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1. 发明申请

WO2004013311A2 COMPOSITIONS AND METHODS RELATING TO OVARIAN SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与OVARIAN特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO2004013311A2
公开(公告)日：2004-02-12
申请号：PCT/US2003/024669
申请日：2003-08-06
申请人： DIADEXUS, INC. , MACINA, Roberto, A. , SALCEDA, Susana , LIU, Chenghua , SUN, Yongming , TURNER, Leah, R.
发明人： MACINA, Roberto, A. , SALCEDA, Susana , LIU, Chenghua , SUN, Yongming , TURNER, Leah, R.
IPC分类号： C12N
CPC分类号： C07K14/82 , A61K38/00 , A61K39/00 , C07K14/47
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and noncancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括在卵巢中识别，诊断，监测，分期，成像和治疗卵巢癌和非癌性疾病状态，鉴定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程化卵巢组织的生产。

2. 发明申请

WO2002068645A3 COMPOSITIONS AND METHODS RELATING TO BREAST SPECIFIC GENES AND PROTEINS 审中-公开
公开(公告)号：WO2002068645A3
公开(公告)日：2002-09-06
申请号：PCT/US2001/045151
申请日：2001-11-20
申请人： DIADEXUS, INC. , SALCEDA, Susana , MACINA, Roberto, A. , RECIPON, Herve , CAFFERKEY, Robert , SUN, Yongming , LIU, Chenghua , TURNER, Leah, R.
发明人： SALCEDA, Susana , MACINA, Roberto, A. , RECIPON, Herve , CAFFERKEY, Robert , SUN, Yongming , LIU, Chenghua , TURNER, Leah, R.
IPC分类号： C12N15/12
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast tissue, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.

3. 发明申请

WO2002068645A2 COMPOSITIONS AND METHODS RELATING TO BREAST SPECIFIC GENES AND PROTEINS 审中-公开
公开(公告)号：WO2002068645A2
公开(公告)日：2002-09-06
申请号：PCT/US2001/045151
申请日：2001-11-20
申请人： DIADEXUS, INC. , SALCEDA, Susana , MACINA, Roberto, A. , RECIPON, Herve , CAFFERKEY, Robert , SUN, Yongming , LIU, Chenghua , TURNER, Leah, R.
发明人： SALCEDA, Susana , MACINA, Roberto, A. , RECIPON, Herve , CAFFERKEY, Robert , SUN, Yongming , LIU, Chenghua , TURNER, Leah, R.
IPC分类号： C12N15/12
CPC分类号： G01N33/57415 , A61K2039/505 , C07K14/47 , C12Q1/6886 , C12Q2600/158
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast tissue, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.

4. 发明申请

WO2003106648A3 COMPOSITIONS AND METHODS RELATING TO BREAST SPECIFIC GENES AND PROTEINS 审中-公开
公开(公告)号：WO2003106648A3
公开(公告)日：2003-12-24
申请号：PCT/US2003/018934
申请日：2003-06-16
申请人： DIADEXUS, INC. , SALCEDA, Susana , MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming , LIU, Chenghua
发明人： SALCEDA, Susana , MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming , LIU, Chenghua
IPC分类号： C12N15/12
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.

5. 发明申请

WO2003106648A2 COMPOSITIONS AND METHODS RELATING TO BREAST SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与乳腺特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO2003106648A2
公开(公告)日：2003-12-24
申请号：PCT/US2003/018934
申请日：2003-06-16
申请人： DIADEXUS, INC. , SALCEDA, Susana , MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming , LIU, Chenghua
发明人： SALCEDA, Susana , MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming , LIU, Chenghua
IPC分类号： C12N
CPC分类号： C12Q1/6886 , A61K38/00 , A61K39/00 , C07K14/4748 , C12Q2600/112
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性乳腺细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括鉴定诊断，监测，分期，成像和治疗乳腺癌和非癌性疾病状态，识别乳腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程乳腺组织的生产。

