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    • 5. 发明申请
    • SELF-ADHESIVE DENTAL RESTORATIVE COMPOSITION
    • 自粘牙科复方组合物
    • WO2008095694A1
    • 2008-08-14
    • PCT/EP2008/000916
    • 2008-02-06
    • DENTSPLY DETREY GMBHKLEE, JoachimLEHMANN, UweGLANER, Anja
    • KLEE, JoachimLEHMANN, UweGLANER, Anja
    • A61K6/00A61K6/083
    • A61K6/0073A61K6/0017A61K6/083
    • Self-adhesive dental restorative composition comprising (i) 10 to 40 percent by weight based on the total weight of the composition of a mixture of hydrolysis-stable polymerizable monomers of the following formula (I): wherein R is a m+n valent organic group having 1 to 20 carbon atoms and optionally 1 to 5 atoms selected from the group of nitrogen, oxygen and sulfur atoms; A independently represents a moiety of the following formula (II): wherein L is a hydrogen atom, a C 1-6 alkyl group, a C 3-8 cycloalkyl group, a C 6-14 aryl group or a group of the following formula (III) wherein R' is a hydrogen atom, a C 1-6 alkyl group, a C 3-8 cycloalkyl group, or a C 6-14 aryl group; X is O, S, NH or NR" wherein R" is a C 1-6 alkyl group, a C 3-8 cycloalkyl group, a C 6-14 aryl group; a is 0 or 1; M is a group of the following formula (IV) wherein Y is O, S, NH or NR'" wherein R'" is a C 1-6 alkyl group, a C 3-8 cycloalkyl group, a C 6-14 aryl group; b is an integer of from O to 3; c is O or 1; d is an integer of from O to 3; provided that when b is O, then Y cannot be O; x is 0 or 1; y is 0 or 1; provided that x and y cannot be both 1, and provided that x cannot be 1 when L or a group of formula (III) is a hydrogen atom, and provided that when x is 0 then a is also 0, and provided that when y is 0 then b is greater than 0 or c is 0; B independently represents an acidic group; m is an integer of from 1 to 5; n is an integer of 0 to 3; and m+n is at least 2; (ii) 60 to 90 percent by weight based on the total weight of the composition of a filler; and (iii) an initiator system; wherein the portion of monomers of formula (I) wherein n is greater than 0 is at least 1 percent by weight based on the total weight of the mixture.
    • 自粘牙科修复组合物,其包含(i)基于组合物总重量的10至40重量%的下式(I)的水解稳定的可聚合单体的混合物:其中R是m + n价有机 具有1至20个碳原子和任选1至5个选自氮,氧和硫原子的原子的基团; A独立地表示下式(II)的部分:其中L是氢原子,C 1-6烷基,C 3-8环烷基, C 6-14芳基或下式(III)的基团,其中R'是氢原子,C 1-6烷基,C 1 -C 6烷基, 或者C 6-14芳基;或者C 6-14芳基; X是O,S,NH或NR“,其中R”是C 1-6烷基,C 3〜8个环烷基,C 6 -14芳基; a是0或1; M是下式(Ⅳ)的基团,其中Y是O,S,NH或NR'“,其中R'”是C 1-6烷基,C 3〜 8个环烷基,C 6-14芳基; b为0〜3的整数; c为O或1; d为0〜3的整数; 条件是当b为O时,则Y不能为O; x为0或1; y为0或1; 条件是x和y不能都是1,并且当L或式(III)的基团是氢原子时x不能为1,并且条件是当x为0时,a也为0,条件是当y 是0,那么b大于0或c是0; B独立地表示酸性基团; m为1〜5的整数, n为0〜3的整数, m + n为2以上。 (ii)60至90重量%,基于组合物的填料的总重量; 和(iii)引发剂体系; 其中n大于0的式(I)单体部分相对于混合物的总重量为至少1重量%。