO2007112330A3 COMPOSITIONS AND METHODS FOR DETECTION, PROGNOSIS AND TREATMENT OF COLON CANCER 审中-公开
标题翻译：用于检测，预防和治疗结肠癌的组合物和方法
公开(公告)号：WO2007112330A3
公开(公告)日：2008-05-02
申请号：PCT/US2007064876
申请日：2007-03-26
申请人： DIADEXUS INC , MACINA ROBERTO A
发明人： MACINA ROBERTO A
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118
摘要： The present invention relates to methods of detection, prognosis and treatment of colon cancer using a plurality genes or gene products present in normal and neoplastic cells, tissues and bodily fluids. Additional uses include identifying, monitoring, staging, imaging and treating colon cancer and non-cancerous diseases of the colon as well as determining the effectiveness of therapies alone or in combination for an individual.
摘要翻译：本发明涉及使用存在于正常和肿瘤细胞，组织和体液中的多个基因或基因产物来检测，预后和治疗结肠癌的方法。额外的用途包括识别，监测，分期，成像和治疗结肠癌和非癌性疾病的结肠，以及确定治疗单独或组合的个人的疗效。

2. 发明申请

WO0172775A3 POLYNUCLEOTIDES AND POLYPEPTIDES AS WELL AS METHODS FOR DIAGNOSING AND TREATING LUNG CANCER 审中-公开
标题翻译：多核苷酸和多肽作为诊断和治疗肺癌的方法
公开(公告)号：WO0172775A3
公开(公告)日：2002-08-22
申请号：PCT/US0110051
申请日：2001-03-29
申请人： DIADEXUS INC , CHEN SEI-YU , HU PING , RECIPON HERVE , MACINA ROBERTO A
发明人： CHEN SEI-YU , HU PING , RECIPON HERVE , MACINA ROBERTO A
IPC分类号： A61K38/00 , A61P35/00 , C07K14/47 , C12N15/12 , A61K39/395 , C07K16/18 , C12N5/10 , C12Q1/68 , G01N33/574
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides polynucleotides and polypeptides which are diagnostic markers for lung cancer. In addition, antibodies immunospecific for these markers are provided. Vectors, hosts cells and methods for producing these markers, as well as methods and tools for using these markers in detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating lung cancer are also provided.
摘要翻译：本发明提供作为肺癌诊断标志物的多核苷酸和多肽。此外，提供了针对这些标记物免疫特异性的抗体。还提供了载体，宿主细胞和用于产生这些标记的方法，以及用于在检测，诊断，监测，分期，预后，成像和治疗肺癌中使用这些标记物的方法和工具。

3. 发明申请

WO0242499A2 COMPOSITIONS AND METHODS RELATING TO PROSTATE SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与前列腺特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO0242499A2
公开(公告)日：2002-05-30
申请号：PCT/US0145179
申请日：2001-11-20
申请人： DIADEXUS INC , SALCEDA SUSANA , MACINA ROBERTO A , RECIPON HERVE , CAFFERKEY ROBERT , ALI SHUJATH , SUN YONGMING , LIU CHENGHUA
发明人： SALCEDA SUSANA , MACINA ROBERTO A , RECIPON HERVE , CAFFERKEY ROBERT , ALI SHUJATH , SUN YONGMING , LIU CHENGHUA
IPC分类号： C07K14/47 , C12N15/12 , C12Q1/68
CPC分类号： C07K14/47
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic prostate cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses includes identifying, diagnosing, monitoring, staging, imaging and treating prostate cancer and non-cancerous disease states in prostate tissue, identifying prostate tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered prostate tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤前列腺细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗前列腺组织中的前列腺癌和非癌性疾病状态，鉴定前列腺组织，监测和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程前列腺组织的生产。

