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1. 发明申请

WO2002064102A1 PROCESS FOR THE PREPARATION OF A POLYMERISABLE DENTAL COMPOSITION 审中-公开
标题翻译：制备聚合物牙科组合物的方法
公开(公告)号：WO2002064102A1
公开(公告)日：2002-08-22
申请号：PCT/EP2002/000338
申请日：2002-01-15
申请人： DENTSPLY DETREY GMBH , KLEE, Joachim, E. , WALZ, Uwe , FACHER, Andreas , WEBER, Christoph , MÜLHAUPT, Rolf , FREY, Holger , MÜH, Ekkehard
发明人： KLEE, Joachim, E. , WALZ, Uwe , FACHER, Andreas , WEBER, Christoph , MÜLHAUPT, Rolf , FREY, Holger , MÜH, Ekkehard
IPC分类号： A61K6/093
CPC分类号： A61K6/0008 , A61K6/083 , C08L51/085
摘要： A process for the preparation of a polymerisable dental composition comprising the steps of (a) preparing a liquid mixture comprising (i) 1 to 99% w/w of a hybrid monomer component containing at least one hybrid monomer compound having one hydrolysable siloxane group and at least one polymerisable organic moiety, and (ii) 99 to 1% w/w of a monomer component polymerisable with the polymerisable organic moiety of the hybrid monomer compounds; and (b) adding at least a stoichiometrically sufficient amount of water to the mixture to hydrolyse the hydrolysable siloxane group of the hybrid monomer compound and to form spherical polymerisable nanoparticles having an average particle size of from 1 to 100 nm dispersed in the monomer component, whereby the nanoparticles have a structure with Si-O-Si bonds and peripherally exposed polymerisable organic moieties.
摘要翻译：一种用于制备可聚合牙科用组合物的方法，包括以下步骤：（a）制备液体混合物，其包含（i）1至99％w / w的含有至少一种具有一个可水解硅氧烷基团的杂化单体化合物的杂化单体组分和至少一个可聚合有机部分，和（ii）99-1％w / w的可与所述杂化单体化合物的可聚合有机部分聚合的单体组分; 和（b）向所述混合物中加入至少一种化学计量的足够量的水以水解所述杂化单体化合物的可水解硅氧烷基团并形成分散在单体组分中的平均粒度为1至100nm的球形可聚合纳米颗粒，由此纳米颗粒具有具有Si-O-Si键和周边暴露的可聚合有机部分的结构。

2. 发明申请

WO2005094756A1 LASER CURABLE POLYMERISABLE COMPOSITION FOR THE PROTECTION OF HARD TISSUE 审中-公开
标题翻译：激光可固化聚合物组合物，用于保护硬组织
公开(公告)号：WO2005094756A1
公开(公告)日：2005-10-13
申请号：PCT/EP2005/002409
申请日：2005-03-07
申请人： DENTSPLY DETREY GMBH , KLEE, Joachim, E. , FACHER, Andreas , WEBER, Christoph , MÜLHAUPT, Rolf , SCHMIDER, Martin
发明人： KLEE, Joachim, E. , FACHER, Andreas , WEBER, Christoph , MÜLHAUPT, Rolf , SCHMIDER, Martin
IPC分类号： A61K6/08
CPC分类号： A61K6/0017 , C08L33/00
摘要： One-component heat-curable sealant composition having a viscosity of at most 5 Pas (23°C) for the protection of exposed dental surfaces, comprising (a) a polymerisable monomer and/or oligomer having at least two polymerizable double bonds per molecule , and (b) an initiator system comprising a thermally stable initiator having a 10 hour half-life decomposition temperature of from 95°C to 135° (0.1 M in benzene); wherein the composition further contains a precursor for a filler which is an alkoxysilane compound undergoing polycondensation reactions during heat curing of the composition, thereby forming a filler.
摘要翻译：包含（a）每分子具有至少两个可聚合双键的可聚合单体和/或低聚物的单组分可热固化密封剂组合物，其具有至多5Pa·s（23℃）的粘度以保护暴露的牙齿表面，和（b）包含具有10分钟半衰期分解温度为95℃至135℃（0.1M苯）的热稳定引发剂的引发剂体系; 其中所述组合物还含有用于填料的前体，其是在组合物热固化期间进行缩聚反应的烷氧基硅烷化合物，从而形成填料。

