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1. 发明申请

WO02055735A3 COMPOSITIONS AND METHODS RELATING TO PROSTATE SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与前列腺特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO02055735A3
公开(公告)日：2003-08-14
申请号：PCT/US0144363
申请日：2001-11-27
申请人： DIADEXUS INC , SALCEDA SUSANA , MACINA ROBERTO A , RECIPON HERVE , CAFFERKEY ROBERT , ALI SHUJATH , SUN YONGMING , LIU CHENGHUA , CHEN SEI-YU
发明人： SALCEDA SUSANA , MACINA ROBERTO A , RECIPON HERVE , CAFFERKEY ROBERT , ALI SHUJATH , SUN YONGMING , LIU CHENGHUA , CHEN SEI-YU
IPC分类号： C07H21/04 , C07K16/30 , C12N15/12 , C12Q1/68 , G01N33/574 , A61K39/00 , C07K14/47 , C07K16/18 , G01N33/53
CPC分类号： C07K16/3069 , C12Q1/6886 , C12Q2600/158
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic prostate cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating prostate cancer and non-cancerous disease states in prostate tissue, identifying prostate tissue, monitoring and identifying and/or designing agonists and antagonists of the invention. The use also include gene therapy, production of transgenic animals and cells, and production of engineered prostate tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤前列腺细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗前列腺组织中的前列腺癌和非癌性疾病状态，鉴定前列腺组织，监测和/或设计本发明的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程前列腺组织的生产。

2. 发明申请

WO2002066488A1 COMPOSITIONS AND METHODS RELATING TO PROSTATE SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与前列腺特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO2002066488A1
公开(公告)日：2002-08-29
申请号：PCT/US2002/004297
申请日：2002-02-14
申请人： DIADEXUS, INC. , ALI, Shujath , SALCEDA, Susana , MACINA, Roberto, A. , HU, Ping , KARRA, Kalpana , CAFFERKEY, Robert , SUN, Yongming , LIU, Chenghua
发明人： ALI, Shujath , SALCEDA, Susana , MACINA, Roberto, A. , HU, Ping , KARRA, Kalpana , CAFFERKEY, Robert , SUN, Yongming , LIU, Chenghua
IPC分类号： C07H21/04
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic prostate cells, including fragments, variants and derivatives of the nucleic acid and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to composition comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating prostate cancer and non-cancerous disease states in prostate tissue, identifying prostate tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered prostate tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤前列腺细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗前列腺组织中的前列腺癌和非癌性疾病状态，鉴定前列腺组织，监测和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程前列腺组织的生产。

3. 发明申请

WO0170095A3 COMPOSITIONS AND METHODS OF DIAGNOSING, MONITORING, STAGING, IMAGING AND TREATING PROSTATE CANCER 审中-公开
标题翻译：诊断，监测，分期，成像和治疗前列腺癌的组成和方法
公开(公告)号：WO0170095A3
公开(公告)日：2006-02-09
申请号：PCT/US0109217
申请日：2001-03-23
申请人： DIADEXUS INC , ALI SHUJATH , RECIPON HERVE , HU PING , CAFFERKEY ROBERT
发明人： ALI SHUJATH , RECIPON HERVE , HU PING , CAFFERKEY ROBERT
IPC分类号： A61K51/10 , A61P35/00 , C12Q1/68 , C07H21/02 , A61K39/395 , C07K14/00 , G01N33/53
CPC分类号： A61K51/10 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention provides polynucleotides and polypeptides which are diagnostic markers for prostate cancer. In addition, antibodies immunospecific for these markers are provided. Vectors, host cells and methods for producing these markers, as well as methods and tools for using these markers in detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating prostate cancer are also provided.
摘要翻译：本发明提供作为前列腺癌的诊断标记物的多核苷酸和多肽。此外，提供了针对这些标记物免疫特异性的抗体。还提供了载体，宿主细胞和用于产生这些标记的方法，以及用于在检测，诊断，监测，分期，预后，成像和治疗前列腺癌中使用这些标记的方法和工具。

4. 发明申请

WO0242463A3 COMPOSITIONS AND METHODS RELATING TO PROSTATE SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与前列腺特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO0242463A3
公开(公告)日：2003-07-10
申请号：PCT/US0145009
申请日：2001-11-20
申请人： DIADEXUS INC , SALCEDA SUSANA , MACINA ROBERTO A , RECIPON HERVE , CAFFERKEY ROBERT , ALI SHUJATH , SUN YONGMING , LIU CHENGHUA
发明人： SALCEDA SUSANA , MACINA ROBERTO A , RECIPON HERVE , CAFFERKEY ROBERT , ALI SHUJATH , SUN YONGMING , LIU CHENGHUA
IPC分类号： C07K14/47 , C12N1/21 , C12N15/12 , A61K39/395 , C07K16/18 , C12N5/10 , C12Q1/68 , G01N33/68
CPC分类号： C07K14/47 , A61K2039/505 , A61K2039/53
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic prostate ells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating prostate cancer and non-cancerous disease states in prostate tissue, identifying prostate tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered prostate tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤前列腺中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗前列腺组织中的前列腺癌和非癌性疾病状态，鉴定前列腺组织，监测和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程前列腺组织的生产。

5. 发明申请

WO2002042499A3 COMPOSITIONS AND METHODS RELATING TO PROSTATE SPECIFIC GENES AND PROTEINS 审中-公开
公开(公告)号：WO2002042499A3
公开(公告)日：2002-05-30
申请号：PCT/US2001/045179
申请日：2001-11-20
申请人： DIADEXUS, INC. , SALCEDA, Susana , MACINA, Roberto, A. , RECIPON, Hervé , CAFFERKEY, Robert , ALI, Shujath , SUN, Yongming , LIU, Chenghua
发明人： SALCEDA, Susana , MACINA, Roberto, A. , RECIPON, Hervé , CAFFERKEY, Robert , ALI, Shujath , SUN, Yongming , LIU, Chenghua
IPC分类号： C12N15/12
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic prostate cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses includes identifying, diagnosing, monitoring, staging, imaging and treating prostate cancer and non-cancerous disease states in prostate tissue, identifying prostate tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered prostate tissue for treatment and research.

6. 发明申请

WO0242499A2 COMPOSITIONS AND METHODS RELATING TO PROSTATE SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与前列腺特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO0242499A2
公开(公告)日：2002-05-30
申请号：PCT/US0145179
申请日：2001-11-20
申请人： DIADEXUS INC , SALCEDA SUSANA , MACINA ROBERTO A , RECIPON HERVE , CAFFERKEY ROBERT , ALI SHUJATH , SUN YONGMING , LIU CHENGHUA
发明人： SALCEDA SUSANA , MACINA ROBERTO A , RECIPON HERVE , CAFFERKEY ROBERT , ALI SHUJATH , SUN YONGMING , LIU CHENGHUA
IPC分类号： C07K14/47 , C12N15/12 , C12Q1/68
CPC分类号： C07K14/47
摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic prostate cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses includes identifying, diagnosing, monitoring, staging, imaging and treating prostate cancer and non-cancerous disease states in prostate tissue, identifying prostate tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered prostate tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤前列腺细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗前列腺组织中的前列腺癌和非癌性疾病状态，鉴定前列腺组织，监测和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程前列腺组织的生产。

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