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    • 1. 发明申请
    • DENTAL ADHESIVE
    • 牙科用粘合剂
    • WO2007045303A1
    • 2007-04-26
    • PCT/EP2006/008612
    • 2006-09-04
    • DENTSPLY DE TREY GMBHKLEE, Joachim, E.LEHMANN, Uwe
    • KLEE, Joachim, E.LEHMANN, Uwe
    • A61K6/00A61K6/083
    • A61K6/0029A61K6/0023C08L33/26C08L43/02
    • A one-part self-etching, self-priming dental adhesive having a pH of at most 2, which comprises an aqueous mixture containing (i) one or more polymerizable monomers optionally containing an acidic group, (ii) optionally one or more organic or inorganic acids, (iii) a polymerization initiator, and (iv) a thermal Polymerisation inhibitor of the following formula (I): wherein R’ 1 represents a hydrogen atom, or a saturated hydrocarbon group having 1 to 18 carbon atoms. R' 2 , which may be the same or different if more than one R' 2 is present, independently represent a saturated hydrocarbon group having 1 to 18 carbon atoms, and c represents an integer of from 1 to 4.
    • 一种pH为至多2的单部分自蚀刻自吸牙科粘合剂,其包含含水混合物,所述混合物含有(i)一种或多种任选含有酸性基团的可聚合单体,( ii)任选的一种或多种有机或无机酸,(iii)聚合引发剂,和(iv)下式(I)的热聚合抑制剂:其中R'1表示氢原子, 或具有1至18个碳原子的饱和烃基。 如果多于一个R'2存在,则R 2 2可以相同或不同,独立地表示具有1至18个碳原子的饱和烃基,并且c 代表一个从1到4的整数。
    • 2. 发明申请
    • A POYMERIZABLE PHOSPHORIC ACID ESTER DERIVATIVE AND A DENTAL COMPOSITION EMPLOYING IT.
    • 一种可磷化的磷酸酯衍生物和一种使用它的牙齿组合物。
    • WO2004078100A2
    • 2004-09-16
    • PCT/EP2004/002289
    • 2004-03-05
    • DENTSPLY DE TREY GMBHKLEE, Joachim, E.LEHMANN, UweWALZ, UweLIU, Huaibing
    • KLEE, Joachim, E.LEHMANN, UweWALZ, UweLIU, Huaibing
    • A61K
    • A61K6/083A61K6/0023C07F9/091C07F9/093C08F30/02C08L43/02C08L33/00
    • The present invention provides a polymerizable phosphoric acid ester derivative having the following formula (A): wherein Z is COOR 1 , COSR 1 , CON(R 1 ) 2 , CONR 1 R 2 , or CONHR 1 , R 1 and R 2 independently are a hydrogen atom, a substituted or unsubstituted C 1 to C 18 alkyl group optionally substituted by a C 3 to C 8 cycloalkyl group, a substituted or unsubstituted C 3 to C 8 cycloalkyl group, a substituted or unsubstituted C 4 to C, 18 aryl or heteroaryl group, a substituted or unsubstituted C 5 to C 18 alkylaryl or alkylheteroaryl group, or a substituted or unsubstituted C 7 to C 30 aralkyl group, whereby two R 1 residues may form together with the N-atom to which they are bonded a 5- to 7-membered heterocyclic ring which may contain beside said N-atom a further nitrogen atom or an oxygen atom, and whereby the substituted groups may be substituted by 1 to 5 C 1 to C 5 alkyl group(s); a is an integer of from 1 to 10, preferably 1 to 5; b is an integer of from 1 to 10, preferably 1 to 5; and R represents an organic residue containing a + b carbon atoms selected from primary and secondary aliphatic carbon atoms, secondary alicyclic carbon atoms, and aromatic carbon atoms, each of said carbon atoms linking a phosphate or 2-(oxa-ethyl)acryl derivative group.