3. 发明申请

WO2012119793A2 DENTAL COMPOSITION 审中-公开
标题翻译：牙科成分
公开(公告)号：WO2012119793A2
公开(公告)日：2012-09-13
申请号：PCT/EP2012/001103
申请日：2012-03-12
申请人： DENTSPLY DETREY GMBH , STELZIG, Simon , KLEE, Joachim, E. , FACHER, Andreas , WEBER, Christoph
发明人： STELZIG, Simon , KLEE, Joachim, E. , FACHER, Andreas , WEBER, Christoph
IPC分类号： A61K6/083
CPC分类号： A61K6/083
摘要： Dental composition selected from a dental cement and a dental adhesive, comprising (i) a water-soluble polymerizable compound of the following formula (1), AX n (1) wherein A is a straight chain or branched linker group containing at least n nitrogen atoms, and optionally one or more acidic groups; X are moieties containing a polymerizable double bond, which X may be the same or different and are represented by the following formula (2), whereby a moiety X of formula (2) is linked to the nitrogen atom of an amino group or a carboxamide group of A, formula (2) wherein R 1 and R 2 are independent from each other and represent a hydrogen atom, a C 1-6 alkyl group or a group -(CH2) m -COOM, wherein M is a hydrogen atom or a metal atom, and m is an integer of from 0 to 6, L is a bond or a C 1-6 alkylene group; and is an integer of at least 1; which is obtainable by a process comprising (a) a step of a step-growth polymerization of a mixture containing a polyamine and a compound having at least two carboxylic acid groups or an anhydride thereof, optionally in the presence of a compound of the following formula (5) for obtaining a polyamide: formula (5) wherein R 1 and R 2 are as defined above, and Y 1 is a leaving group or Y 1 forms an hydrolysable intramolecular group together with a carboxyl group present in R 1 or R 2 and the adjacent carbonyl group; and (b) a step of introducing moieties of the formula (2) by reacting the polyamide obtained in step (i) with a compound of formula (5) wherein Y1 is a leaving group and R 1 and R 2 are as defined above; or (c) a step of reacting a mixture containing a polyamine and a compound of formula (5) for obtaining an amine reaction product; and (d) a step of a step-growth polymerization of a mixture containing the amine reaction product obtained in (c) and a compound having at least two carboxylic acid groups or an anhydride thereof for obtaining the water-soluble polymerizable compound of the formula (1), an initiator system; optionally a polyacidic polymer; and optionally water and/or a water soluble solvent, optionally a particulate filler.
摘要翻译：选自牙科粘固剂和牙科粘合剂的牙科成分，其包含（i）下式（1）的水溶性可聚合化合物，AXn（1）其中A是至少含有n个氮原子的直链或支链连接基团，和任选的一个或多个酸性基团; X是含有可聚合双键的部分，X可以相同或不同，由下式（2）表示，其中式（2）的X部分与氨基或羧酰胺的氮原子连接 A组，式（2）其中R 1和R 2彼此独立并且表示氢原子，C 1-6烷基或基团 - （CH 2）m -COOM，其中M是氢原子或金属原子 m为0〜6的整数，L为碳原子数为1〜6的亚烷基。并且是至少为1的整数; 其可通过以下方法获得，该方法包括（a）含有多胺和具有至少两个羧酸基团的化合物或其酸酐的混合物的步进生长聚合步骤，任选地在下式的化合物（5）其中R 1和R 2如上所定义，Y 1为离去基团或Y 1与R1或R2和相邻羰基中存在的羧基一起形成可水解的分子内基团; 和（b）通过使步骤（i）中获得的聚酰胺与式（5）的化合物反应来引入式（2）的部分的步骤，其中Y1是离去基团，R1和R2如上定义; 或（c）使含有多胺和式（5）化合物的混合物反应以获得胺反应产物的步骤; 和（d）包含（c）中得到的胺反应产物的混合物和具有至少两个羧酸基团的化合物或其酸酐的混合物的步进生长聚合步骤，以获得式（I）的水溶性聚合性化合物（1），发起者系统; 任选的多酸聚合物; 和任选的水和/或水溶性溶剂，任选的颗粒填料。

