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    • 10. 发明申请
    • ELECTRODE SYSTEMS FOR ELECTROCHEMICAL SENSORS
    • 电化学传感器电极系统
    • WO2005012873A2
    • 2005-02-10
    • PCT/US2004/024178
    • 2004-07-21
    • DEXCOM, INC.SIMPSON, Peter, C.PETISCE, James, R.CARR-BRENDEL, VictoriaBRAUKER, James, H.
    • SIMPSON, Peter, C.PETISCE, James, R.CARR-BRENDEL, VictoriaBRAUKER, James, H.
    • G01N
    • G01N27/3274A61B5/14532A61B5/14865C12Q1/001
    • The present invention relates generally to systems and methods for improved electrochemical measurement of analytes. The preferred embodiments employ electrode systems including an analyte-measuring electrode (16a) for measuring the analyte or the product of an enzyme reaction with the analyte and an auxiliary electrode (36) configured to generate oxygen and/or reduce electrochemical interferants. Oxygen generation by the auxiliary electrode (36) advantageously improves oxygen availability to the enzyme (38) and/or counter electrode; thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions. Interferant modification by the auxiliary electrode (36) advantageously renders them substantially non-reactive at the analyte-measuring electrode, thereby reducing or eliminating inaccuracies in the analyte signal due to electrochemical interferants.
    • 本发明一般涉及用于改进分析物的电化学测量的系统和方法。 优选实施例采用电极系统,其包括分析物测量电极(16a),用于测量分析物或与分析物的酶反应产物和配置成产生氧和/或减少电化学干扰剂的辅助电极(36)。 通过辅助电极(36)产生氧气有利地提高了对酶(38)和/或对电极的氧可用性; 从而使得优选实施方案的电化学传感器能够在缺血条件下起作用。 辅助电极(36)的干扰修饰有利地使得它们在分析物测量电极处基本上不反应,从而减少或消除由于电化学干扰剂引起的分析物信号的不准确性。