    • 本发明提供具有下式(A)的可聚合磷酸酯衍生物:其中Z为COOR1,COSR1,CON (R 1)2,CONR 1 R 2或CONHR 1,其中R 1,R 2, R 1和R 2独立地为氢原子,取代或未取代的C 1至C 18烷基 任选被C 3-8 C 1-8环烷基取代,取代或未取代的C 3-8 C 1-8环烷基 基团,取代或未取代的C 4至C 18芳基或杂芳基,取代或未取代的C 5至C 18 烷基芳基或烷基杂芳基,或者取代或未取代的C7-C30芳烷基,其中两个R 1残基可以形成 与它们所键合的N原子一起形成5至7元杂环,其可以在所述N原子旁边含有 另外的氮原子或氧原子,并且其中所述取代的基团可以被1至5个C 1至C 5的烷基取代;并且其中所述取代的基团可以被1至5个C 1至C 5的烷基取代。 a是1至10的整数,优选1至5; b是1至10的整数,优选1至5; R表示选自伯和仲脂族碳原子,仲脂环碳原子和芳族碳原子的含有α+β碳原子的有机残基,每个所述碳原子 连接磷酸酯或2-(氧杂 - 乙基)丙烯酰基衍生物基团。
    • 3. 发明申请
    • DENTAL ADHESIVE COMPOSITION
    • 牙膏组合物
    • WO2008043518A1
    • 2008-04-17
    • PCT/EP2007/008764
    • 2007-10-09
    • DENTSPLY DE TREY GMBHKLEE, Joachim, E.LEHMANN, Uwe
    • KLEE, Joachim, E.LEHMANN, Uwe
    • A61K6/00A61K6/083C07F9/09C08F30/02
    • C07F9/12A61K6/0023C07F9/091C07F9/093C08F216/125C08F220/58C08F222/385C08F230/02C08L43/02C08L33/00
    • Dental composition comprising an aqueous mixture containing: i) a polymerizable acidic phosphoric acid ester monomer of the following formula (A): wherein a is an integer of from 1 to 10; R 1 represents a hydrogen atom or a moiety of the following formula (Y) wherein X independently represent an oxygen atom, a sulfur atom, or a group NR, wherein R may be a hydrogen atom, a C 1-6 alkyl group or an acyl group; L represents an (a+6)-valent organic residue containing 1 to 20 carbon atoms and optionally including ether, thioether or amino groups or further acidic groups, whereby the carbon atoms comprise at least a + b carbon atoms selected from primary and secondary aliphatic carbon atoms, secondary alicyclic carbon atoms, and aromatic carbon atoms, each of said a+b carbon atoms linking a phosphate or 2-(oxaallyl) derivative group; b is an integer of from 1 to 10; R 2 which may be the same or different, independently may be hydrogen, an allyl group or a moiety R 1 wherein b is 1; provided that at least one of R 1 and R 2 is not hydrogen; ii) one or more polymerizable N-substituted alkyl acrylic or acrylic acid amide monomers; iii) an organic water-miscible solvent and/or water; iv) a polymerization initiator; v) an inhibitor and/or a stabilizer; vi) optionally an organic or inorganic acid; and vii) optionally a filler and/or a fluoride releasing compound.
    • 1.含有下列式(A)的可聚合酸性磷酸酯单体:其中a为1〜10的整数的含水混合物; R 1表示氢原子或下式(Y)的部分,其中X独立地表示氧原子,硫原子或基团NR,其中R可以是氢原子,C C 1-6烷基或酰基; L表示含有1至20个碳原子的(a + 6)有机残基,并且任选地包括醚,硫醚或氨基或另外的酸性基团,由此碳原子包含至少一个选自伯和仲脂族 碳原子,仲脂环碳原子和芳族碳原子,所述a + b个碳原子各自连接磷酸酯或2-(氧杂烯丙基)衍生物基团; b为1〜10的整数, R 2可以相同或不同,独立地可以是氢,烯丙基或部分R 1,其中b是1; 条件是R 1和R 2中的至少一个不是氢; ii)一种或多种可聚合的N-取代的烷基丙烯酸或丙烯酸酰胺单体; iii)有机水混溶性溶剂和/或水; iv)聚合引发剂; v)抑制剂和/或稳定剂; vi)任选的有机或无机酸; 和vii)任选的填料和/或释放氟的化合物。