4. 发明申请

WO2012052163A1 DENTAL CEMENT COMPOSITION 审中-公开
标题翻译：牙科水泥组合物
公开(公告)号：WO2012052163A1
公开(公告)日：2012-04-26
申请号：PCT/EP2011/005238
申请日：2011-10-18
申请人： DENTSPLY DETREY GMBH , STELZIG, Simon , KLEE, Joachim, E. , FACHER, Andreas , WEBER, Christoph
发明人： STELZIG, Simon , KLEE, Joachim, E. , FACHER, Andreas , WEBER, Christoph
IPC分类号： A61K6/02 , A61K6/083 , A61K6/00 , C07C233/09 , C07C233/31
CPC分类号： A61K6/0835 , A61K6/0023 , A61K6/0091 , A61K6/09 , C07C233/09 , C07C233/20 , C08F122/385 , C08L33/00 , C08L75/16
摘要： Dental cement composition comprising (i) a particulate filler reactive with a polyacid in a cement reaction; (ii) a water-soluble polymerizable compound of the following formula (1), AXn (1) wherein A is a linker group containing at least n nitrogen atoms and optionally one or more acidic groups, X are moieties containing a polymerizable double bond and forming an amide bond with a nitrogen atom of A, which X may be the same or different and are represented by the following formula (2) wherein R 1 and R 2 are independent from each other and represent a hydrogen atom, a C 1-6 alkyl group or a group -(CH 2 ) m -Z, wherein Z is COOM, OPO 3 M 2 , PO 3 M 2 , SO 3 M, and M is independently a hydrogen atom or a metal atom, and m is an integer of from 0 to 6, L is a bond or a C 1-6 alkylene group; and n is an integer of at least 1; provided that at least one X cannot be a (meth)acryl group; and (iii) an initiator system; optionally a polyacidic polymer having polymerizable double bonds; and optionally water.
摘要翻译：牙科水泥组合物，其包含（i）在水泥反应中与多元酸反应的颗粒填料; （ⅱ）下述式（1）的水溶性聚合性化合物，其中A为含有至少n个氮原子和任意一个以上酸性基团的连接基团，X 1为含有可聚合双键的部分，与A的氮原子形成酰胺键，X可以相同或不同，并由下式（2）表示，其中R 1和R 2彼此独立地表示氢原子，C 1-6烷基或基团 - （CH 2）m Z，其中Z为COOM，OPO 3 M 2，PO 3 M 2，SO 3 M和M独立地为氢原子或金属原子，m为0至6的整数，L为键或C1 -6亚烷基; n为1以上的整数。条件是至少一个X不能是（甲基）丙烯酰基; 和（iii）引发剂体系; 任选的具有可聚合双键的多酸聚合物; 和任选的水。