4. 发明申请

WO2004050900A3 COMPOSITIONS, SPLICE VARIANTS AND METHODS RELATING TO COLON SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：组成特征基因和蛋白质的差异变异和方法
公开(公告)号：WO2004050900A3
公开(公告)日：2005-07-28
申请号：PCT/US0340131
申请日：2003-12-04
申请人： DIADEXUS INC , MACINA ROBERTO A , TURNER LEAH R , SUN YONGMING , RODRIGUEZ MARIA
发明人： MACINA ROBERTO A , TURNER LEAH R , SUN YONGMING , RODRIGUEZ MARIA
IPC分类号： A61K39/00 , C07H21/04 , C07K14/47 , C12Q20060101
CPC分类号： G01N33/57419 , A61K38/00 , A61K39/0011 , A61K48/00 , C07K14/47 , C12Q1/6886
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic colon cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating colon cancer and non-cancerous disease states in colon, identifying colon tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered colon tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性结肠细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗结肠中的结肠癌和非癌性疾病状态，鉴定结肠组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程结肠组织的生产。

5. 发明申请

WO2004053079A3 COMPOSITIONS, SPLICE VARIANTS AND METHODS RELATING TO OVARIAN SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与OVARIAN特异性基因和蛋白质相关的组合物，群体变异和方法
公开(公告)号：WO2004053079A3
公开(公告)日：2005-04-07
申请号：PCT/US0338855
申请日：2003-12-08
申请人： DIADEXUS INC , MACINA ROBERTO A , TURNER LEAH R , SUN YONGMING , LIU SHU-HUI , CHEN HUEI-MEI
发明人： MACINA ROBERTO A , TURNER LEAH R , SUN YONGMING , LIU SHU-HUI , CHEN HUEI-MEI
IPC分类号： C07K14/47 , C12N15/12 , A61K31/7088 , A61K31/711 , C12N15/00 , C12N15/11 , C12P21/02 , C12Q1/68
CPC分类号： C07K14/82 , C07K14/47 , G01N33/57449
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and non-cancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括鉴定，诊断，监测，分期，成像和治疗卵巢癌和非癌性疾病状态，确定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程化卵巢组织的生产。

6. 发明申请

WO2004053077A3 COMPOSITIONS,SPLICE VARIANTS AND METHODS RELATING TO BREAST SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：组合物，与乳腺特异性基因和蛋白相关的差异变异和方法
公开(公告)号：WO2004053077A3
公开(公告)日：2004-11-04
申请号：PCT/US0338815
申请日：2003-12-05
申请人： DIADEXUS INC , MACINA ROBERTO A , TURNER LEAH R , SUN YONGMING , CHEN HUEI-MEI , RODRIGUEZ MARIA
发明人： MACINA ROBERTO A , TURNER LEAH R , SUN YONGMING , CHEN HUEI-MEI , RODRIGUEZ MARIA
IPC分类号： C07K14/47 , C07H21/04 , A01N63/00 , A61K39/02 , C07H21/02 , C12N1/20 , C12N5/00 , C12N15/00 , C12P21/06 , C12Q1/68
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/47 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , G01N33/57415 , G01N2500/00
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.

7. 发明申请

WO0240535A3 COMPOSITIONS AND METHODS RELATING TO OVARY SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO0240535A3
公开(公告)日：2003-08-21
申请号：PCT/US0145011
申请日：2001-11-20
申请人： DIADEXUS INC , SALCEDA SUSANA , MACINA ROBERTO A , RECIPON HERVE , CAFFERKEY ROBERT , SUN YONGMING , LIU CHENGHUA
发明人： SALCEDA SUSANA , MACINA ROBERTO A , RECIPON HERVE , CAFFERKEY ROBERT , SUN YONGMING , LIU CHENGHUA
IPC分类号： G01N33/53 , A61K39/00 , A61K39/395 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/566 , G01N33/574 , G01N33/68 , G01N33/50
CPC分类号： C07K14/47 , A61K39/00 , A61K2039/505 , A61K2039/53 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , G01N33/57449 , G01N33/68
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic ovary cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and non-cancerous disease states in ovary tissue, identifying ovary tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovary tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗卵巢组织中的卵巢癌和非癌性疾病状态，鉴定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程化卵巢组织的生产。