6. 发明申请

WO2002042499A3 COMPOSITIONS AND METHODS RELATING TO PROSTATE SPECIFIC GENES AND PROTEINS 审中-公开
公开(公告)号：WO2002042499A3
公开(公告)日：2002-05-30
申请号：PCT/US2001/045179
申请日：2001-11-20
申请人： DIADEXUS, INC. , SALCEDA, Susana , MACINA, Roberto, A. , RECIPON, Hervé , CAFFERKEY, Robert , ALI, Shujath , SUN, Yongming , LIU, Chenghua
发明人： SALCEDA, Susana , MACINA, Roberto, A. , RECIPON, Hervé , CAFFERKEY, Robert , ALI, Shujath , SUN, Yongming , LIU, Chenghua
IPC分类号： C12N15/12
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic prostate cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses includes identifying, diagnosing, monitoring, staging, imaging and treating prostate cancer and non-cancerous disease states in prostate tissue, identifying prostate tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered prostate tissue for treatment and research.

7. 发明申请

WO2003102137A2 COMPOSITIONS AND METHODS RELATING TO LUNG SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与肺特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO2003102137A2
公开(公告)日：2003-12-11
申请号：PCT/US2003/016810
申请日：2003-05-30
申请人： DIADEXUS, INC. , CHEN, Sei-Yu , MACINA, Roberto, A. , SUN, Yongming , LIU,Chenghua , TURNER, Leah, R.
发明人： CHEN, Sei-Yu , MACINA, Roberto, A. , SUN, Yongming , LIU,Chenghua , TURNER, Leah, R.
IPC分类号： C12N
CPC分类号： C07K14/435 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic lung cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating lung cancer and non-cancerous disease states in lung, identifying lung tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered lung tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性肺细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗肺中的肺癌和非癌性疾病状态，识别肺组织，监测和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程化肺组织的生产。

8. 发明申请

WO2002066605A2 COMPOSITIONS AND METHODS RELATING TO BREAST SPECIFIC GENES AND PROTEINS 审中-公开
公开(公告)号：WO2002066605A2
公开(公告)日：2002-08-29
申请号：PCT/US2002/004284
申请日：2002-02-14
申请人： DIADEXUS, INC. , SALCEDA, Susana , MACINA, Roberto, A. , HU, Ping , RECIPON, Herve , KARRA, Kalpana , CAFFERKEY, Robert , SUN, Yongming , LIU, Chenghua
发明人： SALCEDA, Susana , MACINA, Roberto, A. , HU, Ping , RECIPON, Herve , KARRA, Kalpana , CAFFERKEY, Robert , SUN, Yongming , LIU, Chenghua
IPC分类号： C12N
CPC分类号： C07K14/47 , A61K39/00 , A61K2039/53
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast tissue, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.

9. 发明申请

WO2002088375A3 COMPOSITIONS AND METHODS RELATING TO BREAST SPECIFIC GENES AND PROTEINS 审中-公开
公开(公告)号：WO2002088375A3
公开(公告)日：2002-11-07
申请号：PCT/US2001/051318
申请日：2001-10-29
申请人： DIADEXUS, INC. , SUN, Yongming , RECIPON, Herve , SALCEDA, Susana , LIU, Chenghua , TURNER, Leah, R.
发明人： SUN, Yongming , RECIPON, Herve , SALCEDA, Susana , LIU, Chenghua , TURNER, Leah, R.
IPC分类号： C12Q1/68
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragements, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptiedes, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositons. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast tissue, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.

10. 发明申请

WO2002088375A2 COMPOSITIONS AND METHODS RELATING TO BREAST SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与乳腺特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO2002088375A2
公开(公告)日：2002-11-07
申请号：PCT/US2001/051318
申请日：2001-10-29
申请人： DIADEXUS, INC. , SUN, Yongming , RECIPON, Herve , SALCEDA, Susana , LIU, Chenghua , TURNER, Leah, R.
发明人： SUN, Yongming , RECIPON, Herve , SALCEDA, Susana , LIU, Chenghua , TURNER, Leah, R.
IPC分类号： C12Q
CPC分类号： C07K14/47 , A61K39/00 , A61K2039/505
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragements, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptiedes, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositons. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast tissue, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性乳腺细胞中的新鉴定的核酸和多肽，包括核酸和多肽的残基，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗乳腺组织中的乳腺癌和非癌性疾病状态，鉴定乳腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程乳腺组织的生产。

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