5. 发明申请

WO2012052160A1 DENTAL COMPOSITION 审中-公开
标题翻译：牙科成分
公开(公告)号：WO2012052160A1
公开(公告)日：2012-04-26
申请号：PCT/EP2011/005232
申请日：2011-10-18
申请人： DENTSPLY DETREY GMBH , STELZIG, Simon , KLEE, Joachim, E. , FACHER, Andreas , WEBER, Christoph
发明人： STELZIG, Simon , KLEE, Joachim, E. , FACHER, Andreas , WEBER, Christoph
IPC分类号： A61K6/02 , A61K6/083 , C07C233/31
CPC分类号： A61K6/083 , A61K6/0023 , A61K6/0835 , C07C233/20 , C08L33/00
摘要： Dental composition comprising a water-soluble polymerizable compound of the following formula (1): wherein A is a linear or branched linker group represented by the following formula (3), wherein the nitrogen atom of at least two of the termini forms an amide bond with an X moiety; wherein R' represents a hydrogen atom or a substituted or unsubstituted aliphatic or cycloaliphatic hydrocarbon group, wherein each R may be the same or different L 1 , L 2 , and L 3 which may be the same or different, independently represent a single bond, or a C 2-20 straight-chain, branched or cyclic hydrocarbon group optionally containing from 1 to 6 heteroatoms selected from nitrogen and oxygen in the backbone of the hydrocarbon group, and optionally from 1 to 6 functional groups selected from carboxylic acid groups or a salt thereof, hydroxyl groups, thiol groups and amino groups, and in case a plurality of L 1 and L 2 are present, each of L 1 and L 2 may be the same or different; Q 1 and Q 2 , which may be the same or different, independently represent a single bond or a linkage selected from an amide, a urethane, a urea and a thiourea linkage; k is an integer of at least 0, X are moieties containing a polymerizable double bond and forming an amide bond with a nitrogen atom of A, wherein each X may be the same or different and are represented by the following formula (2): wherein R 1 and R 2 are independent from each other and represent a hydrogen atom, a C 1-6 alkyl group or a group -(CH 2 ) m -COOM, wherein M represents a hydrogen atom or a metal atom, m is an integer of from 0 to 6, L is a bond or a C 1-6 alkylene group; and n is an integer of at least 2; (ii) an initiator system; optionally a polyacidic polymer; optionally water and/or a water soluble solvent; and optionally a particulate filler.
摘要翻译： 1.一种牙科用组合物，其含有下述式（1）所示的水溶性聚合性化合物：式中，A为下述通式（3）所示的直链或支链连接基团，其中，所述末端中的至少2个的氮原子形成酰胺键与X部分; 其中R'表示氢原子或取代或未取代的脂族或脂环族烃基，其中每个R可以相同或不同，可相同或不同的L1，L2和L3独立地表示单键，或C2 -20个直链，支链或环状烃基，任选地含有1至6个选自氮原子和氧的杂原子在烃基的主链中，以及任选地1-6个选自羧酸基团或其盐的官能团，羟基基团，硫醇基和氨基，并且在存在多个L1和L2的情况下，L1和L2中的每一个可以相同或不同; Q1和Q2可以相同或不同，独立地表示单键或选自酰胺，氨基甲酸酯，脲和硫脲键的键; k是至少为0的整数，X是含有可聚合双键并与A的氮原子形成酰胺键的部分，其中每个X可以相同或不同，并由下式（2）表示：其中 R 1和R 2彼此独立地表示氢原子，C 1-6烷基或基团 - （CH 2）m -COOM，其中M表示氢原子或金属原子，m表示0〜 6，L是键或C1-6亚烷基; 且n为至少2的整数; （ii）引发剂体系; 任选的多酸聚合物; 任选的水和/或水溶性溶剂; 和任选的颗粒填料。

6. 发明申请

WO2010102786A1 DENTAL COMPOSITION 审中-公开
标题翻译：牙科成分
公开(公告)号：WO2010102786A1
公开(公告)日：2010-09-16
申请号：PCT/EP2010/001458
申请日：2010-03-09
申请人： DENTSPLY DETREY GMBH , KLEE, Joachim, E. , BRUGGER, Stefan , RITTER, Helmut , WEBER, Christoph , ELSNER, Oliver , BARDTS, Mareike , FACHER, Andreas , POHLE, Sven
发明人： KLEE, Joachim, E. , BRUGGER, Stefan , RITTER, Helmut , WEBER, Christoph , ELSNER, Oliver , BARDTS, Mareike , FACHER, Andreas , POHLE, Sven
IPC分类号： A61K6/083
CPC分类号： A61K6/0835 , A61K6/0023 , A61K6/0038 , C08L33/00
摘要： An aqueous dental glass ionomer composition comprising (a) a reactive particulate glass, and (b) a linear or branched polymer comprising acidic groups, which is reactive with the particulate glass in a cement reaction, whereby the linear or branched polymer comprising acidic groups has a polymer backbone and optionally pendant side chains, (c) optionally dispersed nanoparticles, and (d) optionally a low molecular compound, characterized in that the glass ionomer composition comprises -S x H groups, wherein x is an integer of from 1 to 6, which crosslink the particulate glass and/or the linear polycarboxylic acid and/or the optional dispersed nanoparticles and/or the optional low molecular compound.
摘要翻译：一种水性牙科玻璃离聚物组合物，其包含（a）反应性颗粒玻璃，和（b）包含酸性基团的直链或支链聚合物，其在水泥反应中与颗粒状玻璃反应，由此包含酸性基团的直链或支链聚合物具有聚合物主链和任选的侧链，（c）任选分散的纳米颗粒，和（d）任选的低分子化合物，其特征在于玻璃离聚物组合物包含-SxH基团，其中x是1至6的整数，其中交联颗粒状玻璃和/或线性多元羧酸和/或任选的分散纳米颗粒和/或任选的低分子化合物。