8. 发明申请

WO0242329A3 COMPOSITIONS AND METHODS RELATING TO PROSTATE SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：有关前列腺特异性基因和蛋白质的组合物和方法
公开(公告)号：WO0242329A3
公开(公告)日：2003-06-26
申请号：PCT/US0145177
申请日：2001-11-20
申请人： DIADEXUS INC , SALCEDA SUSANA , MACINA ROBERTO A , RECIPON HERVE , SUN YONGMING , LIU CHENGHUA
发明人： SALCEDA SUSANA , MACINA ROBERTO A , RECIPON HERVE , SUN YONGMING , LIU CHENGHUA
IPC分类号： A61K38/00 , A61K39/00 , C07K14/47 , A61K31/7088 , A61K38/17 , C07K16/18 , C12Q1/68 , G01N33/577
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K2039/53
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic prostate cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating prostate cancer and non-cancerous disease states in prostate tissue, identifying prostate tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered prostate tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤前列腺细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂的组合物以及使用这些组合物的方法。这些用途包括在前列腺组织中鉴定，诊断，监测，分期，成像和治疗前列腺癌和非癌性疾病状态，鉴定前列腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。这些用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程化前列腺组织的生产。

9. 发明申请

WO0175169A3 COMPOSITIONS AND METHODS FOR DIAGNOSING, MONITORING, STAGING, IMAGING AND TREATING STOMACH CANCER 审中-公开
标题翻译：用于诊断，监测，分期，成像和治疗STOMC癌症的组合物和方法
公开(公告)号：WO0175169A3
公开(公告)日：2003-01-23
申请号：PCT/US0110591
申请日：2001-03-30
申请人： DIADEXUS INC , PLUTA JASON , CHEN SEI-YU , HU PING , RECIPON HERVE , MACINA ROBERTO A
发明人： PLUTA JASON , CHEN SEI-YU , HU PING , RECIPON HERVE , MACINA ROBERTO A
IPC分类号： C12Q1/68 , A61K39/00 , A61K39/395 , C07K14/47 , C07K16/18 , C12N5/10 , C12N15/63
CPC分类号： C12Q1/6886 , C12Q2600/136
摘要： The present invention provides polynucleotides and polypeptides which are diagnostic markers for stomach cancer. In addition, antibodies immunospecific for these markers are provided. Vectors, host cells and methods for producing these markers, as well as methods and tools for using these markers in detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating stomach cancer are also provided.
摘要翻译：本发明提供作为胃癌诊断标志物的多核苷酸和多肽。此外，提供了针对这些标记物免疫特异性的抗体。还提供了载体，宿主细胞和用于产生这些标记的方法，以及用于在检测，诊断，监测，分期，预后，成像和治疗胃癌中使用这些标记的方法和工具。

10. 发明申请

WO0192528A3 METHOD OF DIAGNOSING, MONITORING, STAGING, IMAGING AND TREATING COLON CANCER 审中-公开
标题翻译：诊断，监测，分期，成像和治疗结肠癌的方法
公开(公告)号：WO0192528A3
公开(公告)日：2003-01-03
申请号：PCT/US0117583
申请日：2001-05-29
申请人： DIADEXUS INC , MACINA ROBERTO A , CHEN SEI-YU , PLUTA JASON , SUN YONGMING , RECIPON HERVE
发明人： MACINA ROBERTO A , CHEN SEI-YU , PLUTA JASON , SUN YONGMING , RECIPON HERVE
IPC分类号： G01N33/53 , A61K39/00 , A61K45/00 , A61K48/00 , A61K49/00 , A61K51/00 , A61P35/00 , C07K16/18 , C12N15/09 , C12N15/12 , C12Q1/02 , C12Q1/68 , G01N33/574 , G01N33/58 , A61K38/17 , A61K39/395 , C07K14/47
CPC分类号： G01N33/57419 , A61K49/0008 , C12Q1/6886 , C12Q2600/136
摘要： The invention relates to CSG polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及CSG多肽，编码所述多肽的多核苷酸，用于产生所述多肽的方法，特别是通过表达所述多核苷酸，以及所述多肽的激动剂和拮抗剂。本发明还涉及用于应用的这种多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床技术。

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