7. 发明申请

WO2005094757A1 DENTAL SEALANT COMPOSITION FOR THE PROTECTION OF HARD TISSUE 审中-公开
标题翻译：用于保护硬组织的牙科密封剂组合物
公开(公告)号：WO2005094757A1
公开(公告)日：2005-10-13
申请号：PCT/EP2005/002410
申请日：2005-03-07
申请人： DENTSPLY DE TREY GMBH , KLEE, Joachim, E. , FACHER, Andreas , WEBER, Christoph , MÜLHAUPT, Rolf , SCHMIDER, Martin
发明人： KLEE, Joachim, E. , FACHER, Andreas , WEBER, Christoph , MÜLHAUPT, Rolf , SCHMIDER, Martin
IPC分类号： A61K6/087
CPC分类号： A61K6/087 , A61K6/093 , C08L83/16 , C08L79/02
摘要： A dental sealant composition for protection of an exposed dental surface, comprising a heatcurable step-growth polymerization system.
摘要翻译：一种用于保护暴露的牙齿表面的牙科密封剂组合物，其包括可热固化的步进增长聚合体系。

8. 发明申请

WO2005117804A1 DENTAL CEMENT WITH GRAFTED POLYACID COMPOSITE PARTICLES 审中-公开
标题翻译：具有接枝聚氨酯复合颗粒的牙膏
公开(公告)号：WO2005117804A1
公开(公告)日：2005-12-15
申请号：PCT/EP2005/003428
申请日：2005-04-01
申请人： DENTSPLY DETREY GMBH , KLEE, Joachim, E. , BRUGGER, Stefan , WEBER, Christoph , MÜLLER, Axel, H., E. , MORI, Hideharu
发明人： KLEE, Joachim, E. , BRUGGER, Stefan , WEBER, Christoph , MÜLLER, Axel, H., E. , MORI, Hideharu
IPC分类号： A61K6/08
CPC分类号： A61K6/0008 , A61K6/0835 , A61K6/093 , C08L83/10 , C08L33/00 , C08L25/04
摘要： A dental cement composition comprising (i) a particulate reactive inorganic filler capable of leaching metal ions in the presence of an acid, and (ii) composite particles with grafted polyacidic polymer chains, which are obtainable by a process comprising the following steps: (a) polymerizing one or more free radically polymerizable monomers containing optionally protected acidic groups in the presence of (a1) an initiatior system comprising initiator particles displaying a moiety comprising a radically transferable atom or group as a polymerization initiation site; and (a2) a catalyst facilitating controlled/living polymerisation, and (a3) optionally further polymerizable monomers, for forming a composite particle with grafted optionally protected polyacidic polymer chains; and (b) optionally deprotecting protected acidic groups, for forming composite particles with grafted polyacidic polymer chains.
摘要翻译：一种牙科水泥组合物，其包含（i）能够在酸存在下浸出金属离子的颗粒状反应性无机填料，和（ii）具有接枝多酸聚合物链的复合颗粒，其可通过包括以下步骤的方法获得：（a ）在（a1）包含引发颗粒的引发剂体系的存在下聚合含有任选保护的酸性基团的一种或多种可自由基聚合的单体，所述引发剂颗粒显示包含可自由基转移的原子或基团的部分作为聚合引发位点; 和（a2）促进受控/活性聚合的催化剂，和（a3）任选的其它可聚合单体，用于形成具有接枝的任选保护的多酸聚合物链的复合颗粒; 和（b）任选地去保护受保护的酸性基团，以形成具有接枝的多酸聚合物链的复合颗粒。

9. 发明申请

WO2012052161A1 DENTAL COMPOSITION 审中-公开
标题翻译：牙科成分
公开(公告)号：WO2012052161A1
公开(公告)日：2012-04-26
申请号：PCT/EP2011/005233
申请日：2011-10-18
申请人： DENTSPLY DE TREY GMBH , STELZIG, Simon , KLEE, Joachim, E. , FACHER, Andreas , WEBER, Christoph
发明人： STELZIG, Simon , KLEE, Joachim, E. , FACHER, Andreas , WEBER, Christoph
IPC分类号： A61K6/02 , A61K6/083 , C07C233/31 , C07C233/09
CPC分类号： A61K6/0091 , A61K6/0023 , A61K6/08 , A61K6/083 , A61K6/0835 , A61K6/087 , A61K6/09 , C07C231/02 , C08L33/00 , C08L75/16 , C08L33/10 , C07C233/38
摘要： Dental composition comprising (i) a particulate filler; (ii) a polymerizable hydrolysis-stable compound of the following formula (1) AX n wherein A is a linker group containing at least n nitrogen atoms and optionally one or more acidic groups, X are moieties containing a polymerizable double bond and forming an amide bond with a nitrogen atom of A, which X may be the same or different and are represented by the following formula (2) wherein R 1 and R 2 are independent from each other and represent a hydrogen atom, a C 1-6 alkyl group or a group -(CH 2 ) m -Z, wherein Z is COOM, OPO 3 M 2 , PO 3 M 2 , SO 3 M, and M is independently a hydrogen atom or a metal atom, and m is an integer of from 0 to 6, L is a bond, a C 1-6 alkylene group; and n is an integer of at least 1; provided that at least one X cannot be a (meth)acryl group; and (iii) an initiator system.
摘要翻译：牙科组合物，其包含（i）颗粒填料; （ii）下式（1）的可聚合水解稳定化合物AXn其中A是至少含有n个氮原子和任选一个或多个酸性基团的连接基团，X是含有可聚合双键并形成酰胺键的部分与A的氮原子一起，X可以相同或不同，并由下式（2）表示，其中R 1和R 2彼此独立地表示氢原子，C 1-6烷基或基团 - （CH2）mZ，其中Z是COOM，OPO3M2，PO3M2，SO3M和M独立地是氢原子或金属原子，m是0-6的整数，L是一个键，C1-6亚烷基 ; n为1以上的整数。条件是至少一个X不能是（甲基）丙烯酰基; 和（iii）引发剂体系。

10. 发明申请

WO2006010631A1 LASER CURABLE POLYMERISABLE DENTAL COMPOSITION 审中-公开
标题翻译：激光可固化聚合物牙科组合物
公开(公告)号：WO2006010631A1
公开(公告)日：2006-02-02
申请号：PCT/EP2005/008268
申请日：2005-07-29
申请人： DENTSPLY DE TREY GMBH , KLEE, Joachim , FACHER, Andreas , WEBER, Christoph , MÜLHAUPT, Rolf , SCHMIDER, Martin
发明人： KLEE, Joachim , FACHER, Andreas , WEBER, Christoph , MÜLHAUPT, Rolf , SCHMIDER, Martin
IPC分类号： A61K6/08
CPC分类号： A61K6/0017 , C08L33/00 , C08L63/00
摘要： One-component heat-curate sealant composition for the protection of exposed dental surfaces, comprising (a) a polymerisable monomer and/or oligomer which has at least two polymerizable douse bonds per molecule, and (b) an initiator system comprising benzoylperoxide in an amount of at least 2 wt.-% based on the total composition.
摘要翻译：用于保护暴露的牙齿表面的单组分热固化剂密封剂组合物，其包含（a）每分子具有至少两个可聚合的连接键的可聚合单体和/或低聚物，和（b）包含一定量的过氧化苯甲酰的引发剂体系至少为2重量％。

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